ABERG, J.A., M.K. WONG, R. FLAMM, et al., (2001):
Presence of macrolide resistence in respiratory flora of HIV-infected patients receiving either clarithromycin or azithromycin for 0\FREDFWHULXP DYLXP complex prophylaxis.
HIV Clin. Trials., 2, 453-459
AINSWORTH, D.M., S.W. EICKER, A.E. YEAGAR, et al. (1998):
Associations between physical examination, laboratory, and radiographic findings and outcome and subsequent racing performance of foals with 5KRGRFRFFXV HTXL infection: 115 cases (1984-1992).
J. Am. Vet. Med. Assoc., 213, 510-515
ANZAI, T., R. WADA, A. NAKANISHI, et al. (1997):
Comparison of tracheal aspiration with other tests for diagnosis of 5KRGRFRFFXVHTXL pneumonia in foals.
Vet. Microbiol., 56, 335-345
ARDANS, A.A., S.K. HIETALA, M.S. SPENSLEY et al. (1986):
Studies of naturally occurring and experimental Rhodococcus equi (Corynebacterium equi) pneumonia in foals.
In: Proceedings, 32 Ann. Meet. Am. Ass. Equine Pract., 129-144
BALDWIN, J.L., J.J. BERTONE, M.M. SOMMER, et al. (1992):
5KRGRFRFFXVHTXL enteritis, colonic lymphadenitis, and peritonitis in three foals with nonresponsive 5KRGRFRFFXVHTXL bronchopneumonia.
Equine Pract., 14, 15-18
BALSON, G.A., G.D. SMITH und J.A. YAGER (1997):
Immunophenotypic analysis of foal bronchoalveolar lavage lymphocytes.
Vet. Microbiol., 56, 237-246
BARTON, M.D. and K.L. HUGHES (1980):
&RU\QHEDFWHULXPHTXL a review.
Vet. Bull., 50, 65-80
BAUMANN, I. (2006):
Untersuchung der Wirksamkeit des Paramunitätsinducers Zylexis© zur Prophylaxe von Lungenabszessen beim Fohlen.
Hannover, Tierärztl. Hochschule, Diss.
BECÚ, T, G. POLLEDO und J.M. GASKIN (1997):
Immunoprophylaxis of 5KRGRFRFFXVHTXL Pneumonia in foals.
Vet. Microbiol., 56, 193-204
BENSON, C.A. (1994):
Disease due to the 0\FREDFWHULXP DYLXP complex in patients with AIDS:
epidemiology and clinical syndrome.
Clin. Infect. Dis., 18, 218-222
BERNARD, B., J. DUGAN, S. PIERCE, et al. (1991):
The influence of foal pneumonia on future racing performance Proceedings. Annu. Meet. Am. Assoc. Equine. Pract., 17-18
BOSTEDT, H. (1999):
Erkrankungen des neugeborenen Fohlens.
Handbuch Pferdepraxis (O Dietz, B Huskamp, eds) Enke Verlag, Stuttgart, p 157
Brockhaus-Enzyklopädie. (1991):
19. Auflage, Band 14, FA Brockhaus, Mannheim, S.81
BUSCH, W. und E. KLUG. (1999):
Fortpflanzungsstörungen bei der Stute und Krankheiten der weiblichen Geschlechtsorgane.
In: Handbuch Pferdepraxis (O Dietz, B Huskamp, eds), Enke Verlag, Stuttgart, p 599
CARMAN, M.G.und R.T. HODGES (1987):
Distribution of Rhodococcus equi in animals, birds and from the environment.
N. Z. Vet. J., 35, 114-115
CAUCHARD, J., C. SEVIN, J.J. BALLET, et al. (2004):
Foal IgG and opsonizing anti-5KRGRFRFFXV HTXL antibodies after immunization of pregnant mares with a protective VapA candidate vaccine.
Vet. Microbiol., 104, 73-81
CHAFFIN, M.K., C.M. HONNAS, M.R. CRABILL, et al. (1995):
Cauda equina syndrome, diskospondylitis, and a paravertebral abscess caused by 5KRGRFRFFXVHTXL in a foal.
J. Am. Vet. Med. Assoc., 206, 215-220
CHAFFIN, M.K. und R.J. MARTENS (1997):
Extrapulmonary disorders associated with 5KRGRFRFFXV HTXL pneumonia in foals.
Retrospective study of 61 cases (1988-1996) Am. Assoc. Equine. Pract., 43, 79-80
CHAFFIN, M.K., N.D. COHEN und R.J. MARTENS (2003):
Evaluation of equine breeding farm management and preventative health practices as risk factors for development of 5KRGRFRFFXVHTXL pneumonia in foals.
J. Am. Vet. Med. Assoc., 222, 476-485
CHAPMAN, P.S., C. GREEN, J.P. MAIN, et al. (2000):
Retrospective study of the relationship between age, inflammation and the isolation of bacteria from the lower respiratory tract of thoroughbred horses.
