Internetquellen:
www.onmeda.de/lexika/strahlenmedizin www.institut‐heidger.de
Sonstige Quellen:
Aboussekhra, A., M. Biggerstaff, M. K. Shivji, J. A. Vilpo, V. Moncollin, V. N. Podust, M. Protic, U. Hubscher, J. M. Egly and R. D. Wood. 1995. Mammalian DNA nucleotide excision repair reconstituted with purified protein components. Cell 80:859‐868.
Abraham, R. T. 2001. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15:2177‐2196.
Adams, K. E., A. L. Medhurst, D. A. Dart and N. D. Lakin. 2006. Recruitment of ATR to sites of ionising radiation‐induced DNA damage requires ATM and components of the MRN protein complex. Oncogene 25:3894‐3904.
Adams, M. M. and P. B. Carpenter. 2006. Tying the loose ends together in DNA double strand break repair with 53BP1.
Cell Div. 1:19.
Allan, L. A. and M. Fried. 1999. p53‐dependent apoptosis or growth arrest induced by different forms of radiation in U2OS cells: p21WAF1/CIP1 repression in UV induced apoptosis. Oncogene 18:5403‐5412.
Al Mohanna, M.A., F.M. Al Khodairy, Z. Krezolek, P.A. Bertilsson, K.A. Al Houssein and A. Aboussekhra. 2001. p53 is dispensable for UV‐induced cell cycle arrest at late G(1) in mammalian cells. Carcinogenesis, 22, 573‐578.
Amouroux, R., A. Campalans, B. Epe and J. P. Radicella. 2010. Oxidative stress triggers the preferential assembly of base excision repair complexes on open chromatin regions. Nucleic Acids Res. 38:2878‐2890.
Aprelikova, O., A. J. Pace, B. Fang, B. H. Koller and E. T. Liu. 2001. BRCA1 is a selective co‐activator of 14‐3‐3 sigma gene transcription in mouse embryonic stem cells. J. Biol. Chem. 276:25647‐25650.
Araujo, S. J., F. Tirode, F. Coin, H. Pospiech, J. E. Syvaoja, M. Stucki, U. Hubscher, J. M. Egly and R. D. Wood. 2000. Nuc‐
leotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK. Genes Dev. 14:349‐359.
Attardi, L. D., A. de Vries and T. Jacks. 2004. Activation of the p53‐dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer. Oncogene 23:973‐980.
Avantaggiati, M. L., V. Ogryzko, K. Gardner, A. Giordano, A. S. Levine and K. Kelly. 1997. Recruitment of p300/CBP in p53‐dependent signal pathways. Cell 89:1175‐1184.
Bakkenist, C. J. and M. B. Kastan. 2003. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421:499‐506.
Barnes, D. E. and T. Lindahl. 2004. Repair and genetic consequences of endogenous DNA base damage in mammalian cells. Annu. Rev. Genet. 38:445‐476.
Bartek, J. and J. Lukas. 2001. Mammalian G1‐ and S‐phase checkpoints in response to DNA damage. Curr. Opin. Cell Biol.
13:738‐747.
Bartek, J. and J. Lukas. 2001. Pathways governing G1/S transition and their response to DNA damage. FEBS Lett. 490:117‐
122.
Bartek, J., C. Lukas and J. Lukas. 2004. Checking on DNA damage in S phase. Nat. Rev. Mol. Cell Biol. 5:792‐804.
Bassett, E., N. M. King, M. F. Bryant, S. Hector, L. Pendyala, S. G. Chaney and M. Cordeiro‐Stone. 2004. The role of DNA polymerase eta in translesion synthesis past platinum‐DNA adducts in human fibroblasts. Cancer Res. 64:6469‐6475.
Batista,L.F., B. Kaina, R. Meneghini and C.F. Menck. 2009. How DNA lesions are turned into powerful killing structures:
insights from UV‐induced apoptosis. Mutat. Res., 681, 197‐208.
Batty, D. P. and R. D. Wood. 2000. Damage recognition in nucleotide excision repair of DNA. Gene 241:193‐204.
Baumann, P., F. E. Benson and S. C. West. 1996. Human Rad51 protein promotes ATP‐dependent homologous pairing and strand transfer reactions in vitro. Cell 87:757‐766.
Beamish, H., R. Williams, P. Chen and M. F. Lavin. 1996. Defect in multiple cell cycle checkpoints in ataxia‐telangiectasia postirradiation. J. Biol. Chem. 271:20486‐20493.
Bekker‐Jensen, S., C. Lukas, F. Melander, J. Bartek and J. Lukas. 2005. Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1. J. Cell Biol. 170:201‐211.
Seite 165
Bekker‐Jensen, S., C. Lukas, R. Kitagawa, F. Melander, M. B. Kastan, J. Bartek and J. Lukas. 2006. Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J. Cell Biol. 173:195‐206.
