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Table S1. Comparison of dECM@exo with ECM scaffolds and exosome delivery materials in IVDD.

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Table S1. Comparison of dECM@exo with ECM scaffolds and exosome delivery materials in IVDD.

Function Material Comparison(in IVDD)

Transplantation of stem cells Collagen[31] High production cost

3D-printed biphasic scaffolds[33] Unsuitable mechanical properties

Collagen + polydopamine[34] Low action period

Differentiation of stem cells Collagen + graphene[11,12] Unsuitable mechanical properties Decellularized nucleus

pulposus[24]

Biological toxicity of crosslinking agents

Exosome delivery Nanocomplex[35] High clearance of exosomes

Mesoporous silica

nanoparticles[35]

High clearance of exosomes

Magnetic nanoparticles[36] Difficult to remove magnetic particles

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