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In vitro Effects of Chlorpyrifos on the Acetylcholinesterase Activity of Euryhaline Fish, Oreochromis mossambicus

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In vitro Effects of Chlorpyrifos on the Acetylcholinesterase Activity of Euryhaline Fish, Oreochromis mossambicus

Janapala Venkateswara Rao* and Pathakoti Kavitha

Toxicology Unit, Biology Division, Indian Institute of Chemical Technology, Hyderabad 500 607 (AP), India.

Fax: +91 (40) 27 19 32 27.

E-mail: jviict@gmail.com; jvrao@in.com

* Author for correspondence and reprint requests Z. Naturforsch. 65 c, 303 – 306 (2010); received October 12/November 19, 2009

The in vitro effect of a widely used organophosphorus insecticide, chlorpyrifos (CPP), on the acetylcholineste- rase (AChE) activity was studied in vitro. The kinetic constants Km and Vmax and the bimolecular constant ki were determined in vitro. The in vitro AChE study in- dicated that CPP is neurotoxic and that it alters the ap- parent Km values widely in a concentration-dependent manner, resulting in a competitive type of inhibition.

Based on the ki values, the sensitivity of AChE in brain is greater than that in gill tissue, at 7.3 · 10 – 5M and 11.92 · 10 – 5M, respectively. The study points to the im- portance of kinetic studies and the results suggest that in biomonitoring programmes brain AChE activity can be a good diagnostic tool for CPP toxicity.

Key words: Acetylcholinesterase, Chlorpyrifos, Oreo- chromis mossambicus

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In vitro Effects of Chlorpyrifos on the Acetylcholinesterase Activity of Euryhaline Fish, Oreochromis mossambicus

investigate the sensitivity of the AChE activity of euryhaline fi sh (Oreochromis mossambicus) brain and gill against chlorpyrifos [CPP, O,O-diethyl-O-