Bertani, G. 1951. Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. J. Bacteriol., 62, 293‐300.
Bertrand‐Vallery, V., N. Belot, M. Dieu, E. Delaive, N. Ninane, C. Demazy, M. Raes, M. Salmon, Y. Poumay, F. Debacq‐
Chainiaux and O. Toussaint. 2010. Proteomic profiling of human keratinocytes undergoing UVB‐induced alternative diffe‐
rentiation reveals TRIpartite Motif Protein 29 as a survival factor. PLoS. One., 5, e10462.
Beucher, A., J. Birraux, L. Tchouandong, O. Barton, A. Shibata, S. Conrad, A. A. Goodarzi, A. Krempler, P. A. Jeggo and M.
Lobrich. 2009. ATM and Artemis promote homologous recombination of radiation‐induced DNA double‐strand breaks in G2. EMBO J., 28, 3413‐3427.
Beukers, R. and W. Berends. 1960. Isolation and identification of the irradiation product of thymine. Biochim. Biophys.
Acta 41:550‐551.
Birnboim, H.C. and J. Doly. 1979. A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res. 7:1513‐1523.
Blackwell, L. J., D. Martik, K. P. Bjornson, E. S. Bjornson and P. Modrich. 1998. Nucleotide‐promoted release of hMutSal‐
pha from heteroduplex DNA is consistent with an ATP‐dependent translocation mechanism. J. Biol. Chem. 273:32055‐
32062.
Blomen, V. A. and J. Boonstra. 2007. Cell fate determination during G1 phase progression. Cell Mol. Life Sci. 64:3084‐
3104.
Boag, J. W. and W. W. Seelentag. 1975. A general saturation curve for an ionization chamber filled with nitrogen at pres‐
sures up to 8 atmospheres. Phys. Med. Biol., 20, 624‐626.
Boder, E. 1975. Ataxia‐telangiectasia: some historic, clinical and pathologic observations. Birth DefectsOrigArtic Ser 11 (1), 255‐270.
Bodnar, A. G., M. Ouellette, M. Frolkis, S. E. Holt, C. P. Chiu, G. B. Morin, C. B. Harley, J. W. Shay, S. Lichtsteiner and W.
E. Wright. 1998. Extension of life‐span by introduction of telomerase into normal human cells. Science 279:349‐352.
Bohr, V. A., C. A. Smith, D. S. Okumoto and P. C. Hanawalt. 1985. DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall. Cell 40:359‐369.
Bomgarden, R. D., P. J. Lupardus, D. V. Soni, M. C. Yee, J. M. Ford and K. A. Cimprich. 2006. Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling. EMBO J. 25:2605‐2614.
Boonstra, J. 2003. Progression through the G1‐phase of the on‐going cell cycle. J. Cell Biochem., 90, 244‐252.
Boonstra, J. 2007. Identification of a restriction point at the M/G1 transition during the ongoing cell cycle. Adv. Enzyme Regul., 47, 208‐221.
Bravo, R., R. Frank, P. A. Blundell and H. Macdonald‐Bravo. 1987. Cyclin/PCNA is the auxiliary protein of DNA polyme‐
rase‐delta. Nature 326:515‐517.
Brendler‐Schwaab, S., A. Czich, B. Epe, E. Gocke, B. Kaina, L. Muller, D. Pollet and D. Utesch. 2004. Photochemical geno‐
toxicity: principles and test methods. Report of a GUM task force. Mutat. Res. 566:65‐91.
Brown, E. J. and D. Baltimore. 2003. Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance.
Genes Dev. 17:615‐628.
Brown, K. D., C. Barlow and A. Wynshaw‐Boris. 1999. Multiple ATM‐dependent pathways: an explanation for pleiotropy.
Am. J. Hum. Genet. 64:46‐50.
Buck, D., L. Malivert, R. de Chasseval, A. Barraud, M. C. Fondaneche, O. Sanal, A. Plebani, J. L. Stephan, M. Hufnagel, F.
le Deist, A. Fischer, A. Durandy, J. P. de Villartay and P. Revy. 2006. Cernunnos, a novel nonhomologous end‐joining factor, is mutated in human immunodeficiency with microcephaly. Cell 124:287‐299.
Bulavin, D. V., Y. Higashimoto, I. J. Popoff, W. A. Gaarde, V. Basrur, O. Potapova, E. Appella and A. J. Fornace, Jr. 2001.
Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature 411:102‐107.
Bullock, W. O., J. M. Fernandez and J. M. Short. 1987. Biotechniques 5(4):376–378.
Burdak‐Rothkamm, S., K. Rothkamm and K. M. Prise. 2008. ATM acts downstream of ATR in the DNA damage response signaling of bystander cells. Cancer Res. 68:7059‐7065.
