Folgender Anhang beinhaltet Forest Plots mit Heterogenitätstatistik (I2) sowie eine Auswahl der in Tabelle [Tab. 4.1] gelisteten Subgruppen bzw. Subgruppenanalysen.
Einige Studien untersuchten mehrere unterschiedliche Personengruppen von beruflich PAH-Exponierten; aus diesen Studien gingen mehrere Effektschätzer in die Metaanalyse ein. Die nachfolgende Legende dient der eindeutigen Identifizierung die in den Forest Plots dargestellten Schätzern bei Studien, von denen mehrere Effektschätzer in die Metaanalyse eingingen.
Anh. 5, Tab. 1 Kennzeichnungs-Legende7
Effektschätzer Bezeichnung Bedeutung
Eisen_1 MWF 0-1 [mg/m³] x Jahre
Eisen_2 >1-3 [mg/m³] x Jahre
Eisen_3 >3 [mg/m³] x Jahre
Gibbs_50-a1 Fabrik A, vor 1950, BaP 20-<40 (µg/m3) x Jahre Gibbs_50-a2 Fabrik A, vor 1950, BaP 40-<80 (µg/m3) x Jahre Gibbs_50-a3 Fabrik A, vor 1950, BaP 80-<160 (µg/m3) x Jahre Gibbs_50-a4 Fabrik A, vor 1950, BaP 160-<320 (µg/m3) x Jahre Gibbs_50-a5 Fabrik A, vor 1950, BaP >=320 (µg/m3) x Jahre Gibbs_50+a1 Fabrik A, nach 1950, BaP 20-<40 (µg/m3) x Jahre Gibbs_50+a2 Fabrik A, nach 1950, BaP 40-<80 (µg/m3) x Jahre Gibbs_50+a3 Fabrik A, nach 1950, BaP 80-<160 (µg/m3) x Jahre Gibbs_50+a4 Fabrik A, nach 1950, BaP 160-<320 (µg/m3) x Jahre Gibbs_50+a5 Fabrik A, nach 1950, BaP >=320 (µg/m3) x Jahre
Gibbs_50-b Fabrik B, vor 1950
Gibbs_50+b Fabrik B, nach 1950
Gibbs_50-c Fabrik C, vor 1950
Gibbs_50+c Fabrik C, nach 1950
Gustavsson_elgrph Elektrographitherstellung Gustavsson_hiPAH hohe PAH-Exposition
Moulin_a Fabrik A
Moulin_b Fabrik B
Moulin_alu Aluminiumindustrie
Kennaway_metal Metallschleifer
AndjelkovichWgießer Gießereiarbeiter (white men) AndjelkovichNgießer Gießereiarbeiter (non-white men)
Aronson_F Frauen
7 Für Studien die mehrere Effektschätzer berichteten (z.B. für mehrere Berufe, Expositionen) sind Zusatzabkürzungen am Name des Erstautors hinzugefügt worden.
Effektschätzer Bezeichnung Bedeutung
Aronson_M Männer
Cornell_NiCr Ni/Cr Gießer
Cornell_Stahl Stahl Herstellung Kennaway_kamin Schornsteinfeger Hoshuyama_0Stb 0 Staubarten Hoshuyama_1Stb 1 Staubarten
Hoshuyama_2Stb 2 oder mehr Staubarten Ji_Mkamin Schornsteinfeger (Männer)
Ji_Fdruck Drucker (Frauen)
Ji_Mdruck Drucker (Männer)
Kennaway_gas Gas-Hersteller
Kennaway_teer Steinkohlenteer-raffinerien und Kokereien Kennaway_asphalt Straßenbauarbeiter und Asphaltierer Kennaway_metal Metallschleifer
Kennaway_kamin Schornsteinfeger
Kennaway_kokerei Bediener der Kohlebeschickungsvorrichtung in der Herstellung von Stadtgas sowie Bediener der Befüllungseinrichtung in Kokereien
Kennaway_druck Drucker
Olsen_Fdruck Drucker (Frauen)
Olsen_Mgummi Gummi-Herstellung (Männer) Olsen_Mdruck Drucker (Männer)
Pukkala_Fdruck Drucker (Frauen)
Pukkala_Fgießer Gießereiarbeiter (Frauen) Pukkala_Mkamin Schornsteinfeger (Männer) Pukkala_Fdruck Drucker (Frauen)
Pukkala_Mdruck Drucker (Männer)
Pukkala_Mgießer Gießereiarbeiter (Männer) Olsen_Mgummi Gummi-Herstellung (Männer)
Solionova_F Frauen
Swaen_teer Teerschwelerei, Dachdecker Swaen_kokerei Kokereiarbeiter
Anh. 5, Abb. 1 Forest Plot, Inzidenz Studien (bzw. Effektschätzer)
NOTE: Weights are from random effects analysis Overall (I-squared = 29.3%, p = 0.022)
1.47 (1.31, 1.65) 1.05 (0.56, 1.80) 0.80 (0.40, 1.50)
2.10 (1.05, 3.76) 1.03 (0.54, 1.99)
2.10 (1.00, 4.70) 0.81 (0.17, 2.37) 2.66 (0.32, 9.62)
2.30 (1.30, 3.80)
1.30 (0.80, 1.90)
1.30 (0.50, 3.20) 15.40 (1.45, 56.58) 1.18 (0.38, 3.65) 2.11 (0.05, 11.72)
1.44 (0.82, 2.34) 0.70 (0.02, 3.89) 0.50 (0.07, 4.86)
1.53 (0.42, 3.93) 3.33 (0.08, 18.54)
15.38 (1.45, 56.58) 0.90 (0.40, 2.10)
4.35 (0.90, 12.71)
1.42 (0.17, 5.14) 1.36 (0.17, 4.91)
1.80 (0.75, 4.32) 2.09 (1.14, 3.51) 1.47 (0.96, 2.24) 1.22 (0.33, 3.11)
2.67 (1.10, 6.10) 1.57 (0.51, 4.87)
0.79 (0.38, 1.45) 0.63 (0.21, 1.48) 0.60 (0.00, 2.35) ES (95% CI)
1.19 (0.78, 1.73) 1.41 (0.38, 3.62) 3.80 (1.30, 11.10)
1.56 (0.04, 8.69)
1.21 (0.12, 4.60) 1.04 (0.22, 3.04)
1.90 (0.18, 5.46)
