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6. Literatur

Abbas-Terki, T., Blanco-Bose, W., Deglon, N., Pralong, W., and Aebischer, P. (2002).

Lentiviral-mediated RNA interference. Hum Gene Ther 13, 2197-2201.

Abu-Issa, R., and Kirby, M.L. (2007). Heart field: from mesoderm to heart tube. Annu Rev Cell Dev Biol 23, 45-68.

Adjali, O., Montel-Hagen, A., Swainson, L., Marty, S., Vicente, R., Mongellaz, C., Jacquet, C., Zimmermann, V., and Taylor, N. (2009). In vivo and ex vivo gene transfer in thymocytes and thymocyte precursors. Methods Mol Biol 506, 171-190.

Afouda, B.A., Martin, J., Liu, F., Ciau-Uitz, A., Patient, R., and Hoppler, S. (2008).

GATA transcription factors integrate Wnt signalling during heart development.

Development 135, 3185-3190.

Alvarez-Buylla, E.R., Liljegren, S.J., Pelaz, S., Gold, S.E., Burgeff, C., Ditta, G.S., Vergara-Silva, F., and Yanofsky, M.F. (2000). MADS-box gene evolution beyond flowers: expression in pollen, endosperm, guard cells, roots and trichomes. Plant J 24, 457-466.

Bartram, U., Molin, D.G., Wisse, L.J., Mohamad, A., Sanford, L.P., Doetschman, T., Speer, C.P., Poelmann, R.E., and Gittenberger-de Groot, A.C. (2001). Double-outlet right ventricle and overriding tricuspid valve reflect disturbances of looping,

myocardialization, endocardial cushion differentiation, and apoptosis in TGF-beta(2)-knockout mice. Circulation 103, 2745-2752.

Beddington, R.S., and Robertson, E.J. (1999). Axis development and early asymmetry in mammals. Cell 96, 195-209.

Belo, J.A., Bachiller, D., Agius, E., Kemp, C., Borges, A.C., Marques, S., Piccolo, S., and De Robertis, E.M. (2000). Cerberus-like is a secreted BMP and nodal antagonist not essential for mouse development. Genesis 26, 265-270.

Bernstein, E., Caudy, A.A., Hammond, S.M., and Hannon, G.J. (2001). Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409, 363-366.

Boheler, K.R., Czyz, J., Tweedie, D., Yang, H.T., Anisimov, S.V., and Wobus, A.M.

(2002). Differentiation of pluripotent embryonic stem cells into cardiomyocytes. Circ Res 91, 189-201.

Literatur

106 Boutros, M., and Mlodzik, M. (1999). Dishevelled: at the crossroads of divergent

intracellular signaling pathways. Mech Dev 83, 27-37.

Brand, T. (2003). Heart development: molecular insights into cardiac specification and early morphogenesis. Dev Biol 258, 1-19.

Bridge, A.J., Pebernard, S., Ducraux, A., Nicoulaz, A.L., and Iggo, R. (2003). Induction of an interferon response by RNAi vectors in mammalian cells. Nat Genet 34, 263-264.

Brummelkamp, T.R., Bernards, R., and Agami, R. (2002). A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550-553.

Bruneau, B.G., Logan, M., Davis, N., Levi, T., Tabin, C.J., Seidman, J.G., and Seidman, C.E. (1999). Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome. Dev Biol 211, 100-108.

Bruneau, B.G., Nemer, G., Schmitt, J.P., Charron, F., Robitaille, L., Caron, S., Conner, D.A., Gessler, M., Nemer, M., Seidman, C.E., et al. (2001). A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell 106, 709-721.

Buckingham, M., Meilhac, S., and Zaffran, S. (2005). Building the mammalian heart from two sources of myocardial cells. Nat Rev Genet 6, 826-835.

Carmell, M.A., and Hannon, G.J. (2004). RNase III enzymes and the initiation of gene silencing. Nat Struct Mol Biol 11, 214-218.

