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Folgender Anhang beinhaltet Forest Plots mit Heterogenitätstatistik (I2) sowie eine Auswahl der in Tabelle [Tab. 4.1] gelisteten Subgruppen bzw. Subgruppenanalysen.

Einige Studien untersuchten mehrere unterschiedliche Personengruppen von beruflich PAH-Exponierten; aus diesen Studien gingen mehrere Effektschätzer in die Metaanalyse ein. Die nachfolgende Legende dient der eindeutigen Identifizierung die in den Forest Plots dargestellten Schätzern bei Studien, von denen mehrere Effektschätzer in die Metaanalyse eingingen.

Anh. 5, Tab. 1 Kennzeichnungs-Legende7

Effektschätzer Bezeichnung Bedeutung

Eisen_1 MWF 0-1 [mg/m³] x Jahre

Eisen_2 >1-3 [mg/m³] x Jahre

Eisen_3 >3 [mg/m³] x Jahre

Gibbs_50-a1 Fabrik A, vor 1950, BaP 20-<40 (µg/m3) x Jahre Gibbs_50-a2 Fabrik A, vor 1950, BaP 40-<80 (µg/m3) x Jahre Gibbs_50-a3 Fabrik A, vor 1950, BaP 80-<160 (µg/m3) x Jahre Gibbs_50-a4 Fabrik A, vor 1950, BaP 160-<320 (µg/m3) x Jahre Gibbs_50-a5 Fabrik A, vor 1950, BaP >=320 (µg/m3) x Jahre Gibbs_50+a1 Fabrik A, nach 1950, BaP 20-<40 (µg/m3) x Jahre Gibbs_50+a2 Fabrik A, nach 1950, BaP 40-<80 (µg/m3) x Jahre Gibbs_50+a3 Fabrik A, nach 1950, BaP 80-<160 (µg/m3) x Jahre Gibbs_50+a4 Fabrik A, nach 1950, BaP 160-<320 (µg/m3) x Jahre Gibbs_50+a5 Fabrik A, nach 1950, BaP >=320 (µg/m3) x Jahre

Gibbs_50-b Fabrik B, vor 1950

Gibbs_50+b Fabrik B, nach 1950

Gibbs_50-c Fabrik C, vor 1950

Gibbs_50+c Fabrik C, nach 1950

Gustavsson_elgrph Elektrographitherstellung Gustavsson_hiPAH hohe PAH-Exposition

Moulin_a Fabrik A

Moulin_b Fabrik B

Moulin_alu Aluminiumindustrie

Kennaway_metal Metallschleifer

AndjelkovichWgießer Gießereiarbeiter (white men) AndjelkovichNgießer Gießereiarbeiter (non-white men)

Aronson_F Frauen

7 Für Studien die mehrere Effektschätzer berichteten (z.B. für mehrere Berufe, Expositionen) sind Zusatzabkürzungen am Name des Erstautors hinzugefügt worden.

Effektschätzer Bezeichnung Bedeutung

Aronson_M Männer

Cornell_NiCr Ni/Cr Gießer

Cornell_Stahl Stahl Herstellung Kennaway_kamin Schornsteinfeger Hoshuyama_0Stb 0 Staubarten Hoshuyama_1Stb 1 Staubarten

Hoshuyama_2Stb 2 oder mehr Staubarten Ji_Mkamin Schornsteinfeger (Männer)

Ji_Fdruck Drucker (Frauen)

Ji_Mdruck Drucker (Männer)

Kennaway_gas Gas-Hersteller

Kennaway_teer Steinkohlenteer-raffinerien und Kokereien Kennaway_asphalt Straßenbauarbeiter und Asphaltierer Kennaway_metal Metallschleifer

Kennaway_kamin Schornsteinfeger

Kennaway_kokerei Bediener der Kohlebeschickungsvorrichtung in der Herstellung von Stadtgas sowie Bediener der Befüllungseinrichtung in Kokereien

Kennaway_druck Drucker

Olsen_Fdruck Drucker (Frauen)

Olsen_Mgummi Gummi-Herstellung (Männer) Olsen_Mdruck Drucker (Männer)

Pukkala_Fdruck Drucker (Frauen)

Pukkala_Fgießer Gießereiarbeiter (Frauen) Pukkala_Mkamin Schornsteinfeger (Männer) Pukkala_Fdruck Drucker (Frauen)

Pukkala_Mdruck Drucker (Männer)

Pukkala_Mgießer Gießereiarbeiter (Männer) Olsen_Mgummi Gummi-Herstellung (Männer)

Solionova_F Frauen

Swaen_teer Teerschwelerei, Dachdecker Swaen_kokerei Kokereiarbeiter

Anh. 5, Abb. 1 Forest Plot, Inzidenz Studien (bzw. Effektschätzer)

NOTE: Weights are from random effects analysis Overall (I-squared = 29.3%, p = 0.022)

1.47 (1.31, 1.65) 1.05 (0.56, 1.80) 0.80 (0.40, 1.50)

2.10 (1.05, 3.76) 1.03 (0.54, 1.99)

2.10 (1.00, 4.70) 0.81 (0.17, 2.37) 2.66 (0.32, 9.62)

2.30 (1.30, 3.80)

1.30 (0.80, 1.90)

1.30 (0.50, 3.20) 15.40 (1.45, 56.58) 1.18 (0.38, 3.65) 2.11 (0.05, 11.72)

1.44 (0.82, 2.34) 0.70 (0.02, 3.89) 0.50 (0.07, 4.86)

1.53 (0.42, 3.93) 3.33 (0.08, 18.54)

15.38 (1.45, 56.58) 0.90 (0.40, 2.10)

4.35 (0.90, 12.71)

1.42 (0.17, 5.14) 1.36 (0.17, 4.91)

1.80 (0.75, 4.32) 2.09 (1.14, 3.51) 1.47 (0.96, 2.24) 1.22 (0.33, 3.11)

2.67 (1.10, 6.10) 1.57 (0.51, 4.87)

0.79 (0.38, 1.45) 0.63 (0.21, 1.48) 0.60 (0.00, 2.35) ES (95% CI)

1.19 (0.78, 1.73) 1.41 (0.38, 3.62) 3.80 (1.30, 11.10)

1.56 (0.04, 8.69)

1.21 (0.12, 4.60) 1.04 (0.22, 3.04)

1.90 (0.18, 5.46)

0.96 (0.14, 9.35) 3.30 (1.42, 6.50)

6.40 (0.80, 7.90) 5.67 (1.54, 14.52)

1.29 (1.17, 1.43) 2.13 (0.58, 5.46) 0.70 (0.30, 1.70)

1.72 (0.63, 4.70) 1.52 (0.61, 3.14)

1.21 (1.04, 1.41) 1.18 (0.78, 1.71) 1.50 (1.10, 2.20)

1.84 (1.07, 2.82) 2.91 (1.02, 8.33)

10.00 (0.25, 55.60) 0.95 (0.02, 5.28) 0.60 (0.20, 1.90)

1.30 (0.50, 2.60)

100.00 1.47 (1.31, 1.65) 1.05 (0.56, 1.80) 0.80 (0.40, 1.50)

2.10 (1.05, 3.76) 1.03 (0.54, 1.99)

2.10 (1.00, 4.70) 0.81 (0.17, 2.37) 2.66 (0.32, 9.62)

2.30 (1.30, 3.80)

1.30 (0.80, 1.90)

1.30 (0.50, 3.20) 15.40 (1.45, 56.58) 1.18 (0.38, 3.65) 2.11 (0.05, 11.72)

