Studies With Enamines: Synthesis and Reactivity of 4-Nitrophenyl-1-piperidinostyrene. Synthesis of Pyridazine, Oxadiazole, 1,2,3-Triazole and 4-Aminopyrazole Derivatives

In order to obtain novel bioactive compounds with significant antifungal activities, a series of 2H-1,4-benzoxazin-3(4H)-one analogs linked with a 1,2,3-triazole moiety have

The reaction mixture was left to cool to room temperature, and the solid formed was collected by filtration and crystallized from ethanol to afford 12 (yield 60 %)..

After cooling, the resulting precipitate was filtered, washed with dioxane (2 × 10 mL) and re- crystallized from ethanol to give colorless crystals of 7 with m. The mixture was

After N-galactosylation and subsequent O-sil- ylation, nucleophilic addition of organometallic reagents proceeded with high regio- and stereo- selectivity at 4-position. Substituents

The 1 : 1 iminium intermediate, generated by the addition of a secondary amine to acetalde- hyde is trapped by the ( N -isocyanimino)triphenylphosphorane in the presence of an (

b Chemistry Department, Faculty of Science, Menoufi a University, Shebin El-Koam, Egypt.

The antimicrobial activity of the synthesized compounds was evaluated against three micro- organisms; Bacillus subtilis (ATCC 6633) (Gram- positive), Pseudomonas aeruginosa

b Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Bioscience Building 702, 5 – 1-5 Kashiwanoha, Kashiwa 277 – 8562, Japan. *