Burma, S., B. P. Chen, M. Murphy, A. Kurimasa and D. J. Chen. 2001. ATM phosphorylates histone H2AX in response to DNA double‐strand breaks. J. Biol. Chem. 276:42462‐42467.
Callegari, A. J. and T. J. Kelly. 2007. Shedding light on the DNA damage checkpoint. Cell Cycle 6:660‐666.
Cann, K. L. and G. G. Hicks. 2006. Absence of an immediate G1/S checkpoint in primary MEFs following gamma‐irradiation identifies a novel checkpoint switch. Cell Cycle 5:1823‐1830.
Cardoso, M.C., C. Joseph, H.P. Rahn, R. Reusch, B. Nadal‐Ginard and H. Leonhardt. 1997. Mapping and use of a sequence that targets DNA ligase I to sites of DNA replication in vivo. J. Cell Biol., 139, 579‐587.
Carnero, A. and G. J. Hannon. 1998. The INK4 family of CDK inhibitors. Curr. Top. Microbiol. Immunol. 227:43‐55.
Celis, J. E. and A. Celis. 1985. Cell cycle‐dependent variations in the distribution of the nuclear protein cyclin proliferating cell nuclear antigen in cultured cells: subdivision of S phase. Proc. Natl. Acad. Sci. U. S. A 82:3262‐3266.
Celis, J. E. and P. Madsen. 1986. Increased nuclear cyclin/PCNA antigen staining of non S‐phase transformed human am‐
nion cells engaged in nucleotide excision DNA repair. FEBS Lett. 209:277‐283.
Chang, D. K., L. Ricciardiello, A. Goel, C. L. Chang and C. R. Boland. 2000. Steady‐state regulation of the human DNA mismatch repair system. J. Biol. Chem. 275:18424‐18431.
Chehab, N. H., A. Malikzay, M. Appel and T. D. Halazonetis. 2000. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev. 14:278‐288.
Chernov, M. V., C. V. Ramana, V. V. Adler and G. R. Stark. 1998. Stabilization and activation of p53 are regulated inde‐
pendently by different phosphorylation events. Proc. Natl. Acad. Sci. U. S. A 95:2284‐2289.
Chung, C. T., S. L. Niemela and R. H. Miller, 1989. One‐Step Preparation of Competent Escherichia Coli: Transformation and Storage of Bacterial Cells in the Same Solution Proc. Natl. Acad. Sci. USA, 86: 2172‐2175.
Clauß, M., R. Mannesmann and A. Kolch. 2005. Photoreactivation of Escherichia coli and Yersinia enterolytica after Irrad‐
iation with a 222 nm Excimer Lamp Compared to a 254 nm Low‐pressure Mercury Lamp. Published Online: 579‐584.
Cliby, W. A., C. J. Roberts, K. A. Cimprich, C. M. Stringer, J. R. Lamb, S. L. Schreiber and S. H. Friend. 1998. Overexpres‐
sion of a kinase‐inactive ATR protein causes sensitivity to DNA‐damaging agents and defects in cell cycle checkpoints.
EMBO J. 17:159‐169.
Cobrinik, D. 1996. Regulatory interactions among E2Fs and cell cycle control proteins. Curr. Top. Microbiol. Immunol.
208:31‐61.
Coin, F., V. Oksenych and J. M. Egly. 2007. Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair. Mol. Cell 26:245‐256.
Collins, K., T. Jacks and N. P. Pavletich. 1997. The cell cycle and cancer. Proc. Natl. Acad. Sci. U. S. A 94:2776‐2778.
Coltrera, M.D. and A.M. Gown. 1991. PCNA/cyclin expression and BrdU uptake define different subpopulations in differ‐
ent cell lines. J. Histochem. Cytochem., 39, 23‐30.
Coons, A. H. and M. H. Kaplan. 1950. Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. J. Exp. Med., 91, 1‐13.
Cornforth, M. N. and J. S. Bedford. 1993. Ionizing Radiation Damage and Its Early Development in Chromosomes. Ad‐
vances in Radiation Biology, Vol.17, 423‐489.
Cortez, D., Y. Wang, J. Qin and S. J. Elledge. 1999. Requirement of ATM‐dependent phosphorylation of brca1 in the DNA damage response to double‐strand breaks. Science 286:1162‐1166.
Cortez, D., S. Guntuku, J. Qin and S. J. Elledge. 2001. ATR and ATRIP: partners in checkpoint signaling. Science 294:1713‐
1716.
Costanzo, V., K. Robertson, C. Y. Ying, E. Kim, E. Avvedimento, M. Gottesman, D. Grieco and J. Gautier. 2000. Reconsti‐
tution of an ATM‐dependent checkpoint that inhibits chromosomal DNA replication following DNA damage. Mol. Cell 6:649‐659.