0.96 (0.14, 9.35) 3.30 (1.42, 6.50)
6.40 (0.80, 7.90) 5.67 (1.54, 14.52)
1.29 (1.17, 1.43) 2.13 (0.58, 5.46) 0.70 (0.30, 1.70)
1.72 (0.63, 4.70) 1.52 (0.61, 3.14)
1.21 (1.04, 1.41) 1.18 (0.78, 1.71) 1.50 (1.10, 2.20)
1.84 (1.07, 2.82) 2.91 (1.02, 8.33)
10.00 (0.25, 55.60) 0.95 (0.02, 5.28) 0.60 (0.20, 1.90)
1.30 (0.50, 2.60)
100.00 1.47 (1.31, 1.65) 1.05 (0.56, 1.80) 0.80 (0.40, 1.50)
2.10 (1.05, 3.76) 1.03 (0.54, 1.99)
2.10 (1.00, 4.70) 0.81 (0.17, 2.37) 2.66 (0.32, 9.62)
2.30 (1.30, 3.80)
1.30 (0.80, 1.90)
1.30 (0.50, 3.20) 15.40 (1.45, 56.58) 1.18 (0.38, 3.65) 2.11 (0.05, 11.72)
1.44 (0.82, 2.34) 0.70 (0.02, 3.89) 0.50 (0.07, 4.86)
1.53 (0.42, 3.93) 3.33 (0.08, 18.54)
15.38 (1.45, 56.58) 0.90 (0.40, 2.10)
4.35 (0.90, 12.71)
1.42 (0.17, 5.14) 1.36 (0.17, 4.91)
1.80 (0.75, 4.32) 2.09 (1.14, 3.51) 1.47 (0.96, 2.24) 1.22 (0.33, 3.11)
2.67 (1.10, 6.10) 1.57 (0.51, 4.87)
0.79 (0.38, 1.45) 0.63 (0.21, 1.48) 0.60 (0.00, 2.35) ES (95% CI)
1.19 (0.78, 1.73) 1.41 (0.38, 3.62) 3.80 (1.30, 11.10)
1.56 (0.04, 8.69)
1.21 (0.12, 4.60) 1.04 (0.22, 3.04)
1.90 (0.18, 5.46)
0.96 (0.14, 9.35) 3.30 (1.42, 6.50)
6.40 (0.80, 7.90) 5.67 (1.54, 14.52)
1.29 (1.17, 1.43) 2.13 (0.58, 5.46) 0.70 (0.30, 1.70)
1.72 (0.63, 4.70) 1.52 (0.61, 3.14)
1.21 (1.04, 1.41) 1.18 (0.78, 1.71) 1.50 (1.10, 2.20)
1.84 (1.07, 2.82) 2.91 (1.02, 8.33)
10.00 (0.25, 55.60) 0.95 (0.02, 5.28) 0.60 (0.20, 1.90)
1.30 (0.50, 2.60)
100.00
Anh. 5, Abb. 2 Forest Plot, Mortalität Studien (bzw. Effektschätzer)
NOTE: Weights are from random effects analysis Overall (I-squared = 23.8%, p = 0.089)
1.34 (1.18, 1.53) 28.27 (0.00, 99.99)
2.18 (0.26, 7.86) 0.62 (0.20, 1.45)
0.59 (0.08, 3.29) 1.32 (0.43, 3.07)
1.45 (1.06, 1.93) 1.29 (0.42, 3.91)
1.69 (1.05, 2.59) 1.34 (0.82, 2.07)
0.59 (0.06, 2.16)
1.11 (0.45, 2.29) 1.74 (1.05, 2.73) 16.65 (2.26, 122.50)
4.28 (0.25, 72.49)
5.30 (1.30, 21.40) 1.05 (0.81, 1.35)
1.56 (0.62, 3.23) 1.01 (0.20, 2.95)
3.57 (0.00, 20.47) 2.50 (0.00, 14.33) 3.13 (0.00, 17.91)
1.14 (0.93, 1.38) 1.37 (0.65, 2.60) 0.79 (0.21, 2.02)
0.32 (0.06, 0.95) 1.40 (0.75, 2.42) 1.85 (0.86, 3.98)
1.56 (0.75, 2.87) ES (95% CI)
0.39 (0.01, 2.19)
2.13 (1.50, 2.93)
3.29 (0.86, 8.51) 0.17 (0.03, 1.68) 1.14 (0.30, 2.95)
1.64 (0.15, 6.03) 0.16 (0.02, 1.53)
1.28 (0.74, 2.05)
1.33 (0.69, 2.32) 1.17 (0.83, 1.61) 0.52 (0.16, 1.64)
1.36 (0.53, 3.53) 1.73 (0.86, 5.51)
100.00
1.34 (1.18, 1.53) 28.27 (0.00, 99.99)
2.18 (0.26, 7.86) 0.62 (0.20, 1.45)
0.59 (0.08, 3.29) 1.32 (0.43, 3.07)
1.45 (1.06, 1.93) 1.29 (0.42, 3.91)
1.69 (1.05, 2.59) 1.34 (0.82, 2.07)
0.59 (0.06, 2.16)
1.11 (0.45, 2.29) 1.74 (1.05, 2.73) 16.65 (2.26, 122.50)
4.28 (0.25, 72.49)
5.30 (1.30, 21.40) 1.05 (0.81, 1.35)
1.56 (0.62, 3.23) 1.01 (0.20, 2.95)
3.57 (0.00, 20.47) 2.50 (0.00, 14.33) 3.13 (0.00, 17.91)
1.14 (0.93, 1.38) 1.37 (0.65, 2.60) 0.79 (0.21, 2.02)
0.32 (0.06, 0.95) 1.40 (0.75, 2.42) 1.85 (0.86, 3.98)
1.56 (0.75, 2.87) ES (95% CI)
0.39 (0.01, 2.19)
2.13 (1.50, 2.93)
3.29 (0.86, 8.51) 0.17 (0.03, 1.68) 1.14 (0.30, 2.95)
1.64 (0.15, 6.03) 0.16 (0.02, 1.53)
1.28 (0.74, 2.05)
1.33 (0.69, 2.32) 1.17 (0.83, 1.61) 0.52 (0.16, 1.64)
1.36 (0.53, 3.53) 1.73 (0.86, 5.51)
100.00
Anh. 5, Abb. 3 Forest Plot, Qualität (+) Studien (bzw. Effektschätzer)
NOTE: Weights are from random effects analysis Overall (I-squared = 16.0%, p = 0.214)
1.41 (1.20, 1.65) 1.37 (0.65, 2.60)
3.33 (0.08, 18.54)
1.11 (0.45, 2.29) 1.56 (0.04, 8.69)
1.30 (0.80, 1.90) 1.17 (0.83, 1.61)
0.79 (0.38, 1.45) 5.30 (1.30, 21.40) 3.30 (1.42, 6.50) 0.95 (0.02, 5.28)
5.67 (1.54, 14.52) 2.11 (0.05, 11.72) 1.50 (1.10, 2.20)
0.70 (0.02, 3.89) 1.36 (0.53, 3.53)
1.04 (0.22, 3.04) ES (95% CI)
1.30 (0.50, 2.60) 2.13 (0.58, 5.46) 1.36 (0.17, 4.91)
1.28 (0.74, 2.05) 0.62 (0.20, 1.45) 2.66 (0.32, 9.62) 0.50 (0.07, 4.86)
1.22 (0.33, 3.11)
10.00 (0.25, 55.60)
2.10 (1.00, 4.70) 1.85 (0.86, 3.98) 0.80 (0.40, 1.50)
1.47 (0.96, 2.24) 1.52 (0.61, 3.14) 0.70 (0.30, 1.70) 3.80 (1.30, 11.10)
