Number of training tissues Transcription Factor (a) (b)

Alternatively, methyl-CpG binding domain proteins (MBDs) have been proposed to bind arrays of methylated CpGs and induce chromatin compaction by recruiting histone

Figure 2.3: REST is associated with H3K27me3 dynamics at high- and low-CpG regions genome-wide: a) The distribu- tion of CpG dinucleotide frequencies of H3K27me3 regions genome-wide

Conditional over expression of mScrt2.2 in the developing cortex of generated transgenic mice revealed an increase in neuronal differentiation at early stages of

When cotransfected together with the mutated glucagon reporter gene, in which both Pax6 binding sites within G1 and G3 had been mutated into GAL4 binding sites (-

In the cortex we identified two genes (AP2γ and CRALBP) whose expression was downregulated in Pax6 mutants and investigated the roles of these genes in cortical development..

sible for the DNA-binding, transcriptional activation, and effector responsiveness o f the protein and to clarify whether XylS and A raC proteins use

In ISR, ATF4 regulates the expression of the genes involved in protein biosynthesis and in the control of ATF4 pathway activation and the programmed cell death.. The activity of ATF4

The decreased level of C/EBPα observed in the white adipose tissue of Fra1tg mice as well as in the adipogenic cells overexpressing Fra1 strongly suggest that Fra1 was