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Figure S2

H&E

b

c

H&E

a

Colon Small Intestine

Colon Small Intestine

Top-Down-Vil Apc

fl/+

Kras

G12D/+

Bottom-Up-Vil Apc

fl/+

Kras

G12D/+

P<0.0001

Crypt Villus

Bottom- Up Top-

Down WT

d

Apc Kras

(2)

pSMAD3 p21 e

f

Top-Down-Vil Apc

fl/+

Kras

G12D/+

Colon Small Intestine

Figure S2

g

pSMAD3

Bottom-Up-Vil Apc

fl/+

Kras

G12D/+

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