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Synthesis, Characterization, Crystal Structure, and Cytotoxicity of a 7-Coordinate Diorganotin(IV) Complex of 2-Acetylpyrazine N4-Methylthiosemicarbazone

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Synthesis, Characterization, Crystal Structure, and Cytotoxicity of a 7-Coordinate Diorganotin(IV) Complex of 2-Acetylpyrazine N

4

-Methylthiosemicarbazone

Xian Feng Zhub, Li Zhi Zhanga, Min Yanga, Yan Ke Lia, and Ming Xue Lia

aInstitute of Molecular and Crystal Engineering, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, P. R. China

bBioengineering Institute and College of Life Science, Henan University, Kaifeng 475004, P. R. China

Reprint requests to Prof. Ming Xue Li. Fax: +86-378-2853650. E-mail: limingxue@henu.edu.cn Z. Naturforsch.2012,67b,149 – 153; received December 27, 2011

The diorganotin(IV) complex [Ph2Sn(L)(CH3COO)] (1), where HL = 2-acetylpyrazineN4-meth- yl thiosemicarbazone, has been synthesized and characterized by elemental analysis, IR, UV/Vis and NMR spectroscopy, mass spectrometry, and single-crystal X-ray diffraction. Complex1contains mononuclear neutral molecules composed of one N2S tridentate anionic thiosemicarbazone ligand, one acetato group, and one Ph2Sn(IV) group with a seven-coordinated tin atom.In vitrobiological studies have indicated that complex1shows effective cytotoxicity with IC50= 5.4µMagainst the K562 leukaemia cell line.

Key words:Thiosemicarbazone, Diorganotin(IV), Crystal Structure, Cytotoxic Activity

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