1.44 (0.82, 2.34) 0.70 (0.02, 3.89) 0.50 (0.07, 4.86)

1.53 (0.42, 3.93) 3.33 (0.08, 18.54)

15.38 (1.45, 56.58) 0.90 (0.40, 2.10)

4.35 (0.90, 12.71)

1.42 (0.17, 5.14) 1.36 (0.17, 4.91)

1.80 (0.75, 4.32) 2.09 (1.14, 3.51) 1.47 (0.96, 2.24) 1.22 (0.33, 3.11)

2.67 (1.10, 6.10) 1.57 (0.51, 4.87)

0.79 (0.38, 1.45) 0.63 (0.21, 1.48) 0.60 (0.00, 2.35) ES (95% CI)

1.19 (0.78, 1.73) 1.41 (0.38, 3.62) 3.80 (1.30, 11.10)

1.56 (0.04, 8.69)

1.21 (0.12, 4.60) 1.04 (0.22, 3.04)

1.90 (0.18, 5.46)

0.96 (0.14, 9.35) 3.30 (1.42, 6.50)

6.40 (0.80, 7.90) 5.67 (1.54, 14.52)

1.29 (1.17, 1.43) 2.13 (0.58, 5.46) 0.70 (0.30, 1.70)

1.72 (0.63, 4.70) 1.52 (0.61, 3.14)

1.21 (1.04, 1.41) 1.18 (0.78, 1.71) 1.50 (1.10, 2.20)

1.84 (1.07, 2.82) 2.91 (1.02, 8.33)

10.00 (0.25, 55.60) 0.95 (0.02, 5.28) 0.60 (0.20, 1.90)

1.30 (0.50, 2.60)

100.00

Anh. 5, Abb. 2 Forest Plot, Mortalität Studien (bzw. Effektschätzer)

NOTE: Weights are from random effects analysis Overall (I-squared = 23.8%, p = 0.089)

1.34 (1.18, 1.53) 28.27 (0.00, 99.99)

2.18 (0.26, 7.86) 0.62 (0.20, 1.45)

0.59 (0.08, 3.29) 1.32 (0.43, 3.07)

1.45 (1.06, 1.93) 1.29 (0.42, 3.91)

1.69 (1.05, 2.59) 1.34 (0.82, 2.07)

0.59 (0.06, 2.16)

1.11 (0.45, 2.29) 1.74 (1.05, 2.73) 16.65 (2.26, 122.50)

4.28 (0.25, 72.49)

5.30 (1.30, 21.40) 1.05 (0.81, 1.35)

1.56 (0.62, 3.23) 1.01 (0.20, 2.95)

3.57 (0.00, 20.47) 2.50 (0.00, 14.33) 3.13 (0.00, 17.91)

1.14 (0.93, 1.38) 1.37 (0.65, 2.60) 0.79 (0.21, 2.02)

0.32 (0.06, 0.95) 1.40 (0.75, 2.42) 1.85 (0.86, 3.98)

1.56 (0.75, 2.87) ES (95% CI)

0.39 (0.01, 2.19)

2.13 (1.50, 2.93)

3.29 (0.86, 8.51) 0.17 (0.03, 1.68) 1.14 (0.30, 2.95)

1.64 (0.15, 6.03) 0.16 (0.02, 1.53)

1.28 (0.74, 2.05)

1.33 (0.69, 2.32) 1.17 (0.83, 1.61) 0.52 (0.16, 1.64)

1.36 (0.53, 3.53) 1.73 (0.86, 5.51)

100.00

1.34 (1.18, 1.53) 28.27 (0.00, 99.99)

2.18 (0.26, 7.86) 0.62 (0.20, 1.45)

0.59 (0.08, 3.29) 1.32 (0.43, 3.07)

1.45 (1.06, 1.93) 1.29 (0.42, 3.91)

1.69 (1.05, 2.59) 1.34 (0.82, 2.07)

0.59 (0.06, 2.16)

1.11 (0.45, 2.29) 1.74 (1.05, 2.73) 16.65 (2.26, 122.50)

4.28 (0.25, 72.49)

5.30 (1.30, 21.40) 1.05 (0.81, 1.35)

1.56 (0.62, 3.23) 1.01 (0.20, 2.95)

3.57 (0.00, 20.47) 2.50 (0.00, 14.33) 3.13 (0.00, 17.91)

1.14 (0.93, 1.38) 1.37 (0.65, 2.60) 0.79 (0.21, 2.02)

0.32 (0.06, 0.95) 1.40 (0.75, 2.42) 1.85 (0.86, 3.98)

1.56 (0.75, 2.87) ES (95% CI)

0.39 (0.01, 2.19)

2.13 (1.50, 2.93)

3.29 (0.86, 8.51) 0.17 (0.03, 1.68) 1.14 (0.30, 2.95)

1.64 (0.15, 6.03) 0.16 (0.02, 1.53)

1.28 (0.74, 2.05)

1.33 (0.69, 2.32) 1.17 (0.83, 1.61) 0.52 (0.16, 1.64)

1.36 (0.53, 3.53) 1.73 (0.86, 5.51)

100.00

Anh. 5, Abb. 3 Forest Plot, Qualität (+) Studien (bzw. Effektschätzer)

NOTE: Weights are from random effects analysis Overall (I-squared = 16.0%, p = 0.214)

1.41 (1.20, 1.65) 1.37 (0.65, 2.60)

3.33 (0.08, 18.54)

1.11 (0.45, 2.29) 1.56 (0.04, 8.69)

1.30 (0.80, 1.90) 1.17 (0.83, 1.61)

0.79 (0.38, 1.45) 5.30 (1.30, 21.40) 3.30 (1.42, 6.50) 0.95 (0.02, 5.28)

5.67 (1.54, 14.52) 2.11 (0.05, 11.72) 1.50 (1.10, 2.20)

0.70 (0.02, 3.89) 1.36 (0.53, 3.53)

1.04 (0.22, 3.04) ES (95% CI)

1.30 (0.50, 2.60) 2.13 (0.58, 5.46) 1.36 (0.17, 4.91)

1.28 (0.74, 2.05) 0.62 (0.20, 1.45) 2.66 (0.32, 9.62) 0.50 (0.07, 4.86)

1.22 (0.33, 3.11)

10.00 (0.25, 55.60)

2.10 (1.00, 4.70) 1.85 (0.86, 3.98) 0.80 (0.40, 1.50)

1.47 (0.96, 2.24) 1.52 (0.61, 3.14) 0.70 (0.30, 1.70) 3.80 (1.30, 11.10)

100.00

1.41 (1.20, 1.65) 1.37 (0.65, 2.60)

3.33 (0.08, 18.54)

1.11 (0.45, 2.29) 1.56 (0.04, 8.69)

1.30 (0.80, 1.90) 1.17 (0.83, 1.61)

0.79 (0.38, 1.45) 5.30 (1.30, 21.40) 3.30 (1.42, 6.50) 0.95 (0.02, 5.28)

5.67 (1.54, 14.52) 2.11 (0.05, 11.72) 1.50 (1.10, 2.20)

0.70 (0.02, 3.89) 1.36 (0.53, 3.53)

1.04 (0.22, 3.04) ES (95% CI)

1.30 (0.50, 2.60) 2.13 (0.58, 5.46) 1.36 (0.17, 4.91)

1.28 (0.74, 2.05) 0.62 (0.20, 1.45) 2.66 (0.32, 9.62) 0.50 (0.07, 4.86)

