• Keine Ergebnisse gefunden

6. Literaturverzeichnis

Abbas, A.K., Urioste, S., Collins, T.L., Boom, W.H.: Heterogeneity of helper/inducer T lymphocytes. IV. Stimulation of resting and activated B cells by Th1 and Th2 clones. J Immunol. 1990 Mar 15; 144(6):2031-7.

Adolfsson, J., Borge, O.J., Bryder, D., Theilgaard-Mönch, K., Astrand-Grundström, I., Sitnicka, E., Sasaki, Y., Jacobsen, S.E.: Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Immunity. 2001 Oct; 15(4):659-69.

Akiyama, T., Maeda, S., Yamane, S., Ogino, K., Kasai, M., Kajiura, F., Matsumoto, M., Inoue, J.: Dependence of self-tolerance on TRAF6-directed development of thymic stroma.

Science. 2005 Apr 8; 308(5719):248-51. Epub 2005 Feb 10.

Allen, S. J., Crown, S.E., Handel, T, M.: Chemokine: receptor structure, interactions, and antagonism. Annu Rev Immunol. 2007; 25:787-820. Review.

Andersen, M.H., Schrama, D., Thor Straten, P., Becker, J.C.: Cytotoxic T cells. J Invest Dermatol. 2006 Jan; 126(1):32-41.

Anderson, G.,: Jenkinson, E.J.: Lymphostromal interactions in thymic development and function. Nat Rev Immunol. 2001 Okt; 1(1):31-40.

Anderson, M.S., Venanzi, E.S., Klein, L., Chen, Z., Berzins, S.P., Turley, S.J., von Boehmer, H., Bronson, R., Dierich, A., Benoist, C., Mathis, D.: Projection of an immunological self shadow within the thymus by the aire protein. Science. 2002 Nov 15;

298(5597):1395-401. Epub 2002 Oct 10.

Aranami, T., Yamamura, T.: Th17 Cells and autoimmune encephalomyelitis (EAE/MS).

Allergol Int. 2008 Jun; 57(2):115-20.

6. Literaturverzeichnis 65

Balciunaite, G., Ceredig, R., Fehling, H.J., Zúñiga-Pflücker, J.C., Rolink, A.G.: The role of Notch and IL-7 signaling in early thymocyte proliferation and differentiation. Eur J Immunol. 2005 Apr; 35(4):1292-300.

Bhandoola, A., Sambandam, A.: From stem cell to T cell: one route or many? Nat Rev Immunol. 2006 Feb; 6(2):117-26.

Biron, C.A., Nguyen, K.B., Pien, G.C., Cousens, L.P., Salazar-Mather, T.P.: Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu Rev Immunol. 1999; 17:189-220.

Björses, P., Aaltonen, J., Horelli-Kuitunen, N., Yaspo, M.L., Peltonen, L.: Gene defect behind APECED: a new clue to autoimmunity. Hum Mol Genet. 1998; 7(10):1547-53.

Boehm, T., Scheu, S., Pfeffer, K., Bleul, C.C.:. Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR. J Exp Med. 2003 Sep 1; 198(5):757-69.

Borgulya, P., Kishi, H., Uematsu, Y., von Boehmer, H.: Exclusion and inclusion of alpha and beta T cell receptor alleles. Cell 1992 Mai; 69(3):529-37.

Brugnera, E., Bhandoola, A., Cibotti, R., Yu, Q., Guinter, T.I., Yamashita, Y., Sharrow, S.O., Singer, A.: Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells. Immunity. 2000 Jul;

13(1):59-71.

Burchill, M.A., Yang, J., Vogtenhuber, C., Blazar, B.R., Farrar, M.A.: IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol. 2007 Jan 1; 178(1):280-90.

Burchill, M.A., Yang, J., Vang, K.B., Farrar, M.A.: Interleukin-2 receptor signaling in regulatory T cell development and homeostasis. J Imm Immunol Lett. 2007 Nov 30; 114(1):1-8. Epub 2007 Sep 14.

