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ALMER, G. (2003):

Amyotrophe Lateralsklerose: Überlegungen zu Ursprung und Pathophysiologie der Erkrankung.

J Neurol Neurochir Psychiatr 4, 6-12

ALVAREZ, F. J., R. M. VILLALBA, P. A. CARR, P. GRANDES u. P. M. SOMOHANO (2000):

Differential distribution of metabotropic glutamate receptors 1a, 1b, and 5 in the rat spinal cord.

J Comp Neurol 422, 464-487

ANNESER, J. M., C. CHAHLI, P. G. INCE, G. D. BORASIO u. P. J. SHAW (2004):

Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis.

J Neuropathol Exp Neurol 63, 831-840

APOSTOLAKOS, M. J., W. H. SCHUERMANN, M. W. FRAMPTON, M. J. UTEL u. J.

C. WILLEY (1993):

Measurement of gene expression by multiplex competitive polymerase chain reaction.

Anal Biochem 213, 277-284

ARAKAWA, Y., M. SENDTNER u. H. THOENEN (1990):

Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines.

J Neurosci 10, 3507-3515

ARNAUD, E., C. TOURIOL, C. BOUTONNET, M. C. GENSAC, S. VAGNER, H.

PRATS u. A. C. PRATS (1999) :

A new 34-kilodalton isoform of human fibroblast growth factor 2 is cap dependently synthesized by using a non-AUG start codon and behaves as a survival factor.

Mol Cell Biol 19, 505-514

ARONICA, E., M. V. CATANIA, J. GEURTS, B. YANKAYA u. D. TROOST (2001):

Immunohistochemical localization of group I and II metabotropic glutamate receptors in control and amyotrophic lateral sclerosis human spinal cord: upregulation in

reactive astrocytes.

Neuroscience 105, 509-520

BACON, S. J. u. A. D. SMITH (1988):

Preganglionic sympathetic neurons innervating the rat adrenal medulla:

immunocytochemical evidence of synaptic input from nerve terminals.

J Auton Nerv Syst 24, 9-22

BAEG, G. H., X. LIN, N. KHARE, S. BAUMGARTNER u. N. PERRIMON (2001):

Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless.

Development 128, 87-94

BAIRD, A., D. SCHUBERT, N. LING u. R. GUILLEMIN (1988):

Receptor- and heparin-binding domains of basic fibroblast growth factor.

Proc Natl Acad Sci USA 85, 2324-2328 BANNISTER, R. u. C. J. MATHIAS (1992) :

Autonomic Failure: A Textbook of Clinical Disorders of the Autonomic Nervous System.

3. Aufl. Verlag Oxford University Press, Oxford, S. 531-547

BEDOGNI, F., P. FADDA, A. FRESU, G. RACAGNI u. M. A. RIVA (2004):

Hyperactivity and altered dopaminergic function in FGF-2 knock-out mice.

FENS Abstr 2, A090.3

BIKFALVI, A., S. KLEIN, G. PINTUCCI, N. QUARTO, P. MIGNATTI u. D. B. RIFKIN (1995):

Differential modulation of cell phenotype by different molecular weight forms of basic fibroblast growth factor: possible intracellular signaling by the high molecular weight forms.

J Cell Biol 129, 233-243

BIKFALVI, A., S. KLEIN, G. PINTUCCI u. D. B. RIFKIN (1997):

Biological roles of fibroblast growth factor-2.

Endocr Rev 18, 26-45

BIRNBOIM, H. C. u. J. DOLY (1979):

A rapid alkaline extraction procedure for screening recombinant plasmid DNA.

Nucl Acids Res 7, 1513-1523

BJÖRKLUND, A. u. G. SKAGERBERG (1979):

Evidence for a major spinal cord projection from the diencephalic A11 dopamine cell group in the rat using transmitter-specific fluorescent retrograde tracing.

Brain Res 177, 170-175

BLACKBURN, P. u. S. MOORE (1982):

Pancreatic ribonuclease.

in: P. D. BOYER (Hrsg.): The Enzymes.

Verlag Academic Press, New York, S. 317-433 BLESSING, W. W. u. J. P. CHALMERS (1979):

Direct projection of catecholamine (presumably dopamine)-containing neurons from hypothalamus to spinal cord.

