• Keine Ergebnisse gefunden

Synthesis and Cytotoxic Activities of New Fatty Acid Esters of 20(S)-Protopanaxadiol

N/A
N/A
Info
Herunterladen
Protected

Academic year: 2022

Aktie "Synthesis and Cytotoxic Activities of New Fatty Acid Esters of 20(S)-Protopanaxadiol"

Copied!
1
0
0

Wird geladen.... (Jetzt Volltext ansehen)

Jetzt herunterladen ( 1 Seite )

Volltext

(1)

Synthesis and Cytotoxic Activities of New Fatty Acid Esters of 20(S)-Protopanaxadiol

Ning Lia,b,*, Yuan Huanga, Wan Xiaoa, Jinping Liub,*, Xian Lia, and Pingya Lib

a School of Traditional Chinese Materia Medica 49#, Key Laboratory of Structure- Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China. E-mail: liningsypharm@163.com

b Institute of Frontier Medical Science, Jilin University, Changchun 130021, China

* Authors for correspondence and reprint requests

Z. Naturforsch. 66 c, 199 – 204 (2011); received September 14, 2010/March 21, 2011

In order to fi nd new lead compounds with antitumour activies, thirteen new fatty acid esters of 20(S)-protopanaxadiol (PPD) were synthesized using oleoyl chloride or fatty acids and N,N’-dicyclohexylcarbodiimide (DCC). Their cytotoxic activities were tested using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] method, and the struc- ture-activity relationships between the fatty acid esters of PPD and their cytotoxic activities are discussed.

Key words: Protopanaxadiol, Cytotoxic Activities, Structure-Activity Relationships

Referenzen

Jetzt herunterladen ( PDF - 1 Seite - 24.58 KB )

ÄHNLICHE DOKUMENTE

Fatty acid composition of the gestation and Fatty acid composition of the gestation and

Fatty acid composition of adipose tissue lipids closely related to dietary fatty acid intake?. – main impact related to dietary

Synthesis and Cytotoxic Activities of New Fatty Acid Esters of 20(S)-Protopanaxadiol

1) The bioassay results depicted in Table III re- veal that some of the synthesized new fatty acid esters of PPD possess better cytotoxic activities in comparison with PPD, such

Characterization of the Fatty Acid Composition of

Additionally, the characterization of each individual fatty acid ester was discussed with regard to the fuel properties of biodiesel produced by the alga. Key

and Investigation of their Cytotoxic Activities

The cytotoxic activities of the resulting compounds against human leukaemia cell line (HL 60) were determined in a MTT assay, and structure-activity relationships are discussed..

Antimicrobial Activity of Fatty Acid Methyl Esters of Some Members of Chenopodiaceae

Arthrocnemum indicum, Salicornia brachiata, Suaeda maritima and Suaeda monoica belonging to the family Chenopodiaceae, were prepared and their composition was analyzed by GC-MS..

Synthesis and Structure of NbPdSi

The orthorhombic lattice parameters (Table 1) were obtained by a least-squares refinement of the powder data.. The cor- rect indexing of the diffraction lines was ensured by an

Synthesis and Structure of RhMg3

Rodewald, Rolf-Dieter Hoffmann, and Rainer P¨ottgen Institut f¨ur Anorganische und Analytische Chemie, Westf¨alische Wilhelms-Universit¨at M¨unster, Wilhelm-Klemm-Straße 8,

Synthesis and Structure of RE2

Department Chemie, Ludwig-Maximilians- Universität München, Butenandtstraße 5Ð13 (Haus D), D-81377 München, Germany Reprint requests to R.. According to the course of the cell