• Keine Ergebnisse gefunden

Below 50 nm nonlinear core-shell nanomarkers for imaging in turbid media

N/A
N/A
Protected

Academic year: 2022

Aktie "Below 50 nm nonlinear core-shell nanomarkers for imaging in turbid media"

Copied!
1
0
0

Wird geladen.... (Jetzt Volltext ansehen)

Volltext

(1)

Below 50 nm nonlinear core-shell nanomarkers for imaging in turbid media

Eugene Kim March-December 2012

Supervisor: Dr. Rachel Grange (rachel.grange@uni-jena.de, 0049-3641-947848) Location: Multiphoton Lab, Friedrich Schiller University Jena, Germany

Lab website: http://www.asp.uni-jena.de/multiphoton_lab.html

Address: Institute of Applied Physics, Albert-Einstein Strasse 15, D-07745 Jena, Germany

Abstract

Barium titanate (BaTiO₃) nanoparticles are one of the second harmonic generation (SHG) nanoparticles, which can be applied as exogenous probes for imaging systems. In the first part of this project, for the first time to my best knowledge BaTiO₃ nanoparticles whose diameters are below 50 nm have been investigated. The size distribution measurements of BaTiO₃ nanoparticles via dynamic light scattering (DLS) and transmission electron microscopy (TEM) images show that the mean size of the BaTiO₃ nanoparticles is around 15 nm. The SHG signals from the BaTiO₃ nanoparticles with the diameter from 22 to 53 nm are characterized experimentally and theoretically. The SHG power shows the quadratic dependence with respect to the incident power, which proves the obtained signals are indeed SHG. The polarization dependent SHG response is in good agreement with the simulation result while revealing the information on the orientation of the crystal axis of individual particles.

A plasmonic core-shell nanocavity is known to enhance the SHG signal under the resonance conditions. Therefore, in the second part of this project, the plasmonic BaTiO₃/Au core-shell nanostructures were investigated theoretically and experimentally. The theoretical modeling gives the quantitative enhancement value at a given wavelength of the incident light and shows the effects of different shell thickness on the enhancement of the incident light. The BaTiO₃/Au core-shell nanostructures were fabricated via chemical synthesis. The spectral measurements of the core-shell nanostructures determine the resonance wavelength.

As the last part of the project, Imaging through highly scattering media using BaTiO₃ nanoparticles as nanomarkers were studied theoretically and experimentally. The SHG efficiency through a mouse liver tissue with the thickness 10, 20, and 30 μm was calculated using a Multilayer Monte-Carlo approach. Multiphoton imaging of BaTiO₃ nanoparticles demonstrated the comparable value with the simulation result.

Referenzen

ÄHNLICHE DOKUMENTE

In this paper we suggest to understand social media platforms such as YouTube, Instagram, Twitter, Facebook and community forums as a kind of archives for writing African

To provide further evidence of the location of nanoparticles in the cell and to demonstrate that appropriate nanoparticles can be distinguished in optical microscopy after

Novel magnetic iron oxide nanoparticles coated with poly(ethylene imine)-g-poly(ethylene glycol) for potential biomedical application: synthesis, stability,

“We had the best economy in the history of the world, better than China, better than any country in the world, better than any country’s ever had,” he said, waving his hand at

It has been our interest to elaborate another significant catalytic activity of TiO 2 NPs for the synthesis of tetrahydrobenzo[c]acridinone deriva- tives 5a–h by a

Users must submit a registration form (available on the MPBIC website) including a short project outline describing the work plan, preliminary experiments, experience with

• Differentiated tax rates on electricity consumption according to the carbon emis- sions and/or radioactive waste content resulting from its generation could be im- plemented at

Thus, in this thesis the focus regarding ILs in the process of peptide synthesis was laid on two distinct reaction types: first, native chemical ligation (NCL) for the