ABRAHAM, G., O. E. BRODDE u. F. R. UNGEMACH (2002):
Regulation of equine lymphocyte beta-‐adrenoceptors under the influence of clenbuterol and dexamethasone. Equine Internal Medicin
W.B. Saunders Company, Philadelphia, 278 -‐ 290
AKUTSU, S., A. SHIMADA u. A. YAMANE (2006):
Transforming growth factor betas are upregulated in the rat masseter muscle hypertrophied by clenbuterol, a beta2 adrenergic agonist.
British journal of pharmacology 147, 412-‐421 recurrent airway obstruction.
Equine veterinary journal 31, 397-‐401
BAARENDS, E. M., A. M. SCHOLS, K. R. WESTERTERP u. E. F. WOUTERS (1997):
Total daily energy expenditure relative to resting energy expenditure in clinically stable patients with COPD.
Chronic obstructive pulmonary disease.
The Veterinary clinics of North America 7, 79-‐91
BEECH, J. (2002):
Chronic obstructive pulmonary disease (chronic recurrent airway obstruction).
Large animal internal medicine 3. Aufl., Mosby Verlag, 517 -‐ 522
BEEKLEY, M. D., J. M. IDEUS, W. F. BRECHUE, C. F. KEARNS u. K. H. MCKEEVER (2003):
Chronic clenbuterol administration alters myosin heavy chain composition in standardbred mares.
Vet J 165, 234-‐239
BERNARD, S., P. LEBLANC, F. WHITTOM, G. CARRIER, J. JOBIN, R. BELLEAU u. F. MALTAIS (1998):
Peripheral muscle weakness in patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 158, 629-‐634
BILZER, T. (2001):
Biopsiediagnostik von Muskelkrankheiten des Hundes.
Prakt. Tierarzt 82, 424-‐430
BOURGEOIS, J. M. u. M. A. TARNOPOLSKY (2004):
Pathology of skeletal muscle in mitochondrial disorders.
Mitochondrion 4, 441-‐452
Dose-‐dependent apoptotic and necrotic myocyte death induced by the beta2-‐adrenergic receptor agonist, clenbuterol.
Muscle Nerve 32, 767-‐774
BURNISTON, J. G., L. MCLEAN, R. J. BEYNON u. D. F. GOLDSPINK (2007):
Anabolic effects of a non-‐myotoxic dose of the beta2-‐adrenergic receptor agonist clenbuterol on rat plantaris muscle.
Does clenbuterol positively affect racing horses.
Equine Vet. Educ. 19, 228-‐230
CASADEVALL, C., C. CORONELL, A. L. RAMIREZ-‐SARMIENTO, J. MARTINEZ-‐LLORENS, E. BARREIRO, M. OROZCO-‐LEVI u. J. GEA (2007):
Upregulation of pro-‐inflammatory cytokines in the intercostal muscles of COPD patients.
Eur Respir J 30, 701-‐707
COUILLARD, A., C. KOECHLIN, J. P. CRISTOL, A. VARRAY u. C. PREFAUT (2002):
Evidence of local exercise-‐induced systemic oxidative stress in chronic obstructive pulmonary disease patients.
Eur Respir J 20, 1123-‐1129
COUILLARD, A., F. MALTAIS, D. SAEY, R. DEBIGARE, A. MICHAUD, C. KOECHLIN, P. LEBLANC u. C.
PREFAUT (2003):
Exercise-‐induced quadriceps oxidative stress and peripheral muscle dysfunction in patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 167, 1664-‐1669
CRUL, T., M. A. SPRUIT, G. GAYAN-‐RAMIREZ, R. QUARCK, R. GOSSELINK, T. TROOSTERS, F. PITTA u.
M. DECRAMER (2007):
Markers of inflammation and disuse in vastus lateralis of chronic obstructive pulmonary disease patients.
