Anhang I (Gensequenzen)

Kapitel 8 Anhang I (Gensequenzen)

2581 agcatgtaat agagtgtgct aaacagaaag ccctggaact tgaggagttt cagtatattg 2641 gagaatcgca aggatatgat atcatggaac cagcagcaaa gaagtgctat ctggaaagag 2701 agcaaggtga aaaaattatt caggagttcc tgtccaaggt gaaacaaatg ccctttactg 2761 aaatgtcaga agaaaacatc acaataaagt taaaacagct aaaagctgaa gtaatagcaa 2821 agaataatag ctttgtaaat gaaatcattt cacgaataaa agttactacg tgaaaaatcc 2881 cagtaatgga atgaaggtaa tattgataag ctattgtctg taatagtttt atattgtttt 2941 atattaaccc tttttccata gtgttaactg tcagtgccca tgggctatca acttaataag 3001 atatttagta atattttact ttgaggacat tttcaaagat ttttattttg aaaaatgaga 3061 gctgtaactg aggactgttt gcaattgaca taggcaataa taagtgatgt gctgaatttt 3121 ataaataaaa tcatgtagtt tgtgg

Abb.I Basensequenz hMSH2

http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide& val=4557760 NM_000251

8.2 MSH6

1 atttcccgcc agcaggagcc gcgcggtaga tgcggtgctt ttaggagctc cgtccgacag 61 aacggttggg ccttgccggc tgtcggtatg tcgcgacaga gcaccctgta cagcttcttc 121 cccaagtctc cggcgctgag tgatgccaac aaggcctcgg ccagggcctc acgcgaaggc 181 ggccgtgccg ccgctgcccc cggggcctct ccttccccag gcggggatgc ggcctggagc 241 gaggctgggc ctgggcccag gcccttggcg cgatccgcgt caccgcccaa ggcgaagaac 301 ctcaacggag ggctgcggag atcggtagcg cctgctgccc ccaccagttg tgacttctca 361 ccaggagatt tggtttgggc caagatggag ggttacccct ggtggccttg tctggtttac 421 aaccacccct ttgatggaac attcatccgc gagaaaggga aatcagtccg tgttcatgta 481 cagttttttg atgacagccc aacaaggggc tgggttagca aaaggctttt aaagccatat 541 acaggttcaa aatcaaagga agcccagaag ggaggtcatt tttacagtgc aaagcctgaa 601 atactgagag caatgcaacg tgcagatgaa gccttaaata aagacaagat taagaggctt 661 gaattggcag tttgtgatga gccctcagag ccagaagagg aagaagagat ggaggtaggc 721 acaacttacg taacagataa gagtgaagaa gataatgaaa ttgagagtga agaggaagta 781 cagcctaaga cacaaggatc taggcgaagt agccgccaaa taaaaaaacg aagggtcata 841 tcagattctg agagtgacat tggtggctct gatgtggaat ttaagccaga cactaaggag 901 gaaggaagca gtgatgaaat aagcagtgga gtgggggata gtgagagtga aggcctgaac 961 agccctgtca aagttgctcg aaagcggaag agaatggtga ctggaaatgg ctctcttaaa 1021 aggaaaagct ctaggaagga aacgccctca gccaccaaac aagcaactag catttcatca 1081 gaaaccaaga atactttgag agctttctct gcccctcaaa attctgaatc ccaagcccac 1141 gttagtggag gtggtgatga cagtagtcgc cctactgttt ggtatcatga aactttagaa 1201 tggcttaagg aggaaaagag aagagatgag cacaggagga ggcctgatca ccccgatttt 1261 gatgcatcta cactctatgt gcctgaggat ttcctcaatt cttgtactcc tgggatgagg

1321 aagtggtggc agattaagtc tcagaacttt gatcttgtca tctgttacaa ggtggggaaa 1381 ttttatgagc tgtaccacat ggatgctctt attggagtca gtgaactggg gctggtattc 1441 atgaaaggca actgggccca ttctggcttt cctgaaattg catttggccg ttattcagat 1501 tccctggtgc agaagggcta taaagtagca cgagtggaac agactgagac tccagaaatg 1561 atggaggcac gatgtagaaa gatggcacat atatccaagt atgatagagt ggtgaggagg 1621 gagatctgta ggatcattac caagggtaca cagacttaca gtgtgctgga aggtgatccc 1681 tctgagaact acagtaagta tcttcttagc ctcaaagaaa aagaggaaga ttcttctggc 1741 catactcgtg catatggtgt gtgctttgtt gatacttcac tgggaaagtt tttcataggt 1801 cagttttcag atgatcgcca ttgttcgaga tttaggactc tagtggcaca ctatccccca 1861 gtacaagttt tatttgaaaa aggaaatctc tcaaaggaaa ctaaaacaat tctaaagagt 1921 tcattgtcct gttctcttca ggaaggtctg atacccggct cccagttttg ggatgcatcc

