Untersuchungen zum intrazellulären Transportmechanismus von Marburgvirus Nukleokapsiden
Volltext
(2) 5 5 95 95855 4535 5 3 54 ! 845 3"#8 $5 3 9%9 2 . &'()*+,-.,'/)'01,203'(*41)55,56*)'07*4'+89*(: 2)-.4'3+2,+0;9'0<4*=,*/;3*,+0>,?5)9?48+3@)'. 7822 " 335 99 8!2 A 828 4539 45345 B92 C 33583 958D 5 89E 4565 5 54 ! 845 3"#8 $5 3 9%9 2 $ 559$8 F9*@34'0G-.,@(0 H/)=9*)'03'0<4*=,*/I0 <4*=,*/J0KLMN.
(3) 3456789. 488
(4) 97 8557889
(5) 9789579 794 7577
(6) 79899. 9 9 999 9
(7) 9. 75 7944957877 498978! 9457 97 "4 9589. 8#345899$%47 & 98975 794 999 '7 $
(8) 97 87 "4 7989! 94579$4 9 "9 89877 49899795 (7 75# 99(4 997)97
(9) 79*7 7 5+79578,8)4 4----------------------.64 93758487/# 098780997 95(4 9975# 123456789:;18;<2=>?@ABCD:28 E2:2825@6789:;18;A@2FC45G2B328 H;I982:2825@6 . .
(10) . . 34567897 8
(11) 78 778. .
(12) 023456789 90
(13) 3207 0 - )1) )1, )10 )1C )1> G I 01) 01)1) 01)1, 01, 010 01C 01> 01B W C1) C1, C10 C101) C101, C1010 C101C C1C ] . . !"#$ %"&' #('&&"#$ ) *" '+ , 9./ 0 2#345!"#$"#43'6# 7&5827#379"#$:#;79:7# 0 <97#7!"#4='38$#& > ?@89$7"#4%"&' #&3A"#$ B D:7'9E@97!'37#&A+!9"& F ;'$&399"#$ )) 9/H/ ), 9/J )C *3'3$7#A";9"&A#A '!7"#$:#&":7'9#K&3'#4379#"#4 )C 7"&@'37!9# 2#3L75!9"#$7#@9'& 74'&73#26@&&7#&&3'3$7A";9"&M )C A#A '!7"#$:#N"!9!'@&74# 2#3L75!9"#$7#<"A! @9 #3'37#&&3'3$7A";9"&A#A 'M )> !7"#$4&?'376@37#&=CO P#3&"58"#$#A" Q"&$'#$&@"#!34&N"!9!'@&743'#&@3& )B Q#'9+&4N"!9!'@&74L$"#$ )B D7E994&%+3&!933&LR8#47#?QEMS#(!37# )T D77#3'A99"9RU!'97&'37#4S#3'!37#:#?'376@37#=CO"#4 N"!9!'@&74# ,O ;79@47#'9&Q"&3733&@(3#(V?QE ,) XY.Z ,, D7;9"&A#A '!7"#$:#:7'9#< @##3# ,, S#3'!37#:#N"!9!'@&74#734 ?'376@37#=CO ,0 S#3'A99"9R['#&@3:#?QEN"!9!'@&74# ,0 D7D+#' 7!7#3'A99"9R['#&@3@A&&:#N"!9!'@&74# ,0 D7E994&Q!37#A+3&!933&LR8#47#?QES#(!37# ,> D7E99:#;79@47#(V7#?QES#(!37# ,T ,\ ?58'#7& #4&'!37#'8R#$7$#N"!9!'@&743'#&@3& Q73& 499 ,F 5. 0) . . .
(14) 023456789 90
(15) 3207 . !" !G ! ` !" !G h n pq pp ps pv . . . . #$%&'()*$+*,)-(./-01)2-*345*&06)/'(7-8&)%02)*$9:;<=<=><?>@AB>CDECF HI*(8I*/J&02)*$*3K0/5'/L6)/'(M02/)N8/*2-)$OHPQ2/)LL-/(0((-M5&J *3$'%&-*%08(),(R)2I2I-6)/0&-$6-&*8-022I-8&0(M0M-M5/0$- P 9S;A<T=UV;W@><?>@AB>CDECF X)6-%-&&)M0L)$L*3K0/5'/L6)/'()$3-%2-,%-&&('$%*6-/(0%2)$Y,-8-$,-$2 2/0$(8*/2*3$'%&-*%08(),(*6-/&*$L,)(20$%-(9Z[\]^?><?>@AB>CDE_F abccdb ) H'5&)e02)*$-$ ) f*$L/-((5-)2/gL- ) 4abcia6jklmc ))) 4okbcjklmc )6 5cr 6)) 8klmca4aclm5m )N 9mtulm9db N wcbb N) . . .
(16)
(17)
(18)
(19). 02345653789 . 0 .
(20)
(21)
(22) !"
(23) #$
(24) %
(25) &'()!"
(26) *+!",
(27) ( )
(28) -+)$$
(29) )
(30) . $)+$(
(31) $/+$$$
(32) 0+ +)#
(33) $12
(34)
(35) 3$
(36) 4%
(37) $
(38) %
(39) - . $%$+$(
(40) %
(41) &" !".5+4$!"6)!"$
(42) 7!"!"
(43) +$%
(44) %
(45) &%/$!"$
(46) 7!"!"
(47) 68
(48) $
(49) " !".$+4$!"6)!"$
(50) 79!"
(51) %
(52) -")::.;$#9
(53) &+(
(54) #
(55) <=2>?2@>>A
(56) 0B
(57) A1
(58) $9"
(59) )9+2
(60) $!"
(61) "
(62) %
(63) C
(64) +
(65) $
(66) (. $ $
(67) D$)+$(,
(68) $
(69) D($),
(70) %
(71) %
(72)
(73) 7)($%$
(74) +6(68"$
(75) -+)$$
(76) 4
(77) )$(
(78) +$#'66$)!"
(79) $
(80) /+ $6
(81) 4
(82) $
(83) +$)2
(84)
(85) )$(
(86) +$#'66$)!"$
(87) $
(88) 4+%$
(89) $
(90) %
(91) $
(92) $(,
(93) +
(94) $
(95) '()!"
(96) +))
(97) +$%
(98) #))9$%(
(99) E!"+$(
(100) /+
(101) $/))+)9$
(102) F$:
(103) #$
(104) &+(#+
(105) 5+):. %$
(106) ($
(107) /+
(108) '$$$2
(109)
(110)
(111) FG
(112) %
(113) C
(114) #4$%$
(115) C$($,
(116) +
(117) +6
(118) C)%+$($
(119) /+
(120) #4$,
(121) /"$
(122) !"