European journal of clinical investigation 37, 897-‐904
CULLEN, M. J. u. F. L. MASTAGLIA (1982):
Pathological reactions of skeletal muscle IN: F. L. MASTAGLIA u. J. WALTON Skeletal Muscle Pathologie
Churchill Livingstone, New York, 88 -‐ 139.
DAVIS, E. u. B. R. RUSH (2002):
Equine recurrent airway obstruction: pathogenesis, diagnosis, and patient management.
The Veterinary clinics of North America 18, 453-‐467, vi
DE MOFFARTS, B., N. KIRSCHVINK, T. ART, J. PINCEMAIL u. P. LEKEUX (2006):
Effect of exercise on blood oxidant/antioxidant markers in standardbred horses: comparison between treadmill and race track tests.
Equine Vet J Suppl 254-‐257
DEBIGARE, R., K. MARQUIS, C. H. COTE, R. R. TREMBLAY, A. MICHAUD, P. LEBLANC u. F. MALTAIS (2003):
Catabolic/anabolic balance and muscle wasting in patients with COPD.
Chest 124, 83-‐89
DECRAMER, M., V. DE BOCK u. R. DOM (1996):
Functional and histologic picture of steroid-‐induced myopathy in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 153, 1958-‐1964
DECRAMER, M., L. M. LACQUET, R. FAGARD u. P. ROGIERS (1994):
Corticosteroids contribute to muscle weakness in chronic airflow obstruction.
American journal of respiratory and critical care medicine 150, 11-‐16
DECRAMER, M. u. K. J. STAS (1992):
Corticosteroid-‐induced myopathy involving respiratory muscles in patients with chronic obstructive pulmonary disease or asthma.
The American review of respiratory disease 146, 800-‐802
treatment of exacerbations.
Exercise-‐induced lactate increase in relation to muscle substrates in patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 162, 1697-‐1704
ENGELEN, M. P., A. M. SCHOLS, J. D. DOES u. E. F. WOUTERS (2000b):
Skeletal muscle weakness is associated with wasting of extremity fat-‐free mass but not with airflow obstruction in patients with chronic obstructive pulmonary disease.
The American journal of clinical nutrition 71, 733-‐738
Muscle fibre characteristics of active and inactive standardbred horses.
Equine veterinary journal 17, 434-‐438
The contribution of starvation, deconditioning and ageing to the observed alterations in peripheral skeletal muscle in chronic organ diseases.
Clinical nutrition (Edinburgh, Scotland) 21, 1-‐14
FREY, H.-‐H. u. W. H. LÖSCHER (2002):
Lehrbuch der Pharmakologie und Toxikologie für die Veterinärmedizin, 2. Aufl.
Enke Verlag, Stuttgart, Germany
FRYE, M. A., J. M. BRIGHT, D. A. DARGATZ, M. J. FETTMAN, D. D. FRISBIE, D. C. BAKER u. J. L.
TRAUB-‐DARGATZ (2003):
A comparison of dobutamine infusion to exercise as a cardiac stress test in healthy horses.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 17, 58-‐
64
GAN, W., S. MAN u. A. SENTHILSELVAN (2004):
Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-‐analysis.
Thorax 59, 574 -‐ 580
GEA, J. G., M. PASTO, M. A. CARMONA, M. OROZCO-‐LEVI, J. PALOMEQUE u. J. BROQUETAS (2001):
Metabolic characteristics of the deltoid muscle in patients with chronic obstructive pulmonary disease.
Hypoxia increases production of interleukin-‐1 and tumor necrosis factor by human mononuclear cells.
Skeletal muscle fibre-‐type shifting and metabolic profile in patients with chronic obstructive pulmonary disease.
Eur Respir J 19, 617-‐625
GOSKER, H. R., E. F. WOUTERS, G. J. VAN DER VUSSE u. A. M. SCHOLS (2000):
Skeletal muscle dysfunction in chronic obstructive pulmonary disease and chronic heart failure:
underlying mechanisms and therapy perspectives.
