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Pac+BI6727

Pac+BI6727+proTAME BI6727 Paclitaxel

DMSO

40 50 60 70

0 5 10 15

40 45 50 55 60 65

0 5 10

15 DMSO

40 50 60 70 80 90 100 110 120 0

5 10

15 3 nM Paclitaxel

40 50 60 70 80 90 100 0

5 10

15 20 nM BI 6727

80 90 100 110 120 130 0

5 10

15 Pac/BI6727 Pac/BI6727/proTAME

number of cells

Chromosome number

DMSO Paclitaxel BI 6727Pac/BI 6727P/BI/pro TAME 0

50 100 150

Average chromosome number per cell

*** ***

A

B

Figure S6 SKOV-3

C

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