A
nM Paclitaxel (48 h)
cell growth in % of DMSO
Figure S2
nM BI6727 (48 h)
cell growth in % of DMSO
Paclitaxel B BI6727
cell growth in % of DMSO
D
E
0 10 20 30 40 50 60 70 80 90 100 110
DMSO 0.5 1 2.5 4 5.5 7 8.5 10
Paclitaxel
Pac/20 nM BI6727 Pac/20 nM BI6727/
10μM proTAME
nM Paclitaxel/20 nM BI6727 (48 h)
*
*
* *** *** * * **
0 10 20 30 40 50 60 70 80 90 100 110
DMSO 0.5 1 2.5 4 5.5 7 8.5
C
cell growth in % of DMSO
**
**
** ** *
IC50 2.4 nM
PacIC50 1.4 nM
PacSKOV-3
Paclitaxel/20 nM BI6727
nM Paclitaxel (48 h)
proTAME
24 h + 24 h
Paclitaxel/20 nM BI6727 + 10 μM proTAME
0 10 20 30 40 50 60 70 80 90 100
DMSO 0.5 1 2.5 4 5.5 7 8.5 10
IC50 7 nM
Pac0 10 20 30 40 50 60 70 80 90 100 110
DMSO
5 15 25 35 45 100
0 10 20 30 40 50 60 70
DMSO 0.3125 0.625 1.25 2.5 5 10 15 20