Neurosci Lett 11, 35-40

BLOTTNER, D., R. WESTERMANN, C. GROTHE, P. BÖHLEN u. K. UNSICKER (1989):

Basic fibroblast growth factor in the adrenal gland: possible trophic role for preganglionic neurons in vivo.

Eur J Neurosci 1, 471-478

BLOTTNER, D. u. H. G. BAUMGARTEN (1992):

Basic FGF prevents death and atrophy of retrogradely labelled preganglionic neurons in vivo.

Exp Neurol 118, 35-46

BLOTTNER, D., C. STAPF, C. MEISINGER u. C. GROTHE (1997):

Localization, Differential Expression and Retrograde Axonal Transport Suggest Physiological Role of FGF-2 in Spinal Autonomic Neurons of the Rat.

Eur J Neurosci 9, 368-377

BONNAL, S., F. PILEUR, C. ORSINI, F. PARKER, F. PUJOL, A. C. PRATS u. S.

VAGNER (2005) :

Heterogeneous nuclear ribonucleoprotein A1 is a novel internal ribosome entry site trans-acting factor that modulates alternative initiation of translation of the fibroblast growth factor 2 mRNA.

J Biol Chem 280, 4144-4153 BÖHLEN, P. (1989):

Fibroblast growth factor.

in: C. SORG (Hrsg.): Cytokines: Macrophage-Derived Cell Regulatory Factors.

1. Aufl. Verlag Karger, Basel, S. 204-228

BROSI, R., H. P. HAURI u. A. KRÄMER (1993):

Separation of splicing factor SF3a into two components and purification of SF3a activity.

J Biol Chem 268, 17640-17646

BUCKANOVICH, R. J. u. R. B. DARNELL (1997):

The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo.

Mol Cell Biol 17, 3194-3201

BUNZOW, J. R., H. H. VAN TOL, D. K. GRANDY, P. ALBERT, J. SALON, M.

CHRISTIE, C. A. MACHIDA, K. A. NEVE u. O. CIVELLI (1988):

Cloning and expression of a rat D2 dopamine receptor cDNA.

Nature 336, 783-787

BURGE, C., T. TUSCHL u. P. SHARP (1999):

Splicing of precursors to mRNA by the spliceosome.

in: R. GESTELAND, T. CECH u. J. ATKINS (Hrsg.): The RNA World.

2. Aufl. Verlag Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, S. 525-560

BURNASHEV, N., H. MONYER, P. H. SEEBURG u. B. SAKMANN (1992):

Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit.

Neuron 8, 189-198

CHEON, H. G., W. J. LAROCHELLE, D. P. BOTTARO, W. H. BURGESS u. S. A.

AARONSON ( 1994):

High-affinity binding sites for related fibroblast growth factor ligands reside within different receptor immunoglobulin-like domains.

Proc Natl Acad Sci USA 91, 989-993 CHOMCZYNSKI, P. u. N. SACCHI (1987) :

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

Anal Biochem 162, 156-159

CLAUS, P., F. DÖRING, S. GRINGEL, F. MÜLLER-OSTERMEYER, J. FUHLROTT, T. KRAFT u. C. GROTHE (2003):

Differential intranuclear localization of fibroblast growth factor-2 isoforms and specific interaction with the survival of motoneuron protein.

J Biol Chem 278, 479-485

CLAUS, P., A. F. BRUNS u. C. GROTHE (2004):

Fibroblast growth factor-2(23) binds directly to the survival of motoneuron protein and is associated with small nuclear RNAs.

Biochem J 384, 559-565

CLAUS, P., S. WERNER, M. TIMMER u. C. GROTHE (2004):

Expression of the fibroblast growth factor-2 isoforms and the FGF receptor 1-4 transcripts in the rat model system of Parkinson’s disease.

Neurosci Lett 360, 117-120 CONN, P. J. u. J. P. PIN (1997):

Pharmacology and functions of metabotropic glutamate receptors.

Annu Rev Pharmacol Toxicol 37, 205-237

CUEVAS, P., F. CARCELLER, S. ORTEGSA, I. NIETO u. G. GIMENEZ-GALLEGO (1991) :

Hypotensive activity of fibroblast growth factor.

Science 254, 1208-1210

DIETL, M., M. ARLUISON, P. MOUCHET, C. FEUERSTEIN, M. MANIER u. J.

THIBAULT (1985):

Immunohistochemical demonstration of catecholaminergic cell bodies in the spinal cord of the rat.