(123) +6
(124) :+)/
(125) C)%+$($,
(126) 4$$
(127) "68
(128) %
(129) C8/+$(
(130) H7(2
(131) I
(132) J66K
(133) I
(134) %
(135) $:!"$%
(136) -+)$
(137) #4$%
(138) 4+%2
(139) C))
(140) 4$
(141) C)%+$($($
(142) /"$
(143) !"
(144) +6
(145) C)%+$($
(146) +!")L)!"
(147) $
(148) %
(149) $
(150) +$%
(151) 4+%$
(152)
(153) HC2
(154) I
(155) J66K
(156) $$$2
(157)
(158)
(159) <21
(160) F"
(161) M$$,
(162) N%
(163) O2
(164) O" $,
(165) C))$
(166) *",
(167) C%
(168) M4(,
(169) &!")
(170) P,
(171) *%. $
(172) O!"+%,
(173) Q)(
(174) )$,
(175) R":"
(176) 72
(177) E),
(178) O:"$
(179) E!
(180) $%
(181) M$/
(182) 7)% $$2
(183) STUVWXYZT[ \Z]Y^X[_`^[a[bYc^[Zd[efZVagY`WX[h^iVYUacYZTj
(184) k+$)
(185) 6
(186) 3)(l
(187) 0@><@1
(188) mn
(189) 0@<1,
(190) :2
(191) <<??Ao<<?mm
(192) 0M$$
(193) ^c[aVj,
(194) @><@1
(195)
(196) @21
(197) p
(198) q)$#,
(199) D#
(200) &),
(201) *%$
(202) O!"+%,
(203) M
(204) O" .D)%$
(205) $%
(206) O:"$
(207) E!2
(208) rsZXisZ`tVacYZT[Zd[ua`fW`v[gY`WX[wac`Yx[i`Zc^YT[yrz{[c`Yvv^`X[aXX^wfVt[Zd[TWUV^ZUaiXY]X[|Ycs[ cs^[gY`aV[^Tg^VZi^[ac[cs^[iVaXwa[w^wf`aT^j
(209) R))+)
(210) &!)(l
(211) 0@><@1
(212) <}0@1,
(213) <m@o<A?
(214) 0q)$. #
(215) ^c[aV2,
(216) @><@1
(217) ~21
(218) *%$
(219) O!"+%,
(220) p
(221) q)$#,
(222) Q)(
(223) )$,
(224) E
(225) O%,
(226) $%
(227) O:"$
(228) E!2
(229) Yg^[ U^VV[YwavYTv[Zd[ua`fW`v[gY`WX[YTd^Uc^][U^VVX[WTUZg^`X[aUcYT]^i^T]^Tc[c`aTXiZ`c[Zd[TWUV^ZUaiXY]X[ Zg^`[VZTv[]YXcaTU^Xj
(230) -!
(231) 5)
(232) C!%
(233) O!
(234) ;
(235) O
(236) C2
(237) E%2
(238) <<>,
(239) 52
(240) ~=,
(241) ::2
(242) <}}>@.<}}>?,
(243) C+(
(244) <@,
(245) @><~
(246) 0O!"+%
(247) ^c[aVj
(248) @><~1
(249)
(250).
(251). .
(252) . 023455678433279. 0. !"# $%%"& %# !"% '( !" )%" !" *+,-.+/+0123 4"!" 5"& 6"& "% "&78"& &! " &78#9%"&7878"& :%#"& "& #;" 8<%(878" )"9 " %# 8(8" =#"78;"##" 3 " 5"& "#$"& "& "&$"#<&"> &78#9 "%"&#"#" ?@A9B"&(% & &"#" C"&#"& &! "86"& (%# & !" C!&& !" D-E-E2F1.+/1,2G3 " ?@A 7(!"# HI ""& " =#;#J(#"&"> (& !"&"& HI&H ! B"9 &(% "&;J!""&K ! @;"(J(#"& @:> !" "& :(#"&" 5:LM> 5:NO &! 5:NP (Q" !" :(R%"" S3 5:MO %# #TJ(#"& !"& @;"(;J! "$"78&"#"& U(%J"T3 V& !" SJ!8I"> !" ! <&78" 5 %#> # ! BR;(J(#"& B: &""#3 "" A"# "78<H## 78 %# !"% &#$"<"& W&J(# (& @;"(;J!"& & !" 9 &H$"#"& X""3 V& "#" S&" Q!" 8"HI !" "#8(!" !" S""&!$"%;(;(J" "9 Q"&!"#> !" (& ;(&H(;" ;(;(J" &! =7&&& '";#(&"&%;(;(J" "<&$# Q!"3 78 "& """ 9J"$H78" B"&"#;R#"% Q!" "& $<#$78" S""89 %"& HI "& (# %;"#" 5:MO & ! " B"&(% &#""# &! "& ";(%&&#" 5 8""#"# YA?5?):95:MOZ3 V& U(%&#(& %# !" :%!9"#I#$#"& 'TJ"(& (& I& H("$""&!"& 5:NO Y5:NOB):Z ;(&&#" & A?5?):95:MO9&H$"#"& X""&> &""& !"% #9 TJ(#"& 78 ! @;"(;J! 78# "%78# Q"!"&3 " XQ"H%;"& "#" "> ("&&&#" V&7(& !"& [J&(# (& &" "!"#"& @;"(;J!"& $ !"	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
(253)
(254) .