D'Errico, M., M. Teson, A. Calcagnile, D. S. Proietti, O. Nikaido, E. Botta, G. Zambruno, M. Stefanini and E. Dogliotti.
2003. Apoptosis and efficient repair of DNA damage protect human keratinocytes against UVB. Cell Death. Differ. 10:754‐
756.
Da Silva, L. F. and B. P. Duncker. 2007. ORC function in late G1: maintaining the license for DNA replication. Cell Cycle 6:128‐130.
Dahm‐Daphi, J., C. Sass and W. Alberti. 2000. Comparison of biological effects of DNA damage induced by ionizing radia‐
tion and hydrogen peroxide in CHO cells. Int. J. Radiat. Biol. 76:67‐75.
Dai, Y., B. Kysela, L. A. Hanakahi, K. Manolis, E. Riballo, M. Stumm, T. O. Harville, S. C. West, M. A. Oettinger and P. A.
Jeggo. 2003. Nonhomologous end joining and V(D)J recombination require an additional factor. Proc. Natl. Acad. Sci. U. S.
A 100:2462‐2467.
Seite 167
Dash, B. C. and W. S. El Deiry. 2005. Phosphorylation of p21 in G2/M promotes cyclin B‐Cdc2 kinase activity. Mol. Cell Biol. 25:3364‐3387.
de Toledo, S. M., E. I. Azzam, W. K. Dahlberg, T. B. Gooding and J. B. Little. 2000. ATM complexes with HDM2 and pro‐
motes its rapid phosphorylation in a p53‐independent manner in normal and tumor human cells exposed to ionizing radia‐
tion. Oncogene 19:6185‐6193.
DeCaprio, J. A., Y. Furukawa, F. Ajchenbaum, J. D. Griffin and D. M. Livingston. 1992. The retinoblastoma‐susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression. Proc. Natl. Acad. Sci. U.
S. A 89:1795‐1798.
Deckbar, D., J. Birraux, A. Krempler, L. Tchouandong, A. Beucher, S. Walker, T. Stiff, P. Jeggo and M. Lobrich. 2007.
Chromosome breakage after G2 checkpoint release. J. Cell Biol. 176:749‐755.
Deckbar, D., T. Stiff, B. Koch, C. Reis, M. Lobrich and P. A. Jeggo. 2010. The limitations of the G1‐S checkpoint. Cancer Res. 70:4412‐4421.
Demple, B. and S. Linn. 1982. 5,6‐Saturated thymine lesions in DNA: production by ultraviolet light or hydrogen peroxide.
Nucleic Acids Res. 10:3781‐3789.
Di Leonardo, A., S. P. Linke, K. Clarkin and G. M. Wahl. 1994. DNA damage triggers a prolonged p53‐dependent G1 arrest and long‐term induction of Cip1 in normal human fibroblasts. Genes Dev. 8:2540‐2551.
Dikomey, E. and J. Franzke. 1986. DNA repair kinetics after exposure to X‐irradiation and to internal beta‐rays in CHO cells. Radiat. Environ. Biophys. 25:189‐194.
Doetsch, P. W., T. H. Zasatawny, A. M. Martin and M. Dizdaroglu. 1995. Monomeric base damage products from ade‐
nine, guanine, and thymine induced by exposure of DNA to ultraviolet radiation. Biochemistry 34:737‐742.
Dore, A. S., M. L. Kilkenny, N. J. Rzechorzek and L. H. Pearl. 2009. Crystal structure of the rad9‐rad1‐hus1 DNA damage checkpoint complex‐‐implications for clamp loading and regulation. Mol. Cell 34:735‐745.
Douki, T. and J. Cadet. 2001. Individual determination of the yield of the main UV‐induced dimeric pyrimidine photopro‐
ducts in DNA suggests a high mutagenicity of CC photolesions. Biochemistry 40:2495‐2501.
Drapkin, R., J. T. Reardon, A. Ansari, J. C. Huang, L. Zawel, K. Ahn, A. Sancar and D. Reinberg. 1994. Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II. Nature 368:769‐772.
Dulic, V., G. H. Stein, D. F. Far and S. I. Reed. 1998. Nuclear accumulation of p21Cip1 at the onset of mitosis: a role at the G2/M‐phase transition. Mol. Cell Biol. 18:546‐557.
Dyson, N. 1998. The regulation of E2F by pRB‐family proteins. Genes Dev. 12:2245‐2262.
Easwaran, H. P., H. Leonhardt and M. C. Cardoso. 2005. Cell cycle markers for live cell analyses. Cell Cycle 4:453‐455.
Ehmann, U. K., K. H. Cook and E. C. Friedberg. 1978. The kinetics of thymine dimer excision in ultraviolet‐irradiated hu‐
man cells. Biophys. J. 22:249‐264.
Falck, J., N. Mailand, R. G. Syljuasen, J. Bartek and J. Lukas. 2001. The ATM‐Chk2‐Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature, 410, 842‐847.
