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Synthesis and Antimicrobial Activity of New Substituted Fused 1,2,4-Triazole Derivatives

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Synthesis and Antimicrobial Activity of New Substituted Fused 1,2,4-Triazole Derivatives

Wael A. El-Sayeda,*, Omar M. Alib, Marwa M. Hathootb, and Adel A.-H. Abdel-Rahmanb,*

a Photochemistry Department, National Research Centre, Cairo, Egypt.

E-mail: waelshendy@gmail.com

b Chemistry Department, Faculty of Science, Menoufi a University, Shebin El-Koam, Egypt.

E-mail: adelnassar63@hotmail.com

* Authors for correspondence and reprint requests

Z. Naturforsch. 65 c, 22 – 28 (2010); received July 13/August 12, 2009

A number of new substituted 1,2,4-triazole, 1,2,4-triazolo[3,4-b]1,3,4-thiadiazole and 1,2,4-triazolo[3,4-b]1,3,4-thiadiazine derivatives were synthesized and tested for their anti- microbial activity against Bacillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gram- negative), and Streptomyces species (Actinomycetes). The synthesized compounds displayed different degrees of antimicrobial activities or inhibitory actions.

Key words: 1,2,4-Triazoles, 1,2,4-Triazolo[3,4-b]1,3,4-thiadiazoles, 1,2,4-Triazolo[3,4-b]1,3,4- thiadiazines

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