1981 aaaactttga gaactctcct tgaggaagaa tattttaggg aaaagctaag tgatggcatt 2041 ggggtgatgt taccccaggt gcttaaaggt atgacttcag agtctgattc cattgggttg 2101 acaccaggag agaaaagtga attggccctc tctgctctag gtggttgtgt cttctacctc 2161 aaaaaatgcc ttattgatca ggagctttta tcaatggcta attttgaaga atatattccc 2221 ttggattctg acacagtcag cactacaaga tctggtgcta tcttcaccaa agcctatcaa 2281 cgaatggtgc tagatgcagt gacattaaac aacttggaga tttttctgaa tggaacaaat 2341 ggttctactg aaggaaccct actagagagg gttgatactt gccatactcc ttttggtaag 2401 cggctcctaa agcaatggct ttgtgcccca ctctgtaacc attatgctat taatgatcgt 2461 ctagatgcca tagaagacct catggttgtg cctgacaaaa tctccgaagt tgtagagctt 2521 ctaaagaagc ttccagatct tgagaggcta ctcagtaaaa ttcataatgt tgggtctccc 2581 ctgaagagtc agaaccaccc agacagcagg gctataatgt atgaagaaac tacatacagc 2641 aagaagaaga ttattgattt tctttctgct ctggaaggat tcaaagtaat gtgtaaaatt

2701 atagggatca tggaagaagt tgctgatggt tttaagtcta aaatccttaa gcaggtcatc 2761 tctctgcaga caaaaaatcc tgaaggtcgt tttcctgatt tgactgtaga attgaaccga 2821 tgggatacag cctttgacca tgaaaaggct cgaaagactg gacttattac tcccaaagca 2881 ggctttgact ctgattatga ccaagctctt gctgacataa gagaaaatga acagagcctc 2941 ctggaatacc tagagaaaca gcgcaacaga attggctgta ggaccatagt ctattggggg 3001 attggtagga accgttacca gctggaaatt cctgagaatt tcaccactcg caatttgcca 3061 gaagaatacg agttgaaatc taccaagaag ggctgtaaac gatactggac caaaactatt 3121 gaaaagaagt tggctaatct cataaatgct gaagaacgga gggatgtatc attgaaggac 3181 tgcatgcggc gactgttcta taactttgat aaaaattaca aggactggca gtctgctgta 3241 gagtgtatcg cagtgttgga tgttttactg tgcctggcta actatagtcg agggggtgat 3301 ggtcctatgt gtcgcccagt aattctgttg ccggaagata cccccccctt cttagagctt 3361 aaaggatcac gccatccttg cattacgaag actttttttg gagatgattt tattcctaat 3421 gacattctaa taggctgtga ggaagaggag caggaaaatg gcaaagccta ttgtgtgctt 3481 gttactggac caaatatggg gggcaagtct acgcttatga gacaggctgg cttattagct 3541 gtaatggccc agatgggttg ttacgtccct gctgaagtgt gcaggctcac accaattgat 3601 agagtgttta ctagacttgg tgcctcagac agaataatgt caggtgaaag tacatttttt 3661 gttgaattaa gtgaaactgc cagcatactc atgcatgcaa cagcacattc tctggtgctt 3721 gtggatgaat taggaagagg tactgcaaca tttgatggga cggcaatagc aaatgcagtt 3781 gttaaagaac ttgctgagac tataaaatgt cgtacattat tttcaactca ctaccattca 3841 ttagtagaag attattctca aaatgttgct gtgcgcctag gacatatggc atgcatggta 3901 gaaaatgaat gtgaagaccc cagccaggag actattacgt tcctctataa attcattaag 3961 ggagcttgtc ctaaaagcta tggctttaat gcagcaaggc ttgctaatct cccagaggaa 4021 gttattcaaa agggacatag aaaagcaaga gaatttgaga agatgaatca gtcactacga 4081 ttatttcggg aagtttgcct ggctagtgaa aggtcaactg tagatgctga agctgtccat 4141 aaattgctga ctttgattaa ggaattatag actgactaca ttggaagctt tgagttgact 4201 tctgaccaaa ggtggtaaat tcagacaaca ttatgatcta ataaacttta ttttttaaaa 4261 atga

Abb. II Basensequenz hMSH6

http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=4504190 NM_000179

8.3 MLH1

1 attggctgaa ggcacttccg ttgagcatct agacgtttcc ttggctcttc tggcgccaaa 61 atgtcgttcg tggcaggggt tattcggcgg ctggacgaga cagtggtgaa ccgcatcgcg 121 gcgggggaag ttatccagcg gccagctaat gctatcaaag agatgattga gaactgttta 181 gatgcaaaat ccacaagtat tcaagtgatt gttaaagagg gaggcctgaa gttgattcag