Falck, J., J. H. Petrini, B. R. Williams, J. Lukas and J. Bartek. 2002. The DNA damage‐dependent intra‐S phase checkpoint is regulated by parallel pathways. Nat. Genet. 30:290‐294.
Falck, J., J. Coates and S. P. Jackson. 2005. Conserved modes of recruitment of ATM, ATR and DNA‐PKcs to sites of DNA damage. Nature 434:605‐611.
Feng, Z., W. Hu, L. A. Chasin and M. S. Tang. 2003. Effects of genomic context and chromatin structure on transcription‐
coupled and global genomic repair in mammalian cells. Nucleic Acids Res. 31:5897‐5906.
Fernandez‐Capetillo, O., H. T. Chen, A. Celeste, I. Ward, P. J. Romanienko, J. C. Morales, K. Naka, Z. Xia, R. D. Camerini‐
Otero, N. Motoyama, P. B. Carpenter, W. M. Bonner, J. Chen and A. Nussenzweig. 2002. DNA damage‐induced G2‐M checkpoint activation by histone H2AX and 53BP1. Nat. Cell Biol. 4:993‐997.
Fohe, C. and E. Dikomey. 1994. Induction and repair of DNA base damage studied in X‐irradiated CHO cells using the M.
luteus extract. Int. J. Radiat. Biol. 66:697‐704.
Fousteri, M. and L. H. Mullenders. 2008. Transcription‐coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects. Cell Res. 18:73‐84.
Franchitto, A., P. Pichierri, P. Mosesso and F. Palitti. 1998. Caffeine effect on the mitotic delay induced by G2 treatment with UVC or mitomycin C. Mutagenesis 13:499‐505.
Friedberg, E. C., G. C. Walker and W. Siede. 1995. DNA Repair and Mutagenesis. American Society for Microbiology Press, Washington, DC.
Friedberg, E. C., A. Aguilera, M. Gellert, P. C. Hanawalt, J. B. Hays, A. R. Lehmann, T. Lindahl, N. Lowndes, A. Sarasin and R. D. Wood. 2006. DNA repair: from molecular mechanism to human disease. DNA Repair (Amst), 5, 986‐996.
Friedberg E. C., G. C. Walker, W. Siede, R. D. Wood, R. A. Schultz, T. Ellenberger. 2006. DNA Repair and Mutagenesis, ASM Press, 2nd Edition
Frigault, M. M., J. Lacoste, J. L. Swift and C. M. Brown. 2009. Live‐cell microscopy ‐ tips and tools. J. Cell Sci. 122:753‐767.
Gadbois, D. M. and B. E. Lehnert. 1997. Temporal position of G1 arrest in normal human fibroblasts after exposure to gamma‐rays. Exp. Cell Res. 232:161‐166.
Gary, R., D. L. Ludwig, H. L. Cornelius, M. A. MacInnes and M. S. Park. 1997. The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA‐binding regions of FEN‐1 and cyc‐
lin‐dependent kinase inhibitor p21. J. Biol. Chem., 272, 24522‐24529.
Gatei, M., K. Sloper, C. Sorensen, R. Syljuasen, J. Falck, K. Hobson, K. Savage, J. Lukas, B. B. Zhou, J. Bartek and K. K.
Khanna. 2003. Ataxia‐telangiectasia‐mutated (ATM) and NBS1‐dependent phosphorylation of Chk1 on Ser‐317 in re‐
sponse to ionizing radiation. J. Biol. Chem. 278:14806‐14811.
Gatti, R. A., I. Berkel, E. Boder, G. Braedt, P. Charmley, P. Concannon, F. Ersoy, T. Foroud, N. G. Jaspers and K. Lange.
1988. Localization of an ataxia‐telangiectasia gene to chromosome 11q22‐23. Nature, 336, 577‐580.
Gellert, M., J. E. Hesse, K. Hiom, M. Melek, M. Modesti, T. T. Paull, D. A. Ramsden and D. C. van Gent. 1999. V(D)J re‐
combination: links to transposition and double‐strand break repair. Cold Spring Harb. Symp. Quant. Biol. 64:161‐167.
Gellert, M. 2002. V(D)J recombination: RAG proteins, repair factors, and regulation. Annu. Rev. Biochem. 71:101‐132.
Gerber, B., P. Mathys, M. Moser, D. Bressoud and C. Braun‐Fahrlander. 2002. Ultraviolet emission spectra of sunbeds.
Photochem. Photobiol. 76:664‐668.
Giannattasio, M., F. Lazzaro, M. P. Longhese, P. Plevani and M. Muzi‐Falconi. 2004. Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint. EMBO J. 23:429‐438.
Gilbert, D. M. 2001. Making sense of eukaryotic DNA replication origins. Science 294:96‐100.
