3 Material und Methode
4.1 Systematische Literaturrecherche
4.1.1 Verwendete Literatur
4.1.2.1 Hormone des Pankreas
4.1.2.1.1 Insulin
Zum Hormon Insulin wurden bei der systematischen Literatursuche bis einschließlich September 2018 insgesamt 143 relevante Veröffentlichungen gefunden (Tabelle 3), von denen 106 Studien primär dem Hormon Insulin zugeordnet wurden (in den folgenden Tabellen gekennzeichnet durch eine fortlaufende Nummerierung). Die übrigen 37 Veröffentlichungen (gekennzeichnet durch ein Sternchen *) enthalten zwar auch Primärdaten zu Insulin, im Vordergrund stehen bei diesen aber andere Hormone, weshalb solche Studien nachfolgend immer erst unter dem Hormon-Kapitel nummeriert und bearbeitet werden, auf dem der Haupt-Fokus der jeweiligen Arbeit liegt.
Tabelle 3: Übersicht über eingeschlossene Veröffentlichungen die Primärdaten zum Hormon Insulin bei der peripartalen Milchkuh enthalten
Nr. 1. Autor Jahr Titel
* Manns 1972 Separation of Pancreatic and Gut Glucagon-Like Immunoreactivity (G.L.I.) with Observations on Plasma Concentrations of these Hormones during Lactation 1 Schwalm und
Schultz
1976 Relationship of insulin concentration to blood metabolites in the dairy cow
2 Kunz und Blum 1985 Relationships between energy balances and blood levels of hormones and metabolites in dairy cows during late
pregnancy and early lactation
3 Thilsted 1985 Regulation of the partition of nutrients in the dairy cow in late pregnancy and early lactation
* De Boer et al. 1986 Secretion and Clearance Rates of Glucagon in Dairy Cows
44
4 Gerloff et al. 1986 Inositol and hepatic lipidosis. II. Effect of inositol
supplementation and time from parturition on serum insulin, thyroxine and triiodothyronine and their relationship to serum and liver lipids in dairy cows
5 Giesecke 1986 Insulin deficiency and metabolic disorders in high-yielding dairy cows
6 Campbell et al. 1987 Changes in bovine mammary insulin binding during pregnancy and lactation
* Ronge und Blum
1988 Somatomedin C and other hormones in dairy cows around parturition, in newborn calves and in milk
7 Oda et al. 1989 Insulin-like growth factor-I, GH, insulin and glucagon concentrations in bovine colostrum and in plasma of dairy cows and neonatal calves around parturition
8 Schams et al. 1991 Hormonal changes during lactation in cows of three different breeds
* Vicini et al. 1991 Nutrient balance and stage of lactation affect responses of insulin, insulin-like growth factors I and II, and insulin-like growth factor-binding protein 2 to somatotropin
administration in dairy cows 9 Staufenbiel et
al.
1992 Diurnal profile and glucose-tolerance test for studies into insulin function in dairy-cows
10 Studer et al. 1993 Effect of prepartum propylene glycol administration on periparturient fatty liver in dairy cows
11 Studzinski et al.
1994 Periparturient concentrations of insulin, thyroxin (T4) and triiodothyronine (T3) in high producing dairy cow
12 Formigoni et al.
1996 Effect of propylene glycol supplementation around parturition on milk yield, reproduction performance and some hormonal and metabolic characteristics in dairy cows
13 Rukkwamsuk et al.
1998 Effect of overfeeding during the dry period on regulation of adipose tissue metabolism in dairy cows during the
periparturient period 14 Rukkwamsuk
et al.
1999 Effect of Overfeeding During the Dry Period on the Rate of Esterification in Adipose Tissue of Dairy Cows During the Periparturient Period
* Block et al. 2001 Decreased concentration of plasma leptin in periparturient dairy cows is caused by negative energy balance
* Vallimont et al. 2001 Effects of prepartum somatotropin and monensin on metabolism and production of periparturient Holstein dairy cows
15 Hayirli et al. 2002 Effects of slow-release insulin on production, liver triglyceride, and metabolic profiles of Holsteins in early lactation
16 Pechová et al. 2002 Metabolic Effects of Chromium Supplementation in Dairy Cows in the Peripartal Period
* Gulay et al. 2003 Responses of Holstein cows to a low dose of somatotropin (bST) prepartum and postpartum
17 Holtenius et al. 2003 Effects of feeding intensity during the dry period. 2.
Metabolic and hormonal responses
18 Leury et al. 2003 Effect of insulin and growth hormone on plasma leptin in periparturient dairy cows
45
* Nikolić et al. 2003 Periparturient endocrine and metabolic changes in healthy cows and in cows affected by mastitis
* Radcliff et al. 2003a Plasma hormones and expression of growth hormone receptor and insulin-like growth factor-I mRNA in hepatic tissue of periparturient dairy cows
* Reist et al. 2003 Concentrate Feeding Strategy in Lactating Dairy Cows:
Metabolic and Endocrine Changes with Emphasis on Leptin 19 Studzinski et
al.