241 atccaagaca atggcaccgg gatcaggaaa gaagatctgg atattgtatg tgaaaggttc 301 actactagta aactgcagtc ctttgaggat ttagccagta tttctaccta tggctttcga 361 ggtgaggctt tggccagcat aagccatgtg gctcatgtta ctattacaac gaaaacagct 421 gatggaaagt gtgcatacag agcaagttac tcagatggaa aactgaaagc ccctcctaaa 481 ccatgtgctg gcaatcaagg gacccagatc acggtggagg acctttttta caacatagcc 541 acgaggagaa aagctttaaa aaatccaagt gaagaatatg ggaaaatttt ggaagttgtt 601 ggcaggtatt cagtacacaa tgcaggcatt agtttctcag ttaaaaaaca aggagagaca 661 gtagctgatg ttaggacact acccaatgcc tcaaccgtgg acaatattcg ctccatcttt 721 ggaaatgctg ttagtcgaga actgatagaa attggatgtg aggataaaac cctagccttc 781 aaaatgaatg gttacatatc caatgcaaac tactcagtga agaagtgcat cttcttactc 841 ttcatcaacc atcgtctggt agaatcaact tccttgagaa aagccataga aacagtgtat 901 gcagcctatt tgcccaaaaa cacacaccca ttcctgtacc tcagtttaga aatcagtccc 961 cagaatgtgg atgttaatgt gcaccccaca aagcatgaag ttcacttcct gcacgaggag 1021 agcatcctgg agcgggtgca gcagcacatc gagagcaagc tcctgggctc caattcctcc 1081 aggatgtact tcacccagac tttgctacca ggacttgctg gcccctctgg ggagatggtt 1141 aaatccacaa caagtctgac ctcgtcttct acttctggaa gtagtgataa ggtctatgcc 1201 caccagatgg ttcgtacaga ttcccgggaa cagaagcttg atgcatttct gcagcctctg 1261 agcaaacccc tgtccagtca gccccaggcc attgtcacag aggataagac agatatttct 1321 agtggcaggg ctaggcagca agatgaggag atgcttgaac tcccagcccc tgctgaagtg 1381 gctgccaaaa atcagagctt ggagggggat acaacaaagg ggacttcaga aatgtcagag 1441 aagagaggac ctacttccag caaccccaga aagagacatc gggaagattc tgatgtggaa 1501 atggtggaag atgattcccg aaaggaaatg actgcagctt gtaccccccg gagaaggatc 1561 attaacctca ctagtgtttt gagtctccag gaagaaatta atgagcaggg acatgaggtt 1621 ctccgggaga tgttgcataa ccactccttc gtgggctgtg tgaatcctca gtgggccttg 1681 gcacagcatc aaaccaagtt ataccttctc aacaccacca agcttagtga agaactgttc 1741 taccagatac tcatttatga ttttgccaat tttggtgttc tcaggttatc ggagccagca 1801 ccgctctttg accttgccat gcttgcctta gatagtccag agagtggctg gacagaggaa 1861 gatggtccca aagaaggact tgctgaatac attgttgagt ttctgaagaa gaaggctgag 1921 atgcttgcag actatttctc tttggaaatt gatgaggaag ggaacctgat tggattaccc 1981 cttctgattg acaactatgt gccccctttg gagggactgc ctatcttcat tcttcgacta

2041 gccactgagg tgaattggga cgaagaaaag gaatgttttg aaagcctcag taaagaatgc 2101 gctatgttct attccatccg gaagcagtac atatctgagg agtcgaccct ctcaggccag 2161 cagagtgaag tgcctggctc cattccaaac tcctggaagt ggactgtgga acacattgtc 2221 tataaagcct tgcgctcaca cattctgcct cctaaacatt tcacagaaga tggaaatatc 2281 ctgcagcttg ctaacctgcc tgatctatac aaagtctttg agaggtgtta aatatggtta 2341 tttatgcact gtgggatgtg ttcttctttc tctgtattcc gatacaaagt gttgtatcaa 2401 agtgtgatat acaaagtgta ccaacataag tgttggtagc acttaagact tatacttgcc 2461 ttctgatagt attcctttat acacagtgga ttgattataa ataaatagat gtgtcttaac 2521 ataa

Abb.III Basensequenz hMLH1

http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=28559089 NM_000249

8.4 PMS2

1 cgaggcggat cgggtgttgc atccatggag cgagctgaga gctcgagtac agaacctgct 61 aaggccatca aacctattga tcggaagtca gtccatcaga tttgctctgg gcaggtggta 121 ctgagtctaa gcactgcggt aaaggagtta gtagaaaaca gtctggatgc tggtgccact 181 aatattgatc taaagcttaa ggactatgga gtggatctta ttgaagtttc agacaatgga