100.00
1.41 (1.20, 1.65) 1.37 (0.65, 2.60)
3.33 (0.08, 18.54)
1.11 (0.45, 2.29) 1.56 (0.04, 8.69)
1.30 (0.80, 1.90) 1.17 (0.83, 1.61)
0.79 (0.38, 1.45) 5.30 (1.30, 21.40) 3.30 (1.42, 6.50) 0.95 (0.02, 5.28)
5.67 (1.54, 14.52) 2.11 (0.05, 11.72) 1.50 (1.10, 2.20)
0.70 (0.02, 3.89) 1.36 (0.53, 3.53)
1.04 (0.22, 3.04) ES (95% CI)
1.30 (0.50, 2.60) 2.13 (0.58, 5.46) 1.36 (0.17, 4.91)
1.28 (0.74, 2.05) 0.62 (0.20, 1.45) 2.66 (0.32, 9.62) 0.50 (0.07, 4.86)
1.22 (0.33, 3.11)
10.00 (0.25, 55.60)
2.10 (1.00, 4.70) 1.85 (0.86, 3.98) 0.80 (0.40, 1.50)
1.47 (0.96, 2.24) 1.52 (0.61, 3.14) 0.70 (0.30, 1.70) 3.80 (1.30, 11.10)
100.00
Anh. 5, Abb. 4 Forest Plot, Qualität (-) Studien (bzw. Effektschätzer)
NOTE: Weights are from random effects analysis Overall (I-squared = 31.4%, p = 0.010)
1.41 (1.27, 1.56) 2.30 (1.30, 3.80) 0.60 (0.20, 1.90)
0.79 (0.21, 2.02) 1.01 (0.20, 2.95)
2.18 (0.26, 7.86) 1.19 (0.78, 1.73)
1.56 (0.62, 3.23) 1.69 (1.05, 2.59)
15.40 (1.45, 56.58) 1.21 (1.04, 1.41)
1.45 (1.06, 1.93)
15.38 (1.45, 56.58) 3.13 (0.00, 17.91)
1.84 (1.07, 2.82)
1.05 (0.56, 1.80)
0.59 (0.08, 3.29) 1.05 (0.81, 1.35)
3.29 (0.86, 8.51) 0.52 (0.16, 1.64)
1.90 (0.18, 5.46)
1.80 (0.75, 4.32) 1.18 (0.78, 1.71)
1.21 (0.12, 4.60) 2.09 (1.14, 3.51) 4.35 (0.90, 12.71)
1.53 (0.42, 3.93) 0.17 (0.03, 1.68)
1.18 (0.38, 3.65) 2.67 (1.10, 6.10)
1.03 (0.54, 1.99) 1.14 (0.30, 2.95)
0.32 (0.06, 0.95)
2.10 (1.05, 3.76) 1.32 (0.43, 3.07) 16.65 (2.26, 122.50)
1.40 (0.75, 2.42) 2.50 (0.00, 14.33)
1.42 (0.17, 5.14) 0.96 (0.14, 9.35) 28.27 (0.00, 99.99)
1.14 (0.93, 1.38)
1.33 (0.69, 2.32)
1.30 (0.50, 3.20) ES (95% CI)
0.60 (0.00, 2.35) 2.91 (1.02, 8.33) 1.73 (0.86, 5.51)
1.64 (0.15, 6.03) 0.81 (0.17, 2.37) 2.13 (1.50, 2.93)
1.72 (0.63, 4.70) 3.57 (0.00, 20.47)
0.63 (0.21, 1.48) 1.41 (0.38, 3.62)
0.59 (0.06, 2.16)
1.57 (0.51, 4.87)
1.44 (0.82, 2.34)
1.56 (0.75, 2.87) 6.40 (0.80, 7.90) 1.29 (0.42, 3.91) 1.34 (0.82, 2.07)
4.28 (0.25, 72.49) 0.39 (0.01, 2.19)
1.29 (1.17, 1.43) 0.16 (0.02, 1.53)
1.74 (1.05, 2.73) 0.90 (0.40, 2.10)
100.00
1.41 (1.27, 1.56) 2.30 (1.30, 3.80) 0.60 (0.20, 1.90)
0.79 (0.21, 2.02) 1.01 (0.20, 2.95)
2.18 (0.26, 7.86) 1.19 (0.78, 1.73)
1.56 (0.62, 3.23) 1.69 (1.05, 2.59)
15.40 (1.45, 56.58) 1.21 (1.04, 1.41)
1.45 (1.06, 1.93)
15.38 (1.45, 56.58) 3.13 (0.00, 17.91)
1.84 (1.07, 2.82)
1.05 (0.56, 1.80)
0.59 (0.08, 3.29) 1.05 (0.81, 1.35)
3.29 (0.86, 8.51) 0.52 (0.16, 1.64)
1.90 (0.18, 5.46)
1.80 (0.75, 4.32) 1.18 (0.78, 1.71)
1.21 (0.12, 4.60) 2.09 (1.14, 3.51) 4.35 (0.90, 12.71)
1.53 (0.42, 3.93) 0.17 (0.03, 1.68)
1.18 (0.38, 3.65) 2.67 (1.10, 6.10)
1.03 (0.54, 1.99) 1.14 (0.30, 2.95)
0.32 (0.06, 0.95)
2.10 (1.05, 3.76) 1.32 (0.43, 3.07) 16.65 (2.26, 122.50)
1.40 (0.75, 2.42) 2.50 (0.00, 14.33)
1.42 (0.17, 5.14) 0.96 (0.14, 9.35) 28.27 (0.00, 99.99)
1.14 (0.93, 1.38)
1.33 (0.69, 2.32)
1.30 (0.50, 3.20) ES (95% CI)
0.60 (0.00, 2.35) 2.91 (1.02, 8.33) 1.73 (0.86, 5.51)
1.64 (0.15, 6.03) 0.81 (0.17, 2.37) 2.13 (1.50, 2.93)
1.72 (0.63, 4.70) 3.57 (0.00, 20.47)
0.63 (0.21, 1.48) 1.41 (0.38, 3.62)
0.59 (0.06, 2.16)
1.57 (0.51, 4.87)
1.44 (0.82, 2.34)
1.56 (0.75, 2.87) 6.40 (0.80, 7.90) 1.29 (0.42, 3.91) 1.34 (0.82, 2.07)
4.28 (0.25, 72.49) 0.39 (0.01, 2.19)
1.29 (1.17, 1.43) 0.16 (0.02, 1.53)
1.74 (1.05, 2.73) 0.90 (0.40, 2.10)
100.00
Anh. 5, Abb. 5 Forest Plot, Fall-Kontroll-Studien
NOTE: Weights are from random effects analysis Overall (I-squared = 55.1%, p = 0.005)
Zagraniski (1986) DeStefani (1998)
Zheng (1992) Shangina (2006) Maier (1992)
Gustavsson_hiPAH (1998)
Russi (1997) Muscat (1992)
Wortley (1992) Ahrens (1991)
Berrino (2003)
Imbernon (1995) Cauvin (1989) ID
Becher (2005)
Elci (2009) Study
1.55 (1.20, 2.00) 2.10 (1.00, 4.70) 0.80 (0.40, 1.50)
1.30 (0.50, 3.20) 1.72 (0.63, 4.70) 2.67 (1.10, 6.10) 1.47 (0.96, 2.24)
1.05 (0.81, 1.35) 6.40 (0.80, 7.90)
1.30 (0.50, 2.60) 0.60 (0.20, 1.90)
0.70 (0.30, 1.70)
2.30 (1.30, 3.80) 2.91 (1.02, 8.33) ES (95% CI)
