Analgetische medikamentöse Behandlung der alkoholassoziierten Polyneuropathie Die medikamentöse analgetische Behandlung bei polyneuropathischen Schmerzen ist komplex und

detailliert beschrieben (Finnerup et al., 2015, Saarto und Wiffen, 2010). Bei der analgetischen Behandlung der alkoholassoziierten Polyneuropathie sollten analgetische Medikamente mit Suchtpotential nach Möglichkeit vermieden werden (Bonnet und Scherbaum, 2017, Witkiewitz et al., 2018).

3.5.7 Versorgungsalgorithmus

Aufgrund der engen Verknüpfung der alkoholbezogenen Störung als Grunderkrankung und der Erkrankung von Leber, Pankreas sowie Polyneuropathien erscheint es sinnvoll, grundsätzlich von beiden Fachgebieten her die jeweils andere Erkrankung mit zu bedenken und aktiv danach zu suchen, wie es im folgenden Versorgungsalgorithmus dargestellt ist.

S3 LL Screening, Diagnose und Behandlung alkoholbezogener Störungen

Seite | 132 Abbildung 2: Versorgungsalgorithmus bei körperlichen Komplikationen und Komorbidität

3.5.8 Forschungsthemen

1. Langzeitwirkung der Alkoholentwöhnungstherapie auf den Verlauf der chronischen Pankreatitis 2. Bestimmung von Rauchen als unabhängiger Risikofaktor für die chronische Pankreatitis

3. Screening und Behandlung weiterer somatischer Erkankungen, welche in Zusammenhang mit Alkoholkonsum auftreten (z.B. cardiovaskuläre Erkrankungen, Tumore).

3.5.9 Literatur

Addolorato, G., Leggio, L., Ferrulli, A., Cardone, S., Vonghia, L., Mirijello, A., ... & Haber, P. S. (2007).

Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study. The Lancet, 370(9603), 1915-1922.

Agelink, M. W., Malessa, R., Weisser, U., Lemmer, W., Zeit, T., Majewski, T., & Klieser, E. (1998). Alcoholism, peripheral neuropathy (PNP) and cardiovascular autonomic neuropathy (CAN). Journal of the neurological sciences, 161(2), 135-142.

Ammann, R. W., Akovbiantz, A., Largiader, F., & Schueler, G. (1984). Course and outcome of chronic pancreatitis. Longitudinal study of a mixed medical-surgical series of 245 patients. Gastroenterology, 86(5 Pt 1), 820-828.

Ammendola, A., Gemini, D., Iannaccone, S., Argenzio, F., Ciccone, G., Ammendola, E., ... & Bravaccio, F. (2000).

Gender and peripheral neuropathy in chronic alcoholism: A clinical–electroneurographic study. Alcohol and Alcoholism, 35(4), 368-371.

S3 LL Screening, Diagnose und Behandlung alkoholbezogener Störungen

Seite | 133 Ammendola, A., Tata, M. R., Aurilio, C., Ciccone, G., Gemini, D., Ammendola, E., ... & Argenzio, F. (2001).

Peripheral neuropathy in chronic alcoholism: a retrospective cross-sectional study in 76 subjects. Alcohol and Alcoholism, 36(3), 271-275.

Ang, C. D., Alviar, M. J. M., Dans, A. L., Bautista‐Velez, G. G. P., Villaruz‐Sulit, M. V. C., Tan, J. J., ... & Roxas, A.

A. (2008). Vitamin B for treating peripheral neuropathy. Cochrane Database of Systematic Reviews, (3).

Bell, H., Tallaksen, C. M., Try, K., & Haug, E. (1994). Carbohydrate‐deficient transferrin and other markers of high alcohol consumption: A study of 502 patients admitted consecutively to a medical department.

Alcoholism: Clinical and Experimental Research, 18(5), 1103-1108.

Bonnet, U., & Scherbaum, N. (2017). How addictive are gabapentin and pregabalin? A systematic review.

European neuropsychopharmacology, 27(12), 1185-1215.

Buechler, C., Schäffler, A., Johann, M., Neumeier, M., Köhl, P., Weiss, T., ... & Hellerbrand, C. (2009). Elevated adiponectin serum levels in patients with chronic alcohol abuse rapidly decline during alcohol withdrawal.

