Tabelle 1: Standarddatenanforderungen für zu registrierende chemische Stoffe ... 4 Tabelle 2: Biologische Merkmale der Phasen des Mehrstufenmodells der Kanzerogenese ... 8 Tabelle 3: Wichtige Cytochrom-P450-Monooxygenasen (CYP) ... 11 Tabelle 4: Vor- und Nachteile subzellulärer Fraktionen ... 36 Tabelle 5: Verwendete Zellkulturmedien und -zusätze ... 41 Tabelle 6: Zusammensetzung der Zellkulturmedien und Lösungen ... 42 Tabelle 7: Verwendete Leberhomogenate ... 43 Tabelle 8: Informationen zu den verwendeten Chemikalien ... 43 Tabelle 9: Informationen zu den verwendeten Chemikalien ... 43 Tabelle 10: Chemikalien und Lösungen ... 44 Tabelle 11: Verbrauchsmaterialien ... 44 Tabelle 12: Geräte und Hilfsmittel ... 45 Tabelle 13: Lösungsmittel und Konzentrationsbereiche der Testsubstanzen ... 50 Tabelle 14: Behandlungsgruppen im Zwei-Stufen-BALB/c-3T3-Zelltransformationstest ... 55 Tabelle 15: Behandlungsprotokoll des Zwei-Stufen-BALB/c-3T3-Zelltransformationstests . 56 Tabelle 16: Behandlungsprotokoll zur Prüfung tumorpromovierend wirksamer Substanzen . 57 Tabelle 17: Unterscheidung der im Zelltransformationstest gebildeten Zellherde (Foci) ... 58 Tabelle 18: Behandlungsprotokoll zur Prüfung von Prokanzerogenen mit S9-Mix ... 60 Tabelle 19: Unterschiede zwischen 12-Well- und 96-Well-Format im
Weichagar-Koloniebildungstest. ... 66 Tabelle 20: Zusammenfassung der wichtigsten Schlussfolgerungen aus den Ergebnissen der BALB/c-3T3-Zelltransformationstests mit den metabolisierenden Systemen ... 103
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