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Hepatoprotective and Antioxidant Activity of Two Iridoids from Mussaenda ‘dona aurora’

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Hepatoprotective and Antioxidant Activity of Two Iridoids from Mussaenda ‘dona aurora’

Kandulva Sethuraman Vidyalakshmia,*, Sulochana Nagarajanb, Hannah Rachel Vasanthic, Venkappayaa, and Victor Rajamanickamd

a Department of Chemistry, SASTRA University, Thanjavur, Tamilnadu, India. E-mail:

vidyakumbak@yahoo.co.in

b Department of Chemistry, NIT, Trichy, Tamilnadu, India

c Department of Biochemistry, SR University, Porur, Chennai, Tamilnadu, India

d Centre for Advanced Research in Indian System of Medicine, SASTRA University, Thanjavur, Tamilnadu, India

* Author for correspondence and reprint requests

Z. Naturforsch. 64 c, 329 – 334 (2009); received August 26/November 17, 2008

Mussaenda ‘dona aurora’ (sepals) has been investigated for its hepatoprotective and anti- oxidant activities. The highest activity was observed in the ethyl acetate fraction. The separa- tion of the ethyl acetate fraction gave two iridoids, sanshiside-D and lamalbide. Sanshiside-D exhibited a hepatoprotective activity greater than silimarin as was evidenced by signifi cant reduction of ALT and AST in the serum enzyme levels.

Key words: Mussaenda, Iridoids, Sanshiside-D, Antioxidant

NC_5_6_2009.indb 329 22.06.2009 10:02:39

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