Histochemistry 82, 385-389

DIONNE, C. A., G. CRUMLEY, F. BELLOT, J. M. KAPLOW, G. SEARFOSS, M.

RUTA, W. H. BURGESS, M. JAYE u. J. SCHLESSINGER (1990):

Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.

EMBO J 9, 2685-2692

DOHLMAN, H. G., J. THORNER, M. G. CARON u. R. J. LEFKOWITZ (1991):

Model system for the study of seven-transmembrane-segment receptors.

Annu Rev Biochem 60, 653-688

DONO, R., G. TEXIDO, R. DUSSEL, H. EHMKE u. R. ZELLER (1998):

Impaired cerebral cortex development and blood pressure in FGF-2-deficient mice.

EMBO J 17, 4213-4225

DONO, R., J. FAULHABER, A. GALLI, A. ZUNIGA, T. VOLK, G. TEXIDO, R.

ZELLER u. H. EHMKE (2002):

FGF2 Signaling Is Required for the Development of Neuronal Circuits Regulating Blood Pressure.

Circ Res 90, 5-10 DONO, R. (2003):

Fibroblast growth factors as regulators of central nervous system development and function.

Am J Physiol Regul Integr Comp Physiol 284, 867-881

ERIKSSON, A. E., L. S. COUSENS, L. H. WEAVER u. B. W. MATTHEWS (1991):

Three-dimensional structure of human basic fibroblast growth factor.

Proc Natl Acad Sci USA 88, 3441-3445

FAHAM, S., R. E. HILEMAN, J. R. FROMM, R. J. LINHARDT u. D. C. REES (1996):

Heparin structure and interactions with basic fibroblast growth factor.

Science 271, 1116-1120

FAHAM, S., R. J. LINHARDT u. D. C. REES (1998):

Diversity does make a difference: fibroblast growth factor-heparin interactions.

Curr Opin Struct Biol 8, 578-586

FEINBERG, A. P. u. B. VOGELSTEIN (1983):

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

Anal Biochem 132, 6-13

FERRAGUTI, F., F. CONQUET, C. CORTI, P. GRANDES, R. KUHN u. T. KNOPFEL (1998):

Immunohistochemical localization of the mGluR1beta metabotropic glutamate receptor in the adult rodent forebrain: evidence for a differential distribution of mGluR1 splice variants.

J Comp Neurol 400, 391-407 FINKBEINER, S. (1993):

Glial calcium.

Glia 9, 83-104

FLORKIEWICZ, R. Z. u. A. SOMMER (1989):

Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons.

Proc Natl Acad Sci USA 86, 3978-3981

FLORKIEWICZ, R. Z., A. BAIRD u. A. M. GONZALEZ (1991):

Multiple forms of bFGF: differential nuclear and cell surface localization.

Growth Factors 4, 265-275

FRIESEN, W. J. u. G. DREYFUSS (2000):

Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN).

J Biol Chem 275, 26370-26375

GLADWELL, S. J. u. J. H. COOTE (1996):

In vitro effects of dopamine on neonatal rat antidromically identified sympathetic preganglionic neurones.

J Physiol 491, 143-144

GLADWELL, S. J. u. J. H. COOTE (1996):

Dopamine acts via a D1 receptor to inhibit sympathetic preganglionic neurones in the neonatal rat spinal cord in vitro.

J Physiol 497, 73-74

GLADWELL, S. J. u. J. H. COOTE (1997):

Fast synaptic activity induced by dopamine on sympathetic preganglionic neurones in the neonatal rat spinal cord transverse slice is not mediated by glycine, GABA or EAA.

J Physiol 501, 82

GLADWELL, S. J. u. J. H. COOTE (1999):

Inhibitory and indirect excitatory effects of dopamine on sympathetic preganglionic neurones in the neonatal rat spinal cord in vitro.

Brain Res 818, 397-407

GLADWELL, S. J., S. PYNER, N. M. BARNES u. J. H. COOTE (1999):

D1-like dopamine receptors on retrogradely labelled sympathoadrenal neurones in the thoracic spinal cord of the rat.

Exp Brain 128, 377-382 GOLDFARB, M. (2001):

Signaling by Fibroblast Growth Factors: The Inside Story.

Science’s stke 106, 1-5

GOMEZ-PINILLA, F., J. W. LEE u. C. W. COTMAN (1992):

Basic FGF in adult brain: Cellular distribution and response to entorhinal lesion and fimbria-fornix transection.