2003 Hormonal and metabolic adaptations to periparturient and early lactation periods in dairy cows
* Gulay et al. 2004a Low doses of bovine somatotropin during the transition period and early lactation improves milk yield, efficiency of production, and other physiological responses of Holstein cows
* Gulay et al. 2004b Responses of Holstein cows to different bovine somatotropin (bST) treatments during the transition period and early lactation
20 Meikle et al. 2004 Effects of parity and body condition at parturition on endocrine and reproductive parameters of the cow 21 Rhoads et al. 2004 Insulin increases the abundance of the growth hormone
receptor in liver and adipose tissue of periparturient dairy cows
* Accorsi et al. 2005 Leptin, GH, PRL, insulin and metabolic parameters throughout the dry period and lactation in dairy cows 22 Rabelo et al. 2005 Effects of pre- and postfresh transition diets varying in
dietary energy density on metabolic status of periparturient dairy cows
23 Roche et al. 2005 Influence of precalving feed allowance on periparturient metabolic and hormonal responses and milk production in grazing dairy cows
* Nafikov et al. 2006 Prevention of fatty liver in transition dairy cows by subcutaneous injections of glucagon
* Puntenney 2006 The effect of prepartum anionic diets on cortisol, adiponectin, and tumour necrosis factor-α expression at varying levels of body mass index in preparturient dairy Cows: Implications for insulin resistance
* Radcliff et al. 2006 Partial feed restriction decreases growth hormone receptor 1A mRNA expression in postpartum dairy cows
* Burke und Roche
2007 Effects of pasture feeding during the periparturient period on postpartum anovulation in grazed dairy cows
24 Ocylok 2007 Futteraufnahme und endokrinologische Leitparameter hochleistender Milchkühe in aufeinander folgenden Laktationen
* Relling und Reynolds
2007 Plasma Concentrations of Gut Peptides in Dairy Cattle Increase after Calving
25 Van Knegsel et al.
2007a Dietary energy source in dairy cows in early lactation:
metabolites and metabolic hormones 26 Van Knegsel
et al.
2007b Effect of Glucogenic vs. Lipogenic Diets on Energy Balance, Blood Metabolites, and Reproduction in Primiparous and Multiparous Dairy Cows in Early Lactation
46
* Wathes et al. 2007 Differences between primiparous and multiparous dairy cows in the inter-relationships between metabolic traits, milk yield and body condition score in the periparturient period
27 Smith et al. 2008 Metabolism of dairy cows as affected by prepartum dietary carbohydrate source and supplementation with chromium throughout the periparturient period
28 Thorn et al. 2008 Insulin regulates hepatic leptin receptor expression in early lactating dairy cows
29 Alamouti et al. 2009 Effects of prepartum dietary carbohydrate source on metabolism and performance of primiparous Holstein cows during the peri parturient period
30 Cavestany et al.
2009 Effect of prepartum energetic supplementation on productive and reproductive characteristics, and metabolic and
hormonal profiles in dairy cows under grazing conditions 31 Hammon et al. 2009 Performance and metabolic and endocrine changes with
emphasis on glucose metabolism in high-yielding dairy cows with high and low fat content in liver after calving
32 Kerestes et al. 2009 Periparturient insulin secretion and whole-body insulin responsiveness in dairy cows showing various forms of ketone pattern with or without puerperal metritis
33 Larsen und Kristensen
2009 Effect of abomasal glucose infusion on splanchnic amino acid metabolism in periparturient dairy cows
* Lemor et al. 2009 Transition period-related changes in the abundance of the mRNAs of adiponectin and its receptors, of visfatin, and of fatty acid binding receptors in adipose tissue of high-yielding dairy cows
* Lucy et al. 2009 Somatotropic axis components and nutrient partitioning in genetically diverse dairy cows managed under different feed allowances in a pasture system
34 Novotný et al. 2009 Evaluation of changes in metabolic hormones and metabolic indices during physiological and pathological course of puerperium in lactating cows
