Supplementary materials
Table S1 Clinical characteristics of the IgG4-RD patients with malignancies (n=29) No. Sex Age at malignancy
diagnosis, years
Age at IgG4-RD onset, years
Age at IgG4-RD diagnosis, years
Interval between IgG4-RD and malignancy, months
Serum IgG4 level, mg/dL IgG4-RD organ involvement Malignancy type Malignancy treatment
1- M 38 56 58 216 444 Submandibular gland Lung Radiation
2+ F 45 27 32 14 267 Lacrimal gland, submandibular gland,
parotid gland, lymph node
DLBCL Chemotherapy
3+ M 73 64 72 16 4390 Lacrimal gland, submandibular gland,
parotid gland, AIP, prostate, kidney
MM Supporting treatment
4- M 42 54 54 144 610 Lung, retroperitoneum, mesenterium Testis Surgery, radiation
5+ M 73 66 71 15 69.2 Lacrimal gland, submandibular gland,
parotid gland, lung, retroperitoneum
Lung Surgery
6- M 23 34 36 160 445 Lymph node, submandibular gland, lacrimal
gland
Stomach Surgery
7+ M 55 49 49 72 571 AIP Thyroid Surgery
8- F 36 38 38 14 2530 Lacrimal gland, submandibular gland Thyroid Surgery
9- M 63 69 69 84 572 Retroperitoneum Lung Surgery, chemotherapy
10- F 59 67 67 91 149 AIP, lung, submandibular gland, lymph
node
Cervix Surgery
11- F 61 61 65 42 2330 AIP, submandibular gland, lacrimal gland,
lymph node
Lung Surgery
120 M 48 31 48 1 3480 AIP, lacrimal gland, lymph node, orbit and
peri-orbit, kidney, liver, bile duct system, gall bladder
Kidney Surgery
13- M 56 60 61 60 407 Submandibular gland, lymph node, bile duct
system, liver, lung
Stomach Surgery
14+ M 76 71 72 44 7450 AIP, gall bladder, lung, aorta, lymph node Lung Surgery, TCM
15- F 63 59 64 15 7020 Lacrimal gland, submandibular gland,
lymph node
Cervix Surgery, radiation, chemotherapy
16- F 45 49 55 132 470 Submandibular gland, orbit and peri-orbit,
lymph node
Bladder Surgery
170 F 50 48 50 8 455 Lacrimal gland, submandibular gland,
parotid gland
Thyroid Surgery
18+ M 73 70 71 32 1540 AIP, submandibular gland, lacrimal gland,
lymph node, bile duct system
Sarcoma Surgery
190 M 69 63 70 0.25 404 Orbit and peri-orbit, lacrimal gland,
submandibular gland, parotid gland, lymph node, retroperitoneum, liver
Lung Surgery
20- M 60 62 63 31 240 Lymph node HL Radiation, chemotherapy
21+ M 65 61 63 24 592 Lacrimal gland, lung, lymph node, AIP, bile duct system
FL Radiation
22- F 49 51 51 13 1350 Lacrimal gland, submandibular gland,
sublingual gland, lymph node
Lung Surgery
23+ F 64 62 62 27 1100 Submandibular gland, lymph node, AIP, bile
duct system
Cervix Surgery
24- M 51 50 60 108 1052 Lymph node, kidney Colon Surgery
25- F 52 60 62 96 236 Orbit and peri-orbit, lacrimal gland,
submandibular gland
Bladder Chemotherapy
26+ M 75 74 74 14 1390 Lymph node, AIP Esophagus Surgery, radiation
27+ M 74 62 69 67 3560 Submandibular gland, AIP Prostate Radiation
28+ M 39 32 35 45 4750 Lacrimal gland, submandibular gland,
parotid gland, lymph node, lung,
retroperitoneum, AIP, bile duct system, gall bladder, liver, kidney
Lung Surgery
29+ F 67 66 66 14 2130 Submandibular gland, parotid gland,
sublingual gland, lung
Pancreas Chemotherapy, TCM
Abbreviations: M, male; F, female; IgG4-RD, IgG4-related disease; DLBCL, diffuse large B cell lymphoma; MM, multiple myeloma; HL, Hodgkin’s lymphoma; FL, follicular lymphoma; AIP, autoimmune pancreatitis; TCM, traditional Chinese medicine.
-Malignancy diagnosed more than one year[3] before the diagnosis of IgG4 related disease was considered to be diagnosed before the diagnosis of IgG4 related disease.
0Malignancy diagnosed within one year before or after the diagnosis of IgG4 related disease was considered to be diagnosed on the diagnosis of IgG4 related disease.
+Malignancy diagnosed more than one year after the diagnosis of IgG4 related disease was considered to be diagnosed after the diagnosis of IgG4 related disease.
