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Free Radical Scavengers, Antioxidants and Aldose Reductase Inhibitors from Camptosorus sibiricus Rupr.

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Free Radical Scavengers, Antioxidants and Aldose Reductase Inhibitors from Camptosorus sibiricus Rupr.

Ning Li

a

, Xian Li

a,

*, Yi Zhang

b

, Tao Wang

b

, and Wan Xiao

a

a Research Department of Natural Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China. E-mail: proflixian@163.com

bKyoto Pharmaceutical University, Kyoto 607-8412, Japan

* Author for correspondence and reprint requests

Z. Naturforsch.63 c, 66Ð68 (2008); received August 10/September 17, 2007

Flavonoids and organic acids were recommended in the literature as the main active con- stituents ofCamptosorus sibiricusRupr. Assay-guided fractionation led to the isolation of 9 flavonoids and 8 phenolic acids. All compounds were tested for DPPH scavenging activity, SOD-like and aldose reductase inhibition. Among them, compounds1,2,3,5,6,7,8,9,11, 15showed activities. The most active free radical scavenger and antioxidant was compound 8, while compound1exhibited strong inhibiting activityof aldose reductase. The structure- activityrelation was dicussed briefly.

Key words: Camptosorus sibiricus Rupr., DPPH Scavengers, Antioxidants, Aldose Reduc- tase Inhibitors

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