6. Literaturverzeichnis 66

Burkly, L., Hession, C., Ogata, L., Reilly, C., Marconi, L.A., Olson, D., Tizard, R., Cate, R., Lo, D.: Expression of relB is required for the development of thymic medulla and dendritic cells. Nature. 1995 Feb 9; 373(6514):531-6.

Cederbom, L., Hall, H., Ivars, F.: CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells. Eur J Immunol. 2000 Jun; 30(6):1538-43.

Ceredig, R., Rolink, T.: A positive look at double-negative thymocytes. Nat Rev Immunol.

2002 Nov; 2(11):888-97.

Chan, S.H., Cosgrove, D., Waltzinger, C., Benoist, C., Mathis, D.: Another view of the selective model of thymocyte selection. Cell. 1993 Apr 23; 73(2):225-36.

Ciofani, M., Schmitt, T.M., Ciofani, A., Michie, A.M., Cuburu, N., Aublin, A., Maryanski, J.L., Zúñiga-Pflücker, J.C.: Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. J Immunol. 2004 May 1; 172(9):5230-9.

Ciofani, M., Zúñiga-Pflücker, J.C.: Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. Nat Immunol. 2005 Sep; 6(9):881-8.

Epub 2005 Jul 31.

Collison, L.W., Workman, C.J., Kuo, T.T., Boyd, K., Wang, Y., Vignali, K.M., Cross, R., Sehy, D., Blumberg, R.S., Vignali, D.A.: The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature. 2007 Nov 22; 450(7169):566-9.

Crompton, T., Outram, S.V., Buckland, J., Owen, M.J.: A transgenic T cell receptor restores thymocyte differentiation in interleukin-7 receptor alpha chain-deficient mice. Eur J Immunol. 1997 Jan; 27(1):100-4.

Davalos-Misslitz, A.C., Rieckenberg, J., Willenzon, S., Worbs, T., Kremmer, E., Bernhardt, G., Förster, R.: Generalized multi-organ autoimmunity in CCR7-deficient mice.

Eur J Immunol. 2007 Mar; 37(3):613-22.

6. Literaturverzeichnis 67

Davalos-Misslitz, A.C., Worbs, T., Willenzon, S., Bernhardt, G., Förster, R.: Impaired responsiveness to T-cell receptor stimulation and defective negative selection of thymocytes in CCR7-deficient mice. Blood. 2007 Dez 15; 110(13):4351-9. Epub 2007 Sep 4.

Davis, C.B., Killeen, N., Crooks, M.E., Raulet, D., Littman, D.R.: Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell. 1993 Apr 23; 73(2):237-47.

Deaglio, S., Dwyer, K.M., Gao, W., Friedman, D., Usheva, A., Erat, A., Chen, J.F., Enjyoji, K., Linden, J., Oukka, M., Kuchroo, V.K., Strom, T.B., Robson, S.C.: Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med. 2007 Jun 11; 204(6):1257-65. Epub 2007 May 14.

Derbinski, J., Schulte, A., Kyewski, B., Klein, L.: Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat Immunol. 2001 Nov;

2(11):1032-9.

Derbinski, J., Gäbler, J., Brors, B., Tierling, S., Jonnakuty, S., Hergenhahn, M., Peltonen, L., Walter, J., Kyewski, B.: Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J Exp Med. 2005 Jul; 202(1):33-45. Epub 2005 Jun 27.

Eichner, R., Bonitz, P., Sun, T.T.: Classification of epidermal keratins according to their immunoreactivity, isoelectric point, and mode of expression. J Cell Biol. 1984 Apr;

98(4):1388-96.

El Andaloussi, A., Graves, S., Meng, F., Mandal, M., Mashayekhi, M., Aifantis, I.:

Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nat Immunol. 2006 Apr; 7(4):418-26. Epub 2006 Mar 5.

Förster, R., Schubel, A,, Breitfeld, D., Kremmer, E., Renner-Müller, I., Wolf, E., Lipp, M.: CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell. 1999 Okt; 99(1):23-33.

6. Literaturverzeichnis 68

Franke, W.W., Schiller, D.L., Moll, R., Winter, S., Schmid, E., Engelbrecht, I., Denk, H., Krepler, R., Platzer, B.: Diversity of cytokeratins. Differentiation specific expression of cytokeratin polypeptides in epithelial cells and tissues. J Mol Biol. 1981 Dez; 153(4):933-59.