The American journal of clinical nutrition 71, 1033-‐1047
GOSKER, H. R., M. P. ZEEGERS, E. F. WOUTERS u. A. M. SCHOLS (2007b):
Muscle fibre type shifting in the vastus lateralis of patients with COPD is associated with disease severity: a systematic review and meta-‐analysis.
Thorax 62, 944-‐949
GOSSELINK, R., T. TROOSTERS u. M. DECRAMER (1996):
Peripheral muscle weakness contributes to exercise limitation in COPD.
American journal of respiratory and critical care medicine 153, 976-‐980
GOSSELINK, R., T. TROOSTERS u. M. DECRAMER (2000):
Distribution of muscle weakness in patients with stable chronic obstructive pulmonary disease.
J Cardiopulm Rehabil 20, 353-‐360
GÜNNEWIG, T. (2006):
1. Auflage, 463
HALLIWELL, B. (1989):
Free radicals, reactive oxygen species and human disease: a critical evaluation with special reference to atherosclerosis.
British journal of experimental pathology 70, 737-‐757
Respiratory physiology & neurobiology 134, 219-‐229
Chronic obstructive pulmonary disease: capillarity and fiber-‐type characteristics of skeletal muscle.
J Cardiopulm Rehabil 18, 432-‐437
KAKULAS, B. A. (1982):
Toxic and drug-‐ induced myopathies IN: F. L. MASTAGLIA u. J. WALTON Skeletal Muscle Pathology
Churchill Livingstone, New York, 409 -‐ 426.
KARLSON, P., J. DOENECKE u. J. KOOLMAN (1994):
Kurzes Lehrbuch der Biochemie für Mediziner und Naturwissenschaftler 14. Aufl.
Georg-‐Thieme Verlag, Stuttgart -‐ New York
KASTNER, S. B., D. M. HAINES, J. ARCHER u. H. G. TOWNSEND (1999):
Investigations on the ability of clenbuterol hydrochloride to reduce clinical signs and inflammation associated with equine influenza A infection.
Equine veterinary journal 31, 160-‐168
KEARNS, C. F. u. K. H. MCKEEVER (2002):
Clenbuterol diminishes aerobic performance in horses.
Medicine and science in sports and exercise 34, 1976-‐1985
KEARNS, C. F., K. H. MCKEEVER, K. MALINOWSKI, M. B. STRUCK u. T. ABE (2001):
Chronic administration of therapeutic levels of clenbuterol acts as a repartitioning agent.
J Appl Physiol 91, 2064-‐2070
KIM, H. C., M. MOFARRAHI u. S. N. HUSSAIN (2008):
Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease.
International journal of chronic obstructive pulmonary disease 3, 637-‐658
KIRSCHVINK, N., L. FIEVEZ, V. BOUGNET, T. ART, G. DEGAND, N. SMITH, D. MARLIN, C. ROBERTS, P.
HARRIS u. P. LEKEUX (2002a):
Effect of nutritional antioxidant supplementation on systemic and pulmonary antioxidant status, airway inflammation and lung function in heaves-‐affected horses.
Equine veterinary journal 34, 705-‐712
KIRSCHVINK, N., N. SMITH, L. FIEVEZ, V. BOUGNET, T. ART, G. DEGAND, D. MARLIN, C. ROBERTS, B.
GENICOT, P. LINDSEY u. P. LEKEUX (2002b):
Effect of chronic airway inflammation and exercise on pulmonary and systemic antioxidant status of healthy and heaves-‐affected horses.
Equine veterinary journal 34, 563-‐571
KOECHLIN, C., F. MALTAIS, D. SAEY, A. MICHAUD, P. LEBLANC, M. HAYOT u. C. PREFAUT (2005):
Hypoxaemia enhances peripheral muscle oxidative stress in chronic obstructive pulmonary disease.
Recurrent Airway Obstruction (Heaves) and Summer-‐pasture-‐associated Obstructive Pulmonary Disease
IN: Mc Gorum B. C., Dixon P. M., Robinson N. E., Schumacher J.