(255) . 0233456. . 0
(256)
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`aV\][YZ_< ,#. b%'"?O"()'#7 T.97$##.:+%=#< =0.9):1#89'.% 2#.,#7 F4H<. 3G3I@. cdd0e8f cdgfh 0ijklm0l !"# -KLMEK0(/.9)'# ("7, 8#%% 1#()'."#/#7 07, "'.#7 K0(/.0)'(?.%#7 "7 ,#. D+.%# /=2@ ,#. n"(%# =01#?.,7#%@. N#" ;NoMEK0(/.9)'#7 20.,# 70. ,+( p+'. +71#1#/#7@ !"# .?%#7 N#.#")'# "7 ,#. D+.%# :#77=#")'7#7 nS7,#. $"%. q"&?C".0(EK0(/.9)'#7@. J$ p+'. 3465 :+$ #( "7 ,#. !#$?:.+%"()'#7 L#O0/&": D?71?< ,#$ ,+$+&"1#7 r+".#< 07, +0)' "$. (9,&")'#7 *0,+7 /#"7+'# =#"%1&#")' =0 =2#" 07+/'S71"1#7 ;O",#$"#7 $"% '?'#. n#%+&"%S% 07,. #"7 /"( ,+'"7 07/#:+77%#( q"&?C".0( :?77%# "(?&"#.% 2#.,#7@ ;/?&+C".0( F;NoMI "(% ,#$ -KLM. $?.O'?&?1"()' (#'. S'7&")'< :?77%# s#,?)' ,0.)' "$$07?&?1"()'E(#.?&?1"()'# !"+17?(%": 07E %#.()'"#,#7 2#.,#7 F55I@. !+( ;7,#$"#1#/"#% C?7 -KLM 07, ;NoM #.(%.#):% (")' +08 ,#$ K8.":+7"()'#7 D?7%"7#7% /"(. #%2+ 3tu 7B.,&")'#. 07, (9,&")'#. N.#"%# 0$ ,#7 bv0+%?. F33PI@ !"#(# K.#+&# 9/#.&+OO#7 $"%. ,#$ 7+%9.&")'#7 M#./.#"%071(1#/"#% C?7 8.0)'%8.#((#7,#7 q&01'07,(O#="#( Fw4< 3HtE3HPI@ !#.E =#"% 2"., ,+C?7 +0(1#1+71#7< ,+(( q&01'07,# ,#. T+%%071 xY^_V\\^_`aVyzZ\[a{^_ 7+%9.&")'#. L#(#.C?".2".%# 89. -KLM ,+.(%#& F33|< 3Ht< 3HPI@ J7 ,#7 &#%=%#7 p+'.#7 2"., .#1#&$S}"1 9/#.. q"&?C".0(+0(/.9)'# /#.")'%#%@ r0&#%=% 20.,#7 "$ ~?C#$/#. /=2@ !#=#$/#. Pt3P (?2?'& ("#E /#7 ;NoME +&( +0)' PG< =@A@ %B,&")' C#.&+08#7,# -KLMEqS&&# +0( >1+7,+ 1#$#&,#% FP< 5tI@ !"#. .
(259) .
(260) 02345236748 . !" #$ %& ' ''( $ ' '# ' )''*. +, ' -./, ' ' 0 12345262789 :0#)';* < .=''. !' >'? -'' ,' :@23AB C ' >! 0';*. >' '(''" '='' D(E'# ' ') F# #( ' ' 0#)' =' ' ,>' G868BHI45262789" JK8L745262789 '. M46N85262789 ' /'' O4N4N9P8526839QR' :ST;*. UVVWXY6Z[\]\^_`_]a`bcba]d]efghghijklmnkoipW 0! 0' Fqr#)" #) ' .#') $' ' ''' s&= >( >!* & ' :tuS;* .v'w tw -#''##&>' )#' <* x* y#'#)* zw {<{ | 0* *. +&q" t}~S" <wttTt w :S;* uw {<{ | {* s* E# %* .'" <wTuz} w {<{ | -* x* F" <wzt~ Sw. {<{ | <* 0* * +&q" t}~" <wT~T ~w :}t;* Tw :z};* }w {<{|<* 0* * +&q" t}~" <wStt* t w :~t;*. < ''#' y# >! ,r#'# :{,; -./, ' >!'> s&= . :-./,;" s' :s <,;" .'q# :.<.,;" (0# :0,; ' #' :-s,; - #). > : * z;* x= '= $' '('&#' -./,(s&= :tT;*. < .' )#' ,'=>#'" # .' #' '". = '' F#' -./,(s&= >!'" E'' ''). 0#'* .' ' +'' ' '=' )''" $ ' '>( #' -./,( ' '' )#' =' 0' ? )>' ''" $' ' '>#' . -s, ' '('&&' F#'' q&## >#* . +, '. ' > E' #' sv'=' E'= = -./, ' '( ' s&=* +' ' ' =$' '' #'w F#&& :<'". t}S~;" /=#' :#''" t}~;" +# :y'" t}T ;" )' :y'" t}T~;" <{}} :<( # & y#'#" t}}};" '# :'#" z ; ' x' :D'" z T;*. .
(261) .
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`a^bcd`]e^bdfcgc_ch`e ijcklhcd^jb-L D# D I '$,,, $ *NOP-. @#$, A#. FE#,L D$ BE M$E Q!L JE '$,. \#$% *mPL WVL VSL VU-. E#, BD! B G, &%%, % $#$. +J#A#$E M#%B $L A '$B%$# . A M#,$A#,, (, ,%B . ' I$ ! $E A C $ D NS G, H% $! #,A, *mPL NmS-. ' n$ &%%, BD Nm mm G,.. & JB A$ GJ %# $, D%$ D. A . E#, M#%B %#,$#J +J## ! AB '$! C$# B $ *SmL Um-. & , , ! EBL K "J, ,, @$#A. " GA !$. C %# K A# %B% ,B, DL "J,. NPPo!, MB ,, &'( $E *Nm!NSL WN!WOL NNUL NSR-. A$A! J EB %# L D A. * - # %$E M# *M -L BEB$ T K . $#A$ ($EJ# \# $ *SNL WmL WO-. $, p# %. .
(263) .
(264) 02345236748 . ! "# "# $# %. !&' (# ( ) *+,- )./- ) #&"# $"#. 0"## 1.023456. 078 9:;<=:>:?@ABCDEBFGHHACFAIJBC?. K L # ' # # M6 0 $ . "#NO K"# PQ "#"#"# 2N RQQQ . 1S' T456 K U! !& "!' 0"# & 3 6 +$ U! $ "# 0! 1VP' VW56 0. % N RW X$ O ,M+3L "' %"# YZ3TZ3 / 6 - L ! ' $ . N M!$$ "#( 6 K ,MU3X "# . ,M+' M! MU' *!( [ ' O -U\4' -UYQ' -UYT. U] 2' % "# M!! 1S56 ^$ % M!!3 NO 0"#"# * -U4Q 1S' SV3SP56 K !3 U -$ 2#( #' - $6 2#( . 0!3L]! LU #' ]!] X 1S' 4456. _``78a_Bb`GBBCD9:;<=:>:?@Ac:C9_de7 f5 X !!!"# +# "#"# K *+,-3U!6 L(. N$ ! "# $ M!!' ."# # ( ."#' . * -U4Q !6 g5 0"# L *+,-6 h%"# L'. O $ -UYQ -U\4' $ "# "#!$ ."# "# !6. .
(265) .
