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Seasonal Variation of Kaurenoic Acid, a Hypoglycemic Diterpene Present in Wedelia paludosa (Acmela brasiliensis) (Asteraceae)

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Seasonal Variation of Kaurenoic Acid, a Hypoglycemic Diterpene Present in Wedelia paludosa (Acmela brasiliensis) (Asteraceae)

Louisiane Faccio V. Bresciani

a

, Rosendo Augusto Yunes

a

, Cristiani Bürger

b

, Luis Eduardo De Oliveira

b

, Kaueˆ Leal Bo´f

b

, and Valdir Cechinel-Filho

b,

*

a Departamento de Quı´mica, Universidade Federal de Santa Catarina (UFSC), 88040-900, Floriano´polis, SC, Brazil

b Nu´cleo de Investigac¸o˜es Quı´mico-Farmaceˆuticas (NIQFAR), CCS, Universidade do Vale do Itajaı´ (UNIVALI), 88302-202, Itajaı´, SC, Brazil. Fax: 55 02 14 73 41 76 01.

E-mail: cechinel@univali.br

* Author for correspondence and reprint requests

Z. Naturforsch.59 c,229Ð232 (2004); received August 14/September 17, 2003

We evaluated the variation of the concentration of kaurenoic acid (1), which is a bioactive diterpene, in leaves, flowers, stems and roots fromWedelia paludosa(Acmela brasiliensis) for different seasons using the HRGC/FID method. The results indicated that the concentration of1is higher in the roots and stems during the autumn. The pharmacological results sug- gested that kaurenoic acid is responsible, at least in part, for the hypoglycemic potential detected in this plant.

Key words: Wedelia paludosa, Kaurenoic Acid, Hypoglycemic Effect

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