Equine Respiratory Medicine and Surgery.
Saunders Elsevier,
LEGUILLETTE, R. (2003):
Recurrent airway obstruction-‐ heaves.
Vet. Clin. North Am. Equine Pract. 19, 63 -‐ 86
LEVINE, S., T. NGUYEN, L. R. KAISER, N. A. RUBINSTEIN, G. MAISLIN, C. GREGORY, L. C. ROME, G. A.
DUDLEY, G. C. SIECK u. J. B. SHRAGER (2003):
Human diaphragm remodeling associated with chronic obstructive pulmonary disease: clinical implications.
American journal of respiratory and critical care medicine 168, 706-‐713
LÖSCHER, W., F. R. UNGEMACH u. R. KROKER (2003):
Pharmakotherapie bei Haus-‐ und Nutztieren.
Parey Verlag GmbH, , Berlin, Germany
MAIR, T. S. u. F. J. DERKSEN (2000):
Chronic obstructive pulmonary disease: a review.
Equine Vet. Educ. 12, 35 -‐ 44
MALAGUTI, C., L. E. NERY, S. DAL CORSO, L. NAPOLIS, M. B. DE FUCCIO, M. CASTRO u. J. A. NEDER (2006):
Scaling skeletal muscle function to mass in patients with moderate-‐to-‐severe COPD.
European journal of applied physiology 98, 482-‐488
Stressechokardiographie unter aktiver und passiver Belastung beim herzgesunden Pferd.
Hannover, Tierärztl. Hochschule, Klinik f. Pfd., Diss.
MCLOUGHLIN, D. M., E. SPARGO, W. S. WASSIF, D. J. NEWHAM, T. J. PETERS, P. L. LANTOS u. G. F.
RUSSELL (1998):
Structural and functional changes in skeletal muscle in anorexia nervosa.
Acta neuropathologica 95, 632-‐640
MERCKEN, E. M., G. J. HAGEMAN, A. M. SCHOLS, M. A. AKKERMANS, A. BAST u. E. F. WOUTERS (2005):
Rehabilitation decreases exercise-‐induced oxidative stress in chronic obstructive pulmonary disease.
Lower respiratory tract disease.
The Veterinary clinics of North America 12, 457-‐472
O'DONNELL, D. E., S. AARON, J. BOURBEAU, P. HERNANDEZ, D. D. MARCINIUK, M. BALTER, G.
FORD, A. GERVAIS, R. GOLDSTEIN, R. HODDER, A. KAPLAN, S. KEENAN, Y. LACASSE, F. MALTAIS, J.
ROAD, G. ROCKER, D. SIN, T. SINUFF u. N. VODUC (2007):
Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease -‐ 2007 update.
Can Respir J 14 Suppl B, 5B-‐32B
OHNESORGE, B., C. TRÖTSCHEL u. E. DEEGEN (1998):
Bestimmung von Totraum und exspiratorischem Mischvolumen zur Diagnostik chronischer Lungenerkrankungen beim Pferd.
-‐ 14, 450-‐455
International journal of chronic obstructive pulmonary disease 1, 3-‐14
Update in Chronic Obstructive Pulmonary Disease 2006.
Am J Crit Care Med 175, 1222-‐1232
Peroxisome proliferator-‐activated receptor expression is reduced in skeletal muscle in COPD.
Eur Respir J 30, 245-‐252
ROBINSON, N. E. (2001):
International Workshop on Equine Chronic Airway Disease. Michigan State University 16-‐18 June 2000.
Equine veterinary journal 33, 5-‐19
RONEUS, M., B. ESSEN-‐GUSTAVSSON, A. LINDHOLM u. S. G. PERSSON (1992):
Skeletal muscle characteristics in young trained and untrained standardbred trotters.
Equine veterinary journal 24, 292-‐294
RUSH, B. u. T. MAIR (2004):
Equine Respiratory Diseases.