1.22 (0.33, 3.11)

10.00 (0.25, 55.60)

2.10 (1.00, 4.70) 1.85 (0.86, 3.98) 0.80 (0.40, 1.50)

1.47 (0.96, 2.24) 1.52 (0.61, 3.14) 0.70 (0.30, 1.70) 3.80 (1.30, 11.10)

100.00

Anh. 5, Abb. 4 Forest Plot, Qualität (-) Studien (bzw. Effektschätzer)

NOTE: Weights are from random effects analysis Overall (I-squared = 31.4%, p = 0.010)

1.41 (1.27, 1.56) 2.30 (1.30, 3.80) 0.60 (0.20, 1.90)

0.79 (0.21, 2.02) 1.01 (0.20, 2.95)

2.18 (0.26, 7.86) 1.19 (0.78, 1.73)

1.56 (0.62, 3.23) 1.69 (1.05, 2.59)

15.40 (1.45, 56.58) 1.21 (1.04, 1.41)

1.45 (1.06, 1.93)

15.38 (1.45, 56.58) 3.13 (0.00, 17.91)

1.84 (1.07, 2.82)

1.05 (0.56, 1.80)

0.59 (0.08, 3.29) 1.05 (0.81, 1.35)

3.29 (0.86, 8.51) 0.52 (0.16, 1.64)

1.90 (0.18, 5.46)

1.80 (0.75, 4.32) 1.18 (0.78, 1.71)

1.21 (0.12, 4.60) 2.09 (1.14, 3.51) 4.35 (0.90, 12.71)

1.53 (0.42, 3.93) 0.17 (0.03, 1.68)

1.18 (0.38, 3.65) 2.67 (1.10, 6.10)

1.03 (0.54, 1.99) 1.14 (0.30, 2.95)

0.32 (0.06, 0.95)

2.10 (1.05, 3.76) 1.32 (0.43, 3.07) 16.65 (2.26, 122.50)

1.40 (0.75, 2.42) 2.50 (0.00, 14.33)

1.42 (0.17, 5.14) 0.96 (0.14, 9.35) 28.27 (0.00, 99.99)

1.14 (0.93, 1.38)

1.33 (0.69, 2.32)

1.30 (0.50, 3.20) ES (95% CI)

0.60 (0.00, 2.35) 2.91 (1.02, 8.33) 1.73 (0.86, 5.51)

1.64 (0.15, 6.03) 0.81 (0.17, 2.37) 2.13 (1.50, 2.93)

1.72 (0.63, 4.70) 3.57 (0.00, 20.47)

0.63 (0.21, 1.48) 1.41 (0.38, 3.62)

0.59 (0.06, 2.16)

1.57 (0.51, 4.87)

1.44 (0.82, 2.34)

1.56 (0.75, 2.87) 6.40 (0.80, 7.90) 1.29 (0.42, 3.91) 1.34 (0.82, 2.07)

4.28 (0.25, 72.49) 0.39 (0.01, 2.19)

1.29 (1.17, 1.43) 0.16 (0.02, 1.53)

1.74 (1.05, 2.73) 0.90 (0.40, 2.10)

100.00

1.41 (1.27, 1.56) 2.30 (1.30, 3.80) 0.60 (0.20, 1.90)

0.79 (0.21, 2.02) 1.01 (0.20, 2.95)

2.18 (0.26, 7.86) 1.19 (0.78, 1.73)

1.56 (0.62, 3.23) 1.69 (1.05, 2.59)

15.40 (1.45, 56.58) 1.21 (1.04, 1.41)

1.45 (1.06, 1.93)

15.38 (1.45, 56.58) 3.13 (0.00, 17.91)

1.84 (1.07, 2.82)

1.05 (0.56, 1.80)

0.59 (0.08, 3.29) 1.05 (0.81, 1.35)

3.29 (0.86, 8.51) 0.52 (0.16, 1.64)

1.90 (0.18, 5.46)

1.80 (0.75, 4.32) 1.18 (0.78, 1.71)

1.21 (0.12, 4.60) 2.09 (1.14, 3.51) 4.35 (0.90, 12.71)

1.53 (0.42, 3.93) 0.17 (0.03, 1.68)

1.18 (0.38, 3.65) 2.67 (1.10, 6.10)

1.03 (0.54, 1.99) 1.14 (0.30, 2.95)

0.32 (0.06, 0.95)

2.10 (1.05, 3.76) 1.32 (0.43, 3.07) 16.65 (2.26, 122.50)

1.40 (0.75, 2.42) 2.50 (0.00, 14.33)

1.42 (0.17, 5.14) 0.96 (0.14, 9.35) 28.27 (0.00, 99.99)

1.14 (0.93, 1.38)

1.33 (0.69, 2.32)

1.30 (0.50, 3.20) ES (95% CI)

0.60 (0.00, 2.35) 2.91 (1.02, 8.33) 1.73 (0.86, 5.51)

1.64 (0.15, 6.03) 0.81 (0.17, 2.37) 2.13 (1.50, 2.93)

1.72 (0.63, 4.70) 3.57 (0.00, 20.47)

0.63 (0.21, 1.48) 1.41 (0.38, 3.62)

0.59 (0.06, 2.16)

1.57 (0.51, 4.87)

1.44 (0.82, 2.34)

1.56 (0.75, 2.87) 6.40 (0.80, 7.90) 1.29 (0.42, 3.91) 1.34 (0.82, 2.07)

4.28 (0.25, 72.49) 0.39 (0.01, 2.19)

1.29 (1.17, 1.43) 0.16 (0.02, 1.53)

1.74 (1.05, 2.73) 0.90 (0.40, 2.10)

100.00

Anh. 5, Abb. 5 Forest Plot, Fall-Kontroll-Studien

NOTE: Weights are from random effects analysis Overall (I-squared = 55.1%, p = 0.005)

Zagraniski (1986) DeStefani (1998)

Zheng (1992) Shangina (2006) Maier (1992)

Gustavsson_hiPAH (1998)

Russi (1997) Muscat (1992)

Wortley (1992) Ahrens (1991)

Berrino (2003)

Imbernon (1995) Cauvin (1989) ID

Becher (2005)

Elci (2009) Study

1.55 (1.20, 2.00) 2.10 (1.00, 4.70) 0.80 (0.40, 1.50)

1.30 (0.50, 3.20) 1.72 (0.63, 4.70) 2.67 (1.10, 6.10) 1.47 (0.96, 2.24)

1.05 (0.81, 1.35) 6.40 (0.80, 7.90)

1.30 (0.50, 2.60) 0.60 (0.20, 1.90)

0.70 (0.30, 1.70)

2.30 (1.30, 3.80) 2.91 (1.02, 8.33) ES (95% CI)

3.80 (1.30, 11.10)

1.50 (1.10, 2.20)

100.00 6.29 7.44

5.03 4.51 5.57 10.50

12.84 3.74

5.84 3.84

5.48

8.95 4.24 Weight

4.12

11.60

%

1.55 (1.20, 2.00) 2.10 (1.00, 4.70) 0.80 (0.40, 1.50)

1.30 (0.50, 3.20) 1.72 (0.63, 4.70) 2.67 (1.10, 6.10) 1.47 (0.96, 2.24)

1.05 (0.81, 1.35) 6.40 (0.80, 7.90)

1.30 (0.50, 2.60) 0.60 (0.20, 1.90)

0.70 (0.30, 1.70)

2.30 (1.30, 3.80) 2.91 (1.02, 8.33) ES (95% CI)

3.80 (1.30, 11.10)

