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Antifungal Activity of Tetrahydroquinolines against Some Phytopathogenic Fungi

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Antifungal Activity of Tetrahydroquinolines against Some Phytopathogenic Fungi

Margarita Gutiérreza,*, Unai Carmonaa, Gabriel Vallejosb, and Luis Astudilloa

a Laboratory of Organic Synthesis, Institute of Chemistry of Natural Resources, University of Talca, Casilla 747, Talca, Chile. E-mail: mgutierrez@utalca.cl

b Bioorganic Laboratory, Institute of Chemistry, Science Faculty,

Austral University of Chile, Valdivia, Casilla 567, Isla Teja S/N, Valdivia, Chile

* Author for correspondence and reprint requests

Z. Naturforsch. 67 c, 551 – 556 (2012); received January 16/July 27, 2012

Seven synthetic tetrahydroquinolines with different substitution patterns were obtained by an imino Diels-Alder condensation reaction and were evaluated against phytopathogenic fungi. Compounds with a methoxy group showed interesting activity against Cladosporium cladosporoides with a MIC value of 13.75 µg/mL

Key words: Substituted Tetrahydroquinolines, Antifungal, Imino Diels-Alder Reaction

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