3.80 (1.30, 11.10)
1.50 (1.10, 2.20)
100.00 6.29 7.44
5.03 4.51 5.57 10.50
12.84 3.74
5.84 3.84
5.48
8.95 4.24 Weight
4.12
11.60
%
1.55 (1.20, 2.00) 2.10 (1.00, 4.70) 0.80 (0.40, 1.50)
1.30 (0.50, 3.20) 1.72 (0.63, 4.70) 2.67 (1.10, 6.10) 1.47 (0.96, 2.24)
1.05 (0.81, 1.35) 6.40 (0.80, 7.90)
1.30 (0.50, 2.60) 0.60 (0.20, 1.90)
0.70 (0.30, 1.70)
2.30 (1.30, 3.80) 2.91 (1.02, 8.33) ES (95% CI)
3.80 (1.30, 11.10)
1.50 (1.10, 2.20)
100.00 6.29 7.44
5.03 4.51 5.57 10.50
12.84 3.74
5.84 3.84
5.48
8.95 4.24 Weight
4.12
11.60
%
1
.01 .1 1 10 100
Anh. 5, Abb. 6 Forest Plot, Kohortenstudien
NOTE: Weights are from random effects analysis Overall (I-squared = 18.4%, p = 0.080)
1.38 (1.27, 1.51) 1.03 (0.54, 1.99) 2.11 (0.05, 11.72) 1.41 (0.38, 3.62)
1.56 (0.75, 2.87) 1.30 (0.80, 1.90) 0.52 (0.16, 1.64) 1.34 (0.82, 2.07) 1.01 (0.20, 2.95)
0.16 (0.02, 1.53)
1.45 (1.06, 1.93) 1.29 (0.42, 3.91) 1.04 (0.22, 3.04)
2.09 (1.14, 3.51) 0.70 (0.02, 3.89) 2.13 (0.58, 5.46)
1.64 (0.15, 6.03)
1.56 (0.62, 3.23) 1.53 (0.42, 3.93) 0.81 (0.17, 2.37) 2.66 (0.32, 9.62)
4.35 (0.90, 12.71) 0.39 (0.01, 2.19)
1.05 (0.56, 1.80) 1.14 (0.30, 2.95)
0.63 (0.21, 1.48) 1.69 (1.05, 2.59)
1.44 (0.82, 2.34) 1.29 (1.17, 1.43) 1.80 (0.75, 4.32) 0.96 (0.14, 9.35) 2.50 (0.00, 14.33) 1.22 (0.33, 3.11)
3.57 (0.00, 20.47) 0.90 (0.40, 2.10)
0.17 (0.03, 1.68)
15.38 (1.45, 56.58) 0.32 (0.06, 0.95) 1.52 (0.61, 3.14) ES (95% CI)
1.17 (0.83, 1.61)
0.79 (0.38, 1.45) 1.40 (0.75, 2.42) 1.36 (0.17, 4.91)
0.59 (0.06, 2.16) 1.90 (0.18, 5.46)
0.62 (0.20, 1.45) 1.11 (0.45, 2.29)
3.29 (0.86, 8.51) 1.73 (0.86, 5.51)
0.60 (0.00, 2.35)
1.57 (0.51, 4.87) 1.37 (0.65, 2.60) 0.79 (0.21, 2.02)
28.27 (0.00, 99.99) 10.00 (0.25, 55.60) 5.67 (1.54, 14.52)
2.18 (0.26, 7.86) 1.28 (0.74, 2.05) 1.84 (1.07, 2.82)
1.42 (0.17, 5.14) 1.18 (0.78, 1.71)
2.13 (1.50, 2.93)
1.32 (0.43, 3.07) 1.36 (0.53, 3.53)
3.33 (0.08, 18.54)
4.28 (0.25, 72.49) 0.95 (0.02, 5.28)
5.30 (1.30, 21.40) 3.30 (1.42, 6.50)
15.40 (1.45, 56.58) 1.85 (0.86, 3.98)
1.21 (0.12, 4.60) 1.74 (1.05, 2.73) 0.50 (0.07, 4.86)
1.21 (1.04, 1.41) 1.56 (0.04, 8.69)
1.19 (0.78, 1.73)
2.10 (1.05, 3.76) 3.13 (0.00, 17.91)
1.18 (0.38, 3.65) 16.65 (2.26, 122.50)
0.59 (0.08, 3.29) 1.33 (0.69, 2.32) 1.14 (0.93, 1.38)
100.00
1.38 (1.27, 1.51) 1.03 (0.54, 1.99) 2.11 (0.05, 11.72) 1.41 (0.38, 3.62)
1.56 (0.75, 2.87) 1.30 (0.80, 1.90) 0.52 (0.16, 1.64) 1.34 (0.82, 2.07) 1.01 (0.20, 2.95)
0.16 (0.02, 1.53)
1.45 (1.06, 1.93) 1.29 (0.42, 3.91) 1.04 (0.22, 3.04)
2.09 (1.14, 3.51) 0.70 (0.02, 3.89) 2.13 (0.58, 5.46)
1.64 (0.15, 6.03)
1.56 (0.62, 3.23) 1.53 (0.42, 3.93) 0.81 (0.17, 2.37) 2.66 (0.32, 9.62)
4.35 (0.90, 12.71) 0.39 (0.01, 2.19)
1.05 (0.56, 1.80) 1.14 (0.30, 2.95)
0.63 (0.21, 1.48) 1.69 (1.05, 2.59)
1.44 (0.82, 2.34) 1.29 (1.17, 1.43) 1.80 (0.75, 4.32) 0.96 (0.14, 9.35) 2.50 (0.00, 14.33) 1.22 (0.33, 3.11)
3.57 (0.00, 20.47) 0.90 (0.40, 2.10)
0.17 (0.03, 1.68)
15.38 (1.45, 56.58) 0.32 (0.06, 0.95) 1.52 (0.61, 3.14) ES (95% CI)
1.17 (0.83, 1.61)
0.79 (0.38, 1.45) 1.40 (0.75, 2.42) 1.36 (0.17, 4.91)
0.59 (0.06, 2.16) 1.90 (0.18, 5.46)
0.62 (0.20, 1.45) 1.11 (0.45, 2.29)
3.29 (0.86, 8.51) 1.73 (0.86, 5.51)
0.60 (0.00, 2.35)
1.57 (0.51, 4.87) 1.37 (0.65, 2.60) 0.79 (0.21, 2.02)
28.27 (0.00, 99.99) 10.00 (0.25, 55.60) 5.67 (1.54, 14.52)
2.18 (0.26, 7.86) 1.28 (0.74, 2.05) 1.84 (1.07, 2.82)
1.42 (0.17, 5.14) 1.18 (0.78, 1.71)
2.13 (1.50, 2.93)
1.32 (0.43, 3.07) 1.36 (0.53, 3.53)
3.33 (0.08, 18.54)
4.28 (0.25, 72.49) 0.95 (0.02, 5.28)
5.30 (1.30, 21.40) 3.30 (1.42, 6.50)
15.40 (1.45, 56.58) 1.85 (0.86, 3.98)
1.21 (0.12, 4.60) 1.74 (1.05, 2.73) 0.50 (0.07, 4.86)
1.21 (1.04, 1.41) 1.56 (0.04, 8.69)
1.19 (0.78, 1.73)
2.10 (1.05, 3.76) 3.13 (0.00, 17.91)
1.18 (0.38, 3.65) 16.65 (2.26, 122.50)
0.59 (0.08, 3.29) 1.33 (0.69, 2.32) 1.14 (0.93, 1.38)
100.00
Anh. 5, Abb. 7 Forest Plot, Studien (bzw. Effektschätzer) nach Art der Effektschätzer
NOTE: Weights are from random effects analysis .
