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New Carboxylic Acid Amides of the Pyrrole Series: Synthetic Routes and Biological Aspects

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New Carboxylic Acid Amides of the Pyrrole Series:

Synthetic Routes and Biological Aspects

Harald Walter

Syngenta Crop Protection M¨unchwilen AG, Research Chemistry, Schaffhauserstrasse, CH-4332 Stein, Switzerland

Reprint requests to Dr. H. Walter. E-mail: harald.walter@syngenta.com Z. Naturforsch.2008,63b,351 – 362; received December 5, 2007

Complex II inhibitors play an important role in agrochemical fungicide research and have been known for more than 40 years. With the introduction of ortho-substituted heterocyclic amides, a breakthrough in activity level and spectrum within this class was achieved. In the meantime all major agrochemical companies have entered this field. In this paper, a special complex II subclass, the pyrr- ole carboxamides, will be introduced in more detail and the synthesis of selected compounds as well as a short biological SAR analysis of the pyrrole subclass will be discussed.

Key words:Complex II, Fungicidal Activity, Carboxin,ortho-Substituted Anilines, Pyrrole Carboxylic Acids, Pyrrole Carboxamides

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