New Analogues of Acyclovir – Synthesis and Biological Activity Ivanka Stankova

A number of new substituted 1,2,4-triazole {[(1,2,4-triazolyl)ethyl]tetrazolyl} derivatives, their sugar hydrazones, and their acyclic C-nucleoside analogues were

A number of new substituted 1,2,4-triazole {[(1,2,4-triazolyl)ethyl]tetrazolyl} derivatives, their sugar hydrazones, and their acyclic C-nucleoside analogues were synthesized and

New acyclovir esters with peptidomimetics were synthesized and evaluated in vitro for their antiviral activity against the replication of Herpes simplex virus type 1 (HSV-1) and

a Institute of Organic Chemistry, Bulgarian Academy of Sciences, Sofi a-1113, BulgariaZ. b Institute of Biophysics, Bulgarian Academy of Sciences, Sofi

The reaction of succinic anhydride and N-benzylidene-benzylamine gave rise to the correspond- ing substituted trans-5-oxopyrrolidine-3-carboxylic acid, which was

Analysis of cell viability after 24 h of incubation by trypan blue exclusion revealed that compound 1 significantly reduced the number of viable cells at the concentrations of 5 and

The layers were separated and the organic layer was washed with brine (40 mL), dried over Na 2 SO 4 and the solvent was removed under reduced pressure. Analytical data are

Moreover, the synthesis of the building block, as well as the assembling of c-di-GMP, is a rather long process to obtain a small quantity of product, and the overall yield was