Vet. Rec., 146, 91-95
CHEEVER, L.W., R.E. CHAISSON und J.E. GALLANT (1996):
Prophylaxis against opportunistic infections in patients infected with the human immunodeficiency virus.
West. J. Med., 165, 67-73
CHIA, J.K., M.M. NAKATA, J.L. LAMI, et al. (1998):
Azithromycin for the treatment of cat-scratch desease.
Clin. Infect. Dis., 26, 193-194
CHIN, D.P., A.L. REINGOLD, E.N. STONE, et al. (1994):
The impact of 0\FREDFWHULXPDYLXP complex bacteremia in its treatment and survival of AIDS patients – a prospective study.
J. Infect. Dis., 170, 578-584
CHIRINO-TREJO, J.M., J.F. PRESCOTT und J.A. YAGER (1987):
Protection of foals against experimental 5KRGRFRFFXVHTXLpneumonia by oral immunization .
Can. J. Vet. Res., 51, 444-447
COHEN, N.D., M.K. CHAFFIN und R.J. MARTENS (2000):
Control and prevention of 5KRGRFRFFXVHTXL pneumonia in foals.
Equine Compendium, 22, 1062-1069
DARRAH, P.A., M.K. HONDALUS, Q. CHEN, et al. (2000):
Cooperation between reactive oxygen and nitrogen intermediates in killing of 5KRGRFRFFXVHTXL by activated macrophages.
Infect. Immun., 68, 3587-3593
DAVIS, J.L., S.Y. GARDNER, S.L. JONES, et al. (2002):
Pharmacokinetics of azithromycin in foals after i.v. and oral dose and disposition into phagozytes.
J. Vet. Pharmacol. Therap., 25, 99-104
DIMOCK, W.W. (1941):
Horse and mule production.
J. Am. Vet. Med. Assoc., 98, 369-380
DONISI, A., M.G. SUARDI, S. CASARI, et al. (1996):
5KRGRFRFFXVHTXL infection in HIV-infected patients.
A.I.D.S., 10, 359-362
ELISSALDE, G.S., H.W. RENSHAW und J.A. WALBERG (1980):
&RU\QHEDFWHULXPHTXL: an interhost review with emphasis on the foal.
Comp. Immunol. Microbio. Infect. Dis., 3, 433-445
ELLENBERGER, M.A., M.L. KAEBERLE und J.A. ROTH (1984):
Equine cell-mediated immune response to 5KRGRFRFFXV&RU\QHEDFWHULXPHTXL. Am. J. Vet. Res., 45, 2424-2427
ELLENBERGER, M.A. u. R.M. GENETZKY (1986):
Rhodococcus equi infections: literature review.
Compend. Contin. Educ. Practic. Vet., 8, 414-423
FALCON, J., B.P. SMITH, R. O´BRIEN, et al. (1985):
Clinical and radiographic findings in Corynebacterium equi pneumonia of foals.
J. Am. Vet. Med. Assoc. 186, 593-599
FIRTH, E.C., M.R. ALLEY und H. HODGE (1993):
5KRGRFRFFXVHTXL-associated osteomyelitis in foals.
Aust. Vet. J., 70, 304-307
FITZGEORGE, R.B., S. LEVER und A. BASKERVILLE (1993):
A comarison of the efficacy of azithromycin in oral therapy of experimental airborne Legionaires‘ disease.
J. Antimicrob. Chemother., 31, 171-176
FITZGERALD, S.D. und B. YAMINI (1995):
Rhodococcal abortion and pneumonia in an equine fetus.
J. Vet. Diagn. Invest., 7, 157-158
FLAMINIO, M.J., B.R. RUSH und W. SHUMAN (1999):
Peripheral blood lymphozyte subpopulations and immunoglobulin concentrations in healthy foals and foals with 5KRGRFRFFXVHTXL pneumonia.
J. Vet. Int. Med., 13, 206-212
FOY, H. (1993):
Infections caused by 0\FRSODVPDSQHXPRQLDH and possible carrier state in different populations of patients.
Clin. Infect. Dis., 17, 37-46
FREESTONE, J.F., S. HIETALA, J. MOULTON, et al. (1987):
Acquired immunodeficiency in a seven-year-old horse.
J. Am. Vet. Med. Assoc., 190, 689-691
GAGEA, M.I., K.G. BATEMAN, T. van DREUMEL, et al. (2006):
Diseases and pathogens associated with mortality in Ontario beef feedlots.
J. Vet. Diagn. Invest., 18, 18-28
GIGUÈRE, S. und J.P. LAVOIE (1994)
5KRGRFRFFXVHTXL vertebral osteomyelitis in 3 Quater Horse colts.
Equine Vet. J., 26, 74-77
GIGUÈRE, S. und J.F. PRESCOTT (1997):
Clinical manifestations, diagnosis, treatment, and prevention of 5KRGRFRFFXV HTXL infections in foals.
Vet. Microbiol., 14, 313-334
GIGUÈRE, S., M.K. HONDALUS, J.A. YAGER, et al. (1999):
Role of 85-kilobase plasmid and plasmid-encoded virulence-associated protein A in intracellular survival and virulence of 5KRGRFRFFXVHTXL.
