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Synthesis and Antimicrobial Activity of New Substituted 1,2,4-Triazoles and their Acyclic C-Nucleoside Analogues

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Synthesis and Antimicrobial Activity of New Substituted 1,2,4-Triazoles and their Acyclic C-Nucleoside Analogues

Wael A. El-Sayeda,*, Omar M. Alib, Saly R. El-Dakkonyb, and Adel A.-H. Abdel-Rahmanb,*

a Photochemistry Department, National Research Centre, Cairo, Egypt.

E-mail: waelshendy@gmail.com

b Chemistry Department, Faculty of Science, Menoufi a University, Shebin El-Koam, Egypt.

E-mail: adelnassar63@hotmail.com

* Authors for correspondence and reprint requests

Z. Naturforsch. 65 c, 15 – 21 (2010); received July 16/August 12, 2009

A number of new substituted 1,2,4-triazole {[(1,2,4-triazolyl)ethyl]tetrazolyl} derivatives, their sugar hydrazones, and their acyclic C-nucleoside analogues were synthesized and test- ed for their antimicrobial activity against Bacillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gram-negative), and Streptomyces species (Actinomycetes). The synthesized compounds displayed different degrees of antimicrobial activities or inhibitory actions.

Key words: 1,2,4-Triazoles, Sugar Hydrazones, Acyclic Nucleosides

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