241 tgtggggtag aagaagaaaa cttcgaaggc ttaactctga aacatcacac atctaagatt 301 caagagtttg ccgacctaac tcaggttgaa acttttggct ttcgggggga agctctgagc 361 tcactttgtg cactgagcga tgtcaccatt tctacctgcc acgcatcggc gaaggttgga 421 actcgactga tgtttgatca caatgggaaa attatccaga aaacccccta cccccgcccc 481 agagggacca cagtcagcgt gcagcagtta ttttccacac tacctgtgcg ccataaggaa 541 tttcaaagga atattaagaa ggagtatgcc aaaatggtcc aggtcttaca tgcatactgt 601 atcatttcag caggcatccg tgtaagttgc accaatcagc ttggacaagg aaaacgacag 661 cctgtggtat gcacaggtgg aagccccagc ataaaggaaa atatcggctc tgtgtttggg 721 cagaagcagt tgcaaagcct cattcctttt gttcagctgc cccctagtga ctccgtgtgt 781 gaagagtacg gtttgagctg ttcggatgct ctgcataatc ttttttacat ctcaggtttc 841 atttcacaat gcacgcatgg agttggaagg agttcaacag acagacagtt tttctttatc 901 aaccggcggc cttgtgaccc agcaaaggtc tgcagactcg tgaatgaggt ctaccacatg 961 tataatcgac accagtatcc atttgttgtt cttaacattt ctgttgattc agaatgcgtt

1021 gatatcaatg ttactccaga taaaaggcaa attttgctac aagaggaaaa gcttttgttg 1081 gcagttttaa agacctcttt gataggaatg tttgatagtg atgtcaacaa gctaaatgtc 1141 agtcagcagc cactgctgga tgttgaaggt aacttaataa aaatgcatgc agcggatttg 1201 gaaaagccca tggtagaaaa gcaggatcaa tccccttcat taaggactgg agaagaaaaa 1261 aaagacgtgt ccatttccag actgcgagag gccttttctc ttcgtcacac aacagagaac 1321 aagcctcaca gcccaaagac tccagaacca agaaggagcc ctctaggaca gaaaaggggt 1381 atgctgtctt ctagcacttc aggtgccatc tctgacaaag gcgtcctgag acctcagaaa 1441 gaggcagtga gttccagtca cggacccagt gaccctacgg acagagcgga ggtggagaag 1501 gactcggggc acggcagcac ttccgtggat tctgaggggt tcagcatccc agacacgggc 1561 agtcactgca gcagcgagta tgcggccagc tccccagggg acaggggctc gcaggaacat 1621 gtggactctc aggagaaagc gcctgaaact gacgactctt tttcagatgt ggactgccat 1681 tcaaaccagg aagataccgg atgtaaattt cgagttttgc ctcagccaac taatctcgca 1741 accccaaaca caaagcgttt taaaaaagaa gaaattcttt ccagttctga catttgtcaa 1801 aagttagtaa atactcagga catgtcagcc tctcaggttg atgtagctgt gaaaattaat 1861 aagaaagttg tgcccctgga cttttctatg agttctttag ctaaacgaat aaagcagtta 1921 catcatgaag cacagcaaag tgaaggggaa cagaattaca ggaagtttag ggcaaagatt 1981 tgtcctggag aaaatcaagc agccgaagat gaactaagaa aagagataag taaaacgatg 2041 tttgcagaaa tggaaatcat tggtcagttt aacctgggat ttataataac caaactgaat

2101 gaggatatct tcatagtgga ccagcatgcc acggacgaga agtataactt cgagatgctg 2161 cagcagcaca ccgtgctcca ggggcagagg ctcatagcac ctcagactct caacttaact 2221 gctgttaatg aagctgttct gatagaaaat ctggaaatat ttagaaagaa tggctttgat 2281 tttgttatcg atgaaaatgc tccagtcact gaaagggcta aactgatttc cttgccaact 2341 agtaaaaact ggaccttcgg accccaggac gtcgatgaac tgatcttcat gctgagcgac 2401 agccctgggg tcatgtgccg gccttcccga gtcaagcaga tgtttgcctc cagagcctgc 2461 cggaagtcgg tgatgattgg gactgctctt aacacaagcg agatgaagaa actgatcacc 2521 cacatggggg agatggacca cccctggaac tgtccccatg gaaggccaac catgagacac 2581 atcgccaacc tgggtgtcat ttctcagaac tgaccgtagt cactgtatgg aataattggt 2641 tttatcgcag atttttatgt tttgaaagac agagtcttca ctaacctttt ttgttttaaa

2701 atgaaacctg ctacttaaaa aaaatacaca tcacacccat ttaaaagtga tcttgagaac 2761 cttttcaaac c

Abb. IV Basensequenz hPMS1

http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=11125773 NM_000535