Infect. Immun., 67, 3548-3557
GIGUÈRE, S. (2001):
Rhodococcus equi pneumonia.
Am. Assoc. Equine Pract., 47, 456-467
GIGUÈRE, S., J. HERNANDEZ, J. GASKIN, et al. (2003):
Performance of five serological assays for diagnosis of 5KRGRFRFFXV HTXL pneumonia in foals.
Clin.Diagn.Lab.Immunol., 10, 241-245
GIGUÈRE, S, S. JACKS, G.D. ROBERTS, et al. (2004):
Retrospective comparison of azithromycin, clarithromycin and erythromycin for the treatment of foals with 5KRGRFRFFXVHTXL pneumonia.
J. Vet. Int. Med., 18, 568-573
GIRARD, A.E., D. GIRARD, A.R. ENGLISH, et al. (1987):
Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distibution.
Antimicrob. Agents. Chemother., 31, 1948-1954
GODINHO, K.S., R.M. WOLF, J. SHERINGTON, et al. (2005):
Efficacy of tulathromycin in the treatment and prevention of natural outbreaks of bovine respiratory disease in European cattle.
Vet. Ther., 6, 122-135
GOODFELLOW, M. und D.E. MINNIKIN (1977):
Nocardioform bacteria.
Ann. Rev. Microbiol., 31, 159-180
GOODFELLOW, M. (1987):
The taxonomic status of 5KRGRFRFFXVHTXL. Vet. Microbiol., 14, 205-209
GRAY, G.C., D.C. McPHATE, M. LEINONEN, et al. (1998):
Weekly oral azithromycin as prophylaxis for agents causing acute respiratory disease.
Clin. Infect. Dis., 26, 103-110
GRAY, G.C., P.J. WITUCKI, M.T. GOULD, et al. (2001):
Randomized, plazebo-controlled clinical trial of oral Azithromycin prophylaxis against respiratory infections in a high risk, young adult population.
Clin. Infect. Dis., 33, 983-989
GRÖNDAHL, G., A. JOHANNISSON und M. JENSEN-WAERN (1997):
Opsonic effect of equine plasma from different donors.
Vet. Microbiol., 56, 227-235
GUCHEV, I.A., O.I. KLOCHKOV, G.V. IVANITSA, et al. (2004):
Efficacy and safty of azithromycin prophylaxis of respiratory tract infections in military community.
Antibiot. Khimiother., 49, 37-42
GUTHRIE, C., G. VOGEL und S. LAUDERT (2000):
The Effect of Micotil® on controling Bovine Respiratory Disease in high-risk northern feeder calves when used in a metaphylactic program at processing.
Elanco Animal Health, Indianapolis, IN, Tech Report AI8849
GUTHRIE, C.A., B. CARTER und S.B. LAUDERT (2005):
The use of Micotil (tilmicosin injection) metaphylaxis for the control of Undifferentiated Bovine Respiratory Disease: A 29-trial Report.
Research Information for the Veterinarian from Elanco Animal Health
HARVEY, RL und J.C. SUNSTRUM (1991):
5KRGRFRFFXV HTXL infection in patients with and without human immunodeficiency virus infection.
Rev. Infect. Dis., 13, 139-145
HEYERS, P. (2005):
Vergleich des Nachweises von 5KRGRFRFFXVHTXL durch mikrobiologische Kultur mit dem Nachweis durch die Polymerase–chain–reaction in endoskopisch entnommenem Tracheobronchialsekret bei Fohlen.
Hannover, Tierärztl. Hochschule, Diss.
HIETALA, S.K., A.A. ARDANS und A. SANSOME (1985):
Detection of &RU\QHEDFWHULXP HTXL-specific antibody in horses by enzyme-linked immunosorbent assay.
Am. J. Vet. Res., 4, 13-15
HIETALA, S.K. und A.A. ARDANS (1987):
Interaction of Rhodococcus equi with phagozytic cells from Rhodococcus equi exposed and non-exposed foals.
Vet. Microbiol., 14, 307-320
HILLIDGE, C.J. (1986):
Review of &RU\QHEDFWHULXP 5KRGRFRFFXV HTXL lung abscesses in foals:
Pathogenesis, diagnosis and treatment.
Vet. Rec., 119, 261-264
HILLIDGE, C.J. (1987):
Use of erythromycin-rifampin combination in treatment of 5KRGRFRFFXV HTXL pneumonia.
Vet. Microbiol., 14, 337-342
HINES, S.A., S.T. KANALY, B.A. BYRNE, et al. (1997):
Immunity to 5KRGRFRFFXVHTXL. Vet. Microbiol., 56, 177-185
HINES, S.A., D.M. STONE, M.T. HINES, et al. (2003):
Clearance of virulent but not avirulent 5KRGRFRFFXV HTXL from the lungs of adult horses is associated with intracytoplasmatic gamma interferon production by CD4+
and CD8+ T Lymphozytes.
