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Derivatization Does Not Influence Antimicrobial and Antifungal Activities of Applanoxidic Acids and Sterols from Ganoderma spp.

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Derivatization Does Not Influence Antimicrobial and Antifungal Activities of Applanoxidic Acids and Sterols from Ganoderma spp.

Artur Smania Jr.

a,*

, Elza F. A. Smania

a

, Franco Delle Monache

b

, Moacir G. Pizzolatti

c

, and Giuliano Delle Monache

a

a Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Catarina, Florianopolis, SC 88040-900, Brazil. Fax: +55-48-3 31 92 58. E-mail: smania@mbox1.ufsc.br, artursmania@hotmail.com

b Istituto di Biochimica e Biochimica Clinica, Universita` Cattolica Del Sacro Cuore, Roma Italy

c Departamento de Quı´mica, Universidade Federal de Santa Catarina, Florianopolis, Brazil

* Author for correspondence and reprint requests Z. Naturforsch.61 c, 31Ð34 (2006); received July 7, 2005

Applanoxidic acids and sterols, isolated from Ganoderma spp., were acetylated and/or methylated. The antibacterial activity againstEscherichia coliandStaphylococcus aureusand the antifungal activity againstCandida albicansandTrichophyton mentagrophytesof the de- rivatives were investigated by a microdilution method, and compared with those of the natu- ral products. Both natural and modified compounds exhibited comparable antibacterial and antifungal activities in a range of 1.0 to > 2.0 mg/ml minimal inhibitory concentration.

Key words:Applanoxidic Acids, Sterols, Derivatization, Antibacterial and Antifungal Activity

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