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Table S1 List of differentially expressed proteins in ΔstkAccessionDescriptionFold changeP

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Table S1 List of differentially expressed proteins in Δstk

Accession Description Fold change P-value

D5AFG6 DNA-directed RNA polymerase subunit beta 0.5490901 0.0002394 D5AJV4 Translation initiation factor IF-2 0.5930101 8.809E-06 A0A116MPN5 Putative oligopeptide-binding protein, OppA 0.260904 0

A0A0Z8I535 GMP synthase 0.5727787 0.0094332

U5UF92 DNA-directed RNA polymerase subunit alpha 0.5432221 0.0053335 G7SK61 Putative glutamine ABC transporter,

glutamine-binding protein/permease protein 0.4124075 2.959E-05

A0A116LNF0 Asparagine--tRNA ligase 0.6362686 0.0186512

D5AIQ2 Cation transporting ATPase 0.5679228 0.0001723

Q9AIW1 Glutamate dehydrogenase 0.3609139 4.906E-08

D5AKD0 Glutamate--tRNA ligase 0.6659878 0.0326007

A0A0H3MXU4 Anaerobic ribonucleoside-triphosphate

reductase 0.2624537 5.792E-10

D5AF22 tRNA uridine 5-carboxymethylaminomethyl

modification enzyme MnmG 0.5779402 0.0126828

D5AGP0 Glutamine--fructose-6-phosphate

aminotransferase 0.2376141 8.344E-08

D5AG66 Glycosyl transferase, family 51 0.5323612 0.0005361 D5AHG9 Peptide chain release factor 1 0.6542104 0.0287836 A0A0H3MXX6 Putative fumarate reductase flavoprotein

subunit 0.2283907 5.464E-06

U5UC77 Glutamine synthetase 0.3182886 1.098E-05

D5AHL4 DNA topoisomerase 1 0.6528808 0.0003723

U5UKJ5 Ketol-acid reductoisomerase (NADP(+)) 0.5986005 6.38E-05 A5JSI6 Cell wall hydrolase/autolysin 0.500737 0.0005338

D5AJX7 FeS assembly protein SufB 0.4952519 0.0007317

U5UHR8 Sugar ABC transporter substrate-binding

protein 0.4416663 0.0123381

G7SJD5 Basic membrane lipoprotein 0.3076762 1.621E-05

D5AJP4 Mannose-specific EIIAB Phosphotransferase

system 0.3520708 9.777E-05

A0A0H3MYM8 Streptococcal histidine triad-family protein 0.5852909 0.0020781

U5UIY6 Sialic acid synthase 0.3632837 0.00013

U5UJJ2 Amino acid ABC transporter, amino acid-

binding protein 0.2462543 2.072E-08

A0A116KUT0 30S ribosomal protein S3 0.2481996 1.228E-05

A4VSV9 Glycosidase 0.5050864 0.0006987

U5UC21 30S ribosomal protein S8 0.2351972 2.771E-05

U5UFL8 Cps2H 0.5943439 0.0057201

D5AHC7 Homoserine dehydrogenase 0.608379 0.0016522

U5UF65 50S ribosomal protein L3 0.237444 1.198E-05

(2)

U5UKP6 Lipoprotein 0.4671598 3.224E-05 A0A0N0DMG4 S-adenosylmethionine synthase 0.5548203 0.0102318 R9RJ65 Eukaryotic-type serine/threonine kinase 0.0420327 1.71E-10 D5AFF8 Zinc ABC transporter, zinc-binding lipoprotein 0.3120084 2.296E-06

G7SJX4 Uncharacterized protein 0.6272523 0.0366488

A0A0Z8V2Y3 Aspartokinase 0.5867332 0.0012887

D5AEU0 Putative amino acid ABC transporter, ATP-

binding protein 0.651609 0.0284189

U5UC30 30S ribosomal protein S13 0.2570921 0.0001144

U5UGC9 UDP-N-acetylglucosamine 2-epimerase 0.5612243 0.045202

G7SMM0 Ribosome-recycling factor 0.553913 0.0001041

A0A0K2E4M4 Branched-chain amino acid ABC transporter

substrate-binding protein 0.6263624 0.0036225

U5UF76 50S ribosomal protein L14 0.2693799 2.613E-05

D5AEX1 Cell wall surface anchor family protein 0.2002953 0.0003306

U5UFQ7 Adenylate kinase 0.4333582 9.739E-05

A4VXA0 Glutamine amidotransferase, class I 0.2905769 2.601E-05 D5AHC4 Putative ABC transporter, ATP-binding protein 0.57312 0.0081273 A0A0H3MWC3 Putative ferrichrome-binding protein 0.3718117 7.414E-05 A0A116LQH7 ABC transporter ATP-binding protein 0.6416894 0.014054