Clin. Diagn Lab. Immunol., 10, 208-215
HÖHENSTEIGER, N. (2005):
Nachweis der Konzentration von Tulathromycin im Plasma und in der bronchoalveolären Lavageflüssigkeit beim Fohlen mittels Hochdruckflüssigkeitschromatographie mit zweifacher Massenspektroskopie nach i.m. Applikation, mit und ohne Kombination von Rifampicin
Hannover, Tierärztl. Hochschule, Diss.
HOFFMAN, A.M., L. VIEL, J.F. PRESCOTT, et al. (1993):
Association of microbiologic flora with clinical, endoscopic, and pulmonary cytologic findings in foals with distal respiratory tract infection.
Am. J. Vet. Res., 54, 1615-1622
HOLMES, F. (1998):
Case report.
The Johns Hopkins Microbiology Newsletter, Vol. 17, No. 18
HONDALUS, M.K. und D.M. MOSSER (1994):
Survival and replication of 5KRGRFRFFXVHTXL in macrophages.
Infect. Immun., 62, 4167-4175
HONDALUS, M.K. (1997):
Pathogenesis and virulence of Rhodococcus equi.
Vet. Microbiol., 56, 257-268
HOOPER-McGREVY, K.E., S. GIGUÈRE, B.N. WILKIE, et al.(2001):
Evaluation of equine immunglobulin specific for 5KRGRFRFFXV HTXL virulence-associated proteins A and C for use in protecting foals against 5KRGRFRFFXVHTXL -induced pneumonia.
Am. J. Vet. Res., 62, 1307-1313
HOOPER-McGREVY, K.E., B.N. WILKIE und J.F. PRESCOTT (2005):
Virulence-associated protein-specific serum immunglobulin G-isotype expression in young foals protected against 5KRGRFRFFXV HTXL pneumonia by oral immunization with virulent 5HTXL.
Vaccin., 23, 5760-5767
HUNTER, R.P., M.J. LYNCH, J.F. ERICSON, et al. (1995):
Pharmacokinetics, oral bioavailibility and tissue distribution of azithromycin in cats.
J. Vet. Pharmacol. Ther., 18, 38-46
HURLEY, J.R. und A.P. BEGG (1995):
Failure of hyperimmune plasma to prevent pneumonia caused by 5KRGRFRFFXVHTXL in foals.
Aust. Vet. J., 72, 418-420
HYDE, T.B., M. GILBERT, S.B. SCHWARZ, et al. (2001):
Azithromycin prophylaxis during a hospital outbreak of 0\FRSODVPD SQHXPRQLDH pneumonia.
J. Infect. Dis., 183, 907-912
JABLONOWSKI, H., C. ARMBRECHT, S. MAUSS, et al. (1994):
5KRGRFRFFXVHTXL in an HIV-infected patient.
Bildgebung., 61, 206-209
JACKS, S., S. GIGUÈRE, R.R. GRONWALL, et al. (2001):
Pharmacokinetics of azithromycin and concentration in body fluids and bronchoalveolar cells in foals.
Am. J. Vet. Res., 62, 1870-1875
JENSEN, H.L. (1934):
Studies on saprophytic mycobacteria and corynebacteria.
Proc. Linn. Soc. N.S.W. 59, 19-61
JOHNSON, J.A., J.F. PRESCOTT und R.J.F. MARKHAM (1983):
The pathology of experimental &RU\QHEDFWHULXP HTXL infection in foals following intrabronchial challenge.
Vet. Pathol., 20, 440-449
KANALY, S.T., S.A. HINES und G.H. PALMER (1993):
Failor of pulmonary clearance of 5KRGRFRFFXVHTXL infection in CD4+ T-lymphozyte-deficient transgenic mice.
Infect. Immun., 61, 4929-4932
KANALY, S.T., S.A. HINES und G.H. PALMER (1995):
Cytokine modulation alters pulmonary clearance of 5KRGRFRFFXV HTXL and develoment of granulomatous pneumonia.
Infect. Immun., 63, 3037-3041
KANALY, S.T., S.A. HINES und G.H. PALMER (1996):
Transfer of a CD4+ Th1 cell line to nude mice effects clearance of 5KRGRFRFFXVHTXL from the lung.
Infect. Immun., 64, 1126-1132
KAPUSNIK-UNER, J.E., M.A. SANDE und H.F. CHAMBERS (1995):
Antimicrobial agents: Tetracyclines, Chloramphenicol, Erythromycin, and miscellaneous antibacterial agents.
In: Goodman & Gilman’s The pharmacological basis of therapeutics (JG Hardman &
LE Limbird, eds), McGraw-Hill, New York 9: pp 1123-1153
KENNEY, D.G., S.C. ROBBINS, J.F. PRESCOTT, et al. (1994):
Development of reactive arthritis and resistance to erythromycin and rifampin in a foal during treatment for 5KRGRFRFFXVHTXL pneumonia.
Equine Vet. J., 26, 246-248
KERTH, R. (2005):
Untersuchung der Wirksamkeit von Tulathromycin bei der Behandlung von Lungenabszessen bei Fohlen
Hannover, Tierärztl. Hochschule, Diss.