J Neurosci 12, 345-355

GONZALEZ-HERRERA, I. G., L. PRADO-LOURENCO, S. TESHIMA-KONDO, K.

KONDO, F. CABON, J.-F. ARNAL, F. BAYARD u. A.-C. PRATS (2006):

IRES-dependent regulation of FGF-2 mRNA translation in pathophysiological conditions in the mouse.

Biochemical Society Transactions 34, 17-21

GRINGEL, S., J. VAN BERGEIJK, K. HAASTERT, C. GROTHE u. P. CLAUS (2004):

Nuclear fibroblast growth factor-2 interacts specifically with splicing factor subunit SF3a66.

Biol Chem 385, 1203-1208

GROTHE, C. u. K. UNSICKER (1990):

Immunocytochemical mapping of basic fibroblast growth factor in developing and adult rat adrenal gland.

Histochemistry 94, 141-147

GROTHE, C., K. WEWETZER, A. LAGRANGE u. K. UNSICKER (1991):

Effects of basic fibroblast growth factor on survival and choline acetyltransferase development of spinal cord neurons.

Dev Brain Res 62, 257-261

GROTHE, C. u. K. UNSICKER (1992):

Basic fibroblast growth factor in the hypoglossal system: specific retrograde transport, trophic and lesion-related responses.

J Neurosci Res 32, 317-328

GROTHE, C. u. K. WEWETZER (1996):

Fibroblast growth factor and its implications for developing and regenerating neurons.

Int J Dev Biol 40, 403-410

GROTHE, C., A. SCHULZE, I. SEMKOVA, F. MÜLLER-OSTERMEYER, A. REGE u.

K. WEWETZER (2000):

The high molecular weight fibroblast growth factor-2 isoforms (21,000 mol. wt and 23,000 mol. wt) mediate neurotrophic activity on rat embryonic mesencephalic dopaminergic neurons in vitro.

Neuroscience 100, 73-86

GROTHE, C. u. G. NIKKHAH (2001):

The role of basic fibroblast growth factor in peripheral nerve regeneration.

Anat Embryol 204, 171-177

GROTHE, C., K. HAASTERT u. J. JUNGNICKEL (2006):

Physiological function and putative therapeutic impact of the FGF-2 system in peripheral nerve regeneration-Lessons from in vivo studies in mice and rats.

Brain Res Brain Res Rev, in press HANSON, E. u. L. RÖNNBACK (1988):

Neurons from substantia nigra increase the efficacy and potency of second messenger arising from striatal astroglia dopamine receptor.

Glia 1, 393-397

HEATH, P. R. u. P. J. SHAW (2002):

Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis.

Muscle Nerve 26, 438-458

HERMANS, E. u. R. A. CHALLISS (2001):

Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors.

Biochem J 359, 465-484

HERRINGTON, C. S., J. BRUNS, A. K. GRAHAM, M. EVANS u. J. O’D MCGEE (1989):

Interphase cytogenetics using biotin and digoxigenin labelled probes I: relative sensitivity of both reporter molecules for detection of HPV16 CaSki cells.

J Clin Pathol 42, 592-600

HOLLMANN, M. u. S. HEINEMANN (1994):

Cloned glutamate receptors.

Rev Neurosci 17, 31-108

HOLSTEGE, J. C., H. VAN DIJKEN, R. M. BUIJS, H. GOEDKNEGT, T. GOSENS u.

C. M. H. BONGERS (1996):

Distribution of dopamine immunoreactivity in the rat, cat and monkey spinal cord.

J Comp Neurol 376, 631-652

HUGHES, R. A., M. SENDTNER u. H. THOENEN (1993):

Members of several gene families influence survival of rat motoneurons in vitro and in vivo.

J Neurosci Res 36, 663-671 JELLINGER, K. A. (2005):

Neurodegenerative Erkrankungen (ZNS)- Eine aktuelle Übersicht.

J Neurol Neurochir Psychiatr 6, 9-18

JENSEN, K. B., B. K. DREDGE, G. STEFANI, R. ZHONG, R. J. BUCKANOVICH, H.

J. OKANO, Y. Y. L. YANG u. R. B. DARNELL (2000):

Nova-1 Regulates Neuron-Specific Alternative Splicing and Is Essential for Neuronal Viability.

Neuron 25, 359-371

JIN, L. u. R. V. LLOYD (1997):

In situ hybridization: methods and applications.

