A New Synthesis of Two Naturally Occurring Dihydrobenzo[b]furan-Type Neolignans of Potential Biological Activity

Sub- stitution and cyclization was realized in a one-pot route B by reaction of the 2-chloro-3-cyanopyridine with sodium sulfide and methyl bromoacetate in DMF in the presence of

In con- trast to the crystal structure, the structure in CDCl 3 solution, as previously determined in an elaborate NMR-spectroscopic study [9], shows a compactly folded conformation,

Institut f¨ur Chemie, Technische Universit¨at Berlin, Straße des 17.Juni 135, 10623 Berlin, Germany Reprint requests to Dr.Elisabeth Irran.Fax: +49 30 314

a Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06330 Ankara, TurkeyZ.

The results given in Table II indicate that among the new compounds tested, only compound 4h showed a somewhat higher antifungal activity against C.. albicans ATCC 10231 than

b Cancer Biology Laboratory, Center of Excellence for Advanced Sciences, Biochemistry Department, National Research Center, Dokki 12622, Cairo, Egypt..

The effect of the test compounds on the proliferation of macrophages and T-lymphocytes suggested that the skeleton of the bromome- thyl thiazolo[3,2-a]-benzimidazole structure was

c The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofi a 1113, Bulgaria.. * Author for correspondence and