Subtotal (I-squared = 15.7%, p = 0.224) Kennaway_metal (1947)
Subtotal (I-squared = 41.5%, p = 0.091) Kennaway_gas (1947)
Subtotal (I-squared = 18.5%, p = 0.152) Tola (1988)
Subtotal (I-squared = 53.4%, p = 0.006)
Spinelli (2006)
1.41 (1.29, 1.53) 1.52 (0.61, 3.14)
1.85 (0.86, 3.98) 2.50 (0.00, 14.33)
1.18 (0.78, 1.71)
1.36 (0.53, 3.53) 0.62 (0.20, 1.45)
3.33 (0.08, 18.54) 1.05 (0.81, 1.35)
1.19 (0.78, 1.73) 0.79 (0.21, 2.02)
1.18 (0.38, 3.65) 1.28 (0.74, 2.05)
1.57 (0.51, 4.87)
1.64 (0.26, 10.24) 0.16 (0.02, 1.53)
1.22 (0.33, 3.11)
15.40 (1.45, 56.58) 1.32 (0.43, 3.07)
0.59 (0.08, 3.29) 1.34 (0.82, 2.07)
15.38 (1.45, 56.58) 1.34 (1.18, 1.53) 1.74 (1.05, 2.73) 2.67 (1.10, 6.10) 1.72 (0.63, 4.70)
5.30 (1.30, 21.40) 1.30 (0.50, 3.20)
1.05 (0.56, 1.80) 1.36 (0.17, 4.91)
1.21 (1.04, 1.41) 1.40 (0.75, 2.42)
0.17 (0.03, 1.68)
1.79 (1.05, 3.06) 0.59 (0.06, 2.16)
1.53 (0.42, 3.93) 10.00 (0.25, 55.60) 1.01 (0.20, 2.95)
1.21 (0.12, 4.60)
1.37 (0.65, 2.60) 0.52 (0.16, 1.64) 0.80 (0.40, 1.50)
3.13 (0.00, 17.91)
5.67 (1.54, 14.52) 0.70 (0.30, 1.70)
0.50 (0.07, 4.86)
1.29 (0.42, 3.91) 0.60 (0.00, 2.35)
1.30 (0.80, 1.90) 0.95 (0.02, 5.28)
1.04 (0.22, 3.04)
1.03 (0.54, 1.99) 1.14 (0.93, 1.38)
2.10 (1.05, 3.76) 1.56 (0.04, 8.69)
1.40 (1.24, 1.58) 0.63 (0.21, 1.48) 0.90 (0.40, 2.10) ES (95% CI)
1.11 (0.45, 2.29)
1.44 (0.82, 2.34) 1.56 (0.62, 3.23)
2.13 (0.58, 5.46)
2.09 (1.14, 3.51) 2.18 (0.26, 7.86)
0.70 (0.02, 3.89) 1.33 (0.69, 2.32) 3.80 (1.30, 11.10) 0.60 (0.20, 1.90)
1.17 (0.83, 1.61)
1.45 (1.06, 1.93)
0.81 (0.17, 2.37) 1.47 (0.96, 2.24)
4.35 (0.90, 12.71) 2.66 (0.32, 9.62)
16.65 (2.26, 122.50) 1.69 (1.05, 2.59)
1.42 (0.17, 5.14) 0.96 (0.14, 9.35) 3.57 (0.00, 20.47)
1.90 (0.18, 5.46) 1.14 (0.30, 2.95)
2.13 (1.50, 2.93)
3.30 (1.42, 6.50) 1.56 (0.75, 2.87) 0.39 (0.01, 2.19) 2.10 (1.00, 4.70)
1.73 (0.86, 5.51)
1.80 (0.75, 4.32)
1.29 (1.17, 1.43)
1.64 (0.15, 6.03)
28.27 (0.00, 99.99) 4.28 (0.25, 72.49) 1.84 (1.07, 2.82) 6.40 (0.80, 7.90)
1.50 (1.17, 1.92)
0.79 (0.38, 1.45) 0.32 (0.06, 0.95) 1.50 (1.10, 2.20) 2.91 (1.02, 8.33)
1.41 (0.38, 3.62)
2.11 (0.05, 11.72) 3.29 (0.86, 8.51) 2.30 (1.30, 3.80)
1.30 (0.50, 2.60)
100.00
1.41 (1.29, 1.53) 1.52 (0.61, 3.14)
1.85 (0.86, 3.98) 2.50 (0.00, 14.33)
1.18 (0.78, 1.71)
1.36 (0.53, 3.53) 0.62 (0.20, 1.45)
3.33 (0.08, 18.54) 1.05 (0.81, 1.35)
1.19 (0.78, 1.73) 0.79 (0.21, 2.02)
1.18 (0.38, 3.65) 1.28 (0.74, 2.05)
1.57 (0.51, 4.87)
1.64 (0.26, 10.24) 0.16 (0.02, 1.53)
1.22 (0.33, 3.11)
15.40 (1.45, 56.58) 1.32 (0.43, 3.07)
0.59 (0.08, 3.29) 1.34 (0.82, 2.07)
15.38 (1.45, 56.58) 1.34 (1.18, 1.53) 1.74 (1.05, 2.73) 2.67 (1.10, 6.10) 1.72 (0.63, 4.70)
5.30 (1.30, 21.40) 1.30 (0.50, 3.20)
1.05 (0.56, 1.80) 1.36 (0.17, 4.91)
1.21 (1.04, 1.41) 1.40 (0.75, 2.42)
0.17 (0.03, 1.68)
1.79 (1.05, 3.06) 0.59 (0.06, 2.16)
1.53 (0.42, 3.93) 10.00 (0.25, 55.60) 1.01 (0.20, 2.95)
1.21 (0.12, 4.60)
1.37 (0.65, 2.60) 0.52 (0.16, 1.64) 0.80 (0.40, 1.50)
3.13 (0.00, 17.91)
5.67 (1.54, 14.52) 0.70 (0.30, 1.70)
0.50 (0.07, 4.86)
1.29 (0.42, 3.91) 0.60 (0.00, 2.35)
1.30 (0.80, 1.90) 0.95 (0.02, 5.28)
1.04 (0.22, 3.04)
1.03 (0.54, 1.99) 1.14 (0.93, 1.38)
2.10 (1.05, 3.76) 1.56 (0.04, 8.69)
1.40 (1.24, 1.58) 0.63 (0.21, 1.48) 0.90 (0.40, 2.10) ES (95% CI)
1.11 (0.45, 2.29)
1.44 (0.82, 2.34) 1.56 (0.62, 3.23)
2.13 (0.58, 5.46)
2.09 (1.14, 3.51) 2.18 (0.26, 7.86)
0.70 (0.02, 3.89) 1.33 (0.69, 2.32) 3.80 (1.30, 11.10) 0.60 (0.20, 1.90)
1.17 (0.83, 1.61)
1.45 (1.06, 1.93)
0.81 (0.17, 2.37) 1.47 (0.96, 2.24)
4.35 (0.90, 12.71) 2.66 (0.32, 9.62)
16.65 (2.26, 122.50) 1.69 (1.05, 2.59)
1.42 (0.17, 5.14) 0.96 (0.14, 9.35) 3.57 (0.00, 20.47)
1.90 (0.18, 5.46) 1.14 (0.30, 2.95)
2.13 (1.50, 2.93)
3.30 (1.42, 6.50) 1.56 (0.75, 2.87) 0.39 (0.01, 2.19) 2.10 (1.00, 4.70)
1.73 (0.86, 5.51)
1.80 (0.75, 4.32)
1.29 (1.17, 1.43)
1.64 (0.15, 6.03)
28.27 (0.00, 99.99) 4.28 (0.25, 72.49) 1.84 (1.07, 2.82) 6.40 (0.80, 7.90)
1.50 (1.17, 1.92)
0.79 (0.38, 1.45) 0.32 (0.06, 0.95) 1.50 (1.10, 2.20) 2.91 (1.02, 8.33)
1.41 (0.38, 3.62)
2.11 (0.05, 11.72) 3.29 (0.86, 8.51) 2.30 (1.30, 3.80)
1.30 (0.50, 2.60)
100.00
Anh. 5, Abb. 8 Forest Plot, Studien (bzw. Effektschätzer) bei Frauen
NOTE: Weights are from random effects analysis .