J Clin Lab Ana 11, 2-9

JIN, K., M. LAFEVRE-BERNT, Y. SUN, S. CHEN, J. GAFNI, D. CRIPPEN, A.

LOGVINOVA, C. A. ROSS, D. A. GREENBERG u. L. M. ELLERBY (2005):

FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntigton’s disease.

PNAS 102, 18189-18194

JOHN, H. A., M. L. BIRNSTIEL u. K. W. JONES (1969):

RNA-DNA hybrids of the cytological level.

Nature 223, 582-587

JOHNSON, D. E., J. LU, H. CHEN, S. WERNER u. L. T. WILLIAMS (1991):

The human fibroblast growth factor receptor genes: a common structural

arrangement underlies the mechanisms for generating receptor forms that differ in their immunoglobulin domain.

Mol Cell Biol 11, 4627-4634

JOHNSON, D. E. u. L. T. WILLIAMS (1993):

Structural and functional diversity in the FGF receptor multigene family.

Adv Cancer Res 60, 1-41

JUNGNICKEL, J., P. CLAUS, K. GRANSALKE, M. TIMMER u. C. GROTHE (2004):

Targeted disruption of the FGF-2 gene affects the response to peripheral nerve injury.

Mol Cell Neurosci 25, 444-452

JUNGNICKEL, J., A. KLUTZNY, S. GUHR, K. MEYER u. C. GROTHE (2005):

Regulation of neuronal death and calcitonin gene-related peptide by Fibroblast Growth Factor-2 and FGFR3 after peripheral nerve injury: evidence from mouse mutants.

Neuroscience 134, 1343-1350

JUNGNICKEL, J., K. HAASE, J. KONITZER, M. TIMMER u. C. GROTHE (2006):

Faster nerve regeneration after sciatic nerve injury in mice overexpressing basic fibroblast growth factor.

J Neurobiol, in press

JURIKA, M. S. u. M. J. MOORE (2003):

Pre-mRNA splicing: awash in a sea of proteins.

Mol Cell 12, 5-14

KANDEL, E. R., J. H. SCHWARTZ u. T. M. JESSEL (2000):

Principles of Neural Science.

4. Aufl. Verlag Elsevier, New York

KEBABAIN, J. W. u. D. B. CALNE (1979):

Multiple receptors for dopamine.

Nature 277, 93-96

KETTENMANN, H., K. H. BACKUS u. M. SCHACHNER (1984):

Aspartate, glutamate and gamma-aminobutyric acid depolarize cultured astrocytes.

Neurosci Lett 52, 25-29

KLIMASCHEWSKI, L., C. MEISINGER, C. GROTHE (1999):

Localization and regulation of basic fibroblast growth factor (FGF-2) and FGF receptor-1 in rat superior cervical ganglion after axotomy.

J Neurobiol 38, 499-506

KORADA, S., W. ZHENG, C. BASILICO, M. L. SCHWARTZ u. F. M. VACCARINO (2002):

Fibroblast Growth Factor 2 Is Necessary for the Growth of Glutamate Projection Neurons in the Anterior Neocortex.

J Neurosci 22, 863-875

LAFAGE-POCHITALOFF, M., F. GALLAND, J. SIMONETTI, H. PRATS, M. G.

MATTEI u. D. BIRNBAUM (1990):

The human basic fibroblast growth factor gene is located on the long arm of chromosome 4 at bands q26-q27.

Oncogene Res 5, 241-244

LAZAROUS, D. F., E. F. UNGER, S. E. EPSTEIN, A. STINE, J. L. AREVALO, E. Y.

CHEW u. A. A. QUYYUMI (2000):

Basic fibroblast growth factor in patients with intermittent claudication: results of a phase I trail.

J Am Coll Cardiol 85, 1414-1419

LEE, P. L., D. E. JOHNSON, L. S. COUSENS, V. A. FRIED u. L. T. WILLIAMS (1989):

Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor.

Science 245, 57-60

LEITCH, A. R., T. SCHWARZACHER, D. JACKSON u. I. J. LEITCH (1994):

In situ-Hybridisierung.

Spektrum Akademischer Verlag, Heidelberg, Berlin, Oxford LEVANT, B. u. K. E. MCCARSON (2001):

D3 dopamine receptors in rat spinal cord: implications for sensory and motor function.