(266) 02345236748 . 4 !"#$"%!&' ( )&$* +"' *!, !$%!' -!!$,!' *! +&$!' .!'", /"*&!$%0 1 2!&%3%. !&' 4"!$5!)&/6% +"' 78 9&"*%"' :; '* !%3% &/6 <7= >,&'"?$!' :>@; 3,A ,!' :<B;0 1 2&*!% ,!'5!',?C&5 *!' D#%2!%'*%!& *! !"#&*0 &! (A1E#$!&"'. FG6$% )?6$!'* *!$ H'F!%&"' '* /6 2!& #,&*/"*&!$%!$ 1&'3!!E#$!&"' 3$ I&*'5 +"'. #!$&'!?$!' H'/&"' :JK;0 $/6 H'%!$%&"' ,&% ( )!$*!' ! '*!$!' !"#&*#$"A %!&'! &' *&! H'/&"' $!$%&!$%L &' *!'!' +!$,%&/6 *&! +&$! M$'$&#%&"'L N!#&%&"' '*. *!$ !"#&*3,,!'2 %%%F&'*!%0 O?%3&/6 3 *!' !"#&*#$"%!&'!' )&$*. /6 P(8Q &' *&! H'/&"' $!$%&!$% :=8;0. RSTU !$ 3)!&%! -!!$6,!' *! +&$!' .!'", /"*&!$% FG$ P(J=0 J= 5$"C!L ,%&F'%&"'A ! @%$%$#$"%!&' 2!%!6% JV7 >@0 1 &'%!$5&!$% ,&% ( '* )&$% ("W,!$!"F%"$. :KQV;0 P(J= )&$* X'%&"'?Y&+!'% 3 *!' (6"#6"#$"%!&'!' *!$ Z[\[\]^_`ab_c]de'5!A !6!'0 f&! ( &% P(J= I!%'*%!& *! !"#&* '* !!'%&! FG$ *&! +&$! M$'$&#%&"'. '* N!#&%&"' :K=L KQVL KQ8;0. RSgh *$&%%! .!' *! 4>NP .!'", /"*&!$% FG$ * 4%$&E#$"%!&' P(8QL )!/6! JQJ >@ 2!A %!6% '* 3)!& ",?'!' F5!2% &%0 P(8Q 2!&%3% &' !&'!, A%!$,&'!' >2/6'&%%. !&'! ",?'! FG$ *&! D",""&5",!$&&!$'50 XG$ 1IiP P(8Q "''%! 5!3!&5% )!$*!'L * D!A E,!$! !6$ )6$/6!&'&/6 &, O,,!'6'5 ,&% *!, 4%$&E3,,!'2 %!6!'L )"6&'A 5!5!' P(8QAi%,!$! !&'!' 1&'F F *&! M$'$&#%&"'$!5%&"' 62!' :KQL <J;0 !$ jA M!$,&' )&$* 3$ 4!,2$'"3&%&"' 2!'k%&5% :BJL BlL KKlL KVl;0 H' &'F&3&!$%!' /6 &'. %$'F&3&!$%!' O!!' '' !&'! #"%%$'%&"'! (6"#6"$W&!$'5 '/65!)&!!' )!$*!'L ". * P(8Q ,&%%! f!%!$' I"% JB '* J7 AP$&'%! *!%!%&!$% )!$*!' ''0 X!$'!$ %$&%%. P(8Q &'%$3!?$ &' !&'!$ k&/6!' '* &' !&'!$ ,!,2$'"3&&!$%!' X"$, F :B8L B=;0 1. "''%! 5!3!&5% )!$*!'L * P(8Q &'%$3!?$ ,!,2$'"3&&!$%L G2!$ *!' $!%$"5$*!' #?A %!' !'*"",!' M$'#"$%)!5 %$'#"$%&!$% )&$* :B<;0 &! &'5?$! P(8QA1E#$!&"' FG6$%. 3$ X$!&!%3'5 +"' F&,!'%k!' +&$A?6'&/6!' ($%&!' :P-(; :BJL B=;0 &! P-(AX$!&!%3'5. )&$* !$6k6%L )!'' * .W"#$"%!&' :.(; "*!$ ( "!E#$&,&!$% )!$*!' :BlL 77L KQQ;0 H' '&/6%A #"$&&!$%!' O!!' &% P(8Q C!$*!, &' *!$ -5!L ( &' #!$!$! P(8QA#"&%&+! j%!$ 3. $!$%&!$!'L )!/6! >$!! *!$ ($%&!F$!&!%3'5 '5!!6!' )!$*!' :B=L B7;0 4%$&EA #$"%!&' #&!% C!$*!, FG$ *&! N!$%&!$'5 +"' !"#&*!' &' *&! X&"#"*&!' !&'! !!'A %&!! N"!0 X&"#"*&!' &'* *&! i$%! &' *!$ &'F&3&!$%!' O!!L )" 4>NP ($%&! F$!&5!!%3% )!$A *!' :B=L Bl;0 &! 9"!E#$!&"' +"' P(8Q '* .( FG6$% 3 !&'!$ m,+!$%!&'5 +"' .( +",. M$'A."5&A!%3)!$ 6&'!&' &' *&! 2!$!&% !$)?6'%!' #!$!$!' P(8QA#"&%&+!' @%$%$!'0. @"/6! >$!! )!$*!' (%%F"$, FG$ *!' +"$?F&5!' O,,!'2 *!$ P&$6G! '5!!A .
(267) .
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
(269) .