Caudy, A.A., Ketting, R.F., Hammond, S.M., Denli, A.M., Bathoorn, A.M., Tops, B.B., Silva, J.M., Myers, M.M., Hannon, G.J., and Plasterk, R.H. (2003). A micrococcal nuclease homologue in RNAi effector complexes. Nature 425, 411-414.

Caudy, A.A., Myers, M., Hannon, G.J., and Hammond, S.M. (2002). Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev 16, 2491-2496.

Chen, V.C., Stull, R., Joo, D., Cheng, X., and Keller, G. (2008). Notch signaling respecifies the hemangioblast to a cardiac fate. Nat Biotechnol 26, 1169-1178.

Chen, W.V., and Chen, Z. (2004). Differentiation trapping screen in live culture for genes expressed in cardiovascular lineages. Dev Dyn 229, 319-327.

Literatur

107 Ching, Y.H., Ghosh, T.K., Cross, S.J., Packham, E.A., Honeyman, L., Loughna, S., Robinson, T.E., Dearlove, A.M., Ribas, G., Bonser, A.J., et al. (2005). Mutation in myosin heavy chain 6 causes atrial septal defect. Nat Genet 37, 423-428.

Chopra, S.S., Stroud, D.M., Watanabe, H., Bennett, J.S., Burns, C.G., Wells, K.S., Yang, T., Zhong, T.P., and Roden, D.M. (2010). Voltage-gated sodium channels are required for heart development in zebrafish. Circ Res 106, 1342-1350.

Conlon, F.L., Lyons, K.M., Takaesu, N., Barth, K.S., Kispert, A., Herrmann, B., and Robertson, E.J. (1994). A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development 120, 1919-1928.

Coucouvanis, E., and Martin, G.R. (1999). BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo. Development 126, 535-546.

Cripps, R.M., and Olson, E.N. (2002). Control of cardiac development by an evolutionarily conserved transcriptional network. Dev Biol 246, 14-28.

Darken, R.S., Scola, A.M., Rakeman, A.S., Das, G., Mlodzik, M., and Wilson, P.A.

(2002). The planar polarity gene strabismus regulates convergent extension movements in Xenopus. EMBO J 21, 976-985.

Ding, J., Yang, L., Yan, Y.T., Chen, A., Desai, N., Wynshaw-Boris, A., and Shen, M.M.

(1998). Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo. Nature 395, 702-707.

Dudley, A.T., and Robertson, E.J. (1997). Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos. Dev Dyn 208, 349-362.

Dull, T., Zufferey, R., Kelly, M., Mandel, R.J., Nguyen, M., Trono, D., and Naldini, L.

(1998). A third-generation lentivirus vector with a conditional packaging system. J Virol 72, 8463-8471.

Dush, M.K., and Martin, G.R. (1992). Analysis of mouse Evx genes: Evx-1 displays graded expression in the primitive streak. Dev Biol 151, 273-287.

Egea, J., Erlacher, C., Montanez, E., Burtscher, I., Yamagishi, S., Hess, M., Hampel, F., Sanchez, R., Rodriguez-Manzaneque, M.T., Bosl, M.R., et al. (2008). Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation. Genes Dev 22, 3349-3362.

Literatur

108 Elbashir, S.M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., and Tuschl, T.

(2001a). Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498.

Elbashir, S.M., Lendeckel, W., and Tuschl, T. (2001b). RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev 15, 188-200.

Elbashir, S.M., Martinez, J., Patkaniowska, A., Lendeckel, W., and Tuschl, T. (2001c).

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J 20, 6877-6888.

Fassler, R., and Meyer, M. (1995). Consequences of lack of beta 1 integrin gene expression in mice. Genes Dev 9, 1896-1908.

Fassler, R., Rohwedel, J., Maltsev, V., Bloch, W., Lentini, S., Guan, K., Gullberg, D., Hescheler, J., Addicks, K., and Wobus, A.M. (1996). Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin. J Cell Sci 109 ( Pt 13), 2989-2999.

Fijnvandraat, A.C., van Ginneken, A.C., de Boer, P.A., Ruijter, J.M., Christoffels, V.M., Moorman, A.F., and Lekanne Deprez, R.H. (2003a). Cardiomyocytes derived from embryonic stem cells resemble cardiomyocytes of the embryonic heart tube. Cardiovasc Res 58, 399-409.