Gillet, L. C. and O. D. Scharer. 2006. Molecular mechanisms of mammalian global genome nucleotide excision repair.
Chem. Rev. 106:253‐276.
Girard, F., U. Strausfeld, A. Fernandez and N. J. Lamb. 1991. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell 67:1169‐1179.
Goetz, J. D., T. A. Motycka, M. Han, M. Jasin and A. E. Tomkinson. 2005. Reduced repair of DNA double‐strand breaks by homologous recombination in a DNA ligase I‐deficient human cell line. DNA Repair (Amst), 4, 649‐654.
Goldberg, M., M. Stucki, J. Falck, D. D'Amours, D. Rahman, D. Pappin, J. Bartek and S. P. Jackson. 2003. MDC1 is re‐
quired for the intra‐S‐phase DNA damage checkpoint. Nature 421:952‐956.
Goodship, J., H. Gill, J. Carter, A. Jackson, M. Splitt and M. Wright. 2000. Autozygosity mapping of a seckel syndrome locus to chromosome 3q22. 1‐q24. Am. J. Hum. Genet. 67:498‐503.
Gorisch, S. M., A. Sporbert, J. H. Stear, I. Grunewald, D. Nowak, E. Warbrick, H. Leonhardt and M. C. Cardoso. 2008.
Uncoupling the replication machinery: replication fork progression in the absence of processive DNA synthesis. Cell Cycle 7:1983‐1990.
Gradia, S., S. Acharya and R. Fishel. 1997. The human mismatch recognition complex hMSH2‐hMSH6 functions as a novel molecular switch. Cell 91:995‐1005.
Grallert, B. and E. Boye. 2008. The multiple facets of the intra‐S checkpoint. Cell Cycle 7:2315‐2320.
Greener, A. 1990. Strategies 3(1):5–6
Griffiths, T. D. and S. Y. Ling. 1989. Effects of UV light on DNA chain growth and replicon initiation in human cells. Mutat.
Res. 218:87‐94.
Grimes, B. R., J. Babcock, M. K. Rudd, B. Chadwick and H. F. Willard. 2004. Assembly and characterization of heteroch‐
romatin and euchromatin on human artificial chromosomes. Genome Biol. 5:R89.
Gu, W. and R. G. Roeder. 1997. Activation of p53 sequence‐specific DNA binding by acetylation of the p53 C‐terminal domain. Cell 90:595‐606.
Gutierrez, G. J., T. Tsuji, J. V. Cross, R. J. Davis, D. J. Templeton, W. Jiang and Z. A. Ronai. 2010. JNK‐mediated phosphory‐
lation of Cdc25C regulates cell cycle entry and G2/M DNA damage checkpoint. J. Biol. Chem.
Halicka, H. D., X. Huang, F. Traganos, M. A. King, W. Dai and Z. Darzynkiewicz. 2005. Histone H2AX phosphorylation after cell irradiation with UV‐B: relationship to cell cycle phase and induction of apoptosis. Cell Cycle 4:339‐345.
Seite 169
Hall, E. J. and A. J. Giaccia. 2006. Radiobiology for the Radiologist. 6. Auflage
Hall, A. G. and M. J. Tilby. 1992. Mechanisms of action of, and modes of resistance to, alkylating agents used in the treatment of haematological malignancies. Blood Rev. 6:163‐173.
Hanahan, D. 1983. Studies on tranformation of E.coli with plasmids. J. Mol. Biol. 166:557‐580
Hanasoge, S. and M. Ljungman. 2007. H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinase. Carcinogenesis 28:2298‐2304.
Hannan, M. A., A. Hellani, F. M. Al Khodairy, M. Kunhi, Y. Siddiqui, N. Al Yussef, N. Pangue‐Cruz, M. Siewertsen, M. N. Al Ahdal and A. Aboussekhra. 2002. Deficiency in the repair of UV‐induced DNA damage in human skin fibroblasts compro‐
mised for the ATM gene. Carcinogenesis 23:1617‐1624.
Hans, F. and S. Dimitrov. 2001. Histone H3 phosphorylation and cell division. Oncogene 20:3021‐3027.
Harrington, E. A., J. L. Bruce, E. Harlow and N. Dyson. 1998. pRB plays an essential role in cell cycle arrest induced by DNA damage. Proc. Natl. Acad. Sci. U. S. A 95:11945‐11950.
Hartwell, L. H. and T. A. Weinert. 1989. Checkpoints: controls that ensure the order of cell cycle events. Science 246:629‐
634.
Heffernan, T. P., D. A. Simpson, A. R. Frank, A. N. Heinloth, R. S. Paules, M. Cordeiro‐Stone and W. K. Kaufmann. 2002.
An ATR‐ and Chk1‐dependent S checkpoint inhibits replicon initiation following UVC‐induced DNA damage. Mol. Cell Biol.