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`L$&;" !a9"$:$!"&!% WI(5!E&!"(5&"6%E9("&!" !"E& $%&"68!55L5;" L%. %$KI& 6% .!" =56E:6:!:0J "6% 0$%.!& >1bA @@A QbCD O/" .$! OLE$(% .!" '$"65!% :$& .!" !%.(E(:65!% )!:0"6% E$%. %!0!%. W6&I!9E$%!% -!$&!"!A 0$E56%7 %$KI& $.!%&$H$8$!"&! O6F&("!% %(&-!%.$7 >12@CD R6KI .!" !"H(57&!%. OLE$(% '(% '$"65!" L%. 5PE(E(:65!" )!:0"6%A 7!56%7& .!" +R=JT(:95!a $%E MP&(956E:6A -(. 6LKI .$! +!95$F6&$(% E&6&&H$%.!& >c\defgZ\]C >^?A 13^CD 6E 6F&L!55! )(.!55 5!7& %6I!A .6EE E$KI. 8L" 4P%&I!E! '(% :+R*J_"6%EF"$9&!% !$% =(5P:!"6E!F(:95!a 0!E&!I!%. 6LE GA ,=?3 L%.. ,=?2A 0$5.!% :LEEA .!" .6E +R*J<!%(: $% ?hJ2hJ+$KI&L%7 605$!E& >_"6%EF"$9&$(%C >?NA 13^A 13NCD. S% ?hJ+$KI&L%7 .!E !"E&!% L%. $% 2hJ+$KI&L%7 .!E 5!&8&!% <!%E 0!H$%.!% E$KI %$KI&J&"6%EF"$0$!"&!A. I(KI F(%E!"'$!"&! +R*J*0EKI%$&&!A .$! ijfkjY L%. lYfZmjY +!7$(%!%D 4$! !%&I65&!% 4$7%65! H/". .$! ,!"96KFL%7 .!" +R* L%. .!% +!95$F6&$(%E9"(:(&("D O/" R!76&$'E&"6%7 +R*J,$"!% 7!I&. :6% .!"8!$& .6'(% 6LEA .6EE .$! =(5P:!"6E! .$! '$"65! _"6%EF"$9&$(% %L" 6: ?hJ#%.! .!E <!J %(:E E&6"&!% F6%%D 4&no& .$! =(5P:!"6E! 6LH !$% !"E&!E _"6%EF"$9&$(%EE&6"&E$7%65A 0!7$%%& .$!. 4P%&I!E! '(% :+R*D $! U$%.L%7E6HH$%$&;& H/" '$"65! +R* I$%&!" !$%!: G!E!"6I:!% $E& '!":L&J 5$KI 6LH <"L%. '(% 4!FL%.;"E&"LF&L"!% EKI-;KI!"A 65E $% .!% 8L &"6%EF"$0$!"!%.!% U!"!$KI!%D. $!E H/I"& .68LA .6EE .$! =(5P:!"6E! :$& !$%!" 0!E&$::&!% p6I"EKI!$%5$KIF!$& '(% .!: _!:9J 56&! .$EE(8$$!"&D 6 .$! _"6%EF"$9&$(% %L" 6: ?hJ#%.!J5$!7!%.!% _"6%EF"$9&$(%E9"(:(&(" $%$&$$!"&. -!".!% F6%%A H/I"& .$!E 8L" U$5.L%7 !$%!E :+R*J<"6.$!%&!%A .6 %;I!" 6: ?hJ#%.! 5$!7!%.!. <!%! .!L&5$KI I;LH$7!" 607!5!E!% -!".!%A 65E 6: 2hJ#%.! 7!5!7!%! >13?A 132A 11?A 121CD O/". )*+, ="(&!$%! K(.$!"!%.! :(%(JK$E&"(%$EKI! :+R*E -!".!% $: <!7!%E6&8 8L" 7!%(:$EKI!%. +R* %$KI& !%F69E$.$!"&A q!.(KI 9(5P6.!%P5$!"& >^?A 132A 1@?CD $! :+R*E -!".!% 0$E 6LH .$! H/". <= K(.$!"!%.! :+R*A 6% 8!55L5;"!% H"!$!% +$0(E(:!% $: MP&(956E:6 &"6%E56&$!"& >^^CD !". =(5P:!"6E!F(:95!a "!7L5$!"& %$KI& %L" .$! 4P%&I!E! '(% :+R*J_"6%EF"$9&!%A E(%.!"% !" $E&. 6LKI 8L" 4P%&I!E! '(% <!%(:JT(9$!% !EE!%&$!55 >13^CD O/" R!76&$'E&"6%7 +R*J,$"!% F(%%&!. 7!8!$7& -!".!%A .6EE 8L" +!95$F6&$(% .!E <!%(:E 8L%;KIE& !$%! '(55E&;%.$7! *%&$7!%(:JT(9$!. !"8!L7& -!".!% :LEEA -!5KI! !$%! 2rJ?rJV"$!%&$!"L%7 6LH-!$E& >@2A b@CD. .
(271) .
(272) 02345236748 . !"# $%& '()*+(&,)% -%.)(/,0(*1234/)526 7%& 2(89 (11%&9,): +*1 ;< =0517%1 ,:2.(%)06 :%>(110 ?(0 7%& 512.%3('(289%1. @(1751> +*1 AB ,1 3%)5)C&% D:%&')C89%1.&*0%(1%E F:%& G,/&*.(1*340*2% %&'*)>0 7(% B,&0(/%),5'1,9?% HIJKLMNE. O,89 7%? P(10&(00 7%& Q(&%1 R:%& 7,2 %17*2*?,)% S*?.,&0(?%10 T(&7 AB 1,89 .UVW%&0VP&1(%7&(>51> +*1. X,09%.2(1%1 >%2.,)0%1E P2 /*??0 1,89 @(1751> 7%2 (10&,3%)5)C&%1 -%3%.0*&2 OBXY 35& Z52(*1 +*1 +(&,)%& 517. )42*2*?,)%& G%?:&,1 H[J\]^K_J`N6 T,2 35& Z&%(2%0351> 7%2 O5/)%*/,.2(72 (12 a40*.),2?, 'R9&0E $(% B*)4?%&,V 2% b )(%20 7,2 A%1*? ,: 517 24109%0(2(%&0 ?-Oc HdL^JefL_gK_]JNE c1 '&%(%1 -(:*2*?%1 T%&7%1 :(2 ,5' AB ,)%. +(&,)%1 =0&5/05&.&*0%(1% 24109%0(2(%&0 HdL^Jeh^K_]JNE =(17 ,52&%(89%17 B&*0%(1% +*&9,17%16 T(&7 7,2 A%1*? (1. %(1% B*2(0(+20&,1>VG,0&(3% /*.(%&06 7(% T(%7%&5? ,)2 i%?.),0% 'R& 7(% O%>,0(+20&,1>VA%1*?% 7(%10 Hjkgh_f^K_]JNE. $(% -%.)(/,0(*1 517 7%& a52,??%1:,5 7%& B,&0(/%) %&'*)>0 (1 l18)52(*12 351C8920 ?(0 @()751> +*1 O5/)%*/,.2(7V /*?.)%m%1 HneekophMNE AB T(&7 (? &,5%1 %17*.),2?,0(289%1 -%0(/5)5? 24109%0(2(%&06 R:%& A*)>( 517 i&,12>*)>(V O%03T%&/ .*200&,12),0(*1,) .&*3%22(%&0 517 >%),1>0 289)(%q)(89 R:%& G5)0(+%2(85),& @*7(%2 ,1 7(% B),2?,?%?:V &,1E QB<r ,22*3(%&0 1,89 =4109%2% ,1 G%?:&,1%1 517 >%),1>0 %:%1',))2 R:%& G5)0(+%2(85),& @*7(%2 ,1 7(%. B),2?,?%?:&,1E O5/)%*/,.2(7% T%&7%1 ?(0 U()'% 7%2 a40*2/%)%002 ,1 7(% B),2?,?%?:&,1 0&,12.*&0(%&0E QB<r. /**&7(1(%&0 ,)2 G,0&(m.&*0%(1 7%1 S*10,/0 +*1 O5/)%*/,.2(76 b(.(79R))% 517 ABE $(% Z&%(2%0351> +*1 &%('%1 Q(&%1. '(17%0 R:%& )C1>)(89% a%)),52)C5'%&6 Z()*.*7(%1 >%1,1106 20,00 Hstuu_J`NE c7,.0(%&0 +*1 $*)1(/ kKv^hE6 ;rrwE. -%.)(/,0(*1 517 P1/,.2(7(%&51> %&'*)>%1 (1 7%1 l18)52(*126 T%)89% 75&89 7,2 OB (1753(%&0. T%&7%1 517 2(89 5? 7%1 a%))/%&1 9%&5? ,1),>%&1E l1 7%1 l18)52(*12 1%5 ,22%?:)(%&0% O5/)%*V /,.2(7% ?R22%1 'R& 7%1 a52,??%1:,5 517 35? Q%&),22%1 7%& a%))% ,1 7(% S1*2.51>220%))%1. >%),1>%1E G,1 1(??0 ,16 7,22 7,2 a40*2/%)%00 517 7,?(0 ,22*3((%&0% B&*0%(1% 'R& 7%1 i&,12V .*&0 +*1 25:+(&,)%1 @%20,170%()%1 %(1% %22%10(%))% -*))% 2.(%)%1E $,2 G,0&(m.&*0%(1 QB<r ),>%&0. 2(89 1,89 2%(1%& =4109%2% ,1 G%?:&,1%1 ,1 517 T(&7 R:%& 7%1 &%0&*>&,7%1 2.C0%1 %17*2*?,V )%1 i&,12.*&0T%> 35 7%& B),2?,?%?:&,1 0&,12.*&0(%&0 Hx<Vxy6 xzNE QB<r (20 +%&,10T*&0)(89 'R&. 7(% -%/&50(%&51> +*1 -OBVS*?.)%m6 517 AB 35 7%1 c52289)%5251>220%))%1E Gc-Q T(&7 (1 .*),V &(2(%&0%1 P.(09%)3%))%1 :,2*),0%&,) 517 (1 51.*),&(2(%&0%1 a%))%1 9,5.02C89)(89 R:%& Z()*.*7(%1. '&%(>%2%030 Hx{NE $(% '()*.*7(%1:,2(%&0% Z&%(2%0351> %&9|90 +%&?50)(89 7(% P''(3(%13 :%( l1'%/0(V . 0
(273) .
