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Half-inhibition Concentrations of New Cholinesterase Inhibitors Pavla Zdrazˇilova´

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Half-inhibition Concentrations of New Cholinesterase Inhibitors

Pavla Zdrazˇilova´

a,

*, Sˇa´rka Sˇteˇpa´nkova´

b

, Karel Komers

a

, Karel Ventura

b

, and Alexander C ˇ egan

c

a Faculty of Chemical Technology, University of Pardubice, Department of Physical Chemistry, na´m. Cˇ s. legiı´ 565, 532 10 Pardubice, Czech Republic.

Fax: (0 04 20 46) 6 03 70 68. E-mail: ZdrazilovaP@atlas.cz

b Department of Analytical Chemistry, University of Pardubice, na´m. Cˇ s. legiı´ 565, 532 10 Pardubice, Czech Republic

c Department of Biological and Biochemical Sciences, University of Pardubice, Sˇtrossova 239, 532 10 Pardubice, Czech Republic

* Author for correspondence and reprint requests

Z. Naturforsch.59 c,293Ð296 (2004); received July 7/September 26, 2003

The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested.

The determined pI50values (= negative logarithm of the molar concentration inhibiting the enzyme activity by 50%) of the tested substances were compared with pI50values of the commercially used drugs for the Alzheimer’s disease treatmentÐrivastigmine and galanth- amine.

Key words:Cholinesterases, Inhibitors, Index pI50

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