22:8552‐8561.
Helin, K. 1998. Regulation of cell proliferation by the E2F transcription factors. Curr. Opin. Genet. Dev. 8:28‐35.
Helleday, T., J. Lo, D. C. van Gent and B. P. Engelward. 2007. DNA double‐strand break repair: from mechanistic under‐
standing to cancer treatment. DNA Repair (Amst) 6:923‐935.
Helt, C. E., W. A. Cliby, P. C. Keng, R. A. Bambara and M. A. O'Reilly. 2005. Ataxia telangiectasia mutated (ATM) and ATM and Rad3‐related protein exhibit selective target specificities in response to different forms of DNA damage. J. Biol. Chem.
280:1186‐1192.
Henderson, L., H. Cole, C. Arlett, S. E. James, J. Cole, A. Lehmann, L. Rosenbloom, T. Redmond and S. Meller. 1985. Diag‐
nosis of ataxia‐telangiectasia by T‐lymphocyte cloning assay. Lancet 2:1242.
Hengst, L. and S. I. Reed. 1998. Inhibitors of the Cip/Kip family. Curr. Top. Microbiol. Immunol. 227:25‐41.
Hermeking, H., C. Lengauer, K. Polyak, T. C. He, L. Zhang, S. Thiagalingam, K. W. Kinzler and B. Vogelstein. 1997. 14‐3‐3 sigma is a p53‐regulated inhibitor of G2/M progression. Mol. Cell 1:3‐11.
Herrmann T., M. Baumann, W. Dörr. 2006. Klinische Strahlenbiologie, Urban und Fischer Verlag, 4.Auflage
Hess, M.T., D. Gunz, N. Luneva, N.E. Geacintov and H. Naegeli. 1997. Base pair conformation‐dependent excision of benzo[a]pyrene diol epoxide‐guanine adducts by human nucleotide excision repair enzymes. Mol. Cell Biol., 17, 7069‐
7076.
Hockberger, P. E. 2002. A history of ultraviolet photobiology for humans, animals and microorganisms. Photochem. Pho‐
tobiol. 76:561‐579.
Hoeijmakers, J. H. 1994. Human nucleotide excision repair syndromes: molecular clues to unexpected intricacies. Eur. J.
Cancer 30A:1912‐1921.
Hoeijmakers, J. H. 2001. Genome maintenance mechanisms for preventing cancer. Nature 411:366‐374.
Hoffmann, I., G. Draetta and E. Karsenti. 1994. Activation of the phosphatase activity of human cdc25A by a cdk2‐cyclin E dependent phosphorylation at the G1/S transition. EMBO J. 13:4302‐4310.
Hollander, M. C., M. S. Sheikh, D. V. Bulavin, K. Lundgren, L. Augeri‐Henmueller, R. Shehee, T. A. Molinaro, K. E. Kim, E.
Tolosa, J. D. Ashwell, M. P. Rosenberg, Q. Zhan, P. M. Fernandez‐Salguero, W. F. Morgan, C. X. Deng and A. J. Fornace, Jr. 1999. Genomic instability in Gadd45a‐deficient mice. Nat. Genet. 23:176‐184.
Hollick, J. J., B. T. Golding, I. R. Hardcastle, N. Martin, C. Richardson, L. J. Rigoreau, G. C. Smith and R. J. Griffin. 2003.
2,6‐disubstituted pyran‐4‐one and thiopyran‐4‐one inhibitors of DNA‐Dependent protein kinase (DNA‐PK). Bioorg. Med.
Chem. Lett. 13:3083‐3086.
Hozak, P., A. B. Hassan, D. A. Jackson and P. R. Cook. 1993. Visualization of replication factories attached to nucleoskele‐
ton. Cell, 73, 361‐373.
Huang, L. C., K. C. Clarkin and G. M. Wahl. 1996. Sensitivity and selectivity of the DNA damage sensor responsible for activating p53‐dependent G1 arrest. Proc. Natl. Acad. Sci. U. S. A 93:4827‐4832.
Huang, X., M. A. King, H. D. Halicka, F. Traganos, M. Okafuji and Z. Darzynkiewicz. 2004. Histone H2AX phosphorylation induced by selective photolysis of BrdU‐labeled DNA with UV light: relation to cell cycle phase. Cytometry A 62:1‐7.
Iliakis, G., Y. Wang, J. Guan and H. Wang. 2003. DNA damage checkpoint control in cells exposed to ionizing radiation.
Oncogene 22:5834‐5847.
Ivanov, I., B. R. Chapados, J. A. McCammon and J. A. Tainer. 2006. Proliferating cell nuclear antigen loaded onto double‐
stranded DNA: dynamics, minor groove interactions and functional implications. Nucleic Acids Res. 34:6023‐6033.
