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Synthesis and Antiviral Evaluation of 5-(1,2,3-Triazol-1-ylmethyl)- uridine Derivatives

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Synthesis and Antiviral Evaluation of 5-(1,2,3-Triazol-1-ylmethyl)- uridine Derivatives

Adel A.-H. Abdel-Rahman^a,* and Takeshi Wada^b

a Chemistry Department, Faculty of Science, Menouﬁ a University, Shebin El-Koam, Egypt.

E-mail: adelnassar63@hotmail.com

b Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Bioscience Building 702, 5 – 1-5 Kashiwanoha, Kashiwa 277 – 8562, Japan

* Author for correspondence and reprint requests

Z. Naturforsch. 64 c, 163 – 166 (2009); received October 8, 2008

Some 5-(1,2,3-triazol-1-ylmethyl)uridine derivatives were synthesized via the 1,3-dipolar cycloaddition of a 5-azidomethyluridine derivative with substituted acetylenes. The antiviral activities of these compounds against hepatitis A virus (HAV, MBB cell culture-adapted strain) and Herpes simplex virus type-1 (HSV-1) were tested.

Key words: 1,2,3-Triazoles, Uridine Derivatives, Anti-Hepatitis A Virus

NC_3_4_2009.indb 163 04.05.2009 11:08:10

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