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Supplementary Materials

Table S1 Factors associated with preference for treatment mode of bDMARD

Factor name Question items Factor

1 2 3 4

Anxiety or other hurdles related to self-administered SC injection

Anxiety about self-administered SC injection. 0.981 −0.058 −0.038 0.151 I will have pain when I inject myself. 0.837 −0.032 0.116 0.122 It is troublesome to manage injectable drugs by myself. 0.691 0.114 0.037 −0.112 Whenever injectable drugs for rheumatoid arthritis are

needed, I want to see a doctor or nurse.

0.639 0.044 0.053 −0.178 Joint pain makes it difficult to inject myself. 0.634 −0.024 −0.073 0.224 Burden of hospital visits I wish to reduce the time of outpatient visits for the

treatment of rheumatoid arthritis.

0.009 0.906 −0.002 0.038 I wish to reduce the number of visits for the treatment of

rheumatoid arthritis.

0.018 0.880 0.008 −0.020 Reliable or convenient

administration

I would like to have a reliable way to administer the drug. 0.038 −0.063 0.838 −0.153 I don’t want to bother my family to administer injectable

drugs for me.

0.037 0.009 0.588 −0.073 A convenient method of administering injectable drugs is

better.

0.009 0.089 0.499 0.094 Flexible administration setting I wish to inject at my preferred timing. −0.20

8

0.032 0.169 0.664 An appropriate person gives me injections at home. 0.216 0.004 −0.157 0.467 bDMARD, biologic disease-modifying antirheumatic drug; SC, subcutaneous

1

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Fig. S1 Effect of COVID-19 on bDMARD treatment mode and preference for treatment mode on (a) frequency of hospital visits and (b) treatment mode

bDMARD, biologic disease-modifying antirheumatic drug; COVID-19, the 2019 novel coronavirus disease

2

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