Fuchs, E., Marchuk, D.: Type I and type II keratins have evolved from lower eukaryotes to form the epidermal intermediate filaments in mammalian skin. Proc Natl Acad Sci U S A.

1983 Okt; 80(19):5857-61.

Gallegos, A.M., Bevan, M.J.: Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J Exp Med. 2004 Oct 18; 200(8):1039-49.

Garín, M.I., Chu, C.C., Golshayan, D., Cernuda-Morollón, E., Wait, R., Lechler, R.I.:

Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. Blood. 2007 Mar 1; 109(5):2058-65. Epub 2006 Nov 16.

Gillard, G.O., Dooley, J., Erickson, M., Peltonen, L., Farr, A.G.: Aire-dependent alterations in medullary thymic epithelium indicate a role for Aire in thymic epithelial differentiation. J Immunol. 2007 Mar; 178(5):3007-15.

Godfrey, D.I., Zlotnik, A., Suda, T.: Phenotypic and functional characterization of c-kit expression during intrathymic T cell development. J Immunol. 1992 Oct 1; 149(7):2281-5.

Godfrey, D.I., Zlotnik, A.: Control points in early T-cell development. Immunol Today. 1993 Nov; 14(11):547-53.

Gondek, D.C., Lu, L.F., Quezada, S.A., Sakaguchi, S., Noelle, R.J.: Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J Immunol. 2005 Feb 15; 174(4):1783-6.

Gounari, F., Aifantis, I., Martin, C., Fehling, H.J., Hoeflinger, S., Leder, P., von Boehmer, H., Reizis, B.: Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene. Nat Immunol. 2002 May; 3(5):489-96. Epub 2002 Apr 1.

6. Literaturverzeichnis 69

Gray, D.H., Seach, N., Ueno, T., Milton, M.K., Liston, A., Lew, A.M., Goodnow, C.C., Boyd, R.L.: Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood. 2006 Dez; 108(12):3777-85. Epub 2006 Aug 8.

Grossman, W.J., Verbsky, J.W., Barchet, W., Colonna, M., Atkinson, J.P., Ley, T.J.:

Human T regulatory cells can use the perforin pathway to cause autologous target cell death.

Immunity. 2004 Oct; 21(4):589-601.

Groux, H.: Type 1 T-regulatory cells: their role in the control of immune responses.

Transplantation. 2003 May 15; 75(9 Suppl):8S-12S.

Guillemot, J.C., Naspetti, M., Malergue, F., Montcourrier, P., Galland, F., Naquet, P.:

Ep-CAM transfection in thymic epithelial cell lines triggers the formation of dynamic actin-rich protrusions involved in the organization of epithelial cell layers. Histochem Cell Biol.

2001 Okt; 116(4):371-8.

Gunn, M.D., Kyuwa, S., Tam, C., Kakiuchi, T., Matsuzawa, A., Williams, L.T., Nakano, H.: Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J Exp Med. 1999 Feb 1; 189(3):451-60

Hamazaki, Y., Fujita, H., Kobayashi, T., Choi, Y., Scott, H.S., Matsumoto, M., Minato, N.: Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. Nat Immunol. 2007 Mar; 8(3):304-11. Epub 2007 Feb 4.

Harrington, L.E., Hatton, R.D., Mangan, P.R., Turner, H., Murphy, T.L., Murphy, K.M., Weaver, C.T.: Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005 Nov; 6(11):1123-32.

Epub 2005 Oct 2.

Hashimoto, S., Amemiya, E., Tomita, Y., Kobatashi, T., Arai, K., Yamaguchi, M., Horie, T.: Elevation of soluble IL-2 receptor and IL-4, and nonelevation of IFN-gamma in sera from patients with allergic asthma. Ann Allergy. 1993 Nov; 71(5):455-8.

6. Literaturverzeichnis 70

Hogquist, K.A., Baldwin, T.A., Jameson, S.C.: Central tolerance: learning self-control in the thymus. Nat Rev Immunol. 2005 Okt; 5(10):772-82.

