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Antimicrobial Activity of Isopteropodine Rube´n Garcı´a

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Antimicrobial Activity of Isopteropodine

Rube´n Garcı´a

a,

*, Cesia Cayunao

a

, Ronny Bocic

a

, Nadine Backhouse

a

, Carla Delporte

a

, Mercedes Zaldivar

b

, and Silvia Erazo

a

a Department of Pharmacological and Toxicological Chemistry, School of Chemical and Pharmaceutical Sciences, University of Chile, P. O. Box 233, Santiago 1, Chile.

Fax: 56-2-2 22 79 00. E-mail: rgarciam@uchile.cl

b Department of Biochemistry and Molecular Biology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile

* Author for correspondence and reprint requests

Z. Naturforsch.60 c, 385Ð388 (2005); received October 18/November 29, 2004

Bioassay-directed fractionation for the determination of antimicrobial activity ofUncaria tomentosa, has led to the isolation of isopteropodine (0.3%), a knownUncariapentacyclic oxindol alkaloid that exhibited antibacterial activity against Gram positive bacteria.

Key words: Uncaria tomentosa, Isopteropodine, Antibacterial Activity

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