.
Overall (I-squared = 24.2%, p = 0.199) Frauen
Eisen_2 (2001) Eisen_3 (2001)
Subtotal (I-squared = 0.0%, p = 0.434)
Pukkala_Fdruck (2009) Wortley (1992)
Aronson_F (1999)
Pukkala_Fkamin (2009) Männer u. Frauen ID
Becher (2005)
Solionova_F (1993) Ji_Fdruck (2005)
Subtotal (I-squared = 39.4%, p = 0.129) Gustavsson_elgrph (1995)
Eisen_1 (2001) Study
Pukkala_Fgießer (2009) Olsen_Fdruck (1987)
2.00 (1.40, 2.85) 1.36 (0.53, 3.53) 1.85 (0.86, 3.98)
1.70 (1.18, 2.45)
2.09 (1.14, 3.51) 1.30 (0.50, 2.60)
16.65 (2.26, 122.50)
0.96 (0.14, 9.35) ES (95% CI)
3.80 (1.30, 11.10)
15.40 (1.45, 56.58) 0.60 (0.00, 2.35)
2.59 (1.25, 5.36) 10.00 (0.25, 55.60) 1.37 (0.65, 2.60)
1.42 (0.17, 5.14) 1.57 (0.51, 4.87)
100.00 9.97 13.26
60.18
18.59 12.07
2.88
2.65 Weight
8.31
3.37 0.81
39.82 1.63 14.94
%
3.84 7.68
2.00 (1.40, 2.85) 1.36 (0.53, 3.53) 1.85 (0.86, 3.98)
1.70 (1.18, 2.45)
2.09 (1.14, 3.51) 1.30 (0.50, 2.60)
16.65 (2.26, 122.50)
0.96 (0.14, 9.35) ES (95% CI)
3.80 (1.30, 11.10)
15.40 (1.45, 56.58) 0.60 (0.00, 2.35)
2.59 (1.25, 5.36) 10.00 (0.25, 55.60) 1.37 (0.65, 2.60)
1.42 (0.17, 5.14) 1.57 (0.51, 4.87)
100.00 9.97 13.26
60.18
18.59 12.07
2.88
2.65 Weight
8.31
3.37 0.81
39.82 1.63 14.94
%
3.84 7.68
1
.01 .1 1 10 100
Anh. 5, Abb. 9 Forest Plot, Studien (bzw. Effektschätzer) bei Männern
NOTE: Weights are from random effects analysis Overall (I-squared = 23.3%, p = 0.032)
1.37 (1.26, 1.49) 1.64 (0.15, 6.03) 1.29 (0.42, 3.91)
1.30 (0.80, 1.90) 2.91 (1.02, 8.33)
1.44 (0.82, 2.34) 1.17 (0.83, 1.61)
5.30 (1.30, 21.40) 1.52 (0.61, 3.14) 2.66 (0.32, 9.62)
1.05 (0.81, 1.35) 3.57 (0.00, 20.47)
2.67 (1.10, 6.10) 1.19 (0.78, 1.73)
2.10 (1.05, 3.76) 0.80 (0.40, 1.50)
3.30 (1.42, 6.50) 1.41 (0.38, 3.62) 0.16 (0.02, 1.53)
2.18 (0.26, 7.86) 1.74 (1.05, 2.73) 0.59 (0.06, 2.16)
0.81 (0.17, 2.37) 1.22 (0.33, 3.11) 1.14 (0.30, 2.95)
1.90 (0.18, 5.46) 1.36 (0.17, 4.91)
1.29 (1.17, 1.43) 2.13 (0.58, 5.46)
1.69 (1.05, 2.59) 0.95 (0.02, 5.28)
1.30 (0.50, 3.20) 0.62 (0.20, 1.45) 0.52 (0.16, 1.64)
1.45 (1.06, 1.93) 0.17 (0.03, 1.68) 1.32 (0.43, 3.07) 1.84 (1.07, 2.82) 0.39 (0.01, 2.19)
4.35 (0.90, 12.71)
15.38 (1.45, 56.58) 4.28 (0.25, 72.49)
2.13 (1.50, 2.93)
1.53 (0.42, 3.93)
2.10 (1.00, 4.70) 6.40 (0.80, 7.90) 1.11 (0.45, 2.29)
1.05 (0.56, 1.80) 1.18 (0.78, 1.71)
1.14 (0.93, 1.38)
3.29 (0.86, 8.51) ES (95% CI)
0.90 (0.40, 2.10)
0.32 (0.06, 0.95) 5.67 (1.54, 14.52) 3.13 (0.00, 17.91)
1.56 (0.62, 3.23) 3.33 (0.08, 18.54)
1.04 (0.22, 3.04) 2.11 (0.05, 11.72)
1.28 (0.74, 2.05)
1.80 (0.75, 4.32) 2.50 (0.00, 14.33) 1.47 (0.96, 2.24)
1.03 (0.54, 1.99)
1.18 (0.38, 3.65) 0.70 (0.02, 3.89)
28.27 (0.00, 99.99) 1.56 (0.04, 8.69)
1.21 (1.04, 1.41)
1.72 (0.63, 4.70) 1.50 (1.10, 2.20)
1.21 (0.12, 4.60) 1.40 (0.75, 2.42) 1.01 (0.20, 2.95)
0.59 (0.08, 3.29) 0.63 (0.21, 1.48) 0.50 (0.07, 4.86) 0.70 (0.30, 1.70) 1.34 (0.82, 2.07)
0.79 (0.21, 2.02)
1.33 (0.69, 2.32) 1.73 (0.86, 5.51) 0.60 (0.20, 1.90)
0.79 (0.38, 1.45) 2.30 (1.30, 3.80)
1.56 (0.75, 2.87)
100.00
1.37 (1.26, 1.49) 1.64 (0.15, 6.03) 1.29 (0.42, 3.91)
1.30 (0.80, 1.90) 2.91 (1.02, 8.33)
1.44 (0.82, 2.34) 1.17 (0.83, 1.61)
5.30 (1.30, 21.40) 1.52 (0.61, 3.14) 2.66 (0.32, 9.62)
1.05 (0.81, 1.35) 3.57 (0.00, 20.47)
2.67 (1.10, 6.10) 1.19 (0.78, 1.73)
2.10 (1.05, 3.76) 0.80 (0.40, 1.50)
3.30 (1.42, 6.50) 1.41 (0.38, 3.62) 0.16 (0.02, 1.53)
2.18 (0.26, 7.86) 1.74 (1.05, 2.73) 0.59 (0.06, 2.16)
0.81 (0.17, 2.37) 1.22 (0.33, 3.11) 1.14 (0.30, 2.95)
1.90 (0.18, 5.46) 1.36 (0.17, 4.91)
1.29 (1.17, 1.43) 2.13 (0.58, 5.46)
1.69 (1.05, 2.59) 0.95 (0.02, 5.28)
1.30 (0.50, 3.20) 0.62 (0.20, 1.45) 0.52 (0.16, 1.64)
1.45 (1.06, 1.93) 0.17 (0.03, 1.68) 1.32 (0.43, 3.07) 1.84 (1.07, 2.82) 0.39 (0.01, 2.19)
4.35 (0.90, 12.71)
15.38 (1.45, 56.58) 4.28 (0.25, 72.49)
2.13 (1.50, 2.93)
1.53 (0.42, 3.93)
2.10 (1.00, 4.70) 6.40 (0.80, 7.90) 1.11 (0.45, 2.29)
1.05 (0.56, 1.80) 1.18 (0.78, 1.71)
1.14 (0.93, 1.38)
3.29 (0.86, 8.51) ES (95% CI)
0.90 (0.40, 2.10)
0.32 (0.06, 0.95) 5.67 (1.54, 14.52) 3.13 (0.00, 17.91)
1.56 (0.62, 3.23) 3.33 (0.08, 18.54)
1.04 (0.22, 3.04) 2.11 (0.05, 11.72)
