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Synthesis, Crystal Structure and Antitumor Study of a Zinc Complex of the 2-Benzoylpyridine Thiosemicarbazone Ligand

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Synthesis, Crystal Structure and Antitumor Study of a Zinc Complex of the 2-Benzoylpyridine Thiosemicarbazone Ligand

Ming Xue Li, Jing Zhou, Chun Ling Chen, and Jing Ping Wang

Institute of Molecular and Crystal Engineering, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475001, P. R. China

Reprint requests to Prof. Ming Xue Li. Fax: +86-378-2853650. E-mail: limingxue@henu.edu.cn Z. Naturforsch.2008,63b,280 – 284; received October 19, 2007

A zinc complex of the 2-benzoylpyridine thiosemicarbazone (Hbpt) ligand, Zn(bpt)2·DMF, has been synthesized and characterized by elemental analysis, IR spectra and single crystal X-ray diffrac- tion. The molecular structure has a Zn2+cation bonded to two perpendicular bpt ligands in a distorted octahedral geometry through two sulfur and four nitrogen atoms. The crystal contains a disordered DMF solvate molecule. Adjacent molecules are interconnected by means of hydrogen bonding gen- erating a 1-D chain structure. The cytotoxic activity measurement indicates that the complex exhibits higher antitumor activity against lung cancer A549 cell lines than the free ligand.

Key words:Thiosemicarbazone Complex, Crystal Structure, Cytotoxic Activity

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