Neurosci Letters 303, 9-12

LIN, X., E. M. BUFF, N. PERRIMON u. A. M. MICHELSON (1999):

Heparan sulfate proteoglycans are essential for FGF receptor signalling during Drosophila embryonic development.

Development 126, 3715-3723

LIU, M. u. A. L. KIRCHGESSNER (2000):

Agonist- and reflex-evoked internalization of metabotropic glutamate receptor 5 in enteric neurons.

J Neurosci 20, 3200-3205

MALECKI, J., J. WESCHE, C. S. SKJERPEN, A. WIEDLOCHA u. S. OLSNES (2004):

Translocation of FGF-1 and FGF-2 across vesicular membranes occurs during G1-phase by a common mechanism.

Mol Biol Cell 15, 801-814 MARSDEN, C. A. (2006):

Dopamine: the rewarding years.

British Journal of Pharmacology 147, 136-144 MATHIAS, C. J. (1998) :

Cardiovascular autonomic dysfunction in parkinsonian patients.

Clin Neurosci 5, 153-166

MATTEI, M. G., M. J. PEBUSQUE u. D. BIRNBAUM (1992):

Chromosomal localization of mouse Fgf2 and Fgf5 genes.

Mamm Genome 2, 135-137

MCKEEHAN, W. L., F. WANG u. M. KAN (1998):

The heparan sulfate-fibroblast growth factor family: diversity of structure and function.

Prog Nucleic Acid Res Mol Biol 59, 135-176

MEISINGER, C., A. HERTENSTEIN u. C. GROTHE (1996):

Fibroblast growth factor receptor 1 in the adrenal gland and PC12 cells:

developmental expression and regulation by extrinsic molecules.

Mol Brain Res 36, 70-78

MIGNATTI, P., T. MORIMOTO u. D. B. RIFKIN (1992):

FGF2 lacks a signal peptide but is known to act extracellularly. This study shows that FGF2 can be released via an exocytotic mechanism independent of the endoplasmic reticulum-Golgi pathway.

J Cell Physiol 151, 81-93

MILLAR, M. R., R. M. SHARPE, S. M. MAGUIRE u. P. T. K. SAUNDERS (1993):

Cellular localization of messenger RNA in rat testis: application of digoxigenin-labelled ribonucleotide probes to embedded tissue.

Cell Tissue Res 273, 269-277

MILLER, D. L., S. ORTEGA, O. BASHAYAN, R. BASCH u. C. BASILICO (2000):

Compensation by Fibroblast Growth Factor 1 (FGF1) Does Not Account for the Mild Phenotypic Defects Observed in FGF2 Null Mice.

Mol Cell Biol 20, 2260-2268

MIYAKAWA, K., K. HATSUZAWA, T. KUROKAWA, M. ASADA, T. KUROIWA u. T.

IMAMURA (1999):

A hydrophobic region locating at the center of fibroblast growth factor-9 is crucial for its secretion.

J Biol Chem 274, 29352-29357

MIYAKE, A., M. KONISHI, F. H. MARTIN, N. A. HERNADY, K. OZAKI, S.

YAMAMOTO, T. MIKAMI u. N. ITOH (1998):

Structure and expression of a novel member, FGF-16, of the fibroblast growth factor family.

Biochem Biophys Res Commun 243, 148-152

MIYAMOTO, M., K. NARUO, C. SEKO, S. MATSUMOTO, T. KONDO u. T.

KUROKAWA (1993):

Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property.

Mol Cell Biol 13, 4251-4259

MOEPPS, B. u. L. FAGNI (2003):

Mont Sainte-Odile: a sanctuary for GPCRs. Confidence on signal transduction of G-protein-couple receptors.

EMBO Rep 4, 237-243

MONSMA, F. J., L. C. MAHAN, L. D. MCVITTIE, C. R. GERFEN u. D. R. SIBLEY (1990):

Molecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation.

Proc Natl Acad Sci USA 87, 6723-6727 MOSCALETTI, D. (1987):

High and low affinity binding sites for basic fibroblast growth factor on cultured cells:

absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells.

J Cell Physiol 131, 123-130

MUDRICK-DONNON, L. A., P. J. WILLIAMS, Q. J. PITTMAN u. B. A. MACVICAR (1993):

Postsynaptic potentials mediated by GABA and dopamine evoked in stellate glial cells of the pituitary pars intermedia.