Journal of gastroenterology and hepatology, 24(4), 558-563.

Bush, K., Kivlahan, D. R., McDonell, M. B., Fihn, S. D., & Bradley, K. A. (1998). The AUDIT alcohol consumption questions (AUDIT-C): an effective brief screening test for problem drinking. Archives of internal medicine, 158(16), 1789-1795.

Cargiulo, T. (2007). Understanding the health impact of alcohol dependence. American Journal of Health-System Pharmacy, 64(5 Suppl 3), 5-11.

Chaparro, L. E., Wiffen, P. J., Moore, R. A., & Gilron, I. (2012). Combination pharmacotherapy for the treatment of neuropathic pain in adults. Cochrane Database of Systematic Reviews, (7).

Corrao, G., Bagnardi, V., Zambon, A., & Torchio, P. (1998). Meta-analysis of alcohol intake in relation to risk of liver cirrhosis. Alcohol and Alcoholism, 33(4), 381-392.

Corrao, G., Bagnardi, V., Zambon, A., & La Vecchia, C. (2004). A meta-analysis of alcohol consumption and the risk of 15 diseases. Preventive medicine, 38(5), 613-619.

Durbec, J. P., & Sarles, H. (1978). Relationship between the relative risk of developing chronic pancreatitis and alcohol, protein and lipid consumption. Digestion, 18, 337-350

European Association for the Study of the Liver. (2012). EASL clinical practical guidelines: management of alcoholic liver disease. Journal of hepatology, 57(2), 399-420.

European Association for the Study of the Liver. (2018). EASL Clinical Practice Guidelines: Management of alcohol-related liver disease. Journal of hepatology, 69(1), 154-181.

Finnerup, N. B., Attal, N., Haroutounian, S., McNicol, E., Baron, R., Dworkin, R. H., ... & Kamerman, P. R. (2015).

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. The Lancet Neurology, 14(2), 162-173.

Galambos, J. T., & Shapira, R. (1973). Natural history of alcoholic hepatitis. IV. Glycosaminoglycuronans and collagen in the hepatic connective tissue. The Journal of clinical investigation, 52(11), 2952-2962.

Garbutt, J.C. (2010). Efficacy and tolerability of naltrexone in the management of alcohol dependence.

Current pharmaceutical design, 16(19), 2091-2097.

García-Pugés, A. M., Navarro, S., Ros, E., Elena, M., Ballesta, A., Aused, R., & Vilar-Bonet, J. (1986). Reversibility of exocrine pancreatic failure in chronic pancreatitis. Gastroenterology, 91(1), 17-24.

Gerke, P., Hapke, U., Rumpf, H. J., & John, U. (1997). Alcohol-related diseases in general hospital patients.

Alcohol and Alcoholism, 32(2), 179-184.

Ghavanini, A. A., & Kimpinski, K. (2014). Revisiting the evidence for neuropathy caused by pyridoxine deficiency and excess. Journal of clinical neuromuscular disease, 16(1), 25-31.

Gossop, M., Neto, D., Radovanovic, M., Batra, A., Toteva, S., Musalek, M.,…, & Goos, C. (2007). Physical health problems among patients seeking treatment for alcohol use disorders: a study in six European cities. Addiction Biology. 12(2), 190–196.

S3 LL Screening, Diagnose und Behandlung alkoholbezogener Störungen

Seite | 134 Gual, A., Segura, L., Contel, M., Heather, N., & Colom, J. (2002). Audit-3 and audit-4: effectiveness of two short forms of the alcohol use disorders identification test. Alcohol and Alcoholism, 37(6), 591-596.

Hawley, R. J., Kurtzke, J. F., Armbrustmacher, V. W., Saini, N., & Manz, H. (1982). The course of alcoholic‐

nutritional peripheral neuropathy. Acta Neurologica Scandinavica, 66(5), 582-589.

Hayakawa, T., Kondo, T., Shibata, T., Sugimoto, Y., & Kitagawa, M. (1989). Chronic alcoholism and evolution of pain and prognosis in chronic pancreatitis. Digestive diseases and sciences, 34(1), 33-38.