KLAUSNER, J.D., D. PASSERO, J. ROSENBERG, et al. (1998):
Enhanced control of an outbreak of 0\FRSODVPD SQHXPRQLDH with azithromycin prophylaxis.
J. Infect. Dis., 177, 161-166
KNIGHT, H.D. und S. HIETALA (1978):
Transtracheal aspiration revisited.
Annual Veterinary Medical Forum, 120-131
KÖHLER, M. und I. LEENDERTSE (1996):
Fohlenkrankheiten.
Verlag: Gustav Fischer, Jena/Stuttgart, S. 102-104
LADRÓN, N., M. FERNÁNDEZ, J. AGÜERO, et al. (2003):
Rapid identification of 5KRGRFRFFXVHTXL by a PCR assey targeting the choE gene.
J. Clin. Microbiol., 41, 3241-3245
LAVOIE, J.P., L. COUTURE, R. HIGGINS, et al. (1991):
Aerobic bacterial isolates in horses in a university hospital, 1986-1988.
Can. Vet. J., 32, 292-294
LAVOIE, J.P., L. FISET und S. LAVERTY (1994):
Review of 40 cases of lung abscesses in foals and adult horses.
Equine Vet. J., 26, 348-352
LÉGUILLETTE, R., M.F. ROY und J.P. LAVOIE (2002) Foal pneumonia.
In: Equine Respiratory Diseases, P. Lekeux (Ed.)
Publisher: International Veterinary Information Service, Ithaca, N.Y., USA
LÖSCHER, W., F.R. UNGEMACH und R. KROKER (2003):
Pharmakotherapie bei Hausund und Nutztieren.
6. Auflage. Parey Verlag, Berlin
MADIGAN, J.E., S. HIETALA und N. MÜLLER (1991):
Protection against naturally acquired 5KRGRFRFFXV HTXL pneumonia in foals by administration of hyperimmune plasma.
J. Reprod. Fert. Suppl., 44, 571-578
MADISON, J.B. und W.K. SCARRATT (1988):
Immune-mediated polysynovitis in four foals.
J. Am. Vet. Med. Assoc., 192, 1581-1584
MAGNUSSON, H. (1923):
Spezifische infektiöse Pneumonie beim Fohlen. Ein neuer Eitererreger beim Pferd.
Arch. Wiss. Prakt. Tierheilk., 50, 22-38
MAGNUSSON, H. (1938):
Pyaemia in foals caused by &RU\QHEDFWHULXPHTXL. Vet. Rec., 50, 1459-1468
MARTENS, R.J., R.A. FISKE und H.W. RENSHOW. (1982):
Experimental subacute foal pneumonia induced by aerosol administration of
&RU\QHEDFWHULXPHTXL . Equine. Vet. J., 14, 111-116
MARTENS, R.J., J.G. MARTENS und R.A. FISKE. (1989):
5KRGRFRFFXV HTXL foal pneumonia: Protective effects of immune plasma in experimentally infected foals.
Equine Vet. J., 21, 249-255
MARTENS, R.J., J.G. MARTENS und R.A. FISKE. (1992):
Failure of passive immunisation by colostrum from immunised mares to protect foals against 5KRGRFRFFXVHTXL pneumonia.
Equine Vet. J., 12, Suppl., 19-22
MARTENS, R.J., S. TAKAI, N.D. COHEN, et al. (2000):
Association of disease with isolation and virulence of 5KRGRFRFFXVHTXLfrom farm soil and foals with pneumonia.
J. Am. Vet. Med. Assoc. 217, 220-225
MARTENS, R.J., N.D. COHEN, M.K. CHAFFIN, et al. (2002):
Evaluation of 5 serologic assays to detect 5KRGRFRFFXVHTXL pneumonia in foals.
J. Am. Vet. Med. Assoc., 221: 825-833
MARTENS, R.J., N.D. COHEN, S.L. JONES, et al. (2005):
Protective role of neutrophils in mice experimentally infected with 5KRGRFRFFXVHTXL. Infect. Immun., 73, 7040-7042
McEVOY, G.K. (1992):
AHFS Drug Information.
American Society of Hospital Pharmacists Inc, Bethesda (USA); S. 2363 ff.
MECHOR G.D. (2005):
The effects of metaphylaxis with Micotil® on health and performance of northern calves at high risk of contracting Bovine Respiratory Disease.
Elanco Animal Health, Indianapolis, Tech. Report AI 9758
MEYER-HAMME, M.B. (2004):
5KRGRFRFFXV HTXL und 6WUHSWRFRFFXV HTXL VXEVSH]LHV ]RRHSLGHPLFXV aus Nasentupfern und Tracheobronchialsekret von lungenkranken Fohlen.
Hannover, Tierärztl. Hochschule, Diss.
MORCK, D.W., J.K. MERRILL, B.E. THORLAKSON, et al. (1993):
Prophylactic efficacy of tilmicosin for bovine respiratory tract disease.