35 Van Dorland et al.
2009 Variation in hepatic regulation of metabolism during the dry period and in early lactation in dairy cows
36 Ji et al. 2010 Insulin signal transduction in adipose tissue of peripartal dairy cows fed two levels of dietary energy prepartum 37 Kerestes 2010 Role of insulin in the development of metabolic and
reproductive malfunctions of periparturient dairy cows 38 Roche et al. 2010 Dietary structural to nonfiber carbohydrate concentration
during the transition period in grazing dairy cows 39 Sadri et al. 2010 Gene expression of tumour necrosis factor and insulin
signalling-related factors in subcutaneous adipose tissue during the dry period and in early lactation in dairy cows 40 Terao et al. 2010 Insulin dynamics in transition dairy cows as revealed by
intravenous glucose tolerance testing 41 Caldari-Torres
et al.
2011 Performance, metabolic, and endocrine responses of periparturient Holstein cows fed 3 sources of fat 42 Goerigk 2011 Peripartaler Energie- und Fettstoffwechsel sowie
Insulinsensitivität von Färsen bei unterschiedlicher Aufzuchtintensität
47
43 Gross et al. 2011 Endocrine changes and liver mRNA abundance of somatotropic axis and insulin system constituents during negative energy balance at different stages of lactation in dairy cows
44 Hayirli et al. 2011 Peripartum responses of dairy cows to prepartal feeding level and dietary fatty acid source
45 Janovick et al. 2011 Prepartum dietary energy intake affects metabolism and health during the periparturient period in primiparous and multiparous Holstein cows
46 Locher et al. 2011 Hormone-sensitive lipase protein expression and extent of phosphorylation in subcutaneous and retroperitoneal adipose tissues in the periparturient dairy cow 47 Schoenberg et
al.
2011a Effects of prepartum 2,4-thiazolidinedione on insulin
sensitivity, plasma concentrations of tumor necrosis factor-α and leptin, and adipose tissue gene expression
48 Stengärde et al.
2011 Blood parameters in Swedish dairy herds with high or low incidence of displaced abomasum or ketosis
* Cummins et al. 2012 Genetic merit for fertility traits in Holstein cows: III. Hepatic expression of somatotropic axis genes during pregnancy and lactation
* Holzhausen 2012 Einfluss des Insulin-like Growth Factor Systems auf die endokrinologische Antwort nach einer experimentell induzierten Inflammation des Uterus
49 Ji et al. 2012 Overfeeding a moderate energy diet prepartum does not impair bovine subcutaneous adipose tissue insulin signal transduction and induces marked changes in peripartal gene network expression
50 Kabu und Civelek
2012 Effects of Methionine and Lysine on Metabolic Profile in Dairy Cattle During Periparturient Period
51 Kokkonen et al.
2012 Effect of dietary energy level during the dry period on insulin resistance in dairy cows
52 Lee et al. 2012 Slow recovery of blood glucose in the insulin tolerance test during the prepartum transition period negatively impacts the nutritional status and reproductive performance postpartum of dairy cows
* Ohtani et al. 2012 Changes in circulating adiponectin and metabolic hormone concentrations during periparturient and lactation periods in Holstein dairy cows
53 Salin et al. 2012 Effect of diet composition during the dry period on insulin resistance in dairy cows
54 Savić 2012 Effect of prepartal propylthiouracil application on endocrine and metabolic status of Holstein heifers
* Schneider et al.
2012 Effect of prepartum somatotropin injection in late-pregnant Holstein heifers on metabolism, milk production and postpartum resumption of ovulation
55 Sladojević 2012 Effect of energy bilance on endocrine and metabolic status of cows
56 Farney et al. 2013 Anti-inflammatory salicylate treatment alters the metabolic adaptations to lactation in dairy cattle
48
57 Fratrić et al. 2013 Levels of insulin, insulin-like growth factor-I and thyroid hormones in relation to the body condition score changes in periparturient dairy cows
* Mendonça et al.