Holländer, G.A., Wang, B., Nichogiannopoulou, A., Platenburg, P.P., van Ewijk, W., Burakoff, S.J., Gutierrez-Ramos, J.C., Terhorst, C.: Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes. Nature. 1995 Jan;

373(6512):350-3.

Huang, W., Na, L., Fidel, P.L., Schwarzenberger, P.: Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J Infect Dis. 2004 Aug 1; 190(3):624-31.

Epub 2004 Jun 22.

Igarashi, H., Gregory, S.C., Yokota, T., Sakaguchi, N., Kincade, P.W.: Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow. Immunity. 2002 Aug; 17(2):117-30.

Ignatowicz, L., Kappler, J., Marrack, P.: The repertoire of T cells shaped by a single MHC/peptide ligand. Cell. 1996 Feb 23; 84(4):521-9.

Ikuta, K., Weissman, I.L.: Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc Natl Acad Sci U S A. 1992 Feb 15;

89(4):1502-6.

Infante-Duarte, C., Horton, H.F., Byrne, M.C., Kamradt, T.: Microbial lipopeptides induce the production of IL-17 in Th cells. J Immunol. 2000 Dec 1; 165(11):6107-15.

Irving, B.A., Alt, F.W., Killeen, N.: Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains. Science. 1998 May 8; 280(5365):905-8.

Izui S.: Immunopathogenesis of lupus nephritis: new insights from experimental models.

Nippon Jinzo Gakkai Shi. 1995 Nov; 37(11):610-5.

6. Literaturverzeichnis 71

Kajiura, F., Sun, S., Nomura, T., Izumi, K., Ueno, T., Bando, Y., Kuroda, N., Han, H., Li, Y., Matsushima, A., Takahama, Y., Sakaguchi, S., Mitani, T., Matsumoto, M.: NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner. J Immunol. 2004 Feb 15; 172(4):2067-75.

Kang, B.Y., Kim, T.S.: Targeting cytokines of the interleukin-12 family in autoimmunity.

Curr Med Chem. 2006; 13(10):1149-56.

Kaplan, M.H., Schindler, U., Smiley, S.T., Grusby, M.J.: Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity. 1996 Mar; 4(3):313-9.

Kelvin, D.J., Michiel, D.F., Johnston, J.A., Lloyd, A.R., Sprenger, H., Oppenheim, J.J., Wang, J.M.: Chemokines and serpentines: the molecular biology of chemokine receptors. J Leukoc Biol. 1993 Dez; 54(6):604-12.

Khader, S.A., Bell, G.K., Pearl, J.E., Fountain, J.J., Rangel-Moreno, J., Cilley, G.E., Shen, F., Eaton, S.M., Gaffen, S.L., Swain, S.L., Locksley, R.M., Haynes, L., Randall, T.D., Cooper, A.M.: IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol. 2007 Apr; 8(4):369-77. Epub 2007 Mar 11.

King, C., Tangye, S.G., Mackay, C.R.: T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu Rev Immunol. 2008; 26:741-66.

Klug, D.B., Carter, C., Crouch, E., Roop, D., Conti, C.J., Richie, E.R.: Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment. Proc Natl Acad Sci U S A. 1998 Sep; 95(20):11822-7.

Klug, D.B., Carter, C., Gimenez-Conti, I.B., Richie, E.R.: Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus. J Immunol. 2002 Sep 15; 169(6):2842-5.

6. Literaturverzeichnis 72

Kont, V., Laan, M., Kisand, K., Merits, A., Scott, H.S., Peterson, P.: Modulation of Aire regulates the expression of tissue-restricted antigens. Mol Immunol. 2008 Jan; 45(1):25-33.

Epub 2007 Jun 28.

Kurobe, H., Liu, C., Ueno, T., Saito, F., Ohigashi, I., Seach, N., Arakaki, R., Hayashi, Y., Kitagawa, T., Lipp, M., Boyd, R.L., Takahama, Y.: CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance.

Immunity. 2006 Feb; 24(2):165-77.

