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Hydroxycinnamic Acid Amides with Oxazole-Containing Amino Acid: Synthesis and Antioxidant Activity

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Hydroxycinnamic Acid Amides with Oxazole-Containing Amino Acid: Synthesis and Antioxidant Activity

Ivanka Stankova* and Maya Spasova

Department of Chemistry, South-West University “Neofi t Rilski’’, Ivan Michailov Str. 66, 2700 Blagoevgrad, Bulgaria. Fax: ++359 73 88 55 16. E-mail: ivastankova@abv.bg

* Author for correspondence and reprint requests

Z. Naturforsch. 64 c, 176 – 178 (2009); received August 27/September 25, 2008

Three hydroxycinnamic acid derivatives conjugated with glycine-containing oxazole were synthesized. The prepared compounds were tested for their antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH·) test. Among the tested hydroxycinnamic acid amides the highest DPPH scavenging activity has been found for the sinapic acid amide.

Key words: Hydroxycinnamoyl Amides, Oxazole, Radical Scavenging Activity

NC_3_4_2009.indb 176 04.05.2009 11:08:12

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