U5UGE0 Glycosyltransferase 0.6553018 0.0347901

G7SGW9 Deoxyribose-phosphate aldolase 0.6339315 0.0099664

D5AJ13 Putative 5'-nucleotidase 0.3418261 1.383E-06

A0A0Z8GRV4 30S ribosomal protein S7 0.297216 0.0009376

A0A0Z8K531 Aspartate-semialdehyde dehydrogenase 0.5972903 0.0068638

U5UKD0 30S ribosomal protein S6 0.2206902 0.0001113

D5AF69 ChaP 0.5300603 0.0009958

D5AFC8 50S ribosomal protein L24 0.1468604 0.0003207

G7SP72 Transcriptional regulator 0.4912805 0.0324263

G7SLK4 50S ribosomal protein L22 0.2181957 0.0020862

A0A0Z8LWI2 Type I site-specific restriction-modification system, R (Restriction) subunit and related

helicase (hsdR) 0.623129 0.0183101

G7SJM1 Uncharacterized protein 0.4580858 0.0014657

U5UCQ9 50S ribosomal protein L19 0.1759141 9.621E-05

A0A0Z8C892 Dihydropteroate synthase 0.6520267 0.0495451

U5ULT3 50S ribosomal protein L9 0.3960394 0.0002053

U5UGX3 30S ribosomal protein S18 0.6021575 0.0090162

D5AFC1 30S ribosomal protein S19 0.2730748 0.0005612

A0A0Z8JHW7 Phosphotransferase system IIC component,

glucose/maltose/N-acetylglucosamine-specific 0.5300781 0.022709

A0A116PGF8 ABC transporter ATPase 0.6242894 0.0016979

U5UCU6 30S ribosomal protein S17 0.2422639 0.0017337

G7SLG0 Transcription elongation factor GreA 0.3651293 0.0025012

(3)

D5AHN1 Orotate phosphoribosyltransferase 0.4820171 0.0042136

G7SNZ7 50S ribosomal protein L13 0.2653484 0.0040796

G7SIP7 Transcription termination/antitermination

protein NusG 0.5396196 0.0376755

D5AIA1 ABC transporter, ATP binding protein 0.6194478 0.0118608 A0A123TNJ0 Probable transcriptional regulatory protein

yebC 0.3225879 0.0015531

U5UI12 30S ribosomal protein S9 0.4074778 0.0001523

A0A0H3MW10 Putative Mac family protein 0.3892814 2.942E-05

Q5VLQ9 Putative ABC transporter 0.2891151 0.0020169

U5UCV8 30S ribosomal protein S11 0.2975225 0.0265704

G5L2B4 ABC-type multidrug transport system, ATPase

and permease component 0.4892995 0.0068807

A4VTU1 Cps2A 0.4869373 0.0390005

G7SLU7 Glutamine ABC transporter substrate-binding

protein 0.150924 0.0011983

D5AJV3 Ribosome-binding factor A 0.5258536 0.0040827

U5UGQ1 Major membrane immunogen, membrane-

anchored lipoprotein 0.3738372 2.917E-06

U5UJ31 Adenosine deaminase 0.2121406 2.749E-05

D5AEV7 High-affinity zinc uptake system protein znuA 0.3953344 0.0033781

D5AF19 Replicative DNA helicase 0.6637039 0.0190254

U5UGP4 Uncharacterized protein 0.6469067 0.0376455

D5AJY1 FeS assembly protein SufD 0.5539037 0.0265938

U5UIS6 30S ribosomal protein S16 0.1346782 0.0004022

G7SLU8 ABC-type polar amino acid transport system,

ATPase component 0.2701461 1.365E-05

D5AH23 Formate--tetrahydrofolate ligase 0.538794 0.0030572 A0A0N0DQE3 Mannose-specific PTS IID 0.3786954 0.0061454

U5UC17 50S ribosomal protein L29 0.2568763 0.0008228

Q9X4U6 Chain length determinant

protein/polysaccharide export protein, cps2B 0.5196101 0.0295358 A0A116M3A8 Trypsin-like serine protease, htrA 0.6110816 0.0303447

D5AJM4 NADH dehydrogenase 0.5848161 0.0128247

A0A123SYN8 Phosphotransferase family protein 0.5796788 0.0066352 A0A0K2E4Y0 Translation initiation factor IF-3,infC 0.5831232 0.0006908