Kuroda, N., Mitani, T., Takeda, N., Ishimaru, N., Arakaki, R., Hayashi, Y., Bando, Y., Izumi, K., Takahashi, T., Nomura, T., Sakaguchi, S., Ueno, T., Takahama, Y., Uchida, D., Sun, S., Kajiura, F., Mouri, Y., Han, H., Matsushima, A., Yamada, G., Matsumoto, M.: Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J Immunol. 2005 Feb 15; 174(4):1862-70.

Kwan, J., Killeen, N.: CCR7 directs the migration of thymocytes into the thymic medulla. J Immunol. 2004 Apr; 172(7):3999-4007.

Le Gros, G., Ben-Sasson, S.Z., Seder, R., Finkelman, F.D., Paul, W.E.: Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Immunol. 2008 Sep 1; 181(5):2943-51.

Lian, Z., Toki, J., Yu, C., Hayashi, H., Yasumizu, R., Sugiura, K., Jin, T., Inaba, M., Hisha, H., Li, Y., Yu, W., Fan, H., Ikehara, S.: Intrathymically injected hemopoietic stem cells can differentiate into all lineage cells in the thymus: differences between c-kit+ cells and c-kit < low cells. Stem Cells. 1997; 15(6):430-6.

Liang, B., Workman, C., Lee, J., Chew, C., Dale, B.M., Colonna, L., Flores, M., Li, N., Schweighoffer, E., Greenberg, S., Tybulewicz, V., Vignali, D., Clynes, R.: Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II. J Immunol. 2008 May 1; 180(9):5916-26.

6. Literaturverzeichnis 73

Lind, E.F., Prockop, S.E., Porritt, H.E., Petrie, H.T.: Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development. J Exp Med. 2001 Jul 16; 194(2):127-34.

Liston, A., Lesage, S., Wilson, J., Peltonen, L., Goodnow, C.C.: Aire regulates negative selection of organ-specific T cells. Nat Immunol. 2003 Apr; 4(4):350-4. Epub 2003 Mar 3.

Livák, F., Tourigny, M., Schatz, D.G., Petrie, H.T.: Characterization of TCR gene rearrangements during adult murine T cell development. J Immunol. 1999 März; 162(5):2575-80.

Lomada, D., Liu, B., Coghlan, L., Hu, Y., Richie, E.R.: Thymus medulla formation and central tolerance are restored in IKKalpha-/- mice that express an IKKalpha transgene in keratin 5+ thymic epithelial cells. J Immunol. 2007 Jan 15; 178(2):829-37.

Ludwig-Portugall, I., Hamilton-Williams, E.E., Gottschalk, C., Kurts, C.: Cutting edge:

CD25+ regulatory T cells prevent expansion and induce apoptosis of B cells specific for tissue autoantigens. J Immunol. 2008 Okt 1; 181(7):4447-51.

Martin, C.H., Aifantis, I., Scimone, M.L., von Andrian, U.H., Reizis, B., von Boehmer, H., Gounari, F.: Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential. Nat Immunol. 2003 Sep; 4(9):866-73. Epub 2003 Aug 17.

Massa, S., Balciunaite, G., Ceredig, R., Rolink, A.G.: Critical role for c-kit (CD117) in T cell lineage commitment and early thymocyte development in vitro. Eur J Immunol. 2006 Mar; 36(3):526-32.

Misslitz, A., Pabst, O., Hintzen, G., Ohl, L., Kremmer, E., Petrie, H.T., Förster, R.:

Thymic T cell development and progenitor localization depend on CCR7. J Exp Med. 2004 Aug 16; 2004():481-91. Epub 2004 Aug 9.

Misslitz, A., Bernhardt, G., Förster, R.: Trafficking on serpentines: molecular insight on how maturating T cells find their winding paths in the thymus. Immunol Rev. 2006 Feb;

209:115-28.

6. Literaturverzeichnis 74

Moll, R., Franke, W.W., Volc-Platzer, B., Krepler, R.: Different keratin polypeptides in epidermis and other epithelia of human skin: a specific cytokeratin of molecular weight 46,000 in epithelia of the pilosebaceous tract and basal cell - epitheliomas. J Cell Biol. 1982 Okt; 95(1):285-95.

Moore, T.A., Zlotnik, A.: T-cell lineage commitment and cytokine responses of thymic progenitors. Blood. 1995 Sep; 86(5):1850-60.