1.50 (1.10, 2.20)

100.00 6.29 7.44

5.03 4.51 5.57 10.50

12.84 3.74

5.84 3.84

5.48

8.95 4.24 Weight

4.12

11.60

%

1

.01 .1 1 10 100

Anh. 5, Abb. 6 Forest Plot, Kohortenstudien

NOTE: Weights are from random effects analysis Overall (I-squared = 18.4%, p = 0.080)

1.38 (1.27, 1.51) 1.03 (0.54, 1.99) 2.11 (0.05, 11.72) 1.41 (0.38, 3.62)

1.56 (0.75, 2.87) 1.30 (0.80, 1.90) 0.52 (0.16, 1.64) 1.34 (0.82, 2.07) 1.01 (0.20, 2.95)

0.16 (0.02, 1.53)

1.45 (1.06, 1.93) 1.29 (0.42, 3.91) 1.04 (0.22, 3.04)

2.09 (1.14, 3.51) 0.70 (0.02, 3.89) 2.13 (0.58, 5.46)

1.64 (0.15, 6.03)

1.56 (0.62, 3.23) 1.53 (0.42, 3.93) 0.81 (0.17, 2.37) 2.66 (0.32, 9.62)

4.35 (0.90, 12.71) 0.39 (0.01, 2.19)

1.05 (0.56, 1.80) 1.14 (0.30, 2.95)

0.63 (0.21, 1.48) 1.69 (1.05, 2.59)

1.44 (0.82, 2.34) 1.29 (1.17, 1.43) 1.80 (0.75, 4.32) 0.96 (0.14, 9.35) 2.50 (0.00, 14.33) 1.22 (0.33, 3.11)

3.57 (0.00, 20.47) 0.90 (0.40, 2.10)

0.17 (0.03, 1.68)

15.38 (1.45, 56.58) 0.32 (0.06, 0.95) 1.52 (0.61, 3.14) ES (95% CI)

1.17 (0.83, 1.61)

0.79 (0.38, 1.45) 1.40 (0.75, 2.42) 1.36 (0.17, 4.91)

0.59 (0.06, 2.16) 1.90 (0.18, 5.46)

0.62 (0.20, 1.45) 1.11 (0.45, 2.29)

3.29 (0.86, 8.51) 1.73 (0.86, 5.51)

0.60 (0.00, 2.35)

1.57 (0.51, 4.87) 1.37 (0.65, 2.60) 0.79 (0.21, 2.02)

28.27 (0.00, 99.99) 10.00 (0.25, 55.60) 5.67 (1.54, 14.52)

2.18 (0.26, 7.86) 1.28 (0.74, 2.05) 1.84 (1.07, 2.82)

1.42 (0.17, 5.14) 1.18 (0.78, 1.71)

2.13 (1.50, 2.93)

1.32 (0.43, 3.07) 1.36 (0.53, 3.53)

3.33 (0.08, 18.54)

4.28 (0.25, 72.49) 0.95 (0.02, 5.28)

5.30 (1.30, 21.40) 3.30 (1.42, 6.50)

15.40 (1.45, 56.58) 1.85 (0.86, 3.98)

1.21 (0.12, 4.60) 1.74 (1.05, 2.73) 0.50 (0.07, 4.86)

1.21 (1.04, 1.41) 1.56 (0.04, 8.69)

1.19 (0.78, 1.73)

2.10 (1.05, 3.76) 3.13 (0.00, 17.91)

1.18 (0.38, 3.65) 16.65 (2.26, 122.50)

0.59 (0.08, 3.29) 1.33 (0.69, 2.32) 1.14 (0.93, 1.38)

100.00

1.38 (1.27, 1.51) 1.03 (0.54, 1.99) 2.11 (0.05, 11.72) 1.41 (0.38, 3.62)

1.56 (0.75, 2.87) 1.30 (0.80, 1.90) 0.52 (0.16, 1.64) 1.34 (0.82, 2.07) 1.01 (0.20, 2.95)

0.16 (0.02, 1.53)

1.45 (1.06, 1.93) 1.29 (0.42, 3.91) 1.04 (0.22, 3.04)

2.09 (1.14, 3.51) 0.70 (0.02, 3.89) 2.13 (0.58, 5.46)

1.64 (0.15, 6.03)

1.56 (0.62, 3.23) 1.53 (0.42, 3.93) 0.81 (0.17, 2.37) 2.66 (0.32, 9.62)

4.35 (0.90, 12.71) 0.39 (0.01, 2.19)

1.05 (0.56, 1.80) 1.14 (0.30, 2.95)

0.63 (0.21, 1.48) 1.69 (1.05, 2.59)

1.44 (0.82, 2.34) 1.29 (1.17, 1.43) 1.80 (0.75, 4.32) 0.96 (0.14, 9.35) 2.50 (0.00, 14.33) 1.22 (0.33, 3.11)

3.57 (0.00, 20.47) 0.90 (0.40, 2.10)

0.17 (0.03, 1.68)

15.38 (1.45, 56.58) 0.32 (0.06, 0.95) 1.52 (0.61, 3.14) ES (95% CI)

1.17 (0.83, 1.61)

0.79 (0.38, 1.45) 1.40 (0.75, 2.42) 1.36 (0.17, 4.91)

0.59 (0.06, 2.16) 1.90 (0.18, 5.46)

0.62 (0.20, 1.45) 1.11 (0.45, 2.29)

3.29 (0.86, 8.51) 1.73 (0.86, 5.51)

0.60 (0.00, 2.35)

1.57 (0.51, 4.87) 1.37 (0.65, 2.60) 0.79 (0.21, 2.02)

28.27 (0.00, 99.99) 10.00 (0.25, 55.60) 5.67 (1.54, 14.52)

2.18 (0.26, 7.86) 1.28 (0.74, 2.05) 1.84 (1.07, 2.82)

1.42 (0.17, 5.14) 1.18 (0.78, 1.71)

2.13 (1.50, 2.93)

1.32 (0.43, 3.07) 1.36 (0.53, 3.53)

3.33 (0.08, 18.54)

4.28 (0.25, 72.49) 0.95 (0.02, 5.28)

5.30 (1.30, 21.40) 3.30 (1.42, 6.50)

15.40 (1.45, 56.58) 1.85 (0.86, 3.98)

1.21 (0.12, 4.60) 1.74 (1.05, 2.73) 0.50 (0.07, 4.86)

1.21 (1.04, 1.41) 1.56 (0.04, 8.69)

1.19 (0.78, 1.73)

2.10 (1.05, 3.76) 3.13 (0.00, 17.91)

1.18 (0.38, 3.65) 16.65 (2.26, 122.50)

0.59 (0.08, 3.29) 1.33 (0.69, 2.32) 1.14 (0.93, 1.38)

100.00

Anh. 5, Abb. 7 Forest Plot, Studien (bzw. Effektschätzer) nach Art der Effektschätzer

NOTE: Weights are from random effects analysis .