Fijnvandraat, A.C., van Ginneken, A.C., Schumacher, C.A., Boheler, K.R., Lekanne Deprez, R.H., Christoffels, V.M., and Moorman, A.F. (2003b). Cardiomyocytes purified from differentiated embryonic stem cells exhibit characteristics of early chamber

myocardium. J Mol Cell Cardiol 35, 1461-1472.

Filippov, V., Solovyev, V., Filippova, M., and Gill, S.S. (2000). A novel type of RNase III family proteins in eukaryotes. Gene 245, 213-221.

Fire, A., Xu, S., Montgomery, M.K., Kostas, S.A., Driver, S.E., and Mello, C.C. (1998).

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811.

Foley, A., and Mercola, M. (2004). Heart induction: embryology to cardiomyocyte regeneration. Trends Cardiovasc Med 14, 121-125.

Forlani, S., Lawson, K.A., and Deschamps, J. (2003). Acquisition of Hox codes during gastrulation and axial elongation in the mouse embryo. Development 130, 3807-3819.

Literatur

109 Fotaki, V., Larralde, O., Zeng, S., McLaughlin, D., Nichols, J., Price, D.J., Theil, T., and Mason, J.O. (2010). Loss of Wnt8b has no overt effect on hippocampus development but leads to altered Wnt gene expression levels in dorsomedial telencephalon. Dev Dyn 239, 284-296.

Freisinger, C.M., Fisher, R.A., and Slusarski, D.C. (2010). Regulator of g protein signaling 3 modulates wnt5b calcium dynamics and somite patterning. PLoS Genet 6, e1001020.

Frka, K., Facchinello, N., Del Vecchio, C., Carpi, A., Curtarello, M., Venerando, R., Angelin, A., Parolin, C., Bernardi, P., Bonaldo, P., et al. (2009). Lentiviral-mediated RNAi in vivo silencing of Col6a1, a gene with complex tissue specific expression pattern. J Biotechnol 141, 8-17.

Gadue, P., Huber, T.L., Nostro, M.C., Kattman, S., and Keller, G.M. (2005). Germ layer induction from embryonic stem cells. Exp Hematol 33, 955-964.

Gao, C., and Chen, Y.G. (2010). Dishevelled: The hub of Wnt signaling. Cell Signal 22, 717-727.

Gazit, A., Yaniv, A., Bafico, A., Pramila, T., Igarashi, M., Kitajewski, J., and Aaronson, S.A. (1999). Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene 18, 5959-5966.

Gerull, B., Gramlich, M., Atherton, J., McNabb, M., Trombitas, K., Sasse-Klaassen, S., Seidman, J.G., Seidman, C., Granzier, H., Labeit, S., et al. (2002). Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy. Nat Genet 30, 201-204.

Gessert, S., and Kuhl, M. (2010). The multiple phases and faces of wnt signaling during cardiac differentiation and development. Circ Res 107, 186-199.

Gessert, S., Maurus, D., Brade, T., Walther, P., Pandur, P., and Kuhl, M. (2008). DM-GRASP/ALCAM/CD166 is required for cardiac morphogenesis and maintenance of cardiac identity in first heart field derived cells. Dev Biol 321, 150-161.

Gil, J., and Esteban, M. (2000). Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action. Apoptosis 5, 107-114.

Glinka, A., Wu, W., Delius, H., Monaghan, A.P., Blumenstock, C., and Niehrs, C.

(1998). Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 391, 357-362.

Literatur

110 Gomez-Ospina, N., Tsuruta, F., Barreto-Chang, O., Hu, L., and Dolmetsch, R. (2006).

The C terminus of the L-type voltage-gated calcium channel Ca(V)1.2 encodes a transcription factor. Cell 127, 591-606.

Grepin, C., Robitaille, L., Antakly, T., and Nemer, M. (1995). Inhibition of transcription factor GATA-4 expression blocks in vitro cardiac muscle differentiation. Mol Cell Biol 15, 4095-4102.

