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Supplementary Table 1: Causes of Deaths (except relapse)Causes of deaths (n, % of deaths)Children (n=196)APA patients (n=289)Young adults (n=647)

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Supplementary Table 1: Causes of Deaths (except relapse) Causes of deaths

(n, % of deaths)

Children (n=196)

APA patients (n=289)

Young adults (n=647) Infections 21 (10.7%) 53 (18.3%) 142 (21.9%)

GvHD 20 (10.2%) 40 (13.8%) 125 (19.3%)

SOS 5 (2.5%) 14 (4.8%) 21 (3.2%)

Pulmonary toxicity 9 (4.6%) 8 (2.8%) 17 (2.6%) Rejection/Poor

Graft Function

1 (0.5%) 3 (1%) 12 (1.8%) Haemorrhage 6 (3%) 13 (4.5%) 20 (3.1%) Cardiac toxicity 3 (1.5%) 3 (1%) 9 (1.4%) CNS toxicity 2 (1%) 7 (2.4%) 12 (1.8%) GI toxicity 2 (1%) 4 (1.4%) 1 (0.1%) Renal failure 3 (1.5%) 9 (3.1%) 19 (2.9%) Lymphoproliferative

Disorder

2 (1%) 5 (1.7%) 9 (1.4%)

« Multiorgan failure »

15 (7.6%) 30 (10.4%) 79 (12.2%)

APA: Adolescent and post-adolescent; CNS: Central Nervous System; GI: Gastro-Intestinal; GVHD:

Graft Versus Host Disease; SOS: Sinusoïdal Obstruction Syndrome

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