Mori, S., Nakano, H., Aritomi, K., Wang, C.R., Gunn, M.D., Kakiuchi, T.: Mice lacking expression of the chemokines CCL21-ser and CCL19 (plt mice) demonstrate delayed but enhanced T cell immune responses. J Exp Med. 2001 Jan 15; 193(2):207-18.

Muegge, K., Vila, M.P., Durum, S.K.: Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor beta gene. Science. 1993 Jul 2; 261(5117):93-5.

Murphy, K.M., Reiner, S.L.: The lineage decisions of helper T cells. Nat Rev Immunol.

2002 Dec; 2(12):933-44.

Nakano, H., Mori, S., Yonekawa, H., Nariuchi, H., Matsuzawa, A., Kakiuchi, T.: A novel mutant gene involved in T-lymphocyte-specific homing into peripheral lymphoid organs on mouse chromosome 4. Blood. 1998 Apr 15; 91(8):2886-95.

Oberle, N., Eberhardt, N., Falk, C.S., Krammer, P.H., Suri-Payer, E.: Rapid suppression of cytokine transcription in human CD4+CD25 T cells by CD4+Foxp3+ regulatory T cells:

independence of IL-2 consumption, TGF-beta, and various inhibitors of TCR signaling. J Immunol. 2007 Sep 15; 179(6):3578-87.

Onishi, Y., Fehervari, Z., Yamaguchi, T., Sakaguchi, S.: Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation.

Proc Natl Acad Sci U S A. 2008 Jul 22; 105(29):10113-8. Epub 2008 Jul 17.

Palumbo, M.O., Levi, D., Chentoufi, A.A., Polychronakos, C.: Isolation and characterization of proinsulin-producing medullary thymic epithelial cell clones. Diabetes.

2006 Sep; 55(9):2595-601.

6. Literaturverzeichnis 75

Pandiyan, P., Zheng, L., Ishihara, S., Reed, J., Lenardo, M.J.: CD4+CD25+Foxp3+

regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells.

Nat Immunol. 2007 Dec; 8(12):1353-62. Epub 2007 Nov 4.

Park, H., Li, Z., Yang, X.O., Chang, S.H., Nurieva, R., Wang, Y.H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., Dong, C.: A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005 Nov; 6(11):1133-41. Epub 2005 Oct 2.

Pelletier, A.J., van der Laan, L.J., Hildbrand, P., Siani, M.A., Thompson, D.A., Dawson, P.E., Torbett, B.E., Salomon, D.R.: Presentation of chemokine SDF-1 alpha by fibronectin mediates directed migration of T cells. Blood. 2000 Oct 15; 96(8):2682-90.

Petrie, H.T., Livak, F., Schatz, D.G., Strasser, A., Crispe, I.N., Shortman, K.: Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes. J Exp Med. 1993 Aug 1; 178(2):615-22.

Petrie, H.T., Strasser, A., Harris, A.W., Hugo, P., Shortman, K.: CD4+8- and CD4-8+

mature thymocytes require different post-selection processing for final development.

J Immunol. 1993 Aug; 151(3):1273-9.

Porritt, H.E., Gordon, K., Petrie, H.T.: Kinetics of steady-state differentiation and mapping of intrathymic-signaling environments by stem cell transplantation in nonirradiated

mice. J Exp Med. 2003 Sep 15; 198(6):957-62.

Prockop, S.E., Palencia, S., Ryan, C.M., Gordon, K., Gray, D., Petrie, H.T.: Stromal cells provide the matrix for migration of early lymphoid progenitors through the thymic cortex. J Immunol. 2002 Oct 15; 169(8):4354-61.

Radtke, F., Wilson, A., Stark, G., Bauer, M., van Meerwijk, J., MacDonald, H.R., Aguet, M.: Deficient T cell fate specification in mice with an induced inactivation of Notch1.

Immunity. 1999 May; 10(5):547-58.

6. Literaturverzeichnis 76

Robey, E.A., Fowlkes, B.J., Gordon, J.W., Kioussis, D., von Boehmer, H., Ramsdell, F., Axel, R.: Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell. 1991 Jan 11; 64(1):99-107.

