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Synthesis of New Polysubstituted Pyrrolidinones with Potential Biological Activity

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Synthesis of New Polysubstituted Pyrrolidinones with Potential Biological Activity

Nikola T. Burdzhiev and Elena R. Stanoeva

St. Kliment Ohridski University of Sofia, Faculty of Chemistry, Department of Organic Chemistry, 1, J. Bouchier Avenue, 1164 Sofia, Bulgaria

Reprint requests to Assoc. Prof. Elena R. Stanoeva. E-mail: estanoeva@chem.uni-sofia.bg Z. Naturforsch.2008,63b,313 – 320; received October 31, 2007

The reaction of succinic anhydride andN-benzylidene-benzylamine gave rise to the correspond- ing substituted trans-5-oxopyrrolidine-3-carboxylic acid, which was transformed stereoselectively into two series of compounds. The first one consists of carboxamides, and the second one includes aminomethyl derivatives. The compounds prepared incorporate both a pyrrolidinone part and other nitrogen containing heterocyclic fragments of pharmacological interest.

Key words:Succinic Anhydride, Pyrrolidinones, Piperazines, Stereochemistry, Sonication

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