Grey, C., Mery, A., and Puceat, M. (2005). Fine-tuning in Ca2+ homeostasis underlies progression of cardiomyopathy in myocytes derived from genetically modified

embryonic stem cells. Hum Mol Genet 14, 1367-1377.

Guo, N., Hawkins, C., and Nathans, J. (2004). Frizzled6 controls hair patterning in mice.

Proc Natl Acad Sci U S A 101, 9277-9281.

Hamilton, A.J., and Baulcombe, D.C. (1999). A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 286, 950-952.

Hammond, S.M., Boettcher, S., Caudy, A.A., Kobayashi, R., and Hannon, G.J. (2001).

Argonaute2, a link between genetic and biochemical analyses of RNAi. Science 293, 1146-1150.

Hart, A.H., Hartley, L., Sourris, K., Stadler, E.S., Li, R., Stanley, E.G., Tam, P.P., Elefanty, A.G., and Robb, L. (2002). Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo. Development 129, 3597-3608.

Heidel, J.D., Hu, S., Liu, X.F., Triche, T.J., and Davis, M.E. (2004). Lack of interferon response in animals to naked siRNAs. Nat Biotechnol 22, 1579-1582.

Hoffman, J.I., and Kaplan, S. (2002). The incidence of congenital heart disease. J Am Coll Cardiol 39, 1890-1900.

Hoogaars, W.M., Tessari, A., Moorman, A.F., de Boer, P.A., Hagoort, J., Soufan, A.T., Campione, M., and Christoffels, V.M. (2004). The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart. Cardiovasc Res 62, 489-499.

Houweling, A.C., Somi, S., Van Den Hoff, M.J., Moorman, A.F., and Christoffels, V.M.

(2002). Developmental pattern of ANF gene expression reveals a strict localization of cardiac chamber formation in chicken. Anat Rec 266, 93-102.

Literatur

111 Houweling, A.C., van Borren, M.M., Moorman, A.F., and Christoffels, V.M. (2005).

Expression and regulation of the atrial natriuretic factor encoding gene Nppa during development and disease. Cardiovasc Res 67, 583-593.

Hrabchak, C., Ringuette, M., and Woodhouse, K. (2008). Recombinant mouse SPARC promotes parietal endoderm differentiation and cardiomyogenesis in embryoid bodies.

Biochem Cell Biol 86, 487-499.

Huelsken, J., Vogel, R., Brinkmann, V., Erdmann, B., Birchmeier, C., and Birchmeier, W. (2000). Requirement for beta-catenin in anterior-posterior axis formation in mice. J Cell Biol 148, 567-578.

Hulme, J.T., Konoki, K., Lin, T.W., Gritsenko, M.A., Camp, D.G., 2nd, Bigelow, D.J., and Catterall, W.A. (2005). Sites of proteolytic processing and noncovalent association of the distal C-terminal domain of CaV1.1 channels in skeletal muscle. Proc Natl Acad Sci U S A 102, 5274-5279.

Hulme, J.T., Yarov-Yarovoy, V., Lin, T.W., Scheuer, T., and Catterall, W.A. (2006).

Autoinhibitory control of the CaV1.2 channel by its proteolytically processed distal C-terminal domain. J Physiol 576, 87-102.

Ilagan, R., Abu-Issa, R., Brown, D., Yang, Y.P., Jiao, K., Schwartz, R.J., Klingensmith, J., and Meyers, E.N. (2006). Fgf8 is required for anterior heart field development.

Development 133, 2435-2445.

James, R.G., Conrad, W.H., and Moon, R.T. (2008). Beta-catenin-independent Wnt pathways: signals, core proteins, and effectors. Methods Mol Biol 468, 131-144.

Jiao, K., Langworthy, M., Batts, L., Brown, C.B., Moses, H.L., and Baldwin, H.S. (2006).

Tgfbeta signaling is required for atrioventricular cushion mesenchyme remodeling during in vivo cardiac development. Development 133, 4585-4593.

Kamino, K. (1991). Optical approaches to ontogeny of electrical activity and related functional organization during early heart development. Physiol Rev 71, 53-91.