Subtotal (I-squared = 15.7%, p = 0.224) Kennaway_metal (1947)

Subtotal (I-squared = 41.5%, p = 0.091) Kennaway_gas (1947)

Subtotal (I-squared = 18.5%, p = 0.152) Tola (1988)

Subtotal (I-squared = 53.4%, p = 0.006)

Spinelli (2006)

1.41 (1.29, 1.53) 1.52 (0.61, 3.14)

1.85 (0.86, 3.98) 2.50 (0.00, 14.33)

1.18 (0.78, 1.71)

1.36 (0.53, 3.53) 0.62 (0.20, 1.45)

3.33 (0.08, 18.54) 1.05 (0.81, 1.35)

1.19 (0.78, 1.73) 0.79 (0.21, 2.02)

1.18 (0.38, 3.65) 1.28 (0.74, 2.05)

1.57 (0.51, 4.87)

1.64 (0.26, 10.24) 0.16 (0.02, 1.53)

1.22 (0.33, 3.11)

15.40 (1.45, 56.58) 1.32 (0.43, 3.07)

0.59 (0.08, 3.29) 1.34 (0.82, 2.07)

15.38 (1.45, 56.58) 1.34 (1.18, 1.53) 1.74 (1.05, 2.73) 2.67 (1.10, 6.10) 1.72 (0.63, 4.70)

5.30 (1.30, 21.40) 1.30 (0.50, 3.20)

1.05 (0.56, 1.80) 1.36 (0.17, 4.91)

1.21 (1.04, 1.41) 1.40 (0.75, 2.42)

0.17 (0.03, 1.68)

1.79 (1.05, 3.06) 0.59 (0.06, 2.16)

1.53 (0.42, 3.93) 10.00 (0.25, 55.60) 1.01 (0.20, 2.95)

1.21 (0.12, 4.60)

1.37 (0.65, 2.60) 0.52 (0.16, 1.64) 0.80 (0.40, 1.50)

3.13 (0.00, 17.91)

5.67 (1.54, 14.52) 0.70 (0.30, 1.70)

0.50 (0.07, 4.86)

1.29 (0.42, 3.91) 0.60 (0.00, 2.35)

1.30 (0.80, 1.90) 0.95 (0.02, 5.28)

1.04 (0.22, 3.04)

1.03 (0.54, 1.99) 1.14 (0.93, 1.38)

2.10 (1.05, 3.76) 1.56 (0.04, 8.69)

1.40 (1.24, 1.58) 0.63 (0.21, 1.48) 0.90 (0.40, 2.10) ES (95% CI)

1.11 (0.45, 2.29)

1.44 (0.82, 2.34) 1.56 (0.62, 3.23)

2.13 (0.58, 5.46)

2.09 (1.14, 3.51) 2.18 (0.26, 7.86)

0.70 (0.02, 3.89) 1.33 (0.69, 2.32) 3.80 (1.30, 11.10) 0.60 (0.20, 1.90)

1.17 (0.83, 1.61)

1.45 (1.06, 1.93)

0.81 (0.17, 2.37) 1.47 (0.96, 2.24)

4.35 (0.90, 12.71) 2.66 (0.32, 9.62)

16.65 (2.26, 122.50) 1.69 (1.05, 2.59)

1.42 (0.17, 5.14) 0.96 (0.14, 9.35) 3.57 (0.00, 20.47)

1.90 (0.18, 5.46) 1.14 (0.30, 2.95)

2.13 (1.50, 2.93)

3.30 (1.42, 6.50) 1.56 (0.75, 2.87) 0.39 (0.01, 2.19) 2.10 (1.00, 4.70)

1.73 (0.86, 5.51)

1.80 (0.75, 4.32)

1.29 (1.17, 1.43)

1.64 (0.15, 6.03)

28.27 (0.00, 99.99) 4.28 (0.25, 72.49) 1.84 (1.07, 2.82) 6.40 (0.80, 7.90)

1.50 (1.17, 1.92)

0.79 (0.38, 1.45) 0.32 (0.06, 0.95) 1.50 (1.10, 2.20) 2.91 (1.02, 8.33)

1.41 (0.38, 3.62)

2.11 (0.05, 11.72) 3.29 (0.86, 8.51) 2.30 (1.30, 3.80)

1.30 (0.50, 2.60)

100.00

1.41 (1.29, 1.53) 1.52 (0.61, 3.14)

1.85 (0.86, 3.98) 2.50 (0.00, 14.33)

1.18 (0.78, 1.71)

1.36 (0.53, 3.53) 0.62 (0.20, 1.45)

3.33 (0.08, 18.54) 1.05 (0.81, 1.35)

1.19 (0.78, 1.73) 0.79 (0.21, 2.02)

1.18 (0.38, 3.65) 1.28 (0.74, 2.05)

1.57 (0.51, 4.87)

1.64 (0.26, 10.24) 0.16 (0.02, 1.53)

1.22 (0.33, 3.11)

15.40 (1.45, 56.58) 1.32 (0.43, 3.07)

0.59 (0.08, 3.29) 1.34 (0.82, 2.07)

15.38 (1.45, 56.58) 1.34 (1.18, 1.53) 1.74 (1.05, 2.73) 2.67 (1.10, 6.10) 1.72 (0.63, 4.70)

5.30 (1.30, 21.40) 1.30 (0.50, 3.20)

1.05 (0.56, 1.80) 1.36 (0.17, 4.91)

1.21 (1.04, 1.41) 1.40 (0.75, 2.42)

0.17 (0.03, 1.68)

1.79 (1.05, 3.06) 0.59 (0.06, 2.16)

1.53 (0.42, 3.93) 10.00 (0.25, 55.60) 1.01 (0.20, 2.95)

1.21 (0.12, 4.60)

1.37 (0.65, 2.60) 0.52 (0.16, 1.64) 0.80 (0.40, 1.50)

3.13 (0.00, 17.91)

5.67 (1.54, 14.52) 0.70 (0.30, 1.70)

0.50 (0.07, 4.86)

1.29 (0.42, 3.91) 0.60 (0.00, 2.35)

1.30 (0.80, 1.90) 0.95 (0.02, 5.28)

1.04 (0.22, 3.04)

1.03 (0.54, 1.99) 1.14 (0.93, 1.38)

2.10 (1.05, 3.76) 1.56 (0.04, 8.69)

1.40 (1.24, 1.58) 0.63 (0.21, 1.48) 0.90 (0.40, 2.10) ES (95% CI)

1.11 (0.45, 2.29)

1.44 (0.82, 2.34) 1.56 (0.62, 3.23)

2.13 (0.58, 5.46)

2.09 (1.14, 3.51) 2.18 (0.26, 7.86)

0.70 (0.02, 3.89) 1.33 (0.69, 2.32) 3.80 (1.30, 11.10) 0.60 (0.20, 1.90)

1.17 (0.83, 1.61)

1.45 (1.06, 1.93)

0.81 (0.17, 2.37) 1.47 (0.96, 2.24)

4.35 (0.90, 12.71) 2.66 (0.32, 9.62)

16.65 (2.26, 122.50) 1.69 (1.05, 2.59)

1.42 (0.17, 5.14) 0.96 (0.14, 9.35) 3.57 (0.00, 20.47)

1.90 (0.18, 5.46) 1.14 (0.30, 2.95)

2.13 (1.50, 2.93)

3.30 (1.42, 6.50) 1.56 (0.75, 2.87) 0.39 (0.01, 2.19) 2.10 (1.00, 4.70)

1.73 (0.86, 5.51)

1.80 (0.75, 4.32)

1.29 (1.17, 1.43)

1.64 (0.15, 6.03)

28.27 (0.00, 99.99) 4.28 (0.25, 72.49) 1.84 (1.07, 2.82) 6.40 (0.80, 7.90)

1.50 (1.17, 1.92)

0.79 (0.38, 1.45) 0.32 (0.06, 0.95) 1.50 (1.10, 2.20) 2.91 (1.02, 8.33)

1.41 (0.38, 3.62)

2.11 (0.05, 11.72) 3.29 (0.86, 8.51) 2.30 (1.30, 3.80)

1.30 (0.50, 2.60)

100.00

Anh. 5, Abb. 8 Forest Plot, Studien (bzw. Effektschätzer) bei Frauen

NOTE: Weights are from random effects analysis .

