Bei allen berechneten Oberflächen in dieser Arbeit handelt es sich um lösungsmittel-zugängliche Oberflächen („Connolly surfaces“, „solvent accessible surfaces“). Für die Berechnung der Connolly-Oberflächen durch das Programm MS (Connolly, 1983) wurde ein Probenradius von 1.5 Å benutzt.
Der Anteil der polaren Oberfläche beeinhaltet alle Sauerstoff- und Stickstoffatome mit den an ihnen gebundenen Wasserstoffatomen, während sich der nicht-polare Oberflächenanteil aus der Differenz von Gesamtoberfläche und polarem Oberflächenanteil ergibt. Die bei der Ligandenbindung vergrabene Oberfläche ist die Differenz aus der Summe der Oberflächen des freien Liganden und Enzyms einerseits und der Oberfläche der Komplexes andererseits.
Die verwendeten Atomradien wurden Bondi (1968) entnommen.
7 L
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Geburtstag: 31. Dezember 1971
Geburtsort: Osterholz-Scharmbeck (Niedersachsen)
1978 – 1984 Grundschule und Orientierungsstufe in Hambergen 1984 – 1991 Gymnasium in Osterholz-Scharmbeck
Mai 1991 Allgemeine Hochschulreife
1992 / 1993 Grundwehrdienst
1991 – 1996 Studium der Chemie an der Universität Bremen
1992 – 1996 Stipendiat der Begabtenförderung der Konrad-Adenauer-Stiftung
Juli-Dezember 1996 Anfertigung der Diplomarbeit „Synthese von donor-substituierten Chlorinen nach dem Thiadiazolinverfahren“
am Institut für Organische Chemie der Universität Bremen (Betreuer: Prof. Dr. F.-P. Montforts)
Dezember 1996 Verleihung des akademischen Grades „Diplom-Chemiker“
1997 – 2000 Anfertigung der vorliegenden Dissertation
am Institut für Pharmazeutische Chemie der Philipps-Universität Marburg (Betreuer: Prof. Dr. G. Klebe)
Wissenschaftlicher Mitarbeiter am selbigen Institut