1.28 (0.74, 2.05)
1.80 (0.75, 4.32) 2.50 (0.00, 14.33) 1.47 (0.96, 2.24)
1.03 (0.54, 1.99)
1.18 (0.38, 3.65) 0.70 (0.02, 3.89)
28.27 (0.00, 99.99) 1.56 (0.04, 8.69)
1.21 (1.04, 1.41)
1.72 (0.63, 4.70) 1.50 (1.10, 2.20)
1.21 (0.12, 4.60) 1.40 (0.75, 2.42) 1.01 (0.20, 2.95)
0.59 (0.08, 3.29) 0.63 (0.21, 1.48) 0.50 (0.07, 4.86) 0.70 (0.30, 1.70) 1.34 (0.82, 2.07)
0.79 (0.21, 2.02)
1.33 (0.69, 2.32) 1.73 (0.86, 5.51) 0.60 (0.20, 1.90)
0.79 (0.38, 1.45) 2.30 (1.30, 3.80)
1.56 (0.75, 2.87)
100.00
Anh. 5, Abb. 10 Forest Plot, Studien (bzw. Effektschätzer): Aluminium-Herstellung
NOTE: Weights are from random effects analysis Overall (I-squared = 0.0%, p = 0.520)
1.43 (1.13, 1.80) 1.36 (0.17, 4.91) 3.30 (1.42, 6.50)
2.50 (0.00, 14.33)
1.18 (0.38, 3.65) ES (95% CI)
2.66 (0.32, 9.62)
2.13 (0.58, 5.46)
0.79 (0.38, 1.45) 2.11 (0.05, 11.72)
1.30 (0.80, 1.90) 3.33 (0.08, 18.54)
1.04 (0.22, 3.04) 1.52 (0.61, 3.14)
1.22 (0.33, 3.11) 0.95 (0.02, 5.28)
0.70 (0.02, 3.89)
1.11 (0.45, 2.29) 0.81 (0.17, 2.37) 0.50 (0.07, 4.86)
5.67 (1.54, 14.52) 1.56 (0.04, 8.69)
100.00
1.43 (1.13, 1.80) 1.36 (0.17, 4.91) 3.30 (1.42, 6.50)
2.50 (0.00, 14.33)
1.18 (0.38, 3.65) ES (95% CI)
2.66 (0.32, 9.62)
2.13 (0.58, 5.46)
0.79 (0.38, 1.45) 2.11 (0.05, 11.72)
1.30 (0.80, 1.90) 3.33 (0.08, 18.54)
1.04 (0.22, 3.04) 1.52 (0.61, 3.14)
1.22 (0.33, 3.11) 0.95 (0.02, 5.28)
0.70 (0.02, 3.89)
1.11 (0.45, 2.29) 0.81 (0.17, 2.37) 0.50 (0.07, 4.86)
5.67 (1.54, 14.52) 1.56 (0.04, 8.69)
100.00
Anh. 5, Abb. 11 Forest Plot, Studien (bzw. Effektschätzer) : Asphalt/Teer-Exponierte
NOTE: Weights are from random effects analysis Overall (I-squared = 51.0%, p = 0.021)
Zheng (1992)
Kennaway_asphalt (1947) ID
Hansen (1989)
Swaen_teer (1997) Moulin (1988) Ahrens (1991)
Kennaway_teer (1947) Boffetta (2003)
Imbernon (1995)
Stern (2000) DeStefani (1998)
Maier (1992) Study
1.30 (0.95, 1.78) 1.30 (0.50, 3.20) 1.40 (0.75, 2.42) ES (95% CI)
4.35 (0.90, 12.71)
0.59 (0.08, 3.29) 0.17 (0.03, 1.68) 0.60 (0.20, 1.90)
0.32 (0.06, 0.95) 1.34 (0.82, 2.07)
2.30 (1.30, 3.80)
1.45 (1.06, 1.93) 0.80 (0.40, 1.50)
2.67 (1.10, 6.10)
100.00 7.28 11.80 Weight
4.38
2.49 2.02 5.60
4.12 13.98
12.66
17.00 10.62
8.04
%
1.30 (0.95, 1.78) 1.30 (0.50, 3.20) 1.40 (0.75, 2.42) ES (95% CI)
4.35 (0.90, 12.71)
0.59 (0.08, 3.29) 0.17 (0.03, 1.68) 0.60 (0.20, 1.90)
0.32 (0.06, 0.95) 1.34 (0.82, 2.07)
2.30 (1.30, 3.80)
1.45 (1.06, 1.93) 0.80 (0.40, 1.50)
2.67 (1.10, 6.10)
100.00 7.28 11.80 Weight
4.38
2.49 2.02 5.60
4.12 13.98
12.66
17.00 10.62
8.04
%
1
.01 .1 1 10 100
Anh. 5, Abb. 12 Forest Plot, Studien (bzw. Effektschätzer): Drucker
Anh. 5, Abb. 13 Forest Plot, Studien (bzw. Effektschätzer): Electrographit-Herstellung
NOTE: Weights are from random effects analysis Overall (I-squared = 4.2%, p = 0.398)
ID
Olsen_Fdruck (1987)
Pukkala_Mdruck (2009) Kennaway_druck (1947) Kvam (2005)
Pukkala_Fdruck (2009) Ji_Mdruck (2005)
Olsen_Mdruck (1987) Study
Ji_Fdruck (2005)
1.24 (1.10, 1.39) ES (95% CI)
1.57 (0.51, 4.87)
1.21 (1.04, 1.41) 1.14 (0.93, 1.38) 1.19 (0.78, 1.73)
2.09 (1.14, 3.51) 1.84 (1.07, 2.82)
1.03 (0.54, 1.99) 0.60 (0.00, 2.35)
100.00 Weight
1.06
47.19 30.47 8.23
4.20 5.62
3.14
%
0.09
1.24 (1.10, 1.39) ES (95% CI)
1.57 (0.51, 4.87)
1.21 (1.04, 1.41) 1.14 (0.93, 1.38) 1.19 (0.78, 1.73)
2.09 (1.14, 3.51) 1.84 (1.07, 2.82)
1.03 (0.54, 1.99) 0.60 (0.00, 2.35)
100.00 Weight
1.06
47.19 30.47 8.23
4.20 5.62
3.14
%
0.09
1
.01 .1 1 10 100
NOTE: Weights are from random effects analysis Overall (I-squared = 31.4%, p = 0.233)
Study
Donato (2000) ID
Gustavsson_elgrph (1995)
Merlo (2004)
1.33 (0.52, 3.38) 0.79 (0.21, 2.02) ES (95% CI)
10.00 (0.25, 55.60)
1.32 (0.43, 3.07)
100.00
%
41.07 Weight
10.73
48.21
1.33 (0.52, 3.38) 0.79 (0.21, 2.02) ES (95% CI)
10.00 (0.25, 55.60)
1.32 (0.43, 3.07)
100.00
%
41.07 Weight
10.73
48.21
1
.01 .1 1 10 100
Anh. 5, Abb. 14 Forest Plot, Studien (bzw. Effektschätzer): Gießerei
NOTE: Weights are from random effects analysis Overall (I-squared = 0.0%, p = 0.885)
1.27 (1.16, 1.38) 1.33 (0.69, 2.32) 0.90 (0.40, 2.10)
1.29 (1.17, 1.43)
1.44 (0.82, 2.34) 4.28 (0.25, 72.49)