.

Overall (I-squared = 24.2%, p = 0.199) Frauen

Eisen_2 (2001) Eisen_3 (2001)

Subtotal (I-squared = 0.0%, p = 0.434)

Pukkala_Fdruck (2009) Wortley (1992)

Aronson_F (1999)

Pukkala_Fkamin (2009) Männer u. Frauen ID

Becher (2005)

Solionova_F (1993) Ji_Fdruck (2005)

Subtotal (I-squared = 39.4%, p = 0.129) Gustavsson_elgrph (1995)

Eisen_1 (2001) Study

Pukkala_Fgießer (2009) Olsen_Fdruck (1987)

2.00 (1.40, 2.85) 1.36 (0.53, 3.53) 1.85 (0.86, 3.98)

1.70 (1.18, 2.45)

2.09 (1.14, 3.51) 1.30 (0.50, 2.60)

16.65 (2.26, 122.50)

0.96 (0.14, 9.35) ES (95% CI)

3.80 (1.30, 11.10)

15.40 (1.45, 56.58) 0.60 (0.00, 2.35)

2.59 (1.25, 5.36) 10.00 (0.25, 55.60) 1.37 (0.65, 2.60)

1.42 (0.17, 5.14) 1.57 (0.51, 4.87)

100.00 9.97 13.26

60.18

18.59 12.07

2.88

2.65 Weight

8.31

3.37 0.81

39.82 1.63 14.94

%

3.84 7.68

2.00 (1.40, 2.85) 1.36 (0.53, 3.53) 1.85 (0.86, 3.98)

1.70 (1.18, 2.45)

2.09 (1.14, 3.51) 1.30 (0.50, 2.60)

16.65 (2.26, 122.50)

0.96 (0.14, 9.35) ES (95% CI)

3.80 (1.30, 11.10)

15.40 (1.45, 56.58) 0.60 (0.00, 2.35)

2.59 (1.25, 5.36) 10.00 (0.25, 55.60) 1.37 (0.65, 2.60)

1.42 (0.17, 5.14) 1.57 (0.51, 4.87)

100.00 9.97 13.26

60.18

18.59 12.07

2.88

2.65 Weight

8.31

3.37 0.81

39.82 1.63 14.94

%

3.84 7.68

1

.01 .1 1 10 100

Anh. 5, Abb. 9 Forest Plot, Studien (bzw. Effektschätzer) bei Männern

NOTE: Weights are from random effects analysis Overall (I-squared = 23.3%, p = 0.032)

1.37 (1.26, 1.49) 1.64 (0.15, 6.03) 1.29 (0.42, 3.91)

1.30 (0.80, 1.90) 2.91 (1.02, 8.33)

1.44 (0.82, 2.34) 1.17 (0.83, 1.61)

5.30 (1.30, 21.40) 1.52 (0.61, 3.14) 2.66 (0.32, 9.62)

1.05 (0.81, 1.35) 3.57 (0.00, 20.47)

2.67 (1.10, 6.10) 1.19 (0.78, 1.73)

2.10 (1.05, 3.76) 0.80 (0.40, 1.50)

3.30 (1.42, 6.50) 1.41 (0.38, 3.62) 0.16 (0.02, 1.53)

2.18 (0.26, 7.86) 1.74 (1.05, 2.73) 0.59 (0.06, 2.16)

0.81 (0.17, 2.37) 1.22 (0.33, 3.11) 1.14 (0.30, 2.95)

1.90 (0.18, 5.46) 1.36 (0.17, 4.91)

1.29 (1.17, 1.43) 2.13 (0.58, 5.46)

1.69 (1.05, 2.59) 0.95 (0.02, 5.28)

1.30 (0.50, 3.20) 0.62 (0.20, 1.45) 0.52 (0.16, 1.64)

1.45 (1.06, 1.93) 0.17 (0.03, 1.68) 1.32 (0.43, 3.07) 1.84 (1.07, 2.82) 0.39 (0.01, 2.19)

4.35 (0.90, 12.71)

15.38 (1.45, 56.58) 4.28 (0.25, 72.49)

2.13 (1.50, 2.93)

1.53 (0.42, 3.93)

2.10 (1.00, 4.70) 6.40 (0.80, 7.90) 1.11 (0.45, 2.29)

1.05 (0.56, 1.80) 1.18 (0.78, 1.71)

1.14 (0.93, 1.38)

3.29 (0.86, 8.51) ES (95% CI)

0.90 (0.40, 2.10)

0.32 (0.06, 0.95) 5.67 (1.54, 14.52) 3.13 (0.00, 17.91)

1.56 (0.62, 3.23) 3.33 (0.08, 18.54)

1.04 (0.22, 3.04) 2.11 (0.05, 11.72)

1.28 (0.74, 2.05)

1.80 (0.75, 4.32) 2.50 (0.00, 14.33) 1.47 (0.96, 2.24)

1.03 (0.54, 1.99)

1.18 (0.38, 3.65) 0.70 (0.02, 3.89)

28.27 (0.00, 99.99) 1.56 (0.04, 8.69)

1.21 (1.04, 1.41)

1.72 (0.63, 4.70) 1.50 (1.10, 2.20)

1.21 (0.12, 4.60) 1.40 (0.75, 2.42) 1.01 (0.20, 2.95)

0.59 (0.08, 3.29) 0.63 (0.21, 1.48) 0.50 (0.07, 4.86) 0.70 (0.30, 1.70) 1.34 (0.82, 2.07)

0.79 (0.21, 2.02)

1.33 (0.69, 2.32) 1.73 (0.86, 5.51) 0.60 (0.20, 1.90)

0.79 (0.38, 1.45) 2.30 (1.30, 3.80)

1.56 (0.75, 2.87)

100.00

1.37 (1.26, 1.49) 1.64 (0.15, 6.03) 1.29 (0.42, 3.91)

1.30 (0.80, 1.90) 2.91 (1.02, 8.33)

1.44 (0.82, 2.34) 1.17 (0.83, 1.61)

5.30 (1.30, 21.40) 1.52 (0.61, 3.14) 2.66 (0.32, 9.62)

1.05 (0.81, 1.35) 3.57 (0.00, 20.47)

2.67 (1.10, 6.10) 1.19 (0.78, 1.73)

2.10 (1.05, 3.76) 0.80 (0.40, 1.50)

3.30 (1.42, 6.50) 1.41 (0.38, 3.62) 0.16 (0.02, 1.53)

2.18 (0.26, 7.86) 1.74 (1.05, 2.73) 0.59 (0.06, 2.16)

0.81 (0.17, 2.37) 1.22 (0.33, 3.11) 1.14 (0.30, 2.95)

1.90 (0.18, 5.46) 1.36 (0.17, 4.91)

1.29 (1.17, 1.43) 2.13 (0.58, 5.46)

1.69 (1.05, 2.59) 0.95 (0.02, 5.28)

1.30 (0.50, 3.20) 0.62 (0.20, 1.45) 0.52 (0.16, 1.64)

1.45 (1.06, 1.93) 0.17 (0.03, 1.68) 1.32 (0.43, 3.07) 1.84 (1.07, 2.82) 0.39 (0.01, 2.19)

4.35 (0.90, 12.71)

15.38 (1.45, 56.58) 4.28 (0.25, 72.49)