Romagnani, S.: Type 1 T helper and type 2 T helper cells: functions, regulation and role in protection and disease. : Int J Clin Lab Res. 1991; 21(2):152-8.

Rossi, F.M., Corbel, S.Y., Merzaban, J.S., Carlow, D.A., Gossens, K., Duenas, J., So, L., Yi, L., Ziltener, H.J.: Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1. Nat Immunol. 2005 Jun; 6(6):626-34. Epub 2005 May 8.

Rudner, X.L., Happel, K.I., Young, E.A., Shellito, J.E.: Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infection. Infect Immun. 2007 Jun; 75(6):3055-61. Epub 2007 Apr 2.

Sancho, J., Franco, R., Chatila, T., Hall, C., Terhorst, C.: The T cell receptor associated CD3-epsilon protein is phosphorylated upon T cell activation in the two tyrosine residues of a conserved signal transduction motif. Eur J Immunol. 1993 Jul; 23(7):1636-42.

Schmitt, T.M., Zúñiga-Pflücker, J.C.: Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity. 2002 Dec; 17(6):749-56.

Schmitt, T.M., Ciofani, M., Petrie, H.T., Zúñiga-Pflücker, J.C.: Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions. J Exp Med. 2004 Aug 16; 200(4):469-79.

Schulze-Koops, H., Kalden, J.R.: The balance of Th1/Th2 cytokines in rheumatoid arthritis.

Best Pract Res Clin Rheumatol. 2001 Dec; 15(5):677-91.

Shortman, K., Egerton, M., Spangrude, G.J., Scollay, R.: The generation and fate of thymocytes. Semin Immunol. 1990 Jan; 2(1):3-12.

Spangrude, G.,J., Heimfeld, S., Weissman, I.L.: Purification and characterization of mouse hematopoietic stem cells. Science. 1988 Jul 1; 241(4861):58-62.

6. Literaturverzeichnis 77

St-Pierre, Y., Hugo, P., Legault, D., Tremblay, P., Potworowski, E.F.: Modulation of integrin-mediated intercellular adhesion during the interaction of thymocytes with stromal cells expressing VLA-4 and LFA-1 ligands. Eur J Immunol. 1996 Sep; 26(9):2050-5.

Suarez-Pinzon, W.L., Rabinovitch, A.: Approaches to type 1 diabetes prevention by intervention in cytokine immunoregulatory circuits. Int J Exp Diabetes Res. 2001; 2(1):3-17.

Suniara, R.K., Jenkinson, E.J., Owen, J.J.: Studies on the phenotype of migrant thymic stem cells. Eur J Immunol. 1999 Jan; 29(1):75-80.

Szabo, S.J., Dighe, A.S., Gubler, U., Murphy, K.M.: Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J Exp Med. 1997 Mar 3; 185(5):817-24.

Szabo, S.J., Sullivan, B.M., Peng, S.L., Glimcher, L.H.: Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol. 2003; 21:713-58. Epub 2001 Dec 19.

Taguchi, N., Hashimoto, Y., Naiki, M., Farr, A.G., Boyd, R.L., Ansari, A.A., Shultz, L.D., Kotzin, B.L., Dorshkind, K., Ikehara, S., Gershwin, M.E.: Abnormal thymic expression of epithelial cell adhesion molecule (EP-CAM) in New Zealand Black (NZB) mice. J Autoimmun. 1999 Dez; 13(4):393-404.

Takahashi, T., Kuniyasu, Y., Toda, M., Sakaguchi, N., Itoh, M., Iwata, M., Shimizu, J., Sakaguchi, S.: Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol. 1998 Dez; 10(12):1969-80.

Tan, J.B.,Visan, I., Yuan, J.S., Guidos, C.J.: Requirement for Notch1 signals at sequential early stages of intrathymic T cell development. Nat Immunol. 2005 Jul; 6(7): 671-9. Epub 2005 Jun 12.

Thornton, A.M., Shevach, E.M.: CD4+CD25+ immunoregulatory T cells suppress

polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med. 1998 Jul 20; 188(2):287-96.

