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Biotransformation of Indole Derivatives by Mycelial Cultures Julio Alarco´ n

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Biotransformation of Indole Derivatives by Mycelial Cultures

Julio Alarco´n

a,

*, Eliseo Cid

a

, Luis Lillo

a

, Carlos Ce´spedes

a

, Sergio Aguila

b

, and Joel B. Alderete

b

a Departamento de Ciencias Ba´sicas, Universidad del Bı´o-Bı´o, Chilla´n, Chile.

Fax: +56-42-25 30 46. E-mail: jualarcon@ubiobio.cl

bDepartamento de Quı´mica Orga´nica, Facultad de Ciencias Quı´micas, Universidad de Concepcio´n, Concepcio´n, Chile

* Author for correspondence and reprint requests

Z. Naturforsch.63 c, 82Ð84 (2008); received May 25/July 5, 2007

Biotransformation of tryptophan to tryptamine and 3-methyl-indole byPsilocybe copro- philawas performed. On the other hand,Aspergillus nigerwas able to transform tryptophan to 5-hydroxy-tryptophan.P. coprophilabiotransformed 5-hydroxy-tryptophan to 5-hydroxy- tryptamine. These results prove once more that fungi are good tools to establish hydroxy- indole derivatives.

Key words:Biotransformation,Psilocybe coprophila,Aspergillus niger

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