Universität zu Lübeck Sektion Medizin
Institut für Systemische Entzündungsforschung
Research Grants
Current projects
Clinician Scientist School Lübeck: Connecting Brain, Metabolism, and Inflammation (BMI) – Mechanisms and Disease Expression
(Applicant Sadik, Christian David )
IL-10+ plasma cell mediated control of innate immunity (Applicant Manz, Rudolf )
Regulation of B-1 lymphocyte trafficking through the C5a/C5aR1 axis (Applicant Karsten, Christian )
Projects Homepage Website
info@isef.uni-luebeck.de E-Mail
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+49 451 / 500-51401 Telephone
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Deutschland Address
Completed projects
B Cell Autoimmunity in ApoE-deficient (ApoE-/-) Mice
(Applicants Habenicht, Andreas J.R. ; Yin, Ph.D., Changjun )
Charakterisierung von Plasmazell-Überlebensnischen (Applicant Manz, Rudolf )
Die pathogenetische Rolle der Komplementspaltprodukte C3a und C5a bei der septischen Peritonitis
(Applicant Köhl, Jörg )
Die pathogenetische Rolle von C5a und Fc gamma-Rezeptoren in Typ III und Typ IV Überempfindlichkeitsreaktionen
(Applicant Köhl, Jörg )
Entstehung und Homeostase langlebiger Plasmazellen (Applicant Manz, Rudolf )
Functional role of the miR-24-1 cluster in IL-6- and APRIL-dependent survival of plasma cells
(Applicant Abram, Melanie )
Identifizierung und Depletion von krankheitsrelevanten Lymphozyten- Subpopulationen zur Therapie des SLE
(Applicant Manz, Rudolf )
The role of the anaphylatoxin C5a in intestinal immune responses (Applicant Köhl, Jörg )
The role of the anaphylatoxins C3a and C5a in the pathogenesis of experimental allergic asthma
(Applicant Köhl, Jörg )
Untersuchung der Rolle der Chemokinrezeptoren CCR2 und CXCR3 bei B-Zell und Plasmazell-Homing und Differenzierung
(Applicant Manz, Rudolf )
Untersuchungen zur Extravasation und Migration dendritischer Zellen im schwangeren Uterus der Maus
(Applicant Kruse, Andrea )
Priority Programmes
Completed projects
Bone marrow plasma cells in autoimmune lupus modulating the function of bone metabolizing cells - osteoblasts and osteoclasts
(Applicant Manz, Rudolf )
Dissecting the osteoimmunological role of dickkopf-1 in arthritis and glucocorticoidinduced bone loss
(Applicants Hofbauer, Lorenz C. ; Rauner, Martina )
Pasteurella multocida toxin as a tool to modulate bone and immune cell differentiation
(Applicant Hieke-Kubatzky, Katharina )
Clinical Research Units Current projects
KFO 303: Pemphigoid Diseases - Molecular Pathways and their Therapeutic Potential
(Spokesperson Zillikens, Detlef )
The role of C5aR2 in the pathogenesis of pemphigoid diseases (Applicants Karsten, Christian ; Schmidt, Enno )
The Role of Lymphocyte-derived Factors in the Effector Phase of Pemphigoid Diseases
(Applicants Bieber, Ph.D., Katja ; Manz, Rudolf )
Completed projects
Identifizierung von Signalen, die die Differenzierung und das Überleben von humanen Plasmazellen regulieren
(Applicant Manz, Rudolf )
The C5a/C5aR1 axis as a regulator of autoreactive IgG antibody glycosylation in pemphigoid diseases
(Applicant Köhl, Jörg )
CRC/Transfer Units
Completed projects
Analyse von biochemischen Parametern im Plasma von Sepsis-/SIRS-Risikopatienten
(Project Head Köhl, Jörg )
TFB 15: Die Bedeutung des Komplementspaltproduktes C3a als diagnostischer Frühmarker in der Sepsis
(Spokesperson Köhl, Jörg )
Verwaltung und zentrale Aufgaben (Project Head Köhl, Jörg )
Major Research Instrumentation Completed projects
High-End Zellsorter
Multi-Parameter Flow cytometer
Collaborative Research Centres Completed projects
Analyse humoraler und zellulärer Effektorsysteme bei der Xenotransplantation im diskordanten Kleintiermodell Meerschweinchen/Ratte
(Project Heads Köhl, Jörg ; Meyer zu Vilsendorf, Andreas )
Generation und Homeostase von autoreaktiven Plasmazellen bei Autoimmunerkrankungen
(Project Heads Hiepe, Falk ; Manz, Rudolf )
Generation und Homeostase von autoreaktiven Plasmazellen bei Autoimmunerkrankungen
(Project Heads Hiepe, Falk ; Manz, Rudolf )
Interactions between sleep and complement-driven regulation of intestinal dendritic cell functions
(Project Heads Autenrieth, Ph.D., Stella E. ; Köhl, Jörg )
CRC/Transregios
Completed projects
The role of the anaphylatoxins C3a and C5a in the pathogenesis of experimental allergic asthma
(Project Head Köhl, Jörg )
Research Training Groups Current projects
GRK 2633: Defining and Targeting Autoimmune Pre-Disease (Spokesperson Ludwig, Ralf Joachim )
Completed projects
GRK 288: Structures and Mediators of the Interaction of Cells (Spokesperson Jelkmann, Wolfgang )
GRK 1727: Modulation of Autoimmunity (Spokesperson Zillikens, Detlef )
International Research Training Groups Current projects
GRK 1911: Immunregulation of Inflammation in Allergy and Infection (Spokesperson Köhl, Jörg )
Clusters of Excellence Completed projects
EXC 306: Inflammation at Interfaces (Spokesperson Schreiber, Stefan )
Clusters of Excellence (ExStra) Current projects
Precision Medicine in Chronic Inflammation (PMI)
(Spokespersons Niemann, Stefan ; Riemekasten, Gabriela ; Schreiber, Stefan )
GEPRIS is a project of the Deutsche Forschungsgemeinschaft (DFG) Contact GEPRIS at http://www.dfg.de/gepris
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