(274) 02345236748 .
(275)
(276)
(277)
(278) !" !# #
(279) $ %&
(280) ! ## # '" ( )* ## *## + ,
(281) # &
(282)
(283) # # ! #" !
(284) # &
(285)
(286) #
(287) # & -#*** .
(288) ! ./ /0 /12+. 034 56789:;9<<=>8. ?# & # ( @ #
(289) A
(290) BC)$ ,
(291) # ! A# " + D # %
(292) ,
(293) # ! D& -#*** &
(294) ! #. EF * F
(295) ###
(296)
(297) - + CG* # % . ,
(298) # * * B'
(299) $-HI ##
(300) %# J
(301) ! ? & . $
(302) C##!# & ## #+ K* # F *#! C( %(! . L
(303) *
(304) #
(305) #!
(306) ! M *## $ A ?#
(307) #" * % + E# # & N& % +?+ )$ $O$
(308) O$ # & &. .P PP PQ R/ /I PIQ PPI PS/ P0S2+. ?# & %
(309) &# OF#* BC)$ ! A& %#! # ! *M&! %. BC)$ -
(310) #A - BC)$"
(311) # *
(312) " #
(313) #! #! + E A
(314) & C ! * @ #
(315) %& A
(316) BC)$" ,
(317) # !
(318) #
(319) A
(320)
(321) *
(322) # "* $ . N & A
(323) T *
(324) #
(325) ?OT"H"? & & #! +.
(326) & &# & #
(327) * N #! % U. P+. L# # *M&! A ?# % ,
(328) # B'
(329) $-HI
(330) ! "
(331) #A# %+ $#
(332) ! L
(333) #A# * #! !
(334) #" * V. R+. D
(335) & @ #
(336) A
(337) ,
(338) # %
(339) V. S+ D # EF * # ,
(340) # #
(341) #V. H+ D! ?& # F
(342) # * ,
(343) # #
(344) V. 0+. D
(345) # B'
(346) $-HI ,
(347) # #** V. W+ D! N ## ! $-HI"-!
(348) #!
(349) F & ( $ & ,"
(350) #V. /+. D % ,
(351) # BC)$"##! C###
(352)
(353) . #
(354) V. . 00 .
(355) 023425267238694 0 27. !" " # $"%# &' " " " ("! )'*+%, - (-"#**.. / 0-% 1-2 3 4. 4%%2 **- 5"-2 " 1"!#2 6%*% 7"2 489:;<=92 >*#% ?-*+2 @"-A" B. $%*"2 4A% $+" % 1& B*%. CDEFGH IJKDLMKNJOILPQOLRLSJTOLKULVWKFRXJQGILYOZFJERTJKD[ \-'"%* -] ^"-*-#_ `abcad ef `acd2 A. ccgghiccgee `1- OTLRF[2 abcad. Bj" )'*+%- * "% $"%# " ?'"]j"'# " 6+"-, +-AkA". %*] ^-"kA" '" $4l,a,$#'# ' " +m', ""'# " '" $4l,n,$#'# #!- 6+"-+-A% `B#. c2 B#. o ' B#. nd. 7" #% 1*]**'# &'" p%%"'# ' '!"'# " 6+"-+-A% ' !%" % q-""+'"* 6%'+"A *#.. $/ l%"% q-*+-(%2 r(% 6*"2 489:;<=92 1-% 4%,r* % 4A% $+". stKIZtKQuFRTJKDLKULvRQWGQwLXJQGILxRTQJyLZQKTOJDLzs{|LTQJwwOQILRIIOxWFuLKULDGEFOKERZIJNIL}JTtL TtOLXJQRFLODXOFKZOLRTLTtOLZFRIxRLxOxWQRDO[ @**'*%" 6"--*-#_ `abcad cn`ad2 ceaichg `q-*, +-(% OTLRF.2 abcad. ~' " )'*+%- +- " )*%'# ' ?'"]j"'# (- rkA" `B#. o ' B#. fd "%#. 7" !%" " "A"%- " "&* r"# , *#.. @/ 489:;<=92 l%"% q-*+-(%2 >*#% ?-*+2 $% 4-+2 % 4A% $+". JXOL EOFFLJxRwJDwLKULvRQWGQwLXJQGILJDUOETONLEOFFILGDEKXOQILRETJDHNOZODNODTLTQRDIZKQTLKULDGEFOKERZIJNIL KXOQLFKDwLNJITRDEOI[ )"- p%* % 4 4 . abco '# ca `4' OTLRF[ abcod. 6 $"%# &' " )'*+%- !%" % )*% kA"** ?#2 -! ?'"]j"'# " rkA". %"%+"" ("! ]*'-"&&,%"+" ("%* B'-A"- - ' ]'+-** * ^l) 4_ `B#. 4cd. +*-" ' %"%+"" % 3B),^)nb,kA"" "+-% 63^. 6 $"%# !%" %'" ?'"]j"'# %**" l&**,rkA" '" $4l,n,$#'# `B#. c,o2 B#. 2 B#. 4a,4od. ? 7" ]j" %** rkA" +-]-+%* l%",4%, 6+"-+-A '". "]% 6!" ]j" % %*_ ' " #% )"-]. 4A% $+"2 ?". l%"% q-*+-(% ' ?". >*#% ?-*+ % 6%'+"A &' " )'*+%-.. .