2013 Comparison of innate immune responses and somatotropic axis components of Holstein and Montbéliarde-sired
crossbred dairy cows during the transition period
58 Nowak et al. 2013 Dietary energy density in the dry period on the metabolic status of lactating cows
59 Osorio et al. 2013 Supplemental Smartamine M or MetaSmart during the transition period benefits postpartal cow performance and blood neutrophil function
* Piechotta et al. 2013 Hepatic mRNA expression of acid labile subunit and
deiodinase 1 differs between cows selected for high versus low concentrations of insulin-like growth factor 1 in late pregnancy
60 Pires et al. 2013 Effects of body condition score at calving on indicators of fat and protein mobilization of periparturient Holstein-Friesian cows
61 Prodanović et al.
2013 Insulin responses to acute glucose infusions in Busa and Holstein-Friesian cattle breed during the peripartum period:
Comparative study
62 Riuzzi 2013 Evaluation of Glucose Tolerance Test and Surrogate Indexes of Insulin Sensitivity To Detect Insulin Resistance Syndrome
63 Weber et al. 2013 Variation in fat mobilization during early lactation differently affects feed intake, body condition, and lipid and glucose metabolism in high-yielding dairy cows
64 Wiedemann et al.
2013 Intraday variation of metabolic key indicators in serum of dairy cows between week 2 antepartum and week 12 postpartum
65 Zachut et al. 2013 Periparturient dairy cows do not exhibit hepatic insulin resistance, yet adipose-specific insulin resistance occurs in cows prone to high weight loss
66 Djoković et al. 2014 Endocrine and Metabolic Status of Dairy Cows during Transition Period
67 Fiore et al. 2014 Effects of Methionine and Lysine on Metabolic Profile in Dairy Cattle During Periparturient Period
68 Khan et al. 2014 Overfeeding dairy cattle during late-pregnancy alters hepatic PPAR [alpha]-regulated pathways including hepatokines:
impact on metabolism and peripheral insulin sensitivity
* Piechotta et al. 2014 Antepartal insulin-like growth factor concentrations indicating differences in the metabolic adaptive capacity in dairy cows
* Reverchon et al.
2014 Resistin in dairy cows: Plasma concentrations during early lactation, expression and potential role in adipose tissue 69 Selim et al. 2014 Prepartal dietary energy alters transcriptional adaptations of
the liver and subcutaneous adipose tissue of dairy cows during the transition period.
70 Binici 2015 Einfluss einer Supplementation mit konjugierten Linolsäuren auf die Insulinsensitivität und pankreatische
Insulin-Response bei primiparen Milchkühen
49
71 Chen et al. 2015 Effects of dry period length and dietary energy source on metabolic status and hepatic gene expression of dairy cows in early lactation
* Djoković et al. 2015 Relationship between blood metabolic hormones,
metabolites and energy balance in simmental dairy cows during peripartum period and lactation
72 Hashemzadeh-Cigari et al.
2015 Supplementation of herbal plants differently modulated metabolic profile, insulin sensitivity, and oxidative stress in transition dairy cows fed various extruded oil seeds
73 Leiva et al. 2015 Effects of rumen-protected choline supplementation on metabolic and performance responses of transition dairy cows
74 Mann et al. 2015 Dry period plane of energy: Effects on feed intake, energy balance, milk production, and composition in transition dairy cows
75 Rico et al. 2015 Plasma ceramides are elevated in overweight Holstein dairy cows experiencing greater lipolysis and insulin resistance during the transition from late pregnancy to early lactation 76 Selim et al. 2015 Effect of prepartal ad libitum feeding of grass silage on
transcriptional adaptations of the liver and subcutaneous adipose tissue in dairy cows during the periparturient period 77 Vargová et al. 2015 Hormonal profile and body condition scoring in dairy cows
during pre partum and post partum periods
78 Weber et al. 2015 Effects of dry period length on milk production, body condition, metabolites, and hepatic glucose metabolism in dairy cows
79 Zachut 2015 Defining the Adipose Tissue Proteome of Dairy Cows to Reveal Biomarkers Related to Peripartum Insulin Resistance and Metabolic Status
* Zapata et al. 2015 Effects of prepartum fat supplementation on plasma concentrations of glucagon-like peptide-1, peptide YY, adropin, insulin, and leptin in periparturient dairy cows 80 Abuelo et al. 2016a Association of oxidative status and insulin sensitivity in
periparturient dairy cattle: an observational study
81 Abuelo et al. 2016b Effect of Parenteral Antioxidant Supplementation During the Dry Period on Postpartum Glucose Tolerance in Dairy Cows 82 De Koster et
al.