J. Am. Vet. Med. Assoc., 202, 273-77
MÜLLER, N.S. und J.E. MADIGAN (1992):
Methodes of implementation of an immunoprophylaxis program for the prevention of 5KRGGRFRFFXVHTXLpneumonia.
Proc. Am. Ass. Equine Pract., 38, 193-201
NIGHTINGALE, S.D., L.T. BYRD, P.M. SOUHERN, et al. (1992):
Incidence of 0\FREDFWHULXP DYLXPLQWUDFHOOXODUH complex bacteremia in human immunodeficiency virus-positive patients.
J. Infect. Dis., 165, 1082-1085
NORDMANN, P. und E. RONCO. (1992):
In-vitro antimicrobial susceptibility of 5KRGRFRFFXVHTXL. J. Antimicrob. Chemother., 29, 383-393
NORDMANN, P., E. RONCO und C. NAUCIEL. (1992):
Role of T-lymphocyte subsets in 5KRGRFRFFXVHTXL infection.
Infect. Immun., 60, 2748-2752
OIKAWA, M., M. KAMADA, Y. YOSHIKAWA, et al. (1994):
Pathology of equine pneumonia associated with transport and isolation of 6WUHSWRFRFFXVHTXLVXEVS]RRHSLGHPLFXV .
J. Comp. Pathol., 111, 205-212
OLCHOWY, T.W. (1994):
Vertebral body osteomyelitis due to 5KRGRFRFFXVHTXL in two Arabian foals.
Equine Vet. J., 26, 79-82
OLDFIELD, E.C., et al. (1998):
Once weekly azithromycin therapy for prevention of 0\FREDFWHULXPDYLXP complex infection in patients with AIDS: A randomized, double-blind, placebo-controlled multicenter trial.
Clin. Infect. Dis., 26, 611-619
PATTON, K.M., T.C. McGUIRE, D.G. FRASER, et al. (2004):
5KRGRFRFFXV HTXL-infected macrophages are recognized and killed by CD8+ T lymphozytes in a major histocompatibility complex class I-unrestricted fashion.
Infect. Immun., 72, 7073-7083
PERKINS, G.A., A. YEAGER, H.N. ERB, et al. (2001):
Survival of foals with experimentally induced 5KRGRFRFFXVHTXL infection given either hyperimmune plasma containing 5HTXL antibody or normal equine plasma.
Vet. Therapeutics, 2, 334-346
PILTZ, K. (2004):
Vergleichende Behandlung von 5KRGRFRFFXV HTXi-Pneumonien bei Fohlen mit Azithromycin und Rifampicin in Kombination mit Erythromycin bzw.
Trimethoprim/Sulfadiazin.
Hannover, Tierärztl. Hochschule, Diss.
PRESCOTT, J.F., R.J.F. MARKHAM und J.A. JOHNSON. (1979):
Cellular and humoral immune response of foals to vaccination with &RU\QHEDFWHULXP HTXL
Can. J. Comp. Med., 43, 356-364
PRESCOTT, J.F., M. LASTRA und L. BARKSDALE (1982):
Equi factors in the identification of &RU\QHEDFWHULXPHTXLMagnusson.
J. Clin. Microbiol., 16, 988-990
PRESCOTT, J.F. und V.M. NICHOLSON. (1984):
The effects of combination of selected antibiotics on the growth of &RU\QHEDFWHULXP HTXL
J. Vet. Pharmacol. Ther., 7, 61-64
PRESCOTT, J.F. und C.R. SWEENEY. (1985):
Treatment of &RU\QHEDFWHULXPHTXL pneumonia in foals: A review.
J. Am. Vet. Med. Assoc., 187, 725-728
PRESCOTT, J.F. (1987):
Epidemiology of 5KRGRFRFFXVHTXLinfection in horses.
Vet. Microbiol., 14, 211-214
PRESCOTT, J.F. (1991):
5KRGRFRFFXVHTXi: an animal and a human pathogen.
Clin. Microbiol. Rev., 4, 20-34
PRESCOTT, J.F. und A.M. HOFFMAN (1993):
5KRGRFRFFXVHTXL
Vet. Clin. North. Am. Equine Pract., 9, 375-384
PSCHYREMBEL (Hrsg.) (2004):
Klinisches Wörterbuch, de Gruyter, Berlin; S. 777
RAMACHANDRA, R.N., N. RAVINDRANATH, M.S. RAO, et al. (1981):
Isolation of &RU\QHEDFWHULXPHTXL from two cases of abortion in mares.
Indian Vet. J., 58, 83
ROBERTS, M.C., D.R. HODGSON und W.R. KELLY. (1980):
&RU\QHEDFWHULXPHTXL infection in an adult horse.
Aust. Vet. J., 56, 96
ROBINSON, R.C. (1982):
Epidemiological and bacteriological studies of &RU\QHEDFWHULXP5KRGRFRFFXVHTXL. Isolates from California farms.
J. Reprod. Fertil., 32, 477-480
ROSIN, H. und D. HENSCHLER. (1998):
Antibiotika und Chemotherapeutika.