(356) 0
(357) .
(358) 023425267238694. ! " #" $%& '"( & )* +*" , " "--% .&"*!. /"0 1* 234. +*" , .*-! 5! ,6" 7 8#*9 879. .
(359)
(360) .
(361) 02342567882. 0 2. 0
(362) 85 !". #$% &'()$%*%+,% -(.%$/ 0+/%(1023/ ,%+ $+/(45%))0)6(%+ 7(4+18'(/ &'+ 9-:; <0=)%'=481$,%+. >$//%)1 ?)0'(%15%+5>$=('1='8$% $+ )%.%+,%+ @%))%+A B1 1'))/%+ &$(4)% C('/%$+% 4)1 D)0'(%15$%(%+E ,% ?01$'+18('/%$+% F63(%+, %$+%( 9-:;EG+D%=/$'+ %H8($>$%(/ F%(,%+A #4DI( F4( %1 +'/F%+E ,$* 50 *%F63()%$/%+J ,411 ,$% ?01$'+18('/%$+% 50> %$+%+ %$+% >K*)$231/ $+/%+1$&% ?)0'(%15%+5. 40DF$%1%+J 50> 4+,%(%+ 4.%( ,411 ,%(%+ ?0+=/$'+4)$/6/ %(34)/%+ .)$%.A. 0
(363)
(364) 2LM"2N" 6" ?I( ,$% 94(=$%(0+* ,%1 <0=)%'=481$,1 =4>%+ %+/18(%23%+, 1%$+%( @014>>%+1%/50+* DI+D. &$(4)% C('/%$+%J ,41 <CJ ;COPJ ;COQJ ;CRS 0+, T $+ ?(4*%A -01 ;'(1/0,$%+ F4( .%=4++/J ,411. %$+% ?01$'+ >$/ ,%> RU =# *('V%+J *(I+ D)0'(%15$%(%+,%+ C('/%$+ WX?CY ',%( %$+%> #%($&4/. ,4&'+ W:?CYJ -01F$(=0+*%+ 40D ,$% ?0+=/$'+ ,%( &$(4)%+ C('/%$+% 0+, ,4>$/ 40D ,$% G+D%=/$'1$E /6/ ,%( ;$(%+ 34.%+ =4++A B1 F4( ,43%( %(>0/$*%+,J ,411 $+ ,%( C0.)$=4/$'+ &'+ Z'%+%+ [\]^_`J. RQaR W?$*A RbY *%5%$*/ F%(,%+ ='++/%J ,411 %$+% ?)0'(%15%+5>4(=$%(0+* ,%( Bcd; C')e>%(41%. T >$/ ,%> D)0'(%15$%(%+,%+ C('/%$+ >b3%((e +$23/ 50> ;%()01/ ,%( G+D%=/$'1$/6/ &'+ Bcd;. DI3(/J 4)1' 8($+5$8$%)) %$+% ?)0'(%15%+5>4(=$%(0+* ,%( &$(4)%+ C('/%$+% '3+% ;%()01/ ,%( G+D%=E /$'1$/6/ >K*)$23 $1/A -))%(,$+*1 F4( ,$% ?)0'(%15%+5>4(=$%(0+* ,%( C')e>%(41% +$23/ 401(%$E 23%+,J 0> %$+5%)+% <0=)%'=481$,% 50 ,%/%=/$%(%+A #$%1%( -+14/5 F0(,% 4023 DI( ,$% 9-:;. C')e>%(41% &%(F%+,%/J F'.%$ 1$23 ,$% G+1%(/$'+11/%))% 0> %$+$*% <0=)%'/$,% 0+/%(123$%, 0+,. 1/4// %$+%1 >b3%((e1 %$+ *%). D)0'(%15$%(%+,%1 C('/%$+ Wf?CY &%(F%+,%/ F0(,%A g$% ,$%. h
(365) i7jLkMl m! #$% n84)/% 8Q opq *$./ ,$% ,0(23123+$//)$23%J (%)4/$&% :%8'(/%(4=/$&$/6/ $+ rstuvw[sE@%)%+ ,%1 $;TC ne1/%>1 $+. C('5%+/ 4+ 0+, $1/ %$+ 94V DI( ,%+ B$+D)011 ,%1 x%F%$)$*%+ C('/%$+1 40D 7(4+1=($8/$'+ 0+, :%8)$=4/$'+A #$% n84)/%. 8a opq *$./ ,$% ,0(23123+$//)$23%J (%)4/$&% :%8'(/%(4=/$&$/6/ $+ G+,$=4/'(E@%)%+ ,%1 $;TCEne1/%>1 $+ C('5%+/ 4+A n$%. $1/ %$+ 94V1/4. DI( ,$% G+D%=/$'1$/6/ ,%( *%.$),%/%+ C4(/$=%)A g$),/e8En$/04/$'+ y aQQpA #$% n84)/% z{|[s}v{~. .%5$%3/ 1$23 40D ,$% F%$/%(% ;%(F%+,0+* ,%1 '+1/(0=/1 DI( ,$%1% -(.%$/A aY y )'+$%(/ 0+, $> $;TC -114e 234(4=E /%($1$%(/ &'+ #(A dA #')+$=A RY )'+$%(/ &'+ #(A dA #')+$=A OY )'+$%(/ 0+, $> $;TC -114e 4)1 (%='>.$+4+/%1 ;$(01. 234(4=/%($1$%(/ &'+ #(A 7A ZK+%+A. .
(366) .
