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Body weight at 2 month of age

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100 20 25

30 Wildtype

Heterocygote NoxO1 mutant

total bodyweight[g]

Body weight at 2 month of age

Male Female

Supplemental figure 1 ctl

DPI solvent

WT DPI solvent

NoxO1-/- DPI solvent AmplexRed assay from colon tissue

B C

WT NoxO1-/- AmplexRed assay normalized to tissue weight A

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