Blackwell Verlag, Kurfürstendamm 57, 10707 Berlin, Germany,
SANDERS, E. A., R. D. GLEED, R. P. HACKETT u. A. DOBSON (1991):
Action of sympathomimetic drugs on the bronchial circulation of the horse.
Experimental physiology 76, 301-‐304
SCHOLS, A. M., P. B. SOETERS, A. M. DINGEMANS, R. MOSTERT, P. J. FRANTZEN u. E. F. WOUTERS (1993):
pulmonary rehabilitation.
The American review of respiratory disease 147, 1151-‐1156
SCHOLS, A. M., P. B. SOETERS, R. MOSTERT, R. J. PLUYMERS u. E. F. WOUTERS (1995):
Physiologic effects of nutritional support and anabolic steroids in patients with chronic obstructive pulmonary disease. A placebo-‐controlled randomized trial.
American journal of respiratory and critical care medicine 152, 1268-‐1274
SEEMUNGAL, T. A., J. R. HURST u. J. A. WEDZICHA (2009):
Exacerbation rate, health status and mortality in COPD-‐-‐a review of potential interventions.
International journal of chronic obstructive pulmonary disease 4, 203-‐223
SERRES, I., V. GAUTIER, A. VARRAY u. C. PREFAUT (1998):
Impaired skeletal muscle endurance related to physical inactivity and altered lung function in COPD patients.
Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary disease.
Thorax 62, 115-‐120
VALERIO, A., A. CARDILE, V. COZZI, R. BRACALE, L. TEDESCO, A. PISCONTI, L. PALOMBA, O.
CANTONI, E. CLEMENTI, S. MONCADA, M. O. CARRUBA u. E. NISOLI (2006):
TNF-‐alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents.
The Journal of clinical investigation 116, 2791-‐2798
VAN HELVOORT, H. A., Y. F. HEIJDRA, R. C. DE BOER, A. SWINKELS, H. M. THIJS u. P. N. DEKHUIJZEN (2007):
Six-‐minute walking-‐induced systemic inflammation and oxidative stress in muscle-‐wasted COPD patients.
Chest 131, 439-‐445
VAN´T HA, H. J., GOSSELINK R, ET AL. (2004):
Quadriceps muscle endurance in patients with chronic obstructive pulmonary disease.
Muscle Nerve 29, 267-‐274
VENNER, M. (2003):
Akute interstitielle Pneumopathie beim Pferd -‐ Experimentelle Induktion mit Perilla-‐Keton.
Hannover, Tierärztl. Hochschule, Klinik f. Pfd., Ph.D.-‐These
VERMEEREN, M. A., A. M. SCHOLS u. E. F. WOUTERS (1997):
Effects of an acute exacerbation on nutritional and metabolic profile of patients with COPD.
Eur Respir J 10, 2264-‐2269
WHITTOM, F., J. JOBIN, P. M. SIMARD, P. LEBLANC, C. SIMARD, S. BERNARD, R. BELLEAU u. F.
MALTAIS (1998):
Histochemical and morphological characteristics of the vastus lateralis muscle in patients with chronic obstructive pulmonary disease.
Medicine and science in sports and exercise 30, 1467-‐1474
YENDE, S., G. W. WATERER, E. A. TOLLEY, A. B. NEWMAN, D. C. BAUER, D. R. TAAFFE, R. JENSEN, R.
CRAPO, S. RUBIN, M. NEVITT, E. M. SIMONSICK, S. SATTERFIELD, T. HARRIS u. S. B. KRITCHEVSKY (2006):
Inflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjects.
Thorax 61, 10-‐16
ZATTARA-‐HARTMANN, M. C., M. BADIER, C. GUILLOT, C. TOMEI u. Y. JAMMES (1995):
Maximal force and endurance to fatigue of respiratory and skeletal muscles in chronic hypoxemic patients: the effects of oxygen breathing.
Muscle Nerve 18, 495-‐502