G7SJY8 Cell cycle protein GpsB 0.3125086 0.0065513

U5UFQ4 50S ribosomal protein L18 0.3552057 0.0031187

G5L0S6 30S ribosomal protein S15 0.3523914 0.0159549

U5UFP5 50S ribosomal protein L33 0.2082915 0.0010979

U5UEH8 ABC transporter permease protein 0.2020373 0.000877

U5UI26 Uncharacterized protein 0.5369483 0.0177279

U5UCQ3 Ribosomal silencing factor RsfS 0.6098834 0.0198185 D5AIL5 Glucose-6-phosphate isomerase 0.3997848 0.0300247

(4)

A4VVT3 Uncharacterized protein 0.2815363 0.0050042

U5UEM9 Phosphocarrier protein HPr 0.3492422 0.0024466

A0A0Z8ER95 Translation initiation factor 1 0.3581497 0.0005401

U5UBY3 50S ribosomal protein L16 0.4185553 0.0020911

B3GFZ7 Extracellular factor protein (Fragment) 0.2983263 0.0059207 D5AFJ8 Transcriptional regulator, glutamine synthetase

repressor 0.2890887 0.0219527

G5KZ68 50S ribosomal protein L27 0.174395 0.0002352

D5AGX2 Uncharacterized protein 0.2280664 0.033875

A0A0M9FIU4 Cation transport ATPase 0.211174 0.0004152

D5AII5 Glyoxalase/bleomycin resistance

protein/dioxygenase 0.3142942 0.0086231

A0A123TR75 Inosine-5'-monophosphatedehydrogenase ,

impdh 0.6119501 0.031397

A0A160JPX9 30S ribosomal protein S20 0.2457213 0.0413058 G7SH09 Amino acid ABC transporter periplasmic

protein 0.4681827 0.0125487

U5UG04 Isoleucyl-tRNA synthetase, putative 0.3822404 0.0006047 D5AEY4 GCN5-related N-acetyltransferase 0.545919 0.0252011

A4VVZ4 Uncharacterized protein 0.6090744 0.0158629

U5UCM1 50S ribosomal protein L28 0.2873077 0.0032011

G7SMQ5 Muramidase (Flagellum-specific) 0.5615803 0.049877 G7SK43 Sugar metabolism transcriptional regulator 0.5737949 0.0483964 U5UJ32 Multidrug ABC transporter ATPase 0.3992752 0.0454121

U5UDX1 DNA repair ATPase 0.6277826 0.0297081

U5UF16 Ribosome-associated heat shock protein

implicated in the recycling of the 50S subunit 0.6175239 0.0303114 A0A0Z8Y8J2 Phosphoribosylamine--glycine ligase 0.441863 0.0345573

G7SFL8 Mannonate dehydratase 0.5236117 0.0184847

D5AI52 Aconitate hydratase 0.6495672 0.0492683

U5UEE1 Glucose-1-phosphate thymidylyltransferase 1.5484823 0.04489274

A0A0Z8HRX2 DNA repair protein RecN 1.917848 0.01942772

A0A0H3MVS2

UDP-N-acetylmuramoyl-L-alanyl-D-

glutamate--L-lysine ligase 1.7655175 0.03659489

U5UDP7 Uncharacterized protein 3.237645 8.83922E-07

A0A116NL00 Thioredoxin reductase, trxB 1.5870255 0.003798859 A0A0Z8MKD7 DNA polymerase III subunits gamma and tau 1.8514158 0.0258779 A0A123SUF3

S-adenosylmethionine:tRNA

ribosyltransferase-isomerase 1.8537694 0.02730717 D5AFI5 Phenylalanyl-tRNA synthetase-like protein 1.7142354 0.033990972

D5AIR2 UDP-glucose 4-epimerase 1.7497194 0.030800531

U5UGX7 Cytidylate kinase ,cmk 1.6509531 0.022809859

A0A0Z8QJU8 Non-canonical purine NTP pyrophosphatase 1.6506669 0.035158422 U5UG34 Phosphopantothenoylcysteine decarboxylase 2.1541494 0.000452606

(5)

U5UD68 Small-conductance mechanosensitive channel 1.6073879 0.01354421 D5AIS8 Type I restriction enzyme EcoEI M protein 1.5225222 0.005355971 D5AIW8 Tetratricopeptide repeat family protein 1.5605915 0.0141768