In: Allgemeine und spezielle Pharmakologie und Toxikologie (W Forth), 7. Auflage, Spektrum akademischer Verlag, Heidelberg 7: pp 677-787
ROTHHAAR, E. (2006):
Zur Entwicklung der Empfindlichkeit von 5HTXLgegenüber Antibiotika.
Hannover, Tierärztl. Hochschule, Diss.
SANCHEZ, J.L., S.C. CRAIG, S. KOLAVIC, et al. (2003):
An outbreak of pneumococcal pneumonia among military personnel at high risk:
control by low-dose azithromycin postexposure chemoprophylaxis.
Mil. Med., 168, 1-6
SCHUHMANN, F.J., E.D. JANZEN und J.J. McKINNON. (1991):
Prophylactic medication of feddlot calves with tilmicosin.
Vet. Rec., 128, 278-280
SCHULTE, S. (2005):
Wirksamkeit von Hyperimmunserum zur Prophylaxe der 5KRGRFRFFXV HTXL -Pneumonie beim Fohlen.
Hannover, Tierärztl. Hochschule, Diss.
SELBITZ, H.J. (2002):
Bakterielle Krankheiten der Tiere.
in: M. ROLLE u. A. MAYR (Hrsg.): Medizinische Mikrobiologie, Infektions– und Seuchenlehre, 7. Auflage, Enke Verlag, Stuttgart, S. 515-516
SELLON, D.C., T.E. BESSER, S.L. VIVRETTE, et al. (2001):
Comparison of nucleic acid amplification, serology, and microbiologic culture for diagnosis of 5KRGRFRFFXVHTXL pneumonia in foals.
J. Clin. Microbiol., 39, 1289-1293
SHEPARD, R.M. und F.C. FALKNER. (1990):
Pharmacokinetics of azithromycin in rats and dogs.
J. Antimicrob. Chemother., 25, 49-60
SMITH, B.P. und R.C. ROBINSON. (1981):
Studies of an outbreak of &RU\QHEDFWHULXPHTXLpneumonia in foals.
Equine Vet. J., 13, 223-228
SPOO, J.W. und J.E. RIVIERE. (1995):
Chloramphenicol, macrolides, lincosamides, fluoroquinolones and miscellaneous antibiotics.
In: Veterinary pharmacology and therapeutics (HR Adams, ed), Iowa State University Press, Ames (USA); pp 820-855
SWEENEY, C.R., R.W. SWEENEY und T.J. DIVERS. (1987):
5KRGRFRFFXVHTXL pneumonia in 48 foals: Response to antimicrobial therapy.
Vet. Microbiol., 14, 329-336
TAKAI, S., K. NARITA, K. ANDO, et al. (1986):
Ecology of 5KRGRFRFFXV&RU\QHEDFWHULXm) HTXL in soil on a horse-breeding farm.
Vet. Microbiol., 12, 169-177
TAKAI, S., T. FUJIMORI, K. KATSUZAKI, et al. (1987):
Ecology of 5KRGRFRFFXVHTXLin horses and their environment on horse breeding farms.
TAKAI, S., T. SEKIZAKI, T. OZAWA, et al. (1991):
Association between a large plasmid and 15to 17-kilodalton antigens in virulent 5KRGRFRFFXVHTXL.
Infect. Immun., 59, 4056-4060
TAKAI, S., Y. SASAKI und S. TSUBAKI (1995):
5KRGRFRFFXVHTXLinfection in foals - current concepts and implication for future research.
J. Equine Sci., 6, 105-119
TAKAI, S., D. HIDAKA, M. FUJII, et al. (1996):
Serum antibody responses of foals to virulence-associated 15to 17kilodalton antigens of 5KRGRFRFFXVHTXL.
Vet. Microbiol., 52, 63-71
TIMONEY, J.F. (1991):
The role of 6WUHSWRFRFFXVHTXLsubsp. ]RRHSLGHPLFXVin lower respiratory tract infections of foals.
Equine Infect. Dis., 4, 79
TRISKATIS, A.-L. (2004):
Semiquantitative Bestimmung von Antikörpern gegen 5KRGRFRFFXV HTXLin Serum und Kolostrum bei Stuten und Fohlen mittels ELISA und der Vergleich mit Befunden der Lungenuntersuchung.
Hannover, Tierärztl. Hochschule, Diss.
VOGEL, G.J., S.B. LAUDERT, A. ZIMMERMAN, et al. (1998):
Effects of tilmicosin on acute undifferentiated respiratory tract disease in newly arrived feedlot cattle.
J. Am. Vet. Med. Assoc., 212, 1919-1924
WADA, R., M. KAMADA, T. ANZAI, et al. (1997):
Pathogenicity and virulence of 5KRGRFRFFXV HTXL in foals following intratracheal challenge.
Vet. Microbiol., 56, 301-312
WALTHER, S. (2006):
Diagnostik von Lungenabszessen beim Fohlen. Vergleich von sonographischen und röntgenologischen Befunden.
Hannover, Tierärztl. Hochschule, Diss.
WARNER, A.E. (1990):
Bacterial pneumonia in foals.