Kaneda, T., Naruse, C., Kawashima, A., Fujino, N., Oshima, T., Namura, M., Nunoda, S., Mori, S., Konno, T., Ino, H., et al. (2008). A novel beta-myosin heavy chain gene mutation, p.Met531Arg, identified in isolated left ventricular non-compaction in humans, results in left ventricular hypertrophy that progresses to dilation in a mouse model. Clin Sci (Lond) 114, 431-440.

Literatur

112 Kelly R.G., Franco D., Moorman A.F.M., Buckingham M. (1999): Regionalization of Transcriptional Potential in the Myocardium. In: Harvey R.P. and Rosenthal N. (Hrsg.) Heart Development, 1.Auflage, 333-355, Academic Press, London

Ketting, R.F., Haverkamp, T.H., van Luenen, H.G., and Plasterk, R.H. (1999). Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD. Cell 99, 133-141.

Kim, D.H., Longo, M., Han, Y., Lundberg, P., Cantin, E., and Rossi, J.J. (2004).

Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase. Nat Biotechnol 22, 321-325.

Kinder, S.J., Tsang, T.E., Quinlan, G.A., Hadjantonakis, A.K., Nagy, A., and Tam, P.P.

(1999). The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo. Development 126, 4691-4701.

Kinder, S.J., Tsang, T.E., Wakamiya, M., Sasaki, H., Behringer, R.R., Nagy, A., and Tam, P.P. (2001). The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm. Development 128, 3623-3634.

Kispert, A., and Herrmann, B.G. (1994). Immunohistochemical analysis of the Brachyury protein in wild-type and mutant mouse embryos. Dev Biol 161, 179-193.

Kraus, F., Haenig, B., and Kispert, A. (2001). Cloning and expression analysis of the mouse T-box gene tbx20. Mech Dev 100, 87-91.

Kuhl, M., Geis, K., Sheldahl, L.C., Pukrop, T., Moon, R.T., and Wedlich, D. (2001).

Antagonistic regulation of convergent extension movements in Xenopus by Wnt/beta-catenin and Wnt/Ca2+ signaling. Mech Dev 106, 61-76.

Kuhl, M., Sheldahl, L.C., Malbon, C.C., and Moon, R.T. (2000). Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. J Biol Chem 275, 12701-12711.

Kumar, A., Lualdi, M., Lewandoski, M., and Kuehn, M.R. (2008). Broad mesodermal and endodermal deletion of Nodal at postgastrulation stages results solely in left/right axial defects. Dev Dyn 237, 3591-3601.

Kuo, C.T., Morrisey, E.E., Anandappa, R., Sigrist, K., Lu, M.M., Parmacek, M.S., Soudais, C., and Leiden, J.M. (1997). GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev 11, 1048-1060.

Literatur

113 Kwee, L., Baldwin, H.S., Shen, H.M., Stewart, C.L., Buck, C., Buck, C.A., and Labow, M.A. (1995). Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice. Development 121, 489-503.

Laasberg, T. (1990). Ca2(+)-mobilizing receptors of gastrulating chick embryo. Comp Biochem Physiol C 97, 9-12.

Laemmli, U.K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.

Lawson, K.A., Dunn, N.R., Roelen, B.A., Zeinstra, L.M., Davis, A.M., Wright, C.V., Korving, J.P., and Hogan, B.L. (1999). Bmp4 is required for the generation of primordial germ cells in the mouse embryo. Genes Dev 13, 424-436.

Lee, N.S., Dohjima, T., Bauer, G., Li, H., Li, M.J., Ehsani, A., Salvaterra, P., and Rossi, J. (2002). Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nat Biotechnol 20, 500-505.

Liberatore, C.M., Searcy-Schrick, R.D., and Yutzey, K.E. (2000). Ventricular expression of tbx5 inhibits normal heart chamber development. Dev Biol 223, 169-180.

Lin, Q., Schwarz, J., Bucana, C., and Olson, E.N. (1997). Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science 276, 1404-1407.