U5UE19 ABC transporter 1.5740543 0.01642615

A0A116KBQ0 Dehydrogenase and related proteins 2.4291271 0.000909265

D5AGW4 ArcT 1.5896418 0.026682369

G7SNQ1 ATP synthase subunit b 1.9363525 0.01046527

G7SGL7 Putative protease 1.631779 0.002280322

A0A0Z8FLR7 Dihydroorotase ,pyrC 2.2753905 0.01061619

G7SJD2 Pyrimidine-nucleoside phosphorylase 2.0642261 0.002021482 A0A116KXV7 Glutamine amidotransferase 2.3032418 0.041020371 U5UHN7 ATP synthase subunit delta, atpH 1.7164064 0.03684631 A0A116M090

Holliday junction ATP-dependent DNA

helicase RuvB 1.7496919 0.03333253

U5UH19 Uncharacterized protein 3.1413322 3.15655E-05

G7SK03 Sensor histidine kinase 1.6454012 0.002504769

D5AIA5 Tagatose 1,6-diphosphate aldolase 1.6505953 0.006543686

A0A0N0DLY9 ATPase 3.4395097 7.37832E-05

D5AIL1 Peptidase M24 1.7917257 0.002553939

U5UGG4 Collagenase-like protease 1.5127468 0.019796031

G7SKZ8 Peptide ABC transporter permease 1.6634352 0.0124507 A0A168YWM4 LysR family transcriptional regulator 1.5974098 0.023970351

G7SLU0 Glycosyltransferase 1.8532377 0.000973199

G7SJK2 Cystathionine gamma-synthase 1.7041389 0.01067416

U5UET1 Thymidylate synthase 1.5402547 0.02311404

U5UEN0 Uncharacterized protein 1.6310835 0.001579916

A4VWB3

Predicted sugar phosphatases of the HAD

superfamily 2.4358285 0.008287761

D5AHF0 4-hydroxy-tetrahydrodipicolinate reductase 1.8042092 0.017543331 D5AGX6 Putative extramembranal protein, DltD protein 1.9863959 0.007545507

U5UFT3 Uncharacterized protein 1.9466195 0.003317242

D5AK62 Glycerone kinase 2.3347569 0.000322562

D5AFI9 10 kDa chaperonin 2.0082726 0.001806473

D5AIC6 Glycosyl transferase, family 2 1.6998268 0.03228385

D5AJI4 rRNA methyltransferase 1.6035513 0.02235448

A0A0Z8I8M7 HTH DNA-binding protein 3.6328652 0.001101631 D5AKC6

Uncharacterized conserved protein, phnB

family 1.6758534 0.0210538

A4VTT8 Uncharacterized protein conserved in bacteria 1.7858986 0.02541207

A0A142USF6 Cell surface protein 4.5403659 0.000385999

A0A0Z8MHH3 Cell division protein DivIB 2.0380576 0.008572645 G7SNC3 Peptide methionine sulfoxide reductase 1.7983347 0.020918891

G7SNQ6 ATP synthase epsilon chain 1.7359168 0.01319804

G5L152 MarR family regulatory protein 1.6179768 0.0126177

(6)

A0A168YTG7 Protein GrpE 1.6399504 0.000965257 D5AHN0 Putative glycosyltransferase 1.8984674 0.01284168 A0A116LXX9 30S ribosomal protein S21 1.8938924 0.003285797

U5UJR0 ADP-ribose pyrophosphatase 2.0943586 0.037278999

D5AJE2

ABC-type molybdenum transport system,

ATPase component 1.6774747 0.007432571

A4VTQ9 Uncharacterized protein 1.7075491 0.03281128

A0A0Z8IRA9 Permease 1.9728113 0.022752989

U5UHK2 Carbonic anhydrase 3.8537782 0.004025419

U5UFH3 Uncharacterized protein 2.2648037 0.031845659

G7SMS8 50S ribosomal protein L35 2.221746 0.026703199

G7SNY8 Uncharacterized protein 1.8740049 0.02830475

A0A0Z8IRK2 Segregation and condensation protein B 1.511739 0.02841734

A0A0M9FLF6 Dihydroxyacetone kinase 3.3106588 0.01101587

A0A0Z8DMS4 Recombination protein RecR 1 1.82657 0.03749986

D5AJ33 Aminotransferase 1.5323351 0.021838531

A4VUP9 Hypothetical cytosolic protein 1.95397 0.023828691 D5AIW5 Transcriptional antiterminator bglG 1.5324179 0.009689404 D5AFX4 Heat-inducible transcription repressor HrcA 3.0274035 0.040966172 Q8L0S0 Chloramphenicol acetyltransferase 8.3101189 0.02295992

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