(367) 02342567882. !"#$% & ' (&$ ) &* +, -. & /01+!"#$% (2 3 .4 5 . &4 .2 . / %$# 3 +4 *(22 & 6&2$ &3 & ., 7 & /01+!"#$% . .4 (. #&2 82&&&3 98/: 7& ;<= 9(>. ?@ABCDEFGHGIEJIKLIGMACENOEPCDMQMDBHLERALISBLIETIGB@C: 90**, UV :, =. *2* +( & <& 2* 0(2WW &2 /&$ &3 224 2 /2&>2 "2 X*2$ *2 22 822 9YZ4 [\]:, 8 4 % >* +$ 3&2 2 2 8 & 90**, U:, <)$ . *( = %$/2&>2 +,. ^__` abcdefghi_jklcmjn_oepqfemr^3stub v` w: 0(2*2 /01+!"#$%$( x$Z -224 yY 3,, % & (( -32 . & 2 V <*$/& z <& 2, {: 82&&&$ 3( /01+!"#$%, 0 1 ;# & 9#(2:4 / 6&2&3 9#(23:,. |: ;<=$0( /01+!"#$%$#&2, !"#$%$# >* +3&2 2 )( . * 8,. 6 + "2& /01+ 6&2&33. (> 2z2 32> 8}3 +#\~;"# (2 /&. 6&2&3 .) /01+$(&, = "3 . =, 2. =2& &24 +%# 0 &, +#\~;"# . +%# 0 22 (&(),. 8 . 2 & ( 2 #&2 * 9< IGEHL,. y~[\4 ", <[0 =:,. 0`
(368) ` 2egnloepjnejmmjo fijjeggnfekkgmgjpnj omuofmjk je mnjmoepjk rgmnimfgjneksb ;2 6&2&3 22 /}3 +#Y~ (2&. ., =2* "2 . ., = /}3 +#Y~. )z )( + & #, 8 *$ .
(369) .
(370) 02342567882. ! "#$% & '(). * +, - ' %.$ #- /01* 23456 7)89 # 07: !; < '=$0> . 1* #- & "#$'() 1* ?@A '() ,*. , B1* & &1* , "#$'() A. ,-*. %+"'$< @A , . ' ,1* . C -1* =* . D "#$'() 1 /EFGHH IGJK L62J2M353NGM4+; < O1* & %+"'"#$'() ,1* ' . P7 * A &1*. ** Q , %+"', /01* 23456 7)89 # 09:; < . < , "#$'() ,* R>A 1* <1 . , 7( * A 1* S 0 R /01* 23456. # 09! T U;. . 0VW XYZ[\]^_`^Ya[Yb^cd^]aeYa]f^YgZh[]6^gi[jgef]khZ\eY]fj\Z]. <1 l - % &$ R = R , &$ m "A BA. ., " & ,. BA . A , < +. & 01* 23456. 7)89 , <1 l #A 1* /# 8+ l :n # 09!. T U; l U@A & '9)C# ,-* %+"'$< 1* '9)C#. ** %o <1 & /# 08l; R-1* , 8p * A< $ o % S 0 ..1* , =- /1 8 q; *$ 1* *. '9)C#$ BA * '9r . B /01* 23456 7)89 # 8+; /P PP; 0,* . 1* @. R <1 l s & BA , /# 8;. < @ R , BA 1* + $ <1 . =.A % !>. ..1* , /# 8l; ! # BA . <1 , % + * . , l *. BA . % & '() & ,. /01* 23456t # 8:; ! , D.1* '() <1 & . . & ,1* " 1* . BAA A$ D /98;. . 0V0 dYeiu][h[\6^gi[jgef]khv[w[a^Ya. ? # BA <1 & QA. 1* #A 0 # . .
(371) .
(372) 02342567882. ! "!# $% $ &$. $!'# '($ $) *( ! +$ ! $! $! ' +,-.. /($ '0! ( $$&! 1) 2 ! % $ /($% . *&!$$ $! % (!! 314 ! ' 566 7 89 : ; < 6=> $(01 ;"(! ?@A BC)% DE6F% G) F>) H1( I #J (. K!( 0) 2 $ $ $(. '% $ /($ H1( ( 4 *!(! (!) L$ K!(4 '($!% ! $ ($) 2 ! $ !. /($ $!! 1% 1 1 "4 ( MN( ( $ 9E 3$ $(0!!!). gkkTlm5XW\nWXZcoi_XVod\_XZZpeqrYe MN( 1$ ' ( !% $ /(4 6p`ZXY`on\W[kXaXqpeqXeT $ 0O "!(!( I) /(4 QE "( (N! L! ' $! ' $% -$ * 0%. /($ +,-.1!4 ! (!! !1$ '0$ $ $. 0!% .jFE3Gj4O. s(s494* 1( $!) 31!% $ *!( * ;"(! ?@ABC)%. DE6F% G) F>) P ,) Q H1( (! ' $! (! /($. $ *!$( ' +(! !) +! '$(0 H1( M(4 '% $ ! '% $ /($ $ -!( 1) H14 ( 0! !! R!( % $ J!% ( ! !!. -!( 1!(1% ( /($ ( ( 68E 3$ ') $. (!!% $ ' /($ (!! ' ! 2) 2 K!4 ( /($1( % 0! ' -N1#!1( ( %. 1(% $( 1 ! ( M$4# $ '$(0 H1( % $!!). +!! ! !! 1% $ /($ !$4 (# N 1! "! !$!! 1) " !% $# $'% 1 $ 4 $(0$ ( 0N! 1(% (N! "! ' N DQ +!. $!! 1) 2 ! $' $(( % $ /($ * 6EE. S (N I% ' G (!! 1) /(4 $1( J 0$ /! 3N +$! ;.. 2Q> $!). 0TU VWX3YZZX[X\]^_Y\`XZX__\abcdXe[XWeXdfg3h 7eiX`_WYe. "!( ' M'$ ?@ABC)% DEE9 ! ! - ' ,! 1# . +,-.4P0! $1 ;9=>) H$ $ $' $(% $ ,! !. "N j .($((( !!) P ' "!( '. .
(373) .
ÄHNLICHE DOKUMENTE
Ich bedanke mich herzlich für seinen Mut und dieses Vertrauen, für die hervorragende Ausstattung eines eigenen Projektlabors zum Teil inklusive Mitarbeitern und für die Freiheit
From investigations using unlabeled testosterone (T) combined with a LC/MS assay and from incubations with tritium labeled substrate it was shown that the HaCaT cell line expresses
Jedoch zeigte der Einsatz einer VP30-spezifischen siRNA in der Infektion, dass das VP30 des MARV für die Vorgänge der Transkription und Replikation durchaus eine Rolle spielt,
Zu der strukturellen und funktionellen Bedeutung des MARV Glykoproteins wurden bereits ausgedehnte Untersuchungen durchgeführt, wobei die cytoplasmatische Domäne des
Für die Replikation und Transkription in einem MARV-spezifischen Minige- nomsystem ist VP30 nicht essentiell (106, 155), eine Herunterregulation von VP30 in der Virus-
Im ersten Teil dieser Arbeit konnte mit Hilfe verschiedener Kernimport- und Kernexport-Mutanten und Immunfluoreszenzanalysen in fixierten und lebenden Zellen gezeigt
[r]
pcDNA3.1/Zeo (+) (5015 bp) CMV‐Promotor; ‐origin; BGH reverse priming site und pA; Zeocinresistenz‐Gen; Ampicillinresistenz‐Gen;