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Anticancer Activity of Tirucallane Triterpenoids from Amoora dasyclada Shu-Min Yang

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Anticancer Activity of Tirucallane Triterpenoids from Amoora dasyclada

Shu-Min Yang

a,b

, Qi-Shi Song

a

, Chen Qing

c

, Da-Gang Wu

b

, and Xi-Kui Liu

b,

*

a Xishuangbanna Tropical Botanical Garden, the Chinese Academy of Sciences, Kunming, Yunnan 650223, P.R. China

b State Key Laboratory of Phytochemistry and Plant Resources in West China,

Kunming Institute of Botany, the Chinese Academy of Sciences, Kunming, Yunnan 650204, P.R. China. Fax: +86-8 71-5 15 02 27. E-mail: liuxikui@mail.kib.ac.cn

c Yunnan Pharmacological Laboratory of Natural Products, Kunming Medical College, Kunming, Yunnan 650031, P.R. China

* Author for correspondence and reprint requests

Z. Naturforsch.61 c,193Ð195 (2006); received August9/October 17, 2005

A new tetranortriterpene 3α-acetoxy-24,25,26,27-tetranortirucalla-7-ene-23(21)-lactone (3), and eleven other compounds were isolated from the twigs ofAmoora dasyclada. The struc- ture of compound 3 was identified on the basis of spectroscopic data, and the bioactive experiments of 1and3Ð5againstAGZY 83-a (human lung cancer cells) and SMMC-7721 (human liver cancer cells) are documented. Among them, compound 5exhibited a strong activity against SMMC-7721.

Key words: Amoora dasyclada, Tirucallane Triterpenoid, Anticancer Activity

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