Linask, K.L., and Linask, K.K. (2010). Calcium channel blockade in embryonic cardiac progenitor cells disrupts normal cardiac cell differentiation. Stem Cells Dev 19, 1959-1965.

Lindsley, R.C., Gill, J.G., Kyba, M., Murphy, T.L., and Murphy, K.M. (2006). Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm.

Development 133, 3787-3796.

Liu, J., Carmell, M.A., Rivas, F.V., Marsden, C.G., Thomson, J.M., Song, J.J.,

Hammond, S.M., Joshua-Tor, L., and Hannon, G.J. (2004). Argonaute2 is the catalytic engine of mammalian RNAi. Science 305, 1437-1441.

Liu, P., Wakamiya, M., Shea, M.J., Albrecht, U., Behringer, R.R., and Bradley, A.

(1999). Requirement for Wnt3 in vertebrate axis formation. Nat Genet 22, 361-365.

Lyons, I., Parsons, L.M., Hartley, L., Li, R., Andrews, J.E., Robb, L., and Harvey, R.P.

(1995). Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev 9, 1654-1666.

Literatur

114 Maltsev, V.A., Rohwedel, J., Hescheler, J., and Wobus, A.M. (1993). Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types. Mech Dev 44, 41-50.

Maltsev, V.A., Wobus, A.M., Rohwedel, J., Bader, M., and Hescheler, J. (1994).

Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents. Circ Res 75, 233-244.

Martinez, J., and Tuschl, T. (2004). RISC is a 5' phosphomonoester-producing RNA endonuclease. Genes Dev 18, 975-980.

Marvin, M.J., Di Rocco, G., Gardiner, A., Bush, S.M., and Lassar, A.B. (2001).

Inhibition of Wnt activity induces heart formation from posterior mesoderm. Genes Dev 15, 316-327.

McCulley, D.J., Kang, J.O., Martin, J.F., and Black, B.L. (2008). BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development. Dev Dyn 237, 3200-3209.

Meacham, C.E., Ho, E.E., Dubrovsky, E., Gertler, F.B., and Hemann, M.T. (2009). In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression. Nat Genet 41, 1133-1137.

Meno, C., Ito, Y., Saijoh, Y., Matsuda, Y., Tashiro, K., Kuhara, S., and Hamada, H.

(1997). Two closely-related left-right asymmetrically expressed genes, 1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos. Genes Cells 2, 513-524.

Mery, A., Aimond, F., Menard, C., Mikoshiba, K., Michalak, M., and Puceat, M. (2005).

Initiation of embryonic cardiac pacemaker activity by inositol 1,4,5-trisphosphate-dependent calcium signaling. Mol Biol Cell 16, 2414-2423.

Mesaeli, N., Nakamura, K., Zvaritch, E., Dickie, P., Dziak, E., Krause, K.H., Opas, M., MacLennan, D.H., and Michalak, M. (1999). Calreticulin is essential for cardiac development. J Cell Biol 144, 857-868.

Milner, D.J., Weitzer, G., Tran, D., Bradley, A., and Capetanaki, Y. (1996). Disruption of muscle architecture and myocardial degeneration in mice lacking desmin. J Cell Biol 134, 1255-1270.

Miyagishi, M., and Taira, K. (2002). U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells. Nat Biotechnol 20, 497-500.

Literatur

115 Molkentin, J.D., Lin, Q., Duncan, S.A., and Olson, E.N. (1997). Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev 11, 1061-1072.

Moretti, A., Caron, L., Nakano, A., Lam, J.T., Bernshausen, A., Chen, Y., Qyang, Y., Bu, L., Sasaki, M., Martin-Puig, S., et al. (2006). Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell 127, 1151-1165.

Moss, E.G., and Taylor, J.M. (2003). Small-interfering RNAs in the radar of the interferon system. Nat Cell Biol 5, 771-772.

Muley, A., Majumder, S., Kolluru, G.K., Parkinson, S., Viola, H., Hool, L., Arfuso, F., Ganss, R., Dharmarajan, A., and Chatterjee, S. (2010). Secreted frizzled-related protein 4: an angiogenesis inhibitor. Am J Pathol 176, 1505-1516.

