Supplementary Materials
Supplementary Table 1. Methods - Databases and Case definitions
Data type Database Data collected
Population data CNEPCE
(Centro Nacional de Epidemiología, Prevención y Control de
Enfermedades [Center for Disease Control, Epidemiology and
Prevention]) INEI
(Instituto Nacional de Estadística e Informática [National Statistics and Informatics Institute])
GE cases and deaths
Population statistics
Vaccine coverage Dirección General de Intervenciones Estratégicas en Salud Pública
[Department of Health]
RV vaccine coverage
Case definitions ICD-10 Codes ICD-9 Codes
GE A00 -A09: Intestinal Infectious
Disease
001-009
ICD: International Classification of Diseases; GE: gastroenteritis; RV: rotavirus
Supplementary Table 2. Percent change in GE morbidity (/1,000) and mortality (/100,000) incidence in children <5 years of age post-vaccination (multivariate Poisson model)
% reduction (95%CI), p GE ambulatory care
National -10.7 (-11.4, -10.1), p<0.0001
Costa -24.2 (-24.8, -23.6), p<0.0001
Sierra -3.4 (-6.0, -0.8), p=0.0001
Selva 44.8 (42.0, 47.7), p<0.0001a
GE hospitalization
National -17.2 (-23.1, -10.8), p<0.0001
Costa -21.2 (-27.5, -14.4), p<0.0001
Sierra -21.7 (-40.5, 3.0), p=0.1473
Selva -8.7 (-26.2, 12.9), p=0.1514
GE mortality
National -37.3 (-41.7, -32.5), p<0.0001
Costa -69.4 (-72.5, -66.1), p<0.0001
Sierra -17.9 (-30.2, -3.4), p=0.0527
Selva 152.4 (118.7, 191.2), p<0.0001a
a These values represent a percent increase; 95%CI: 95% confidence interval; GE:
gastroenteritis
Supplementary Figure 1. Regional graphs (GE mortality and morbidity incidence trends)
Vertical bar: transition period when vaccination was implemented; GE: gastroenteritis, N:
number, y: years.
