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A New Active Compound from Centaurea Species

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A New Active Compound from Centaurea Species

Melek U. Dumlu

*

and Elcin Gürkan

Marmara University, Faculty of Pharmacy, Department of Pharmacognosy, I˙stanbul, Turkey.

Fax: +90 21 64 18 77 39. E-mail: melekulusoylu@hotmail.com

* Author for correspondence and reprint requests

Z. Naturforsch.61 c, 44Ð46 (2006); received June 6/August 1, 2005

The extract containing sesquiterpene lactones ofCentaurea iberica(Asteraceae) isolated was separated and a steroidal compound, which is stigmast-1,5-dien-3β-ol, was purified. The chemical structure was established based on spectroscopic data (UV, IR, MS,1H NMR,13C NMR). Both the extract and the compound showed significant antioxidant and antimicro- bial activities.

Key words: Centaurea, Antimicrobial, Stigmast-1,5-dien-3β-ol

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A New Active Compound from Centaurea Species

The extract containing sesquiterpene lactones of Centaurea iberica (Asteraceae) isolated was separated and a steroidal compound, which is stigmast-1,5-dien-3 β -ol, was purified..