2016a Influence of adipocyte size and adipose depot on the in vitro lipolytic activity and insulin sensitivity of adipose tissue in dairy cows at the end of the dry period
83 De Koster et al.
2016b Validation of different measures of insulin sensitivity of glucose metabolism in dairy cows using the hyperinsulinemic euglycemic clamp test as the gold standard
84 Humer et al. 2016 Metabolic adaptation and reticuloruminal pH in periparturient dairy cows experiencing different lipolysis early postpartum
* Jacobs 2016 Untersuchungen zur Assoziation zwischen Ketose und dem Insulin-like Growth Faktor-1 System
* Kedves 2016 Charakterisierung des antepartalen Hormonstatus von Milchkühen unter besonderer Berücksichtigung der Insulin-like Growth Factor I ( IGF-I ) -Konzentration im Plasma
50
85 Mann et al. 2016a Insulin signaling and skeletal muscle atrophy and autophagy in transition dairy cows either overfed energy or fed a
controlled energy diet prepartum
86 Mann et al. 2016b Insulin signaling, inflammation, and lipolysis in subcutaneous adipose tissue of transition dairy cows either overfed energy during the prepartum period or fed a controlled-energy diet 87 Mecitoglu et al. 2016 Changes in circulating adiponectin and tumour necrosis
factor-α and their relationship with insulin resistance in periparturient dairy cows
88 Yousefi et al. 2016 Effects of dietary supplementation of pioglitazone on metabolism, milk yield, and reproductive performance in transition dairy cows
89 Weber et al. 2016c Insulin-dependent glucose metabolism in dairy cows with variable fat mobilization around calving
90 Alves-Nores et al.
2017 Comparison of surrogate indices for insulin sensitivity with parameters of the intravenous glucose tolerance test in early lactation dairy cattle
91 Cincović et al. 2017 Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation
* Csillik et al. 2017 Effect of pre- and postpartum supplementation with lipid-encapsulated conjugated linoleic acid on reproductive performance and the growth hormone–insulin-like growth factor-I axis in multiparous high-producing dairy cows 92 De Koster et
al.
2017a Short communication: Limitations of glucose tolerance tests in the assessment of peripheral tissue insulin sensitivity during pregnancy and lactation in dairy heifers
93 De Koster et al.
2017b Relationship between serum adiponectin concentration, body condition score, and peripheral tissue insulin response of dairy cows during the dry period
* Fiore et al. 2017 Changes in thyroid hormones levels and metabolism in dairy cows around calving
94 Gross et al. 2017 Effects of elevated BHB concentrations on glucose metabolism in dairy cows before and after parturition
* Hernández-Castellano et al.
2017 Endocrine and metabolic changes in transition dairy cows are affected by prepartum infusions of a serotonin precursor 95 Hristovska et
al.
2017 Effects of niacin supplementation on the insulin resistance in Holstein cows during early lactation
96 Pantelić et al. 2017 The impact of the chromium supplementation on insulin signalling pathway in different tissues and milk yield in dairy cows
97 Rico et al. 2017 Temporal changes in sphingolipids and systemic insulin sensitivity during the transition from gestation to lactation 98 Salin et al. 2017 Effects of dietary energy allowance and decline in dry matter
intake during the dry period on responses to glucose and insulin in transition dairy cows
* Silva et al. 2017b Hepatic mRNA expression for genes related to somatotropic axis, glucose and lipid metabolisms, and inflammatory response of periparturient dairy cows treated with recombinant bovine somatotropin
51
99 Van Hoeij et al. 2017 The effect of dry period length and postpartum level of concentrate on milk production, energy balance, and plasma metabolites of dairy cows across the dry period and in early lactation
100 Zarrin et al. 2017 Elevation of blood β-hydroxybutyrate concentration affects glucose metabolism in dairy cows before and after parturition 101 Alharthi et al. 2018 Body condition score prior to parturition is associated with
plasma and adipose tissue biomarkers of lipid metabolism and inflammation in Holstein cows
102 De Koster et al.
2018 The contribution of hormone sensitive lipase to adipose tissue lipolysis and its regulation by insulin in periparturient dairy cows
103 Jaakson et al. 2018 Adipose tissue insulin receptor and glucose transporter 4 expression, and blood glucose and insulin responses during
103 Jaakson et al. 2018 Adipose tissue insulin receptor and glucose transporter 4 expression, and blood glucose and insulin responses during