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Anhang
Abbildungsverzeichnis
Abbildung 1 : Clenbuterol 21
Abbildung 2 : Steranskelett 26
Abbildung 3 : Testosteron 27
Abbildung 4 : 17-beta-hydroxyestra-4en-3on = 17-beta-19-Nortestosteron
= Nortestosteron = Nandrolon
27 Abbildung 5 : 17-alpha-hydrosyestra-4en-3on =
17-alpha-19-Nortestosteron = epi-17-alpha-19-Nortestosteron = epi-Nandrolon
28 Abbildung 6 : Stoffwechselwege der Phase I und Phase II
Biotransformation von Nandrolon
34 Abbildung 7 : Schematische Darstellung des Analysenganges einer
Dopingprobe
36 Abbildung 8 : Längsschnitt durch Haar und Haarfollikel mit Darstellung
der Verteilung des weichen und harten Keratins
45 Abbildung 9 : Potentielle Wege der Einlagerung von Medikamenten und
anderen Substanzen ins Haar
49 Abbildung 10 : Kalibriergeraden für Nandrolon und Nandrolonmetaboliten
im Pferdeurin
72 Abbildung 11 : Kalibriergeraden für Nandrolon und Nandrolonmetaboliten
im Pferdeplasma
73 Abbildung 12 : Mittlere Länge des Mähnen- und Schweifhaares [cm] der 7
Versuchstiere in dem 11wöchigen Untersuchungszeitraum
79 Abbildung 13 : Plasma-Clenbuterolkonzentration der 4 Versuchspferde
während und nach 10tägiger oraler Applikation von 2x täglich 0,8 µg Clenbuterol/kg KM
80
Abbildung 14 : Urin-Clenbuterolkonzentration der 4 Versuchspferde während und nach 10tägiger oraler Applikation von 2x täglich 0,8µg Clenbuterolhydrochlorid/kg KM
81
Abbildung 15 : Vergleich der Schweifhaar-Clenbuterolkonzentrationen [pg/mg] in den einzelnen Abschnitten im Verlauf der ersten 120 Versuchstage bei 4 Pferden
83
Abbildung 16 : Clenbuterolkonzentrationen ± sd in den Schweifhaarsegmenten als Durchschnitt der 4 Versuchspferde am 360. Versuchstag
84
Abbildung 17 : Vergleich der Clenbuterolkonzentration in Schweif- und Mähnenhaar von Versuchspferd „Archi“ am 360.
Versuchstag
84
Abbildung 18 : Clenbuterolkonzentration in den jeweiligen
Schweifhaarabschnitten des Versuchspferdes „Sinus“ an den einzelnen Probentagen im Verlauf des
Schweifhaarabschnitten des Versuchspferdes „Sinus“ an den einzelnen Probentagen im Verlauf des