Heuß, D., Hund, E., & Klehmet, J., Kurth, I., Lehmann, H., & Sommer, C. (2019). Diagnostik bei Polyneuropathien, S1-Leitlinie. In: Deutsche Gesellschaft für Neurologie (Hrsg.) Leitlinien für Diagnostik und Therapie in der Neurologie (AWMF-Register-Nr. 030/067). Abgerufen von https://www.dgn.org/leitlinien Hock, B., Schwarz, M., Domke, I., Grunert, V. P., Wuertemberger, M., Schiemann, U., ... & Soyka, M. (2005).

Validity of carbohydrate‐deficient transferrin (% CDT), γ‐glutamyltransferase (γ‐GT) and mean corpuscular erythrocyte volume (MCV) as biomarkers for chronic alcohol abuse: a study in patients with alcohol dependence and liver disorders of non‐alcoholic and alcoholic origin. Addiction, 100(10), 1477-1486.

Hoffmeister, A., Mayerle, J., Beglinger, C., Büchler, M. W., Bufler, P., Dathe, K., ... & Klar, E. (2012). S3-Consensus guidelines on definition, etiology, diagnosis and medical, endoscopic and surgical management of chronic pancreatitis German Society of Digestive and Metabolic Diseases (DGVS). Zeitschrift für Gastroenterologie, 50(11), 1176-1224.

Janssens, F., de Suray, N., Piessevaux, H., Horsmans, Y., de Timary, P., & Stärkel, P. (2010). Can transient elastography replace liver histology for determination of advanced fibrosis in alcoholic patients: a real-life study. Journal of clinical gastroenterology, 44(8), 575-582.

Johnson, C. D., & Hosking, S. (1991). National statistics for diet, alcohol consumption, and chronic pancreatitis in England and Wales, 1960-88. Gut, 32(11), 1401-1405.

Julian, T., Glascow, N., Syeed, R., & Zis, P. (2018). Alcohol-related peripheral neuropathy: a systematic review and meta-analysis. Journal of neurology 266(12), 2907-2919.

Koike, H., Iijima, M., Sugiura, M., Mori, K., Hattori, N., Ito, H., ... & Sobue, G. (2003). Alcoholic neuropathy is clinicopathologically distinct from thiamine‐deficiency neuropathy. Annals of neurology, 54(1), 19-29.

Kondo, T., Hayakawa, T., Noda, A., Ito, K., Yamazaki, Y., Iinuma, Y., ... & Naruse, S. (1981). Follow-up study of chronic pancreatitis. Gastroenterologia Japonica, 16(1), 46-53.

Lankisch, P. G., Löhr-Happe, A., Otto, J., & Creutzfeldt, W. (1993). Natural course in chronic pancreatitis.

Digestion, 54(3), 148-155.

Latvala, J., Hietala, J., Koivisto, H., Järvi, K., Anttila, P., & Niemelä, O. (2005). Immune responses to ethanol metabolites and cytokine profiles differentiate alcoholics with or without liver disease. American Journal of Gastroenterology, 100(6), 1303-1310.

Lévy, P., Mathurin, P., Roqueplo, A., Rueff, B., & Bernades, P. (1995). A multidimensional case-control study of dietary, alcohol, and tobacco habits in alcoholic men with chronic pancreatitis. Pancreas, 10(3), 231-238.

Lin, Y., Tamakoshi, A., Hayakawa, T., Ogawa, M., Ohno, Y., & Research Committee on Intractable Pancreatic Diseases. (2001). Associations of alcohol drinking and nutrient intake with chronic pancreatitis: findings from a case-control study in Japan. The American journal of gastroenterology, 96(9), 2622-2627.

Lowenfels, A. B., Maisonneuve, P., Cavallini, G., Ammann, R. W., Lankisch, P. G., Andersen, J. R., ... & Pederzoli, P. (1994). Prognosis of chronic pancreatitis: an international multicenter study. American Journal of Gastroenterology, 89(9), 1467-1471. Maddrey, W. C., Boitnott, J. K., Bedine, M. S., Weber, F. L., Mezey, E., &

White, R. I. (1978). Corticosteroid therapy of alcoholic hepatitis. Gastroenterology, 75(2), 193-199.