Murry, C.E., and Keller, G. (2008). Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell 132, 661-680.

Nagy, II, Railo, A., Rapila, R., Hast, T., Sormunen, R., Tavi, P., Rasanen, J., and Vainio, S.J. (2009). Wnt-11 signalling controls ventricular myocardium development by

patterning N-cadherin and {beta}-catenin expression. Cardiovasc Res.

Nakamura, T., Sano, M., Songyang, Z., and Schneider, M.D. (2003). A Wnt and beta -catenin-dependent pathway for mammalian cardiac myogenesis. Proc Natl Acad Sci U S A 100, 5834-5839.

Niederreither, K., Vermot, J., Messaddeq, N., Schuhbaur, B., Chambon, P., and Dolle, P.

(2001). Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse. Development 128, 1019-1031.

Nykanen, A., Haley, B., and Zamore, P.D. (2001). ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell 107, 309-321.

Oshima, M., Oshima, H., and Taketo, M.M. (1996). TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. Dev Biol 179, 297-302.

Paddison, P.J., Caudy, A.A., and Hannon, G.J. (2002). Stable suppression of gene expression by RNAi in mammalian cells. Proc Natl Acad Sci U S A 99, 1443-1448.

Paddison, P.J., Silva, J.M., Conklin, D.S., Schlabach, M., Li, M., Aruleba, S., Balija, V., O'Shaughnessy, A., Gnoj, L., Scobie, K., et al. (2004). A resource for large-scale RNA-interference-based screens in mammals. Nature 428, 427-431.

Literatur

116 Pandur, P., Lasche, M., Eisenberg, L.M., and Kuhl, M. (2002). Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis. Nature 418, 636-641.

Papadatos, G.A., Wallerstein, P.M., Head, C.E., Ratcliff, R., Brady, P.A., Benndorf, K., Saumarez, R.C., Trezise, A.E., Huang, C.L., Vandenberg, J.I., et al. (2002). Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a. Proc Natl Acad Sci U S A 99, 6210-6215.

Parameswaran, M., and Tam, P.P. (1995). Regionalisation of cell fate and morphogenetic movement of the mesoderm during mouse gastrulation. Dev Genet 17, 16-28.

Park, M., and Moon, R.T. (2002). The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos. Nat Cell Biol 4, 20-25.

Park, M., Wu, X., Golden, K., Axelrod, J.D., and Bodmer, R. (1996). The wingless signaling pathway is directly involved in Drosophila heart development. Dev Biol 177, 104-116.

Paul, C.P., Good, P.D., Winer, I., and Engelke, D.R. (2002). Effective expression of small interfering RNA in human cells. Nat Biotechnol 20, 505-508.

Pedrazzini, T. (2007). Control of cardiogenesis by the notch pathway. Trends Cardiovasc Med 17, 83-90.

Perea-Gomez, A., Vella, F.D., Shawlot, W., Oulad-Abdelghani, M., Chazaud, C., Meno, C., Pfister, V., Chen, L., Robertson, E., Hamada, H., et al. (2002). Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks. Dev Cell 3, 745-756.

Pereira, F.A., Qiu, Y., Zhou, G., Tsai, M.J., and Tsai, S.Y. (1999). The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. Genes Dev 13, 1037-1049.

Pfeifer, A., Ikawa, M., Dayn, Y., and Verma, I.M. (2002). Transgenesis by lentiviral vectors: lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos. Proc Natl Acad Sci U S A 99, 2140-2145.

Pikkarainen, S., Tokola, H., Kerkela, R., and Ruskoaho, H. (2004). GATA transcription factors in the developing and adult heart. Cardiovasc Res 63, 196-207.

Literatur

117 Przemeck, G.K., Heinzmann, U., Beckers, J., and Hrabe de Angelis, M. (2003). Node and midline defects are associated with left-right development in Delta1 mutant embryos.

Development 130, 3-13.

Puceat, M., and Jaconi, M. (2005). Ca2+ signalling in cardiogenesis. Cell Calcium 38, 383-389.