Iwamoto, K., Y. Tashima, H. Hamada, Y. Eguchi and M. Okamoto. 2008. Mathematical modeling and sensitivity analysis of G1/S phase in the cell cycle including the DNA‐damage signal transduction pathway. Biosystems 94:109‐117.
Jackman, M., Y. Kubota, N. den Elzen, A. Hagting and J. Pines. 2002. Cyclin A‐ and cyclin E‐Cdk complexes shuttle be‐
tween the nucleus and the cytoplasm. Mol. Biol. Cell 13:1030‐1045.
Jain, S., M. I. Filipe, P. A. Hall, N. Waseem, D. P. Lane and D. A. Levison. 1991. Prognostic value of proliferating cell nuc‐
lear antigen in gastric carcinoma. J. Clin. Pathol. 44:655‐659.
Jascur, T. and C. R. Boland. 2006. Structure and function of the components of the human DNA mismatch repair system.
Int. J. Cancer 119:2030‐2035.
Jeggo, P. A. 1998. DNA breakage and repair. Adv. Genet. 38:185‐218.
Jiang, G. and A. Sancar. 2006. Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontran‐
scribed sequences. Mol. Cell Biol. 26:39‐49.
Jinno, S., K. Suto, A. Nagata, M. Igarashi, Y. Kanaoka, H. Nojima and H. Okayama. 1994. Cdc25A is a novel phosphatase functioning early in the cell cycle. EMBO J. 13:1549‐1556.
Jonsson, Z. O. and U. Hubscher. 1997. Proliferating cell nuclear antigen: more than a clamp for DNA polymerases. Bioes‐
says 19:967‐975.
Kastan, M. B., O. Onyekwere, D. Sidransky, B. Vogelstein and R. W. Craig. 1991. Participation of p53 protein in the cellu‐
lar response to DNA damage. Cancer Res. 51:6304‐6311.
Kastan, M. B., Q. Zhan, W. S. El Deiry, F. Carrier, T. Jacks, W. V. Walsh, B. S. Plunkett, B. Vogelstein and A. J. Fornace, Jr.
1992. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia‐telangiectasia. Cell 71:587‐597.
Kastan, M .B. and D. S. Lim. 2000. The many substrates and functions of ATM. Nat. Rev. Mol. Cell Biol., 1, 179‐186.
Kaufmann, W. K. and J. E. Cleaver. 1981. Mechanisms of inhibition of DNA replication by ultraviolet light in normal human and xeroderma pigmentosum fibroblasts. J. Mol. Biol. 149:171‐187.
Kaufmann, W. K. and S. J. Wilson. 1994. G1 arrest and cell‐cycle‐dependent clastogenesis in UV‐irradiated human fibrob‐
lasts. Mutat. Res. 314:67‐76.
Kaufmann, W. K., T. P. Heffernan, L. M. Beaulieu, S. Doherty, A. R. Frank, Y. Zhou, M. F. Bryant, T. Zhou, D. D. Luche, N.
Nikolaishvili‐Feinberg, D. A. Simpson and M. Cordeiro‐Stone. 2003. Caffeine and human DNA metabolism: the magic and the mystery. Mutat. Res. 532:85‐102.
Kegel, P., E. Riballo, M. Kuhne, P. A. Jeggo and M. Lobrich. 2007. X‐irradiation of cells on glass slides has a dose doubling impact. DNA Repair (Amst) 6:1692‐1697.
Kelman, Z. and M. O'Donnell. 1995. Structural and functional similarities of prokaryotic and eukaryotic DNA polymerase sliding clamps. Nucleic Acids Res. 23:3613‐3620.
Kelman, Z. 1997. PCNA: structure, functions and interactions. Oncogene 14:629‐640.
Khanna, K. K. and M. F. Lavin. 1993. Ionizing radiation and UV induction of p53 protein by different pathways in ataxia‐
telangiectasia cells. Oncogene 8:3307‐3312.
Khanna, K. K. and S. P. Jackson. 2001. DNA double‐strand breaks: signaling, repair and the cancer connection. Nat. Genet.
27:247‐254.
Kiefer J., I. Kiefer. 2003. Allgemeine Radiologie. Parey Buchverlag 1. Auflage
Kim, S. T., K. Malhotra, C. A. Smith, J. S. Taylor and A. Sancar. 1994. Characterization of (6‐4) photoproduct DNA photo‐
lyase. J. Biol. Chem. 269:8535‐8540.
Kinner, A., W. Wu, C. Staudt and G. Iliakis. 2008. Gamma‐H2AX in recognition and signaling of DNA double‐strand breaks in the context of chromatin. Nucleic Acids Res. 36:5678‐5694.
Koch, C. A., R. Agyei, S. Galicia, P. Metalnikov, P. O'Donnell, A. Starostine, M. Weinfeld and D. Durocher. 2004. Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV. EMBO J. 23:3874‐3885.