J Neurosci 13, 4660-4668

MULLIS, K. B. u. F. A. FALOONA (1987):

Specific Synthesis of DNA in vitro via a polymerase-catalyzed chain reaction.

Methods Enzymol 155, 335-350

MUNOZ-SANJUAN, I., P. M. SMALLWOOD u. J. NATHANS (2000):

Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing.

J Biol Chem 275, 2589-2597

MURASHOV, A. K. u. D. J. WOLGEMUTH (1996):

Sense and antisense transcripts of the developmentally regulated murine hsp 70.2 gene are expressed in distinct and only partially overlapping areas in the adult brain.

Brain Res Mol Brain Res 37, 85-95 NILSEN, T. W. (2003):

The spliceosome: the most complex macromolecular machine in the cell?

Bioessays 25, 1147-1149

OHMACHI, S., Y. WATANABE, T. MIKAMI, N. KUSU, T. IBI, A. AKAIKE u. N. ITOH (2000):

FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain.

Biochem Biophys Res Commun 277, 355-360

ORNITZ, D. M., A. YAYON, J. G. FLANAGAN, C. m. SVAHN, E. LEVI u. P. LEDER (1992):

Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.

Mol Cell Biol 12, 240-247

ORNITZ, D. M., J. XU, J. S. COLVIN, D. G. MCEWEN, C. A. MACARTHUR, F.

COULIER, G. GAO u. M. GOLDFARB (1996):

Receptor specificity of the fibroblast growth factor family.

J Biol Chem 271, 15292-15297 ORNITZ, D. M. u. N. ITOH (2001):

Fibroblast growth factors.

Genome Biol 2, 3005.1-3005.12

ORTEGA, S., M. ITTMANN, S. H. TSANG, M. EHRLICH u. C. BASILICO (1998):

Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2.

Proc Natl Acad Sci 95, 5672-5677 PARDUE, M. u. J. C. GALL (1969):

Molecular hybridization of radioactive DNA to the DNA of cytological preparations.

Proc Natl Acad Sci USA 64, 600-604

PAXINOS, G. u. K. B. J. FRANKLIN (2001):

The Mouse Brain in Stereotaxic Coordinates.

2. Aufl. Verlag Academic Press, San Diego

PETRI, S., S. SCHMALBACH, J. GROSSKREUTZ, K. KRAMPFL, C. GROTHE, R.

DENGLER, L. VAN DEN BOSCH, W. ROBBERECHT u. J. BUFLER (2005):

The cellular mRNA expression of GABA and glutamate receptors in spinal motor neurons of SOD1 mice.

J Neurol Sci 238, 25-30

PIN, J. P. u. F. ACHER (2002):

The metabotropic glutamate receptors: structure, activation mechanism and pharmacology.

Curr Drug Targets CNS Neurol Disord 3, 297-317

PLOTNIKOV, A. N., J. SCHLESSINGER, S. R. HUBBARD u. M. MOHAMMIDI (1999):

Structural basis for FGF receptor dimerization and activation.

Cell 98, 641-650

PRATS, H., M. KAGHAD, A. C. PRATS, M. KLAGSBRUN, J. M. LELIAS, P.

LIAUZUN, P. CHALON, J. P. TAUBER, F. AMALRIC u. J. A. SMITH (1989):

High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons.

Proc Natl Acad Sci USA 86, 1836-1840

PRICE, T., J. AITKEN u. E. R. SIMPSON (1992):

Relative expression of aromatase cytochrome P450 in human fetal tissues as determined by competitive polymerase chain reaction amplification.

J Clin Endocrin & Metabolism 74, 879-883

RABALLO, R., J. RHEE, R. LYN-COOK, J. F. LECKMAN, M. L. SCHWARTZ u. F. M.

VACCARINO (2000):

Basic fibroblast growth factor (Fgf2) is necessary for cell proliferation, neurogenesis in the developing cerebral cortex.

J Neurosci 20, 5012-5023 RAPPOLEE, D. A. (1990):

Optimizing the sensitivity of RT-PCR.

Amplifications A Forum for PCR Users 7, 1-4 RAY, J., A. BAIRD u. F. H. GAGE (1997):

A 10-amino acid sequence of fibroblast growth factor 2 is sufficient for its mitogenic activity on neuronal progenitor cells.