Rapila, R., Korhonen, T., and Tavi, P. (2008). Excitation-contraction coupling of the mouse embryonic cardiomyocyte. J Gen Physiol 132, 397-405.

Riley, P., Anson-Cartwright, L., and Cross, J.C. (1998). The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis. Nat Genet 18, 271-275.

Rossant, J., and Tam, P.P. (2009). Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development 136, 701-713.

Saiki, R.K., Bugawan, T.L., Horn, G.T., Mullis, K.B., and Erlich, H.A. (1986). Analysis of enzymatically amplified beta-globin and HLA-DQ alpha DNA with allele-specific oligonucleotide probes. Nature 324, 163-166.

Sasaki, H., and Hogan, B.L. (1993). Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development 118, 47-59.

Sasse, P., Zhang, J., Cleemann, L., Morad, M., Hescheler, J., and Fleischmann, B.K.

(2007). Intracellular Ca2+ oscillations, a potential pacemaking mechanism in early embryonic heart cells. J Gen Physiol 130, 133-144.

Sauer H., Wartenberg M., Sachinidis A., Hescheler J. (2004): Development oft he Cardi-ovascular System in Embryoid Bodies Derived from Embryonic Stem Cells. In: Sell S.

(Hrsg.)Stem Cells Handbook, 1.Auflage,229-238, Humana Press Inc., Totowa, NJ

Schneider, V.A., and Mercola, M. (2001). Wnt antagonism initiates cardiogenesis in Xenopus laevis. Genes Dev 15, 304-315.

Schultheiss, T.M., Burch, J.B., and Lassar, A.B. (1997). A role for bone morphogenetic proteins in the induction of cardiac myogenesis. Genes Dev 11, 451-462.

Schwarz, D.S., Hutvagner, G., Du, T., Xu, Z., Aronin, N., and Zamore, P.D. (2003).

Asymmetry in the assembly of the RNAi enzyme complex. Cell 115, 199-208.

Literatur

118 Shai, S.Y., Harpf, A.E., Babbitt, C.J., Jordan, M.C., Fishbein, M.C., Chen, J., Omura, M., Leil, T.A., Becker, K.D., Jiang, M., et al. (2002). Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. Circ Res 90, 458-464.

Sheldahl, L.C., Slusarski, D.C., Pandur, P., Miller, J.R., Kuhl, M., and Moon, R.T.

(2003). Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos. J Cell Biol 161, 769-777.

Singh, M.K., Christoffels, V.M., Dias, J.M., Trowe, M.O., Petry, M., Schuster-Gossler, K., Burger, A., Ericson, J., and Kispert, A. (2005). Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2. Development 132, 2697-2707.

Sledz, C.A., Holko, M., de Veer, M.J., Silverman, R.H., and Williams, B.R. (2003).

Activation of the interferon system by short-interfering RNAs. Nat Cell Biol 5, 834-839.

Solloway, M.J., and Harvey, R.P. (2003). Molecular pathways in myocardial development: a stem cell perspective. Cardiovasc Res 58, 264-277.

Solloway, M.J., and Robertson, E.J. (1999). Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup.

Development 126, 1753-1768.

Somi, S., Buffing, A.A., Moorman, A.F., and Van Den Hoff, M.J. (2004). Dynamic patterns of expression of BMP isoforms 2, 4, 5, 6, and 7 during chicken heart development. Anat Rec A Discov Mol Cell Evol Biol 279, 636-651.

Srinivas, S. (2006). The anterior visceral endoderm-turning heads. Genesis 44, 565-572.

Srivastava, D. (1999). HAND proteins: molecular mediators of cardiac development and congenital heart disease. Trends Cardiovasc Med 9, 11-18.

Srivastava, D., Thomas, T., Lin, Q., Kirby, M.L., Brown, D., and Olson, E.N. (1997).

Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat Genet 16, 154-160.

Sui, G., Soohoo, C., Affar el, B., Gay, F., Shi, Y., and Forrester, W.C. (2002). A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci U S A 99, 5515-5520.

Sun, X., Meyers, E.N., Lewandoski, M., and Martin, G.R. (1999). Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev 13, 1834-1846.