6. Literaturverzeichnis 78

Uehara, S., Hayes, S.M., Li, L., El-Khoury, D., Canelles, M., Fowlkes, B.J., Love, P.E.:

Premature expression of chemokine receptor CCR9 impairs T cell development. J Immunol.

2006 Jan 1; 176(1):75-84.

Ueno, T., Saito, F., Gray, D.H., Kuse, S., Hieshima, K., Nakano, H., Kakiuchi, T., Lipp, M., Boyd, R.L., Takahama, Y.: CCR7 signals are essential for cortex-medulla migration of developing thymocytes. J Exp Med. 2004 Aug 16; 200(4):493-505. Epub 2004 Aug 9.

van Ewijk, W., Wang, B., Hollander, G., Kawamoto, H., Spanopoulou, E., Itoi, M., Amagai, T., Jiang, Y.F., Germeraad, W.T., Chen, W.F., Katsura, Y.: Thymic microenvironments, 3-D versus 2-D? Semin Immunol. 1999 Feb; 11(1):57-64.

van Ewijk, W., Holländer, G., Terhorst, C., Wang, B.: Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets. Development. 2000 Apr;

127(8):1583-91.

Vang, K.B., Yang, J., Mahmud, S.A., Burchill, M.A., Vegoe, A.L., Farrar, M.A.: IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development. J Immunol. 2008 Sep 1; 181(5):3285-90.

Vogel, A., Strassburg, C.P., Obermayer-Straub, P., Brabant, G., Manns, M.P.: The genetic background of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy and its autoimmune disease components. J Mol Med. 2002 Apr; 80(4):201-11. Epub 2002 Feb.

Wang, H., Pierce, L.J., Spangrude, G.J.: Distinct roles of IL-7 and stem cell factor in the OP9-DL1 T-cell differentiation culture system. Exp Hematol. 2006 Dec; 34(12):1730-40.

Weiner, H.L.: Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol Rev. 2001 Aug; 182:207-14.

6. Literaturverzeichnis 79

Wildin, R.S., Ramsdell, F., Peake, J., Faravelli, F., Casanova, J.L., Buist, N., Levy-Lahad, E., Mazzella, M., Goulet, O., Perroni, L., Bricarelli, F.D., Byrne, G., McEuen, M., Proll, S., Appleby, M., Brunkow, M.E.: X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet. 2001 Jan; 27(1):18-20.

Woodcock-Mitchell, J., Eichner, R., Nelson, W.G., Sun, T.T.: Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies. J Cell Biol. 1982 Nov;

95(2 Pt 1):580-8.

Wu, L., Kincade, P.W., Shortman, K.: The CD44 expressed on the earliest intrathymic precursor population functions as a thymus homing molecule but does not bind to hyaluronate. Immunol Lett. 1993 Sep; 38(1):69-75.

Wu, L., Shortman, K.: Heterogeneity of thymic dendritic cells. Semin Immunol. 2005 Aug;

17(4):304-12.

Yamasaki, S., Ishikawa, E., Sakuma, M., Ogata, K., Sakata-Sogawa, K., Hiroshima, M., Wiest, D.L., Tokunaga, M., Saito, T.: Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development. Nat Immunol. 2006 Jan;7(1):67-75. Epub 2005 Dec 4.

Yasutomo, K., Doyle, C., Miele, L., Fuchs, C., Germain, R.N.: The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate. Nature. 2000 Mar 30;404(6777):506-10.

Ye, P., Rodriguez, F.H., Kanaly, S., Stocking, K.L., Schurr, J., Schwarzenberger, P., Oliver, P., Huang, W., Zhang, P., Zhang, J., Shellito, J.E., Bagby, G.J., Nelson, S., Charrier, K., Peschon, J.J., Kolls, J.K.: Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med. 2001 Aug 20; 194(4):519-27.

6. Literaturverzeichnis 80

Yin, X., Ladi, E., Chan, S.W., Li, O., Killeen, N., Kappes, D.J., Robey, E.A.: CCR7

Yin, X., Ladi, E., Chan, S.W., Li, O., Killeen, N., Kappes, D.J., Robey, E.A.: CCR7