2.13 (1.50, 2.93)

1.53 (0.42, 3.93)

2.10 (1.00, 4.70) 6.40 (0.80, 7.90) 1.11 (0.45, 2.29)

1.05 (0.56, 1.80) 1.18 (0.78, 1.71)

1.14 (0.93, 1.38)

3.29 (0.86, 8.51) ES (95% CI)

0.90 (0.40, 2.10)

0.32 (0.06, 0.95) 5.67 (1.54, 14.52) 3.13 (0.00, 17.91)

1.56 (0.62, 3.23) 3.33 (0.08, 18.54)

1.04 (0.22, 3.04) 2.11 (0.05, 11.72)

1.28 (0.74, 2.05)

1.80 (0.75, 4.32) 2.50 (0.00, 14.33) 1.47 (0.96, 2.24)

1.03 (0.54, 1.99)

1.18 (0.38, 3.65) 0.70 (0.02, 3.89)

28.27 (0.00, 99.99) 1.56 (0.04, 8.69)

1.21 (1.04, 1.41)

1.72 (0.63, 4.70) 1.50 (1.10, 2.20)

1.21 (0.12, 4.60) 1.40 (0.75, 2.42) 1.01 (0.20, 2.95)

0.59 (0.08, 3.29) 0.63 (0.21, 1.48) 0.50 (0.07, 4.86) 0.70 (0.30, 1.70) 1.34 (0.82, 2.07)

0.79 (0.21, 2.02)

1.33 (0.69, 2.32) 1.73 (0.86, 5.51) 0.60 (0.20, 1.90)

0.79 (0.38, 1.45) 2.30 (1.30, 3.80)

1.56 (0.75, 2.87)

100.00

Anh. 5, Abb. 10 Forest Plot, Studien (bzw. Effektschätzer): Aluminium-Herstellung

NOTE: Weights are from random effects analysis Overall (I-squared = 0.0%, p = 0.520)

1.43 (1.13, 1.80) 1.36 (0.17, 4.91) 3.30 (1.42, 6.50)

2.50 (0.00, 14.33)

1.18 (0.38, 3.65) ES (95% CI)

2.66 (0.32, 9.62)

2.13 (0.58, 5.46)

0.79 (0.38, 1.45) 2.11 (0.05, 11.72)

1.30 (0.80, 1.90) 3.33 (0.08, 18.54)

1.04 (0.22, 3.04) 1.52 (0.61, 3.14)

1.22 (0.33, 3.11) 0.95 (0.02, 5.28)

0.70 (0.02, 3.89)

1.11 (0.45, 2.29) 0.81 (0.17, 2.37) 0.50 (0.07, 4.86)

5.67 (1.54, 14.52) 1.56 (0.04, 8.69)

100.00

1.43 (1.13, 1.80) 1.36 (0.17, 4.91) 3.30 (1.42, 6.50)

2.50 (0.00, 14.33)

1.18 (0.38, 3.65) ES (95% CI)

2.66 (0.32, 9.62)

2.13 (0.58, 5.46)

0.79 (0.38, 1.45) 2.11 (0.05, 11.72)

1.30 (0.80, 1.90) 3.33 (0.08, 18.54)

1.04 (0.22, 3.04) 1.52 (0.61, 3.14)

1.22 (0.33, 3.11) 0.95 (0.02, 5.28)

0.70 (0.02, 3.89)

1.11 (0.45, 2.29) 0.81 (0.17, 2.37) 0.50 (0.07, 4.86)

5.67 (1.54, 14.52) 1.56 (0.04, 8.69)

100.00

Anh. 5, Abb. 11 Forest Plot, Studien (bzw. Effektschätzer) : Asphalt/Teer-Exponierte

NOTE: Weights are from random effects analysis Overall (I-squared = 51.0%, p = 0.021)

Zheng (1992)

Kennaway_asphalt (1947) ID

Hansen (1989)

Swaen_teer (1997) Moulin (1988) Ahrens (1991)

Kennaway_teer (1947) Boffetta (2003)

Imbernon (1995)

Stern (2000) DeStefani (1998)

Maier (1992) Study

1.30 (0.95, 1.78) 1.30 (0.50, 3.20) 1.40 (0.75, 2.42) ES (95% CI)

4.35 (0.90, 12.71)

0.59 (0.08, 3.29) 0.17 (0.03, 1.68) 0.60 (0.20, 1.90)

0.32 (0.06, 0.95) 1.34 (0.82, 2.07)

2.30 (1.30, 3.80)

1.45 (1.06, 1.93) 0.80 (0.40, 1.50)

2.67 (1.10, 6.10)

100.00 7.28 11.80 Weight

4.38

2.49 2.02 5.60

4.12 13.98

12.66

17.00 10.62

8.04

%

1.30 (0.95, 1.78) 1.30 (0.50, 3.20) 1.40 (0.75, 2.42) ES (95% CI)

4.35 (0.90, 12.71)

0.59 (0.08, 3.29) 0.17 (0.03, 1.68) 0.60 (0.20, 1.90)

0.32 (0.06, 0.95) 1.34 (0.82, 2.07)

2.30 (1.30, 3.80)

1.45 (1.06, 1.93) 0.80 (0.40, 1.50)

2.67 (1.10, 6.10)

100.00 7.28 11.80 Weight

4.38

2.49 2.02 5.60

4.12 13.98

12.66

17.00 10.62

8.04

%

1

.01 .1 1 10 100

Anh. 5, Abb. 12 Forest Plot, Studien (bzw. Effektschätzer): Drucker

Anh. 5, Abb. 13 Forest Plot, Studien (bzw. Effektschätzer): Electrographit-Herstellung

NOTE: Weights are from random effects analysis Overall (I-squared = 4.2%, p = 0.398)

ID

Olsen_Fdruck (1987)

Pukkala_Mdruck (2009) Kennaway_druck (1947) Kvam (2005)

Pukkala_Fdruck (2009) Ji_Mdruck (2005)

Olsen_Mdruck (1987) Study

Ji_Fdruck (2005)

1.24 (1.10, 1.39) ES (95% CI)

1.57 (0.51, 4.87)

1.21 (1.04, 1.41) 1.14 (0.93, 1.38) 1.19 (0.78, 1.73)

2.09 (1.14, 3.51) 1.84 (1.07, 2.82)

1.03 (0.54, 1.99) 0.60 (0.00, 2.35)

100.00 Weight

1.06

47.19 30.47 8.23

4.20 5.62

3.14

%

0.09

1.24 (1.10, 1.39) ES (95% CI)

1.57 (0.51, 4.87)

1.21 (1.04, 1.41) 1.14 (0.93, 1.38) 1.19 (0.78, 1.73)

2.09 (1.14, 3.51) 1.84 (1.07, 2.82)

1.03 (0.54, 1.99) 0.60 (0.00, 2.35)

100.00 Weight

1.06

47.19 30.47 8.23

4.20 5.62

3.14

%

0.09

1

.01 .1 1 10 100

NOTE: Weights are from random effects analysis Overall (I-squared = 31.4%, p = 0.233)

Study

Donato (2000) ID

Gustavsson_elgrph (1995)

Merlo (2004)

1.33 (0.52, 3.38) 0.79 (0.21, 2.02) ES (95% CI)

10.00 (0.25, 55.60)

1.32 (0.43, 3.07)

100.00

%

41.07 Weight

10.73

48.21

1.33 (0.52, 3.38) 0.79 (0.21, 2.02) ES (95% CI)

10.00 (0.25, 55.60)