Large Animal Internal Medicine, 511-515
WELSH, R.D. (1984):
The significance of 6WUHSWRFRFFXV]RRHSLGHPLFXV in the horse.
Equine Pract., 6, 6-16
WILSON, M.M. (1955):
A study of &RU\QHEDFWHULXP HTXL infection in a study of Thoroughbred horses in Victoria.
Aust. Vet. J., 31, 175-181
WOOLCOCK, J.B. und M.D. MUTIMER. (1978):
The capsules of &RU\QHEDFWHULXPHTXL and 6WUHSWRFRFFXVHTXL. J. Gen. Microbiol., 109, 127-130
YAGER, J.A. (1987):
The pathogenesis of 5KRGRFRFFXVHTXL pneumonia in foals.
Vet. Microbiol., 14, 225-232
ZINK MC, JA YAGER und NL SMART. (1986):
&RU\QHEDFWHULXPHTXL infections in horses, 1958-1984. A review of 131 cases.
Can. Vet. J., 27, 213-217
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7DE (UJHEQLVVH GHU NOLQLVFKHQ XQG VRQRJUDSKLVFKHQ 8QWHUVXFKXQJ XQGGLHJHPHVVHQH%OXWOHXNR]\WHQ]DKOGHUHUNUDQNWHQ)RKOHQDP
21 2 67 0 14.400 20 2 Str.+,R -
22 2 123 1 13.300 60 2 -
23 2 83 1 15.900 30 2 Str.+,R+
24 2 128 4 10.100 20 1 Str.+,R -
25 2 113 3 14.300 30 2 Str.+,R -
26 2 104 1 15.100 40 2 Str.+,R -
27 2 78 2 12.000 18 1 -
28 2 60 0 14.600 95 4 -
29 2 129 3 18.700 50 3 -
30 2 122 1 20.300 15 1 -
31 2 123 4 10.900 40 2 -
32 2 58 0 13.000 40 2 -
33 3 37 4 9.900 20 1 -
34 3 22 1 10.300 10 1 Str.+,R -
35 3 86 0 8.800 10 1 -
36 3 28 7 11.400 10 1 -
37 3 39 1 14.500 25 2 -
38 3 117 3 8.300 60 2 -
39 3 95 1 11.300 35 2 -
40 3 55 0 16.100 30 3 -
41 3 25 3 10.800 30 3 -
42 3 48 5 9.200 20 2 -
43 3 120 1 16.300 40 3 -
44 3 45 1 13.700 10 1 -
45 3 24 0 15.300 10 1 -
46 3 62 1 15.200 20 1 -
7DE 0HGLDQH 0LQLPD 0D[LPD XQWHUH XQG REHUH 4XDUWLOH GHV NOLQLVFKHQ 6FRUHV GHU %OXWOHXNR]\WHQ]DKO $EV]HVV]DKO GHV
$EV]HVV6FRUHVXQGGHV$OWHUVLQGHQGUHL*UXSSHQDP7DJGHU 'LDJQRVH
Gruppe Minimum 25.Perzentil Median 75.Perzentil Maximum
Klinischer Score 1 0 1 2 3 7
Leukozyten x 106/l Blut 1 8.500 11.000 13.500 16.400 22.700
Abszesszahl (n) 1 1 1 1 3 6
Abszess Score (mm) 1 10 15 20 32 75
Erkrankungs-alter (d) 1 29 52 54 82 119
Klinischer Score 2 0 1 1 3 4
Leukozyten x 106/l Blut 2 10.100 12.900 14.400 16.300 20.300
Abszesszahl (n) 2 1 1 2 2 4
Abszess Score (mm) 2 10 20 40 50 95
Erkrankungs-alter (d) 2 58 67 83 123 129
Klinischer Score 3 0 1 1 3 7
Leukozyten x 106/l Blut 3 8.300 9.900 11.350 15.200 16.300
Abszesszahl (n) 3 1 1 1,5 2 3
Abszess Score (mm) 3 10 10 20 30 60
Erkrankungs-alter (d) 3 22 28 46,5 86 120
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Herrn Prof. Dr. K. Feige danke ich für die Überlassung des Dissertationsthemas und die freundlichen und konstruktiven Vorschläge.
Einen gedanklichen Blumenstrauß und ein herzliches Dankeschön an Frau Dr.
Monica Venner, Ph.D. für die kompetente, persönliche und engagierte Betreuung.
Herrn Paul Schockemöhle danke ich für die die Bereitstellung der Pferde für die Studie und die finanzielle Unterstützung.
Ich danke „Intervet International“ für die finanzielle Unterstützung und namentlich Peter van Laar für die gute Zusammenarbeit.
Ein großer Dank gilt allen Mitarbeitern des Gestüts Lewitz, besonders Franz Pieper und Philipp Baumgart, für die große Hilfe und die nette Arbeitsathmosphäre.
Ein herzlicher Dank allen Doktoranden und Praktikanten 2005/2006, insbesonder Ina
Ein herzlicher Dank allen Doktoranden und Praktikanten 2005/2006, insbesonder Ina