1.64 (0.15, 6.03) 1.42 (0.17, 5.14) 0.39 (0.01, 2.19) 1.01 (0.20, 2.95) ES (95% CI)
1.28 (0.74, 2.05) 28.27 (0.00, 99.99) 1.73 (0.86, 5.51)
1.17 (0.83, 1.61)
0.62 (0.20, 1.45) 1.18 (0.78, 1.71) 1.14 (0.30, 2.95) 1.29 (0.42, 3.91) 0.16 (0.02, 1.53)
100.00
1.27 (1.16, 1.38) 1.33 (0.69, 2.32) 0.90 (0.40, 2.10)
1.29 (1.17, 1.43)
1.44 (0.82, 2.34) 4.28 (0.25, 72.49)
1.64 (0.15, 6.03) 1.42 (0.17, 5.14) 0.39 (0.01, 2.19) 1.01 (0.20, 2.95) ES (95% CI)
1.28 (0.74, 2.05) 28.27 (0.00, 99.99) 1.73 (0.86, 5.51)
1.17 (0.83, 1.61)
0.62 (0.20, 1.45) 1.18 (0.78, 1.71) 1.14 (0.30, 2.95) 1.29 (0.42, 3.91) 0.16 (0.02, 1.53)
100.00
Anh. 5, Abb. 15 Forest Plot, Studien (bzw. Effektschätzer): Gummi-Herstellung
NOTE: Weights are from random effects analysis Overall (I-squared = 39.1%, p = 0.118) Muscat (1992)
Veys (2004) Solionova_F (1993)
Wingren (2007) Straif (2000) ID
Solionova_M (1993) Olsen_Mgummi (1987)
Szeszenia (1991) Study
2.41 (1.54, 3.79) 6.40 (0.80, 7.90)
1.56 (0.75, 2.87) 15.40 (1.45, 56.58)
2.10 (1.05, 3.76) 5.30 (1.30, 21.40) ES (95% CI)
1.21 (0.12, 4.60) 1.80 (0.75, 4.32)
1.56 (0.62, 3.23)
100.00 10.71
19.57 5.16
20.42 7.98 Weight
5.16 15.01
15.98
%
2.41 (1.54, 3.79) 6.40 (0.80, 7.90)
1.56 (0.75, 2.87) 15.40 (1.45, 56.58)
2.10 (1.05, 3.76) 5.30 (1.30, 21.40) ES (95% CI)
1.21 (0.12, 4.60) 1.80 (0.75, 4.32)
1.56 (0.62, 3.23)
100.00 10.71
19.57 5.16
20.42 7.98 Weight
5.16 15.01
15.98
%
1
.01 .1 1 10 100
Anh. 5, Abb. 16 Forest Plot, Studien (bzw. Effektschätzer): Kokereiarbeiter
NOTE: Weights are from random effects analysis Overall (I-squared = 0.0%, p = 0.476) Study
Swaen_kokerei (1991) Kennaway_kokerei (1947) ID
2.20 (1.60, 3.04) 3.29 (0.86, 8.51) 2.13 (1.50, 2.93) ES (95% CI)
100.00
%
7.91 92.09 Weight
2.20 (1.60, 3.04) 3.29 (0.86, 8.51) 2.13 (1.50, 2.93) ES (95% CI)
100.00
%
7.91 92.09 Weight
1
.01 .1 1 10 100
Anh. 5, Abb. 17 Forest Plot, Studien (bzw. Effektschätzer): MWF- Exponierte/Automobil-Herstellung
NOTE: Weights are from random effects analysis Overall (I-squared = 58.4%, p = 0.006)
Eisen_2 (2001) Eisen_1 (2001)
Eisen_3 (2001)
Waldron (1975) ID
Aronson_F (1999)
Tola (1988)
Kennaway_metal (1947)
Wortley (1992) Cauvin (1989) Aronson_M (1999)
Zagraniski (1986) Russi (1997) Study
1.55 (1.10, 2.20) 1.36 (0.53, 3.53) 1.37 (0.65, 2.60)
1.85 (0.86, 3.98)
15.38 (1.45, 56.58) ES (95% CI)
16.65 (2.26, 122.50)
0.63 (0.21, 1.48) 1.74 (1.05, 2.73)
1.30 (0.50, 2.60) 2.91 (1.02, 8.33) 0.52 (0.16, 1.64)
2.10 (1.00, 4.70) 1.05 (0.81, 1.35)
100.00 7.59 10.29
9.44
2.98 Weight
2.58
7.34 13.10
8.80 6.73 5.90
9.35 15.92
%
1.55 (1.10, 2.20) 1.36 (0.53, 3.53) 1.37 (0.65, 2.60)
1.85 (0.86, 3.98)
15.38 (1.45, 56.58) ES (95% CI)
16.65 (2.26, 122.50)
0.63 (0.21, 1.48) 1.74 (1.05, 2.73)
1.30 (0.50, 2.60) 2.91 (1.02, 8.33) 0.52 (0.16, 1.64)
2.10 (1.00, 4.70) 1.05 (0.81, 1.35)
100.00 7.59 10.29
9.44
2.98 Weight
2.58
7.34 13.10
8.80 6.73 5.90
9.35 15.92
%
1
.01 .1 1 10 100
Anh. 5, Abb. 18 Forest Plot, Studien (bzw. Effektschätzer): Schornsteinfeger
NOTE: Weights are from random effects analysis Overall (I-squared = 0.0%, p = 0.852) Ji_Mkamin (2005)
ID
Grimm (1987) Evanoff (1993)
Pukkala_Fkamin (2009) Kennaway_kamin (1947)
Pukkala_Mkamin (2009) Study
1.42 (1.02, 1.98) 1.90 (0.18, 5.46) ES (95% CI)
3.57 (0.00, 20.47) 1.41 (0.38, 3.62)
0.96 (0.14, 9.35) 1.69 (1.05, 2.59)
1.05 (0.56, 1.80)
100.00 3.74 Weight
0.47 8.56
2.49 52.84
31.90
%
1.42 (1.02, 1.98) 1.90 (0.18, 5.46) ES (95% CI)
3.57 (0.00, 20.47) 1.41 (0.38, 3.62)
0.96 (0.14, 9.35) 1.69 (1.05, 2.59)
1.05 (0.56, 1.80)
100.00 3.74 Weight
0.47 8.56
2.49 52.84
31.90
%
1
.01 .1 1 10 100
Danksagung
Wir möchten uns bei Claudia Fenz'l, Dr. Frank Thalau, Dr. Angela Neumeyer-Gromen und Mario Müller für ihre wertvolle Unterstützung bedanken. Unser Dank gilt auch Dr.
Gabriele Menzel und Soja Nazarov für die kompetente Beteiligung an der Entwick-lung und Umsetzung des Suchstrings. Besonders gedankt sei Prof. Peter Schlatt-mann für die Unterstützung bei der Metaanalyse sowie Verena-Maria Weihofen für die Koordination der Erstellung des Abschlussberichts.