Maejima, S. Y., Kawa, S., Hasebe, O., & Homma, T. (1996). The relationship between drinking status and serial changes of pancreatographic findings in patients with suspected early chronic alcoholic pancreatitis.

Pancreas, 13(2), 209-214.

Mandayam, S., Jamal, M. M., & Morgan, T. R. (2004). Epidemiology of alcoholic liver disease. Seminars in liver disease, 24(3), 217-232).

S3 LL Screening, Diagnose und Behandlung alkoholbezogener Störungen

Seite | 135 Marbet, U. A., Bianchi, L., Meury, U., & Stalder, G. A. (1987). Long-term histological evaluation of the natural history and prognostic factors of alcoholic liver disease. Journal of hepatology, 4(3), 364-372.

Maruyama, K., & Otsuki, M. (2007). Incidence of alcoholic pancreatitis in Japanese alcoholics: survey of male sobriety association members in Japan. Pancreas, 34(1), 63-65.

Mathurin, P., Beuzin, F., Louvet, A., Carrié‐Ganne, N., Balian, A., Trinchet, J. C., ... & Naveau, S. (2007). Fibrosis progression occurs in a subgroup of heavy drinkers with typical histological features. Alimentary pharmacology & therapeutics, 25(9), 1047-1054.

Mellion, M., Gilchrist, J. M., & De La Monte, S. (2011). Alcohol‐related peripheral neuropathy: nutritional, toxic, or both?. Muscle & nerve, 43(3), 309-316.

Menon, D. K., Harris, M., Sargentoni, J., Taylor-Robinson, S. D., Cox, I. J., & Morgan, M. Y. (1995). In vivo hepatic 31P magnetic resonance spectroscopy in chronic alcohol abusers. Gastroenterology, 108(3), 776-788.

Miyake, H., Harada, H., Kunichika, K., Ochi, K., & Kimura, I. (1987). Clinical course and prognosis of chronic pancreatitis. Pancreas, 2(4), 378-385.

Monforte, R., Estruch, R., Valls-Solé, J., Nicolás, J., Villalta, J., & Urbano-Marquez, A. (1995). Autonomic and peripheral neuropathies in patients with chronic alcoholism: a dose-related toxic effect of alcohol. Archives of neurology, 52(1), 45-51.

Moreno, C., Mueller, S., & Szabo, G. (2019). Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Journal of hepatology, 70(2), 273-283.

Moussavian, S. N., Becker, R. C., Piepmeyer, J. L., Mezey, E., & Bozian, R. C. (1985). Serum gamma-glutamyl transpeptidase and chronic alcoholism. Digestive diseases and sciences, 30(3), 211-214.

Mueller S. (Hrsg.) (2020). Liver elastography: Clinical Use and Interpretation. Springer International Publishing.

Mueller, S., Englert, S., Seitz, H. K., Badea, R. I., Erhardt, A., Bozaari, B., ... & Lupșor‐Platon, M. (2015).

Inflammation‐adapted liver stiffness values for improved fibrosis staging in patients with hepatitis C virus and alcoholic liver disease. Liver International, 35(12), 2514-2521.

Mueller, S., Millonig, G., Sarovska, L., Friedrich, S., Reimann, F. M., Pritsch, M., ... & Seitz, H. K. (2010).

Increased liver stiffness in alcoholic liver disease: differentiating fibrosis from steatohepatitis. World journal of gastroenterology: WJG, 16(8), 966-972.

Naveau, S., Gaudé, G., Asnacios, A., Agostini, H., Abella, A., Barri‐Ova, N., ... & Balian, A. (2009). Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease.

Hepatology, 49(1), 97-105.

Nei, J., Matsuda, Y., & Takada, A. (1983). Chronic hepatitis induced by alcohol. Digestive diseases and sciences, 28(3), 207-215.

Nguyen‐Khac, E., Chatelain, D., Tramier, B., Decrombecque, C., Robert, B., Joly, J. P., ... & Dupas, J. L. (2008).

Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non‐invasive laboratory tests. Alimentary pharmacology & therapeutics, 28(10), 1188-1198.

Nguyen-Khac, E., Thiele, M., Voican, C., Nahon, P., Moreno, C., Boursier, J., ... & Fernandez, M. (2018). Non-invasive diagnosis of liver fibrosis in patients with alcohol-related liver disease by transient elastography: an individual patient data meta-analysis. The Lancet Gastroenterology & Hepatology, 3(9), 614-625.

Nordback, I., Pelli, H., Lappalainen–Lehto, R., Järvinen, S., Räty, S., & Sand, J. (2009). The recurrence of acute alcohol-associated pancreatitis can be reduced: a randomized controlled trial. Gastroenterology, 136(3), 848-855.

Parés, A., Caballería, J., Bruguera, M., Torres, M., & Rodés, J. (1986). Histological course of alcoholic hepatitis:

influence of abstinence, sex and extent of hepatic damage. Journal of hepatology, 2(1), 33-42.

Pelli, H., Lappalainen-Lehto, R., Piironen, A., Sand, J., & Nordback, I. (2008). Risk factors for recurrent acute alcohol-associated pancreatitis: a prospective analysis. Scandinavian journal of gastroenterology, 43(5), 614-621.

S3 LL Screening, Diagnose und Behandlung alkoholbezogener Störungen

Seite | 136 Pelli, H., Lappalainen-Lehto, R., Piironen, A., Järvinen, S., Sand, J., & Nordback, I. (2009). Pancreatic damage after the first episode of acute alcoholic pancreatitis and its association with the later recurrence rate.

Pancreatology, 9(3), 245-251.

Peters, T. J., Kotowicz, J., Nyka, W., Kozubski, W., Kuznetsov, V., Vanderbist, F., ... & Coffiner, M. (2006).

Treatment of alcoholic polyneuropathy with vitamin B complex: a randomised controlled trial. Alcohol and Alcoholism, 41(6), 636-642.

Ramstedt, M. (2001). Per capita alcohol consumption and liver cirrhosis mortality in 14 European countries.

Addiction, 96(1s1), 19-33.

Raynard, B., Balian, A., Fallik, D., Capron, F., Bedossa, P., Chaput, J. C., & Naveau, S. (2002). Risk factors of fibrosis in alcohol-induced liver disease. Hepatology, 35(3), 635-638.

Rehm, J., Taylor, B., Mohapatra, S., Irving, H., Baliunas, D., Patra, J., & Roerecke, M. (2010). Alcohol as a risk factor for liver cirrhosis: a systematic review and meta‐analysis. Drug and alcohol review, 29(4), 437-445.

Röjdmark, S., & Brismar, K. (2001). Decreased IGF-I bioavailability after ethanol abuse in alcoholics: partial restitution after short-term abstinence. Journal of endocrinological investigation, 24(7), 476-482.

Roulot, D., Costes, J. L., Buyck, J. F., Warzocha, U., Gambier, N., Czernichow, S., ... & Beaugrand, M. (2011).

Transient elastography as a screening tool for liver fibrosis and cirrhosis in a community-based population aged over 45 years. Gut, 60(7), 977-984.

Saarto, T., & Wiffen, P. J. (2010). Antidepressants for neuropathic pain: a Cochrane review. Journal of Neurology, Neurosurgery & Psychiatry, 81(12), 1372-1373.

Sarles, H., Cros, R. C., & Bidart, J. M. (1979). A multicenter inquiry into the etiology of pancreatic diseases.

Digestion, 19(2), 110-125.

Saunders, J. B., Aasland, O. G., Babor, T. F., De la Fuente, J. R., & Grant, M. (1993). Development of the alcohol use disorders identification test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption‐II. Addiction, 88(6), 791-804.

Singer, M. V., Pfutzer, R. H., Kiefer, F. (2009). Striving for abstinence in alcoholic pancreatitis: act of humanity, economic necessity, or flogging a dead horse after all? Gastroenterology. 136(3), 757-760.

Stigendal, L., & Olsson, R. (1984). Alcohol consumption pattern and serum lipids in alcoholic cirrhosis and pancreatitis: a comparative study. Scandinavian journal of gastroenterology, 19(5), 582-587.