Proc Natl Acad Sci USA 94, 7047-7052

REVEST, J. M., L. DEMOERLOOZE u. C. DICKSON (2000):

Fibroblast growth factor 9 secretion is mediated by a non-cleaved amino-terminal signal sequence.

J Biol Chem 275, 8083-8090

RIDET, J.-L., F. SANDILLON, N. RAJAOFETRA, M. GEFFARD u. A. PRIVAT (1992):

Spinal dopaminergic system of the rat: light and electron microscopic study using an antiserum against dopamine, with particular emphasis on synaptic incidence.

Brain Res 598, 233-241

ROTHSTEIN, J. D., M. VAN KAMMEN, A. I. LEVEY, L. J. MARTIN u. R. W. KUNCI (1995):

Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis.

Ann Neurol 38, 73-84

ROTHSTEIN, J. D., M. DYKES-HOBERG, C. A. PADO, L. A. BRISTOL, L. JIN, R. W.

KUNCL, Y. KANAI, M. A. HEDINGER, Y. WANG, J. P. SCHIELKE u. D. F. WETLY (1996):

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearence of glutamate.

Neuron 16, 675-686 ROWLAND, L. P. (2004):

Amyotrophic lateral sclerosis: theories and therapies.

Ann Neurol 35, 129-130

SAIKI, R. K., D. H. GELFAND, S. STOFFEL, S. J. SCHARF, R. HIGUCHI, G. T.

HORN, K. B. MULLIS u. H. A. ERLICH (1988):

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.

Science 239, 487-491

SANGER, F., S. NICKLEN, A. R. COULSON (1977):

DNA sequencing with chain-terminating inhibitors.

Proc Nat Acad Sci USA 74, 5463-5467

SCHENBORN, E. T. u. C. MIERENDORF (1985):

A novel transcription property of SP6 and T7 polymerases: dependence on template structure.

Nucleic Acids Res 13, 6223-6236

SCHLESSINGER, J., A. N. PLOTNIKOV, O. A. IBRAHIMI, A. V. ELISEENKOVA, B.

K. YEH, A. YAYON, R. J. LINHARDT u. M. MOHAMMADI (2000):

Crystal structure of a tertiary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.

Mol Cell 6, 743-750

SELA, M., C. B. ANIFINSEN u. W. F. HARRINGTON (1957):

The correlation of ribonuclease activity with specific aspects of tertiary structure.

Biochem Biophys Acta 26, 502

SHAHAR, A., J. DE VELLIS, A. VERNADAKIS u. B. HABER (1989) : A Dissection and Tissue Culture Manual of the Nervous System.

1. Aufl. Verlag Wiley-Liss, New York, S. 23-25

SINGER, R. H., J. B. LAWRENCE u. C. VILLNAVE (1986):

Optimization of in situ hybridization using isotopic and non-isotopic detection methods.

Biotechniques 4, 230-245

SLACK, J. M. W., B. G. DARLINGTON, J. K. HEATH u. S. F. GODSAVE (1987):

Mesoderm induction in early Xenopus embryos by heparin-binding growth factors.

Nature 326, 197-200

SMALLWOOD, P. M., I. MUNOZ-SANJUAN, P. TONG, J. P. MACKE, S. H.

HENDRY, D. J. GILBERT, N. G. COPELAND, N. A. JENKINS u. J. NATHAN (1996):

Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

Proc Natl Acad Sci USA 93, 9850-9857

SOUAZE, F., A. NTODOU-THOME, C. Y. TRAN, W. ROSTENE u. P. FORGEZ (1996):

Quantitative RT-PCR: limits and accuracy.

Biotechniques 21, 280-285

SPIVAK-KROIZMAN, T., M. A. LEMMON, I. DIKIC, J. E. LADBURY, D. PINCHASI, J.

HUANG, M. JAYE, G. CRUMLEY, J. SCHLESSINGER u. I. LAX (1994):

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation and cell proliferation.

Cell 79, 1015-1024

STACHOWIAK, M. K., J. MOFFET, A. JOY, E. PUCHACZ, R. FLORKIEWICZ u. E.

K. STACHOWIAK (1994):

Regulation and bFGF gene expression and subcellular distribution of bFGF protein in adrenal medullary cells.

J Cell Biol 127, 203-223

STRACK, A. M., W. B. SAWYER, L. M. MARUBIO u. A. D. LOEWY (1988):

STRACK, A. M., W. B. SAWYER, L. M. MARUBIO u. A. D. LOEWY (1988):