1.32 (0.43, 3.07)

100.00

%

41.07 Weight

10.73

48.21

1

.01 .1 1 10 100

Anh. 5, Abb. 14 Forest Plot, Studien (bzw. Effektschätzer): Gießerei

NOTE: Weights are from random effects analysis Overall (I-squared = 0.0%, p = 0.885)

1.27 (1.16, 1.38) 1.33 (0.69, 2.32) 0.90 (0.40, 2.10)

1.29 (1.17, 1.43)

1.44 (0.82, 2.34) 4.28 (0.25, 72.49)

1.64 (0.15, 6.03) 1.42 (0.17, 5.14) 0.39 (0.01, 2.19) 1.01 (0.20, 2.95) ES (95% CI)

1.28 (0.74, 2.05) 28.27 (0.00, 99.99) 1.73 (0.86, 5.51)

1.17 (0.83, 1.61)

0.62 (0.20, 1.45) 1.18 (0.78, 1.71) 1.14 (0.30, 2.95) 1.29 (0.42, 3.91) 0.16 (0.02, 1.53)

100.00

1.27 (1.16, 1.38) 1.33 (0.69, 2.32) 0.90 (0.40, 2.10)

1.29 (1.17, 1.43)

1.44 (0.82, 2.34) 4.28 (0.25, 72.49)

1.64 (0.15, 6.03) 1.42 (0.17, 5.14) 0.39 (0.01, 2.19) 1.01 (0.20, 2.95) ES (95% CI)

1.28 (0.74, 2.05) 28.27 (0.00, 99.99) 1.73 (0.86, 5.51)

1.17 (0.83, 1.61)

0.62 (0.20, 1.45) 1.18 (0.78, 1.71) 1.14 (0.30, 2.95) 1.29 (0.42, 3.91) 0.16 (0.02, 1.53)

100.00

Anh. 5, Abb. 15 Forest Plot, Studien (bzw. Effektschätzer): Gummi-Herstellung

NOTE: Weights are from random effects analysis Overall (I-squared = 39.1%, p = 0.118) Muscat (1992)

Veys (2004) Solionova_F (1993)

Wingren (2007) Straif (2000) ID

Solionova_M (1993) Olsen_Mgummi (1987)

Szeszenia (1991) Study

2.41 (1.54, 3.79) 6.40 (0.80, 7.90)

1.56 (0.75, 2.87) 15.40 (1.45, 56.58)

2.10 (1.05, 3.76) 5.30 (1.30, 21.40) ES (95% CI)

1.21 (0.12, 4.60) 1.80 (0.75, 4.32)

1.56 (0.62, 3.23)

100.00 10.71

19.57 5.16

20.42 7.98 Weight

5.16 15.01

15.98

%

2.41 (1.54, 3.79) 6.40 (0.80, 7.90)

1.56 (0.75, 2.87) 15.40 (1.45, 56.58)

2.10 (1.05, 3.76) 5.30 (1.30, 21.40) ES (95% CI)

1.21 (0.12, 4.60) 1.80 (0.75, 4.32)

1.56 (0.62, 3.23)

100.00 10.71

19.57 5.16

20.42 7.98 Weight

5.16 15.01

15.98

%

1

.01 .1 1 10 100

Anh. 5, Abb. 16 Forest Plot, Studien (bzw. Effektschätzer): Kokereiarbeiter

NOTE: Weights are from random effects analysis Overall (I-squared = 0.0%, p = 0.476) Study

Swaen_kokerei (1991) Kennaway_kokerei (1947) ID

2.20 (1.60, 3.04) 3.29 (0.86, 8.51) 2.13 (1.50, 2.93) ES (95% CI)

100.00

%

7.91 92.09 Weight

2.20 (1.60, 3.04) 3.29 (0.86, 8.51) 2.13 (1.50, 2.93) ES (95% CI)

100.00

%

7.91 92.09 Weight

1

.01 .1 1 10 100

Anh. 5, Abb. 17 Forest Plot, Studien (bzw. Effektschätzer): MWF- Exponierte/Automobil-Herstellung

NOTE: Weights are from random effects analysis Overall (I-squared = 58.4%, p = 0.006)

Eisen_2 (2001) Eisen_1 (2001)

Eisen_3 (2001)

Waldron (1975) ID

Aronson_F (1999)

Tola (1988)

Kennaway_metal (1947)

Wortley (1992) Cauvin (1989) Aronson_M (1999)

Zagraniski (1986) Russi (1997) Study

1.55 (1.10, 2.20) 1.36 (0.53, 3.53) 1.37 (0.65, 2.60)

1.85 (0.86, 3.98)

15.38 (1.45, 56.58) ES (95% CI)

16.65 (2.26, 122.50)

0.63 (0.21, 1.48) 1.74 (1.05, 2.73)

1.30 (0.50, 2.60) 2.91 (1.02, 8.33) 0.52 (0.16, 1.64)

2.10 (1.00, 4.70) 1.05 (0.81, 1.35)

100.00 7.59 10.29

9.44

2.98 Weight

2.58

7.34 13.10

8.80 6.73 5.90

9.35 15.92

%

1.55 (1.10, 2.20) 1.36 (0.53, 3.53) 1.37 (0.65, 2.60)

1.85 (0.86, 3.98)

15.38 (1.45, 56.58) ES (95% CI)

16.65 (2.26, 122.50)

0.63 (0.21, 1.48) 1.74 (1.05, 2.73)

1.30 (0.50, 2.60) 2.91 (1.02, 8.33) 0.52 (0.16, 1.64)

2.10 (1.00, 4.70) 1.05 (0.81, 1.35)

100.00 7.59 10.29

9.44

2.98 Weight

2.58

7.34 13.10

8.80 6.73 5.90

9.35 15.92

%

1

.01 .1 1 10 100

Anh. 5, Abb. 18 Forest Plot, Studien (bzw. Effektschätzer): Schornsteinfeger

NOTE: Weights are from random effects analysis Overall (I-squared = 0.0%, p = 0.852) Ji_Mkamin (2005)

ID

Grimm (1987) Evanoff (1993)

Pukkala_Fkamin (2009) Kennaway_kamin (1947)

Pukkala_Mkamin (2009) Study

1.42 (1.02, 1.98) 1.90 (0.18, 5.46) ES (95% CI)

3.57 (0.00, 20.47) 1.41 (0.38, 3.62)

0.96 (0.14, 9.35) 1.69 (1.05, 2.59)

1.05 (0.56, 1.80)

100.00 3.74 Weight

0.47 8.56

2.49 52.84

31.90

%

1.42 (1.02, 1.98) 1.90 (0.18, 5.46) ES (95% CI)

3.57 (0.00, 20.47) 1.41 (0.38, 3.62)

0.96 (0.14, 9.35) 1.69 (1.05, 2.59)

1.05 (0.56, 1.80)

100.00 3.74 Weight

0.47 8.56

2.49 52.84

31.90

%

1

.01 .1 1 10 100

Danksagung

Wir möchten uns bei Claudia Fenz'l, Dr. Frank Thalau, Dr. Angela Neumeyer-Gromen und Mario Müller für ihre wertvolle Unterstützung bedanken. Unser Dank gilt auch Dr.

Gabriele Menzel und Soja Nazarov für die kompetente Beteiligung an der Entwick-lung und Umsetzung des Suchstrings. Besonders gedankt sei Prof. Peter Schlatt-mann für die Unterstützung bei der Metaanalyse sowie Verena-Maria Weihofen für die Koordination der Erstellung des Abschlussberichts.