Strum, W. B. (1995). Abstinence in alcoholic chronic pancreatitis. Effect on pain and outcome. Journal of clinical gastroenterology, 20(1), 37-41.

Talamini, G., Bassi, C., Falconi, M., Sartori, N., Salvia, R., Rigo, L., ... & Vaona, B. (1999). Alcohol and smoking as risk factors in chronic pancreatitis and pancreatic cancer. Digestive diseases and sciences, 44(7), 1303-1311.

Thiele, M., Rausch, V., Fluhr, G., Kjærgaard, M., Piecha, F., Mueller, J., ... & Detlefsen, S. (2018). Controlled attenuation parameter and alcoholic hepatic steatosis: diagnostic accuracy and role of alcohol detoxification.

Journal of hepatology, 68(5), 1025-1032.

Thomson, S. J., Westlake, S., Rahman, T. M., Cowan, M. L., Majeed, A., Maxwell, J. D., & Kang, J. Y. (2008).

Chronic liver disease—an increasing problem: a study of hospital admission and mortality rates in England, 1979–2005, with particular reference to alcoholic liver disease. Alcohol & Alcoholism, 43(4), 416-422.

Thursz, M. R., Richardson, P., Allison, M., Austin, A., Bowers, M., Day, C. P., ... & Hood, S. (2015). Prednisolone or pentoxifylline for alcoholic hepatitis. New England Journal of Medicine, 372(17), 1619-1628.

Trabut, J. B., Thépot, V., Nalpas, B., Lavielle, B., Cosconea, S., Corouge, M., ... & Pol, S. (2012). Rapid decline of liver stiffness following alcohol withdrawal in heavy drinkers. Alcoholism: Clinical and Experimental Research, 36(8), 1407-1411.

Tsujimoto, T., Kawaratani, H., Yoshiji, H., Uemura, M., & Fukui, H. (2008). Recent developments in the treatment of alcoholic chronic pancreatitis. Current drug abuse reviews, 1(2), 197-202.

Vege, S. S., Yadav, D., & Chari, S. T. (2007). Pancreatitis. In N. J. Talley, G. R. Locke III, & Y. A. Saito (Hrsg.) GI Epidemiology. Hoboken, NJ: Blackwell Publishing.

S3 LL Screening, Diagnose und Behandlung alkoholbezogener Störungen

Seite | 137 Vittadini, G., Buonocore, M., Colli, G., Terzi, M., Fonte, R., & Biscaldi, G. (2001). Alcoholic polyneuropathy: a clinical and epidemiological study. Alcohol and Alcoholism, 36(5), 393-400.

Welch, C., Harrison, D., Short, A., & Rowan, K. (2008). The increasing burden of alcoholic liver disease on United Kingdom critical care units: secondary analysis of a high quality clinical database. Journal of health services research & policy, 13 Suppl 2, 40–44.

Welch, K. A. (2011). Neurological complications of alcohol and misuse of drugs. Practical neurology, 11(4), 206-219.

Wetterling, T., Veltrup, C., Driessen, M., & John, U. (1999). Drinking pattern and alcohol-related medical disorders. Alcohol and Alcoholism, 34(3), 330-336.

Witkiewitz, K., Votaw, V. R., Vowles, K. E., & Kranzler, H. R. (2018). Opioid misuse as a predictor of alcohol treatment outcomes in the COMBINE study: mediation by medication adherence. Alcoholism: Clinical and Experimental Research, 42(7), 1249-1259.

Woelk, H., Lehrl, S., Bitsch, R., & Köpcke, W. (1998). Benfotiamine in treatment of alcoholic polyneuropathy:

an 8-week randomized controlled study (BAP I Study). Alcohol and Alcoholism, 33(6), 631-638.

Yang, A. L., Vadhavkar, S., Singh, G., & Omary, M. B. (2008). Epidemiology of alcohol-related liver and pancreatic disease in the United States. Archives of internal medicine, 168(6), 649-656.

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Seite | 138

Im Dokument S3-Leitlinie „Screening, Diagnose und Behandlung alkoholbezogener Störungen“ (Seite 131-138)